scholarly journals Specificity Protein 1 Regulates Gene Expression Related to Fatty Acid Metabolism in Goat Mammary Epithelial Cells

2015 ◽  
Vol 16 (1) ◽  
pp. 1806-1820 ◽  
Author(s):  
Jiangjiang Zhu ◽  
Yuting Sun ◽  
Jun Luo ◽  
Min Wu ◽  
Jianhua Li ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Epithelial Cells ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Specificity Protein 1 ◽  
Specificity Protein ◽  
Goat Mammary Epithelial Cells

miR-497 regulates fatty acid synthesis via LATS2 in bovine mammary epithelial cells

2020 ◽  
Vol 11 (10) ◽  
pp. 8625-8636
Author(s):  
Zhi Chen ◽  
Shuangfeng Chu ◽  
Yusheng Liang ◽  
Tianle Xu ◽  
Yujia Sun ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Fatty Acid Synthesis ◽  
Milk Fat ◽  
Acid Metabolism ◽  
Mammary Epithelial Cells ◽  
Acid Synthesis ◽  
Mammary Epithelial ◽  
Bovine Mammary Epithelial Cells ◽  
Fat Synthesis

Both mRNA and miRNA play an important role in the regulation of mammary fatty acid metabolism and milk fat synthesis.

scholarly journals Influence of fatty acid diets on gene expression in rat mammary epithelial cells

2009 ◽  
Vol 38 (1) ◽  
pp. 80-88 ◽  
Author(s):  
M. Medvedovic ◽  
R. Gear ◽  
J. M. Freudenberg ◽  
J. Schneider ◽  
R. Bornschein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Cycle ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Epithelial Cells ◽  
Differential Expression ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Differentially Expressed ◽  
Cell Cycle Genes

Background: This study examines the impact of dietary fatty acids on regulation of gene expression in mammary epithelial cells before and during puberty. Methods: Diets primarily consisted of n-9 monounsaturated fatty acids (olive oil), n-6 polyunsaturated fatty acids (safflower), saturated acids (butter), and the reference AIN-93G diet (soy oil). The dietary regimen mimics the repetitive nature of fatty acid exposure in Western diets. Diet-induced changes in gene expression were examined in laser capture microdissected mammary ductal epithelial cells at day of weaning and end of puberty. PCNA immunohistochemistry analysis compared proliferation rates between diets. Results: Genes differentially expressed between each test diets and the reference diet were significantly enriched by cell cycle genes. Some of these genes were involved in activation of the cell cycle pathway or the G2/M check point pathway. Although there were some differences in the level of differential expression, all diets showed qualitatively the same pattern of differential expression compared to the reference diet. Cluster analysis identified an expanded set of cell cycle as well as immunity and sterol metabolism related clusters of differentially expressed genes. Conclusion: Fatty acid-enriched diets significantly upregulated proliferation above normal physiological levels during puberty. Higher cellular proliferation during puberty caused by enriched fatty acid diets poses a potential increase risk of mammary cancer in later life. The human homologs of 27 of 62 cell cycle rat genes are included in a human breast cancer cluster of 45 cell cycle genes, further emphasizing the importance of our findings in the rat model.

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