scholarly journals Mechanisms of Cell Killing Response from Low Linear Energy Transfer (LET) Radiation Originating from 177Lu Radioimmunotherapy Targeting Disseminated Intraperitoneal Tumor Xenografts

2016 ◽  
Vol 17 (5) ◽  
pp. 736 ◽  
Author(s):  
Kwon Yong ◽  
Diane Milenic ◽  
Kwamena Baidoo ◽  
Martin Brechbiel
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Cell Killing ◽  
Tumor Xenografts ◽  
Killing Response

DOSE-RATE AND CELL-KILLING SENSITIVITY OF HIGH-LINEAR ENERGY TRANSFER ION BEAM

2018 ◽  
Vol 183 (1-2) ◽  
pp. 219-222
Author(s):  
Y Furusawa ◽  
Y Matsumoto ◽  
R Hirayama ◽  
D Ohsawa ◽  
T Konishi
Keyword(s):  
Energy Transfer ◽  
Dose Rate ◽  
Linear Energy Transfer ◽  
Ion Beam ◽  
Cell Killing ◽  
High Linear Energy Transfer

scholarly journals Differences in Linear Energy Transfer Affect Cell-killing and Radiosensitizing Effects of Spread-out Carbon-ion Beams

2020 ◽  
Vol 40 (10) ◽  
pp. 5497-5502
Author(s):  
SHINTARO SHIBA ◽  
MASARU WAKATSUKI ◽  
TATSUYA OHNO ◽  
TAKASHI NAKANO
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Ion Beams ◽  
Cell Killing ◽  
Carbon Ion

scholarly journals Distinct Roles of Ape1 Protein, an Enzyme Involved in DNA Repair, in High or Low Linear Energy Transfer Ionizing Radiation-induced Cell Killing

2014 ◽  
Vol 289 (44) ◽  
pp. 30635-30644 ◽  
Author(s):  
Hongyan Wang ◽  
Xiang Wang ◽  
Guangnan Chen ◽  
Xiangming Zhang ◽  
Xiaobing Tang ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Cell Killing ◽  
Dna Fragments ◽  
End Joining ◽  
Heavy Charged Particles ◽  
High Let Radiation ◽  
High Let ◽  
Radiation Induced ◽  
Non Homologous End Joining

High linear energy transfer (LET) radiation from space heavy charged particles or a heavier ion radiotherapy machine kills more cells than low LET radiation, mainly because high LET radiation-induced DNA damage is more difficult to repair. Relative biological effectiveness (RBE) is the ratio of the effects generated by high LET radiation to low LET radiation. Previously, our group and others demonstrated that the cell-killing RBE is involved in the interference of high LET radiation with non-homologous end joining but not homologous recombination repair. This effect is attributable, in part, to the small DNA fragments (≤40 bp) directly produced by high LET radiation, the size of which prevents Ku protein from efficiently binding to the two ends of one fragment at the same time, thereby reducing non-homologous end joining efficiency. Here we demonstrate that Ape1, an enzyme required for processing apurinic/apyrimidinic (known as abasic) sites, is also involved in the generation of small DNA fragments during the repair of high LET radiation-induced base damage, which contributes to the higher RBE of high LET radiation-induced cell killing. This discovery opens a new direction to develop approaches for either protecting astronauts from exposure to space radiation or benefiting cancer patients by sensitizing tumor cells to high LET radiotherapy.

scholarly journals Withdrawal: Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing.

2020 ◽  
Vol 295 (18) ◽  
pp. 6249-6249
Author(s):  
Hongyan Wang ◽  
Xiang Wang ◽  
Guangnan Chen ◽  
Xiangming Zhang ◽  
Xiaobing Tang ◽  
...  
Keyword(s):  
Dna Repair ◽  
Energy Transfer ◽  
Ionizing Radiation ◽  
Linear Energy Transfer ◽  
Cell Killing ◽  
Radiation Induced

Unresectable Chondrosarcomas Treated With Carbon Ion Radiotherapy: Relationship Between Dose-averaged Linear Energy Transfer and Local Recurrence

2020 ◽  
Vol 40 (11) ◽  
pp. 6429-6435
Author(s):  
SHINNOSUKE MATSUMOTO ◽  
SUNG HYUN LEE ◽  
REIKO IMAI ◽  
TAKU INANIWA ◽  
NARUHIRO MATSUFUJI ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Local Recurrence ◽  
Linear Energy Transfer ◽  
Carbon Ion Radiotherapy ◽  
Carbon Ion

Low-linear energy transfer radiolysis of liquid water at elevated temperatures up to 350°C: Monte-Carlo simulations

2011 ◽  
Vol 508 (4-6) ◽  
pp. 224-230 ◽  
Author(s):  
S. Sanguanmith ◽  
Y. Muroya ◽  
J. Meesungnoen ◽  
M. Lin ◽  
Y. Katsumura ◽  
...  
Keyword(s):  
Monte Carlo ◽  
Energy Transfer ◽  
Monte Carlo Simulations ◽  
Liquid Water ◽  
Linear Energy Transfer ◽  
Elevated Temperatures

scholarly journals Influence of dose-averaged linear energy transfer on tumour control after carbon-ion radiation therapy for pancreatic cancer

2020 ◽  
Vol 21 ◽  
pp. 19-24 ◽  
Author(s):  
Yasuhito Hagiwara ◽  
Tapesh Bhattacharyya ◽  
Naruhiro Matsufuji ◽  
Yuka Isozaki ◽  
Hirotoshi Takiyama ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Radiation Therapy ◽  
Energy Transfer ◽  
Linear Energy Transfer ◽  
Carbon Ion ◽  
Tumour Control
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