scholarly journals Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury

2015 ◽  
Vol 16 (12) ◽  
pp. 28931-28942 ◽  
Author(s):  
Hiroaki Tsurumaki ◽  
Chihiro Mogi ◽  
Haruka Aoki-Saito ◽  
Masayuki Tobo ◽  
Yosuke Kamide ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protective Role

scholarly journals Protective role of caffeine versus N-acetylcysteine in hyperoxic acute lung injury in neonatal rats

2017 ◽  
Vol 34 (02) ◽  
pp. 058-067
Author(s):  
A. Sadek ◽  
R. Khattab ◽  
A. Amer ◽  
A. Youssef
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Immune Reaction ◽  
Interleukin 1 ◽  
Protective Role ◽  
High Oxygen ◽  
Control Group ◽  
Albino Rats ◽  
Neonatal Rats

Abstract Introduction: Prolonged breathing of high oxygen concentration leads to hyperoxic acute lung injury. Neonatal Respiratory diseases usually require increased supplement of high oxygen concentrations, so neonates are more susceptible to hyperoxic acute lung injury. The aim of this work was to investigate the protective role of caffeine versus N-acetylcysteine against hyperoxic acute lung injury in neonatal rats. Materials and Methods: 32 albino rats aged seven days were used in this experiment. The pups were divided into four groups; 1) Control or normoxic group; rats placed in normoxic chamber where fraction of inspired oxygen (FiO2) was 0.21, 2) Hyperoxic group; rats were placed in hyperoxic chamber (FiO2>0.8) using an oxygen flow of 1.5 Litre/min, 3) Hyperoxia-CAF group; rats exposed to hyperoxia and received a single intra-peritoneal injection of 20 mg/kg caffeine just prior to exposure, and 4) Hyperoxia-NAC group; rats exposed to hyperoxia and received a single intra-peritoneal injection of 150 mg/kg N-acetylcysteine just prior to exposure. 48 hours after exposure, lung specimens were processed for histological and immunohistochemical study using caspase-3, cluster of differentiation-68-antibody (CD68) and interleukin-1-beta (IL-1β). Results: Neonatal hyperoxia led to severe impairment in lung architecture, with a highly significant increase in alveolar macrophages. Also, caspase and IL-1β immune-reaction were increased significantly as compared to control group. Caffeine could improve the histolopathological picture of hyperoxic acute lung injury, and also could decrease alveolar macrophage count and IL-1β immune-reaction better than N-acetylcysteine. Conclusion: Caffeine is more effective than N-acetylcysteine in prophylaxis against hyperoxic acute lung injury in neonates.

Respiratory Defense Mechanisms. The Protective Role of Thioredoxin/ADF in Bleomycin-induced, Acute Lung Injury.

1998 ◽  
Vol 49 (2) ◽  
pp. 109-112
Author(s):  
Shu Hashimoto ◽  
Yasuhiro Gon ◽  
Jyunji Yodoi ◽  
Takashi Horie
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Defense Mechanisms ◽  
Protective Role

Legionella-induced acute lung injury in the setting of hyperoxia: protective role of tumour necrosis factor-α

2004 ◽  
Vol 53 (8) ◽  
pp. 727-733 ◽  
Author(s):  
Chiharu Nara ◽  
Kazuhiro Tateda ◽  
Tetsuya Matsumoto ◽  
Akira Ohara ◽  
Shuichi Miyazaki ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Protective Role ◽  
Tumour Necrosis Factor Α ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Oxidative stress-induced FABP5 S-glutathionylation protects against acute lung injury by suppressing inflammation in macrophages

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuxian Guo ◽  
Yaru Liu ◽  
Shihao Zhao ◽  
Wangting Xu ◽  
Yiqing Li ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Target Genes ◽  
Nuclear Translocation ◽  
Protein S ◽  
Protective Role ◽  
Fatty Acid Binding ◽  
Proteomics Approach

AbstractOxidative stress contributes to the pathogenesis of acute lung injury. Protein S-glutathionylation plays an important role in cellular antioxidant defense. Here we report that the expression of deglutathionylation enzyme Grx1 is decreased in the lungs of acute lung injury mice. The acute lung injury induced by hyperoxia or LPS is significantly relieved in Grx1 KO and Grx1fl/flLysMcre mice, confirming the protective role of Grx1-regulated S-glutathionylation in macrophages. Using a quantitative redox proteomics approach, we show that FABP5 is susceptible to S-glutathionylation under oxidative conditions. S-glutathionylation of Cys127 in FABP5 promotes its fatty acid binding ability and nuclear translocation. Further results indicate S-glutathionylation promotes the interaction of FABP5 and PPARβ/δ, activates PPARβ/δ target genes and suppresses the LPS-induced inflammation in macrophages. Our study reveals a molecular mechanism through which FABP5 S-glutathionylation regulates macrophage inflammation in the pathogenesis of acute lung injury.

scholarly journals The protective role of Prolyl oligopeptidase (POP) inhibition in acute lung injury induced by intestinal ischemia-reperfusion

Oncotarget ◽  
2021 ◽  
Vol 12 (17) ◽  
pp. 1663-1676
Author(s):  
Giovanna Casili ◽  
Sarah Adriana Scuderi ◽  
Marika Lanza ◽  
Alessia Filippone ◽  
Rossella Basilotta ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion ◽  
Protective Role ◽  
Prolyl Oligopeptidase ◽  
Intestinal Ischemia Reperfusion

scholarly journals Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function

2021 ◽  
Vol 16 (1) ◽  
pp. 1064-1081
Author(s):  
Bingnan Guo ◽  
Yigen Peng ◽  
Yuting Gu ◽  
Yi Zhong ◽  
Chenglei Su ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Enhanced Recovery ◽  
Lavage Fluid ◽  
Protective Role ◽  
High Morbidity ◽  
And Function

Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a severe syndrome lacking efficient therapy and resulting in high morbidity and mortality. Although resveratrol (RES), a natural phytoalexin, has been reported to protect the ALI by suppressing the inflammatory response, the detailed mechanism of how RES affected the immune system is poorly studied. Pulmonary conventional dendritic cells (cDCs) are critically involved in the pathogenesis of inflammatory lung diseases including ALI. In this study, we aimed to investigate the protective role of RES via pulmonary cDCs in lipopolysaccharide (LPS)-induced ALI mice. Murine ALI model was established by intratracheally challenging with 5 mg/kg LPS. We found that RES pretreatment could mitigate LPS-induced ALI. Additionally, proinflammatory-skewed cytokines decreased whereas anti-inflammatory-related cytokines increased in bronchoalveolar lavage fluid by RES pretreatment. Mechanistically, RES regulated pulmonary cDCs’ maturation and function, exhibiting lower level of CD80, CD86, major histocompatibility complex (MHC) II expression, and IL-10 secretion in ALI mice. Furthermore, RES modulated the balance between proinflammation and anti-inflammation of cDCs. Moreover, in vitro RES pretreatment regulated the maturation and function of bone marrow derived dendritic cells (BMDCs). Finally, the adoptive transfer of RES-pretreated BMDCs enhanced recovery of ALI. Thus, these data might further extend our understanding of a protective role of RES in regulating pulmonary cDCs against ALI.

Protective Role of Liriodendrin in Sepsis-Induced Acute Lung Injury

Inflammation ◽  
2016 ◽  
Vol 39 (5) ◽  
pp. 1805-1813 ◽  
Author(s):  
Lei Yang ◽  
Dihua Li ◽  
Yuzhen Zhuo ◽  
Shukun Zhang ◽  
Ximo Wang ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Protective Role
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