scholarly journals Generation of Potent Anti-Vascular Endothelial Growth Factor Neutralizing Antibodies from Mouse Phage Display Library for Cancer Therapy

2016 ◽  
Vol 17 (2) ◽  
pp. 214 ◽  
Author(s):  
Yan-Da Lai ◽  
Yen-Yu Wu ◽  
Yi-Jiue Tsai ◽  
Yi-San Tsai ◽  
Yu-Ying Lin ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Therapy ◽  
Phage Display ◽  
Neutralizing Antibodies ◽  
Phage Display Library ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Novel Short Peptides Isolated From Phage Display Library Inhibit Vascular Endothelial Growth Factor Activity

2007 ◽  
Vol 35 (1) ◽  
pp. 51-64 ◽  
Author(s):  
Berrin Erdag ◽  
Koray B. Balcioglu ◽  
Asli Kumbasar ◽  
Omur Celikbicak ◽  
Gabrielle Zeder-Lutz ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Phage Display ◽  
Phage Display Library ◽  
Short Peptides ◽  
Vascular Endothelial ◽  
Factor Activity ◽  
Endothelial Growth Factor

scholarly journals Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor

2001 ◽  
Vol 47 (4) ◽  
pp. 617-623 ◽  
Author(s):  
Wolfgang Jelkmann
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Neutralizing Antibodies ◽  
Inflammatory Diseases ◽  
Vascular Endothelial ◽  
Malignant Diseases ◽  
Vegf Mrna ◽  
Medline Search ◽  
Healthy Humans ◽  
Endothelial Growth Factor

Abstract Background: Vascular endothelial growth factor (VEGF) is a protein with antiapoptotic, mitogenic, and permeability-increasing activities specific for vascular endothelium. VEGF mRNA, which has five isoforms, is produced by nonmalignant cells in response to hypoxia and inflammation and by tumor cells in constitutively high concentrations. Because VEGF plays a crucial role in physiological and pathophysiological angiogenesis, measurements of circulating VEGF are of diagnostic and prognostic value, e.g., in cardiovascular failures, inflammatory diseases, and malignancies. However, there are major quantitative differences in the published results. This review attempts to identify reasons for these disparities. Approach: The literature was reviewed through a Medline search covering 1995 to 2000. A selection of exemplary references had to be made for this perspective overview. Content: Data are included from studies on healthy humans, gynecological patients, and persons suffering from inflammatory or malignant diseases. The results indicate that competitive immunoassays detect the total amount of circulating VEGF, which enables observations regarding the increase in VEGF in pregnancy and preeclampsia to be made. In these cases, capture immunoassays utilizing neutralizing antibodies are insufficient because of an accompanying increase in VEGF-binding soluble receptors (sFlt-1). Measurements of circulating free VEGF are useful for study of malignant diseases, which are associated with both genetically and hypoxia-induced overproduction of VEGF. The VEGF isoform specificity of the antibodies is also critical because both VEGF121 and VEGF165 are secreted. It is important to consider that platelets and leukocytes release VEGF during blood clotting. Conclusions: Future efforts should concentrate on the balance between free VEGF, total VEGF, and sFlt-1. Plasma, rather than serum, should be used for analysis.

Vascular endothelial growth factor (VEGF) inhibitorsin cancer therapy: an update

2006 ◽  
Vol 6 (3-4) ◽  
pp. 127-136
Author(s):  
Jade Homsi ◽  
Lori C. Kim ◽  
Pamela N. Munster ◽  
Catherine Chodkiewicz ◽  
Adil Daud
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Therapy ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

Vascular endothelial growth factor (VEGF) inhibitorsin cancer therapy: an update

2006 ◽  
Vol 6 (3) ◽  
pp. 127-136
Author(s):  
Jade Homsi ◽  
Lori C. Kim ◽  
Pamela N. Munster ◽  
Catherine Chodkiewicz ◽  
Adil Daud
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cancer Therapy ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor
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