scholarly journals Proteomics-Based Analysis of Protein Complexes in Pluripotent Stem Cells and Cancer Biology

2016 ◽  
Vol 17 (3) ◽  
pp. 432 ◽  
Author(s):  
Putty-Reddy Sudhir ◽  
Chung-Hsuan Chen
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Cancer Biology ◽  
Protein Complexes

scholarly journals Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development

2019 ◽  
Author(s):  
Tomoyuki Koga ◽  
Isaac A. Chaim ◽  
Jorge A. Benitez ◽  
Sebastian Markmiller ◽  
Alison D. Parisian ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Cancer Biology ◽  
Tumor Heterogeneity ◽  
Tumor Development ◽  
Human Tumor ◽  
Genetically Engineered ◽  
Tumor Evolution ◽  
Longitudinal Assessment ◽  
Cellular Models

ABSTRACTMany current cellular models aimed at elucidating cancer biology do not recapitulate pathobiology including tumor heterogeneity, an inherent feature of cancer that underlies treatment resistance. Here we introduce a new cancer modeling paradigm using genetically engineered human pluripotent stem cells (hiPSCs) that capture authentic cancer pathobiology. Orthotopic engraftment of neural progenitor cells derived from hiPSCs that have been genome-edited to contain tumor-associated genetic driver mutations revealed by The Cancer Genome Atlas project for glioblastoma (GBM) result in formation of high-grade gliomas. As observed in GBM patient samples, these models harbor inter-tumor heterogeneity resembling different GBM molecular subtypes, and intra-tumor heterogeneity. Further, re-engraftment of primary tumor neurospheres generates secondary tumors with features characteristic of patient samples and present mutation-dependent patterns of tumor evolution. Thus, these cancer avatar models provide a platform for a comprehensive longitudinal assessment of human tumor development as governed by molecular subtype mutations and lineage-restricted differentiation.

A coherent roadmap to generate either pancreatic acinar or duct-like cells from human pluripotent stem cells challenges pancreatic cancer biology

Pancreatology ◽  
2018 ◽  
Vol 18 (4) ◽  
pp. S123
Author(s):  
Maike Hohwieler ◽  
Markus Breunig ◽  
Jessica Merkle ◽  
Sandra Heller ◽  
Thomas Seufferlein ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Cancer Biology ◽  
Human Pluripotent Stem Cells

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent

Human myocardial extracellular matrix directs the differentiation of pluripotent stem cells toward a cardiomyocyte phenotype

2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
B. Oberwallner ◽  
A. Brodarac ◽  
P. Anic ◽  
T. Saric ◽  
K. Bieback ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Pluripotent Stem Cells

Generation of Clara cells from murine pluripotent stem cells – a new tool to explore airway epithelial regeneration

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
K Katsirntaki ◽  
C Mauritz ◽  
S Schmeckebier ◽  
M Sgodda ◽  
V Puppe ◽  
...  
Keyword(s):  
Stem Cells ◽  
Pluripotent Stem Cells ◽  
Airway Epithelial ◽  
Clara Cells ◽  
Epithelial Regeneration

Differentiation of human pluripotent stem cells into airway epithelial cells

Pneumologie ◽  
2015 ◽  
Vol 69 (07) ◽  
Author(s):  
S Ulrich ◽  
S Weinreich ◽  
R Haller ◽  
S Menke ◽  
R Olmer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epithelial Cells ◽  
Pluripotent Stem Cells ◽  
Airway Epithelial Cells ◽  
Human Pluripotent Stem Cells ◽  
Airway Epithelial
Sign in / Sign up

Export Citation Format

Share Document