scholarly journals Protective Effect of Resveratrol against IL-1β-Induced Inflammatory Response on Human Osteoarthritic Chondrocytes Partly via the TLR4/MyD88/NF-κB Signaling Pathway: An “in Vitro Study”

2014 ◽  
Vol 15 (4) ◽  
pp. 6925-6940 ◽  
Author(s):  
Li Liu ◽  
Hailun Gu ◽  
Huimin Liu ◽  
Yongliang Jiao ◽  
Keyu Li ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Protective Effect ◽  
Signaling Pathway ◽  
In Vitro Study ◽  
Vitro Study ◽  
Osteoarthritic Chondrocytes

scholarly journals Evaluation of the post-treatment anti-inflammatory capacity of osteoarthritic chondrocytes: An in vitro study using baicalein

2020 ◽  
Vol 14 ◽  
pp. 177-183
Author(s):  
Chang-Chin Wu ◽  
Yi-Ru Chen ◽  
Dai-Hua Lu ◽  
Li-Ho Hsu ◽  
Kai-Chiang Yang ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Post Treatment ◽  
Vitro Study ◽  
Osteoarthritic Chondrocytes ◽  
Anti Inflammatory

Hepatotoxic effect of ochratoxin A and citrinin, alone and in combination, and protective effect of vitamin E: In vitro study in HepG2 cell

2015 ◽  
Vol 83 ◽  
pp. 151-163 ◽  
Author(s):  
Loganathan Gayathri ◽  
Rajakumar Dhivya ◽  
Dharumadurai Dhanasekaran ◽  
Vaiyapuri S. Periasamy ◽  
Ali A. Alshatwi ◽  
...  
Keyword(s):  
Vitamin E ◽  
Protective Effect ◽  
Ochratoxin A ◽  
Hepg2 Cell ◽  
In Vitro Study ◽  
Vitro Study ◽  
Hepatotoxic Effect

Platelet Protective Effect of TAK-029, A Novel Glycoprotein IIb/IIIa Antagonist: An In Vitro Study

1998 ◽  
Vol 22 (4) ◽  
pp. 348-352 ◽  
Author(s):  
Koji Kawahito ◽  
Akio Fujimura ◽  
Eiji Kobayashi ◽  
Yoshio Misawa ◽  
Katsuo Fuse
Keyword(s):  
Protective Effect ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals The Melatonin Signaling Pathway in a Long-Term Memory In Vitro Study

Molecules ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 737 ◽  
Author(s):  
Jin-Young Sung ◽  
Ji-Hyun Bae ◽  
Jong-Ha Lee ◽  
Yoon-Nyun Kim ◽  
Dae-Kwang Kim
Keyword(s):  
Signaling Pathway ◽  
In Vitro Study ◽  
Vitro Study ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Possible chondroprotective effect of canakinumab: An in vitro study on human osteoarthritic chondrocytes

2014 ◽  
Vol 22 ◽  
pp. S148
Author(s):  
S. Cheleschi ◽  
N.A. Pascarelli ◽  
O.M. Lucherini ◽  
E. Crainz ◽  
S. Tenti ◽  
...  
Keyword(s):  
In Vitro Study ◽  
Vitro Study ◽  
Osteoarthritic Chondrocytes ◽  
Chondroprotective Effect

scholarly journals Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study

Oncotarget ◽  
2017 ◽  
Vol 8 (24) ◽  
pp. 38602-38617 ◽  
Author(s):  
Yi-Xun Liu ◽  
Guo-Dong Wang ◽  
Xiao Wang ◽  
Yong-Le Zhang ◽  
Tian-Lun Zhang
Keyword(s):  
Knee Osteoarthritis ◽  
Signaling Pathway ◽  
In Vitro Study ◽  
Vitro Study

scholarly journals Kanglexin promotes diabetic wound healing through activating FGFR/ERK1/2 signaling pathway mediated angiogenesis.

2020 ◽  
Author(s):  
Zhao Yixiu ◽  
Xinhui Wang ◽  
Shuang Yang ◽  
Xia Song ◽  
Chao Chen ◽  
...  
Keyword(s):  
Structure Formation ◽  
Signaling Pathway ◽  
In Vitro Study ◽  
Tubular Structure ◽  
Vitro Study ◽  
Diabetic Patients ◽  
Therapeutic Effects ◽  
Study Results ◽  
Diabetic Wounds

Abstract Background: Diabetic wounds (DWs), especially leg or foot ulcers, are common diabetic complications, accounting for about 20% of diabetic patients. At present, there is still lack of effective measures to treat DWs in clinical practice. Kanglexin (KLX) is an anthraquinone compound with vasoprotective effect. This study will explore the therapeutic effects of KLX on DWs and the underlying mechanisms.Method: KM mice were injected with streptozocin (180 mg/kg) intraperitoneally to establish animal model of Type 1 Diabetes. The full-thickness skin wounds with the diameter of 5 mm were prepared on the back of diabetic mice with a skin punch. KLX is dissolved in sterile injection oil and applied to the wound once a day for 14 consecutive days. The wounds were photographed every day and the wound size was analyzed by Image Pro Plus software. On the 3rd, 7th, 11th day after KLX administration, skin tissues with a diameter of 1cm around the wound were fixed in paraformaldehyde and subjected to HE, Masson and immunohistochemical staining. Collagen deposition were evaluated by hydroxyproline kit. Angiogenesis of wound skin was evaluated by recording the formation of new blood vessels on its subsurface. In vitro study, human umbilical vein endothelial cells (HUVECs) were treated with advanced glycation end products (AGEs, 100 μg/mL) to establish the cell model of DWs. The proliferation, migration and tubular structure formation of HUVECs were measured by MTT, scratch and tubule formation experiments, respectively. Phosphorylation of ERK1/2 was detected by Western blot analysis.ResultsFirstly, in-vivo study showed that KLX significantly accelerated the closure of diabetic wounds through promoting granulation tissue formation, collagen synthesis and angiogenesis. Secondly, in vitro study results further confirmed that KLX promoted the proliferation, migration and tubular structure formation of HUVECs. Besides, KLX significantly up-regulated phospho-ERK1/2 both in diabetic wounds and AGEs-treated HUVECs. Thirdly, molecular docking simulation results indicated that there were multiple hydrogen bonds between KLX and FGFR amino acid residues, and FGFR inhibitor PD173074 significantly reversed KLX’s promotion of ERK1/2 phosphorylation and angiogenesis. Conclusions:KLX promotes angiogenesis and accelerates the healing of diabetic wounds by activating FGFR and ERK1/2 signaling pathway.

scholarly journals Alpha-1-antitrypsin suppresses oxidative stress in preeclampsia by inhibiting the p38MAPK signaling pathway: An in vivo and in vitro study

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173711 ◽  
Author(s):  
Ya-Ling Feng ◽  
Yong-Xiang Yin ◽  
Jian Ding ◽  
Hua Yuan ◽  
Lan Yang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
In Vitro Study ◽  
Vitro Study ◽  
P38mapk Signaling ◽  
Alpha 1 Antitrypsin
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