scholarly journals Neuroprotective Effect of Melatonin against Kainic Acid-Induced Oxidative Injury in Hippocampal Slice Culture of Rats

2014 ◽  
Vol 15 (4) ◽  
pp. 5940-5951 ◽  
Author(s):  
Hyung Kim ◽  
Kyung Lee ◽  
Bae Lee
Keyword(s):  
Kainic Acid ◽  
Hippocampal Slice ◽  
Neuroprotective Effect ◽  
Oxidative Injury ◽  
Slice Culture ◽  
Hippocampal Slice Culture

scholarly journals ESP-102, a Combined Herbal Extract ofAngelica gigas,Saururus chinensis, andSchisandra chinensis, Changes Synaptic Plasticity and Attenuates Scopolamine-Induced Memory Impairment in Rat Hippocampus Tissue

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Hyun-Bum Kim ◽  
Eun-Sang Hwang ◽  
Ga-Young Choi ◽  
Seok Lee ◽  
Tae-Suk Park ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Hippocampal Slice ◽  
Neuroprotective Effect ◽  
Long Term Potentiation ◽  
Herbal Extract ◽  
Excitatory Postsynaptic Potential ◽  
Slice Culture ◽  
Neuroprotective Effects ◽  
Hippocampal Slice Culture ◽  
Saururus Chinensis

ESP-102, an extract fromAngelica gigas, Saururus chinensis, andSchisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivitiesin vitroandin vivostudies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array. Our results showed an increase in excitatory postsynaptic potential (EPSP), indicating the induction of long-term potentiation (LTP), in the presence of ESP-102. In addition, the neuroprotective effect of ESP-102 was also tested by application of scopolamine to the hippocampal slice. Interestingly, ESP-102 competitively antagonized the preventative LTP effect induced by scopolamine. The scopolamine-induced reduction in brain-derived neurotrophic factor (BDNF) and GluR-2 expression was also rescued by ESP-102. In terms of mode of action, ESP-102 appears to act on the presynaptic region independent of AMPA/NMDA receptors. Based on these findings, ESP-102 can be suggested as a novel herbal ingredient with memory enhancing as well as neuroprotective effects.

Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture

2010 ◽  
Vol 474 (3) ◽  
pp. 126-130 ◽  
Author(s):  
Kyung Hee Lee ◽  
Ran Won ◽  
Un Jeng Kim ◽  
Ga Min Kim ◽  
Myung-Ae Chung ◽  
...  
Keyword(s):  
Hippocampal Slice ◽  
Slice Culture ◽  
Neuroprotective Effects ◽  
Organotypic Hippocampal Slice Culture ◽  
Hippocampal Slice Culture

Development of mossy fiber synapses in hippocampal slice culture

1994 ◽  
Vol 80 (1-2) ◽  
pp. 244-250 ◽  
Author(s):  
O. Robain ◽  
G. Barbin ◽  
Th. Billette de Villemeur ◽  
L. Jardin ◽  
Th. Jahchan ◽  
...  
Keyword(s):  
Hippocampal Slice ◽  
Mossy Fiber ◽  
Slice Culture ◽  
Hippocampal Slice Culture

P4-169: β-amyloid neurotoxicity in organotypic hippocampal slice culture is attenuated by melatonin: involvement of GSK-3β, tau and neuroinflammation

2009 ◽  
Vol 5 (4S_Part_16) ◽  
pp. P481-P481
Author(s):  
Christianne Salbego ◽  
Juliana B. Hoppe ◽  
Rudimar L. Frozza ◽  
Ana Paula Horn ◽  
Ricardo A. Comiran ◽  
...  
Keyword(s):  
Hippocampal Slice ◽  
Slice Culture ◽  
Organotypic Hippocampal Slice Culture ◽  
Hippocampal Slice Culture ◽  
Β Amyloid ◽  
Gsk 3Β
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