scholarly journals Kidney Injury Molecule-1 Is Specifically Expressed in Cystically-Transformed Proximal Tubules of the PKD/Mhm (cy/+) Rat Model of Polycystic Kidney Disease

2016 ◽  
Vol 17 (6) ◽  
pp. 802 ◽  
Author(s):  
Stefan Gauer ◽  
Anja Urbschat ◽  
Norbert Gretz ◽  
Sigrid Hoffmann ◽  
Bettina Kränzlin ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Kidney Injury ◽  
Proximal Tubules ◽  
Polycystic Kidney ◽  
Kidney Injury Molecule 1

Kidney injury molecule-1 expression in murine polycystic kidney disease

2002 ◽  
Vol 283 (6) ◽  
pp. F1326-F1336 ◽  
Author(s):  
E. Wolfgang Kuehn ◽  
Kwon Moo Park ◽  
Stefan Somlo ◽  
Joseph V. Bonventre
Keyword(s):  
Kidney Disease ◽  
Mouse Model ◽  
Polycystic Kidney Disease ◽  
Autosomal Dominant ◽  
Interstitial Fibrosis ◽  
Kidney Injury ◽  
Polycystic Kidney ◽  
Tubular Cells ◽  
Autosomal Dominant Polycystic Kidney ◽  
Kidney Injury Molecule 1

Kidney injury molecule-1 (Kim-1) is a type 1 membrane protein maximally upregulated in proliferating and dedifferentiated tubular cells after renal ischemia. Because epithelial dedifferentiation, proliferation, and local ischemia may play a role in the pathophysiology of autosomal dominant polycystic kidney disease, we investigated Kim-1 expression in a mouse model of this disease. In the Pkd2WS25/− mouse model for autosomal dominant polycystic kidney disease, cystic kidneys show markedly upregulated Kim-1 levels compared with noncystic control kidneys. Kim-1 is present in a subset of cysts of different sizes and segmental origins and in clusters of proximal tubules near cysts. Kim-1-expressing tubular cells show decreased complexity and quantity of basolateral staining for Na-K-ATPase. Other changes in polarity characteristic of ischemic injury are not present in Kim-1-expressing pericystic tubules. Polycystin-2 expression is preserved in Kim-1-expressing tubules. The interstitium surrounding Kim-1-expressing tubules shows high proliferative activity and staining for smooth muscle α-actin, characteristic of myofibroblasts. Although the functional role of the protein in cysts remains unknown, Kim-1 expression in tubules is strongly associated with partial dedifferentiation of epithelial cells and may play a role in the development of interstitial fibrosis.

scholarly journals Development of multiorgan pathology in thewpk rat model of polycystic kidney disease

2004 ◽  
Vol 277A (2) ◽  
pp. 384-395 ◽  
Author(s):  
Vincent H. Gattone ◽  
Benjamin A. Tourkow ◽  
Chad M. Trambaugh ◽  
Alexander C. Yu ◽  
Shelly Whelan ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Polycystic Kidney

A Rat Model of Chemical-Induced Polycystic Kidney Disease With Multistage Tumors

1999 ◽  
pp. 1738-1739
Author(s):  
F. Ito ◽  
H. Toma ◽  
Y. Yamaguchi ◽  
H. Nakazawa ◽  
S. Onitsuka ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Polycystic Kidney

scholarly journals Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease

1994 ◽  
Vol 46 (1) ◽  
pp. 134-152 ◽  
Author(s):  
Katrin Schäfer ◽  
Norbert Gretz ◽  
Michael Bader ◽  
Ilse Oberbäumer ◽  
Kai-Uwe Eckardt ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Polycystic Kidney

scholarly journals Effects of MCP-1 Inhibition by Bindarit Therapy in a Rat Model of Polycystic Kidney Disease

Nephron ◽  
2014 ◽  
Vol 129 (1) ◽  
pp. 52-61 ◽  
Author(s):  
Carlamaria Zoja ◽  
Daniela Corna ◽  
Monica Locatelli ◽  
Daniela Rottoli ◽  
Anna Pezzotta ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Polycystic Kidney

scholarly journals Effects of lovastatin treatment on the metabolic distributions in the Han:SPRD rat model of polycystic kidney disease

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Jelena Klawitter ◽  
Iram Zafar ◽  
Jost Klawitter ◽  
Alexander T Pennington ◽  
Jacek Klepacki ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Polycystic Kidney ◽  
Lovastatin Treatment

Metabolomic profiling of the autosomal dominant polycystic kidney disease rat model

2011 ◽  
Vol 15 (5) ◽  
pp. 676-687 ◽  
Author(s):  
Takafumi Toyohara ◽  
Takehiro Suzuki ◽  
Yasutoshi Akiyama ◽  
Daisuke Yoshihara ◽  
Yoichi Takeuchi ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Polycystic Kidney Disease ◽  
Rat Model ◽  
Autosomal Dominant ◽  
Polycystic Kidney ◽  
Metabolomic Profiling ◽  
Autosomal Dominant Polycystic Kidney
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