scholarly journals TLR4 Endogenous Ligand S100A8/A9 Levels in Adult-Onset Still’s Disease and Their Association with Disease Activity and Clinical Manifestations

2016 ◽  
Vol 17 (8) ◽  
pp. 1342 ◽  
Author(s):  
Hyoun-Ah Kim ◽  
Jae Han ◽  
Woo-Jung Kim ◽  
Hyun Noh ◽  
Jeong-Mi An ◽  
...  
Keyword(s):  
Disease Activity ◽  
Clinical Manifestations ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Endogenous Ligand ◽  
Still's Disease ◽  
Adult Onset Still's Disease

scholarly journals Pure Red Cell Aplasia with Adult Onset Still’s Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Nicholas Robillard ◽  
Paul Van Nguyen ◽  
Robert Wistaff ◽  
Mikhael Laskine
Keyword(s):  
Clinical Manifestations ◽  
Pure Red Cell Aplasia ◽  
Adult Onset Still’S Disease ◽  
Red Cell ◽  
Adult Onset ◽  
Still’S Disease ◽  
Red Cell Aplasia ◽  
Still's Disease ◽  
Wide Range ◽  
Adult Onset Still's Disease

Adult Onset Still’s Disease (AOSD) is a rare inflammatory syndrome mostly seen in young adults. Known for its wide range of clinical manifestations, AOSD often presents with nonremitting systemic signs and symptoms. Many rare case associations have been described with AOSD, but only few with pure red cell aplasia (PRCA). We are presenting a fourth known case of a young female adult with AOSD and PRCA in the literature.

scholarly journals Serum sTREM-1 in adult-onset Still’s disease: a novel biomarker of disease activity and a potential predictor of the chronic course

Rheumatology ◽  
2020 ◽  
Vol 59 (11) ◽  
pp. 3293-3302 ◽  
Author(s):  
Zhihong Wang ◽  
Huihui Chi ◽  
Yue Sun ◽  
Jialin Teng ◽  
Tienan Feng ◽  
...  
Keyword(s):  
Disease Activity ◽  
Multivariate Logistic Regression Analysis ◽  
Soluble Form ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Potential Predictor ◽  
Still's Disease ◽  
Chronic Course ◽  
Adult Onset Still's Disease

Abstract Objectives Triggering receptor expressed on myeloid cells-1 (TREM-1) is an amplifier of inflammatory signals. Recently, a soluble form of TREM-1 (sTREM-1) was described. This study aimed to investigate the role of serum sTREM-1 in patients with adult-onset Still’s disease (AOSD). Methods Serum sTREM-1 levels were detected in 108 AOSD patients, 88 RA patients and 112 healthy controls (HC). The correlations of sTREM-1 with disease activity, clinical characteristics and laboratory parameters in AOSD patients were analysed by the Spearman correlation test. Risk factors for the chronic course of AOSD were evaluated by multivariate logistic regression analysis. Results AOSD patients had significantly higher serum sTREM-1 levels than RA patients and HC, and serum sTREM-1 levels were correlated with the systemic score, ferritin, leucocyte count, CRP, IL-1β and IL-6. The elevation in the initial sTREM-1 level by itself could discriminate patients developing the chronic course from patients developing the nonchronic course. Moreover, an elevated sTREM-1 level (> 526.4475 pg/ml) was an independent risk factor for the chronic course in active AOSD patients. Furthermore, interfering with TREM-1 engagement led to reductions in the secretion of pro-inflammatory cytokines, such as IL-1β, IL-6 and TNF-α, in neutrophils and monocytes from active AOSD patients. Conclusion Serum sTREM-1 levels are correlated with disease activity, and an elevation in the initial serum sTREM-1 level is a potential predictor of the chronic course in AOSD patients, which currently provides the best predictive model for identifying patients prone to developing the chronic course of AOSD.

Elevated Levels of G-CSF in Patients with Active Phase of Adult-onset Still’s Disease

2020 ◽  
pp. jrheum.200617
Author(s):  
Yudong Liu ◽  
Shulan Zhang ◽  
Changshe Xia ◽  
Jiali Chen ◽  
Chunhong Fan
Keyword(s):  
Disease Activity ◽  
Therapeutic Potential ◽  
Assessment System ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Still's Disease ◽  
Elevated Liver Enzymes ◽  
Csf Levels ◽  
Adult Onset Still's Disease

Objective Neutrophilia is a hallmark of adult-onset Still’s disease (AoSD). We aimed to investigate the levels of granulocyte colony-stimulating factor (G-CSF), an essential regulator of neutrophil production and function, in the pathogenesis of AoSD. Methods Sera were collected from 70 patients with AoSD and 20 healthy controls (HCs). The levels of G-CSF were determined by ELISA. Low-density granulocytes (LDGs) were quantified by flow cytometry. Correlations between G-CSF levels and disease activity, laboratory parameters, or LDGs levels in patients with AoSD were analyzed by Spearman’s correlation test. Results Active AoSD patients presented significantly higher levels of G-CSF compared to inactive AoSD patients (p<0.001) and HCs (p<0.0001). The levels of G-CSF were significantly decreased after active AoSD patients achieved disease remission (p=0.0015). The levels of G-CSF were significantly correlated with CRP, ESR, ferritin and systemic score in AoSD (p<0.0001). Significant correlations between the levels of G-CSF and circulating neutrophils (p<0.0001), neutrophil-to-lymphocyte ratio (p<0.0001), percentages of LDGs in the PBMCs (p=0.0042) as well as absolute numbers of circulating LDGs (p=0.0180) were identified. Patients with fever, evanescent rash, sore throat, arthralgia, myalgia, lymphadenopathy or hepatomegaly/elevated liver enzymes displayed significantly higher levels of G-CSF compared to patients without these manifestations (p<0.05). Conclusion Our findings indicate that G-CSF is implicated in the pathogenesis of AoSD, and targeting G-CSF may have therapeutic potential for AoSD. In addition, introducing circulating G-CSF levels into the clinical assessment system may help to monitor disease activity.

Elevated plasma galectin-3 levels and their correlation with disease activity in adult-onset Still’s disease

2020 ◽  
Vol 39 (6) ◽  
pp. 1945-1952 ◽  
Author(s):  
Po-Ku Chen ◽  
Joung-Liang Lan ◽  
Ju-Pi Li ◽  
Ching-Kun Chang ◽  
Shih-Hsin Chang ◽  
...  
Keyword(s):  
Disease Activity ◽  
Adult Onset Still’S Disease ◽  
Adult Onset ◽  
Still’S Disease ◽  
Elevated Plasma ◽  
Still's Disease ◽  
Galectin 3 ◽  
Adult Onset Still's Disease
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