scholarly journals Dual Drug Release Electrospun Core-Shell Nanofibers with Tunable Dose in the Second Phase

2014 ◽  
Vol 15 (1) ◽  
pp. 774-786 ◽  
Author(s):  
Wei Qian ◽  
Deng-Guang Yu ◽  
Ying Li ◽  
Yao-Zu Liao ◽  
Xia Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Second Phase ◽  
Dual Drug

Dual Drug Release from Core–Shell Nanoparticles with Distinct Release Profiles

2014 ◽  
Vol 103 (10) ◽  
pp. 3205-3216 ◽  
Author(s):  
Yang Cao ◽  
Bochu Wang ◽  
Yazhou Wang ◽  
Deshuai Lou
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles ◽  
Dual Drug ◽  
Release Profiles

scholarly journals Dual-drug release from chitin-based core-shell microspheres fabricated by coaxial electrospray

2017 ◽  
Vol 37 (5) ◽  
pp. 1366-1373 ◽  
Author(s):  
Yu Shang ◽  
Fuyuan Ding ◽  
Jian Liu ◽  
Ling Xiao ◽  
Hongbing Deng ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Coaxial Electrospray ◽  
Dual Drug

Fabrication of core–shell micro/nanoparticles for programmable dual drug release by emulsion electrospraying

2013 ◽  
Vol 15 (6) ◽  
Author(s):  
Yazhou Wang ◽  
Yiqiong Zhang ◽  
Bochu Wang ◽  
Yang Cao ◽  
Qingsong Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Dual Drug

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2351
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Release Rate ◽  
Composite System ◽  
Methyl Blue ◽  
Burst Release ◽  
Fluorescein Sodium ◽  
Photothermal Conversion ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against E. coli and S. aureus, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.

scholarly journals Multi-Functional Core-Shell Nanofibers for Wound Healing

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1546
Author(s):  
Zhen Li ◽  
Shunqi Mei ◽  
Yajie Dong ◽  
Fenghua She ◽  
Puwang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Drug Release ◽  
Release Rate ◽  
Healing Process ◽  
Wound Healing Process ◽  
Core Shell ◽  
High Production Rate ◽  
Centrifugal Spinning ◽  
Multiple Drugs

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

Up-Conversion Cell Imaging and pH-Induced Thermally Controlled Drug Release from NaYF4:Yb3+/Er3+@Hydrogel Core–Shell Hybrid Microspheres

ACS Nano ◽  
2012 ◽  
Vol 6 (4) ◽  
pp. 3327-3338 ◽  
Author(s):  
Yunlu Dai ◽  
Ping’an Ma ◽  
Ziyong Cheng ◽  
Xiaojiao Kang ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Cell Imaging ◽  
Controlled Drug Release ◽  
Core Shell

Fabrication and characterization of monodisperse PLGA–alginate core–shell microspheres with monodisperse size and homogeneous shells for controlled drug release

2013 ◽  
Vol 9 (7) ◽  
pp. 7410-7419 ◽  
Author(s):  
Jun Wu ◽  
Tiantian Kong ◽  
Kelvin Wai Kwok Yeung ◽  
Ho Cheung Shum ◽  
Kenneth Man Chee Cheung ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Core Shell ◽  
Fabrication And Characterization

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-drug Release, Antimicrobial, and Photothermal Conversion Functions

2021 ◽  
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Composite System ◽  
Near Infrared ◽  
Environment Friendly ◽  
Photothermal Conversion ◽  
E Coli ◽  
Nanocomposite System ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system which consists of chitosan, raspberry-like silver nanoparticles and graphene oxide. Room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environment-friendly method for introducing silver nanoparticles into the composite system. By loading different drugs onto the polymer matrix and/or graphene oxide, our composite can achieve a pH controlled dual drug release with release profile specific to the drugs used. In addition to its strong antibacterial ability against E. coli and S. aureus, our composite also demonstrates excellent photothermal conversion effect under irradiation of near infrared lasers. These unique functionalities point to it’s the potential of nanocomposite system in multiple applications areas such as multimodal therapeutics in healthcare, water treatment, and anti-microbial, etc.

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