scholarly journals The Clinical Value of High-Intensity Signals on the Coronary Atherosclerotic Plaques: Noncontrast T1-Weighted Magnetic Resonance Imaging

2016 ◽  
Vol 17 (7) ◽  
pp. 1187 ◽  
Author(s):  
Shoichi Ehara ◽  
Kenji Matsumoto ◽  
Kenei Shimada
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Atherosclerotic Plaques ◽  
Resonance Imaging ◽  
Clinical Value ◽  
Weighted Magnetic Resonance Imaging

P3098Association with coronary high-intensity plaque on T1-weighted magnetic resonance imaging and circulating levels of malondialdehyde-modified low-density lipoprotein

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
D Hiraya ◽  
A Sato ◽  
T Hoshi ◽  
T Ichinohe ◽  
S Sakai ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Coronary Artery ◽  
Magnetic Resonance ◽  
High Intensity ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Resonance Imaging ◽  
Weighted Magnetic Resonance Imaging ◽  
Circulating Levels

Abstract Objectives This study aimed to evaluate the association with coronary high-intensity plaque (HIP) on non-contrast T1-weighted magnetic resonance imaging (T1WI) and circulating levels of malondialdehyde-modified low-density lipoprotein (MDA-LDL). Methods A total of 139 patients with coronary artery stenosis (>70%) were imaged with non-contrast T1WI by using a 1.5-T magnetic resonance system (HIP: n=60, non-HIP: n=79). HIP was defined as a signal intensity of coronary plaque to cardiac muscle ratio (PMR) of ≥1.4. At admission, circulating levels of MDA-LDL and other lipid-related markers (triglyceride, HDL, LDL, Lp(a), RLP-C, and EPA/AA) were measured. Results Circulating levels of MDA-LDL (p=0.001) and LDL (p=0.041) were significantly higher in patients with HIP than those without, whereas the other lipid-related markers were not significantly different between both groups. In multivariable logistic regression analysis, MDA-LDL levels were independently associated with the presence of HIP (OR 1.03; 95% CI, 1.00–1.06, p=0.015) after adjusting for cofounding factors (age, sex, triglyceride, LDL, Lp(a), RLP-C, and EPA/AA). The optimal MDA-LDL threshold for predicting coronary HIP was 90.4 U/L, identified by the receiver operating characteristic curve. Conclusion MDA-LDL levels might be associated with the presence of HIP in patients with coronary artery disease.

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