scholarly journals Combined Phosphatase and Tensin Homolog (PTEN) Loss and Fatty Acid Synthase (FAS) Overexpression Worsens the Prognosis of Chinese Patients with Hepatocellular Carcinoma

2012 ◽  
Vol 13 (8) ◽  
pp. 9980-9991 ◽  
Author(s):  
Xuehua Zhu ◽  
Xia Qin ◽  
Maogui Fei ◽  
Wenmin Hou ◽  
Joel Greshock ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Synthase ◽  
Chinese Patients ◽  
Phosphatase And Tensin Homolog ◽  
Pten Loss ◽  
Tensin Homolog

scholarly journals High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma

2012 ◽  
Vol 4 (6) ◽  
pp. 999-1004 ◽  
Author(s):  
WENMIN HOU ◽  
MAOGUI FEI ◽  
XIA QIN ◽  
XUEHUA ZHU ◽  
JOEL GRESHOCK ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Gastric Carcinoma ◽  
Fatty Acid Synthase ◽  
Chinese Patients ◽  
Poor Survival

scholarly journals MiR-718 mediates the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells

2019 ◽  
Vol 51 (10) ◽  
pp. 500-505 ◽  
Author(s):  
Yuchuan Zhong ◽  
Yan Li ◽  
Tao Song ◽  
Dapeng Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Carcinoma Cells ◽  
Gastric Cardia Adenocarcinoma ◽  
Indirect Interaction ◽  
Poor Survival ◽  
Hepatocellular Carcinoma Cells ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog ◽  
B Virus ◽  
Hcc Cells

It has been reported that SEMA3B-AS1 is a tumor-suppressive lncRNA in gastric cardia adenocarcinoma. We explored the possible involvement of SEMA3B-AS1 in hepatocellular carcinoma (HCC). We found that SEMA3B-AS1 was downregulated in HCC tissues compared with noncancer tissues and was not affected by hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In addition, SEMA3B-AS1 expression was not affect by cancer development, and low SEMA3B-AS1 levels were closely correlated with poor survival. SEMA3B-AS1 in HCC tissues was inversely correlated with microRNA (miR)-718 and positively correlated with PTEN. In HCC cells, SEMA3B-AS1 overexpression resulted in upregulated, while miR-718 overexpression resulted in downregulated phosphatase and tensin homolog (PTEN) expression. In addition, miR-718 overexpression attenuated the effects of SEMA3B-AS1 overexpression. SEMA3B-AS1 and PTEN overexpression resulted in a reduced proliferation rate of HCC cells, while miR-718 overexpression resulted in an increased rate. In addition, miR-718 overexpression attenuated the effects of SEMA3B-AS1 overexpression. Therefore, miR-718 may mediate the indirect interaction between lncRNA SEMA3B-AS1 and PTEN to regulate the proliferation of hepatocellular carcinoma cells.

scholarly journals Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma

2019 ◽  
Vol 20 (21) ◽  
pp. 5447 ◽  
Author(s):  
Rossi ◽  
Schinzari ◽  
Maiorano ◽  
Pagliara ◽  
Di Stefani ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Mammalian Target Of Rapamycin ◽  
Heat Shock Protein 90 ◽  
Distinct Type ◽  
Biological Behavior ◽  
Conjunctival Melanoma ◽  
Phosphatase And Tensin Homolog ◽  
Pten Loss ◽  
Tensin Homolog ◽  
Neurofibromin 1

Conjunctival melanoma (CjM) is a rare, primary cancer of the ocular region. Genetic and epigenetic characteristics of conjunctival melanoma have not been completely elucidated yet. Conjunctival melanoma presents similarities with cutaneous melanoma, with substantial differences in the biological behavior. We reviewed the genetic and epigenetic insights of CjM involved in invasion and metastatic spread. CjM is commonly characterized by mutations of v-raf murine sarcoma viral oncogene homolog B1 (BRAF), neurofibromin 1 (NF1) and telomerase reverse transcriptase (TERT), high expression of mammalian target of rapamycin (mTOR) and heat shock protein 90 (HSP90), frequent phosphatase and tensin homolog (PTEN) loss and upregulation of specific miRNAs. These features should identify CjM as a distinct subset of melanoma with its own profile, which is more similar to cutaneous melanoma than mucosal melanoma and remarkably different from uveal melanoma.

scholarly journals Celastrol delays hepatic steatosis and carcinogenesis in a rapid AKT/c-Met-transfected hepatocellular carcinoma modelviasuppressing fatty acid synthase expression and AKT/ERK phosphorylation

RSC Advances ◽  
2018 ◽  
Vol 8 (25) ◽  
pp. 13976-13983 ◽  
Author(s):  
Junjie Hu ◽  
Xin Li ◽  
Junxuan Zhou ◽  
Cong Zhang ◽  
Guohua Zheng ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Hepatic Steatosis ◽  
Fatty Acid Synthase ◽  
Erk Phosphorylation ◽  
Co Activation

In this study, the effect of celastrol on a rapid HCC model featuring co-activation of AKT/c-Met oncogenes in mice was studied.

scholarly journals Decreased Expression of Phosphatase and Tensin Homolog Is Related with the Development of Non-B and Non-C Hepatocellular Carcinoma

2020 ◽  
Vol 66 (4) ◽  
pp. 346-353
Author(s):  
YUSHI SORIN ◽  
KAZUYOSHI KON ◽  
HIROSHI SONOUE ◽  
AKIRA UCHIYAMA ◽  
KYOKO FUKUHARA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Phosphatase And Tensin Homolog ◽  
Tensin Homolog

scholarly journals The Prognostic Significance of Phosphatase and Tensin Homolog Loss in Breast Cancer

2019 ◽  
Vol 7 (21) ◽  
pp. 3716-3720
Author(s):  
Indri Windarti ◽  
Wirsma Arif Harahap ◽  
Ricvan Dana Nindrea ◽  
Eti Yerizel ◽  
Primaria Dewi Rustamadji
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Random Effect ◽  
Prognostic Significance ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Breast Cancer Patients ◽  
Phosphatase And Tensin Homolog ◽  
Pten Loss ◽  
Tensin Homolog

AIM: This study aims to determine the prognostic significance of phosphatase and tensin homolog (PTEN) loss in breast cancer. METHODS: We conducted a meta-analysis study. Sample of this study were research articles that evaluated PTEN loss and prognosis in breast cancer patients. We searched for relevant studies published in PubMed and Proquest from January 2010 to July 2018. We reviewed studies that examined the association between immunohistochemical expression of PTEN and breast cancer prognosis using meta-analysis methods. Pooled risk ratios (RR) were calculated using fixed and random-effect models. Data were processed using Review Manager 5.3 (RevMan 5.3). RESULTS: There were 7 studies conducted a systematic review then continued to evaluate the association of PTEN loss and breast cancer prognosis by meta-analysis. There was a significant association of PTEN loss with poor prognosis of breast cancer (RR = 0.76 [95% CI 0.59-0.98 p <0.07), and there was not any significant publication bias for studies included. CONCLUSION: This study confirmed PTEN loss is an important independent factor for breast cancer prognosis.

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