scholarly journals Effect of Cistanches Herba Aqueous Extract on Bone Loss in Ovariectomized Rat

2011 ◽  
Vol 12 (8) ◽  
pp. 5060-5069 ◽  
Author(s):  
Haidong Liang ◽  
Fang Yu ◽  
Zhihong Tong ◽  
Zaiguo Huang
Keyword(s):  
Bone Loss ◽  
Aqueous Extract ◽  
Ovariectomized Rat

Physiological plasma levels of androgens reduce bone loss in the ovariectomized rat

1998 ◽  
Vol 274 (2) ◽  
pp. E328-E335 ◽  
Author(s):  
C. K. Lea ◽  
A. M. Flanagan
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Protective Effect ◽  
Cancellous Bone ◽  
Plasma Levels ◽  
Slow Release ◽  
Bone Volume ◽  
Ovariectomized Rat ◽  
Ovx Rats ◽  
Reduce Bone Loss

The effect of androstenedione (ADIONE) slow-release pellets on cancellous bone volume (BV/TV) at the tibial metaphysis was investigated in ovariectomized (OVX) rats at various times from 21 to 180 days. Plasma levels of ADIONE and testosterone (T) in OVX rats were significantly reduced at 21 days and were restored close to levels in the sham rats with the 1.5-mg ADIONE pellet. OVX animals with and without ADIONE pellets resulted in close to a 50% reduction in BV/TV by day 21. By day 180, OVX rats had only ∼5% BV/TV, whereas that in ADIONE-treated OVX rats was significantly greater at ∼12%. The reduced BV/TV was associated with increased bone resorption and formation. In a separate 90-day experiment, we found that the antiandrogen, Casodex, abrogated the ADIONE-induced skeletal-protective effect in OVX rats, whereas the antiaromatase, Arimidex, had no effect. This provides evidence that ADIONE protects against the development of osteopenia in the estrogen-deficient rat and mediates its effect through androgens and not estrogens.

scholarly journals Crataegus pinnatifida Bunge Inhibits RANKL-Induced Osteoclast Differentiation in RAW 264.7 Cells and Prevents Bone Loss in an Ovariectomized Rat Model

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Minsun Kim ◽  
MinBeom Kim ◽  
Jae-Hyun Kim ◽  
SooYeon Hong ◽  
Dong Hee Kim ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Osteoclast Differentiation ◽  
Ovariectomized Rat ◽  
Raw 264.7 Cells ◽  
Raw 264.7 ◽  
Mineral Density ◽  
Crataegus Pinnatifida

Osteoporosis is characterized by a decrease in bone microarchitecture with an increased risk of fracture. Long-term use of primary treatments, such as bisphosphonates and selective estrogen receptor modulators, results in various side effects. Therefore, it is necessary to develop alternative therapeutics derived from natural products. Crataegus pinnatifida Bunge (CPB) is a dried fruit used to treat diet-induced indigestion, loss of appetite, and diarrhea. However, research into the effects of CPB on osteoclast differentiation and osteoporosis is still limited. In vitro experiments were conducted to examine the effects of CPB on RANKL-induced osteoclast differentiation in RAW 264.7 cells. Moreover, we investigated the effects of CPB on bone loss in the femoral head in an ovariectomized rat model using microcomputed tomography. In vitro, tartrate-resistant acid phosphatase (TRAP) staining results showed the number of TRAP-positive cells, and TRAP activity significantly decreased following CPB treatment. CPB also significantly decreased pit formation. Furthermore, CPB inhibited osteoclast differentiation by suppressing NFATc1, and c-Fos expression. Moreover, CPB treatment inhibited osteoclast-related genes, such as Nfatc1, Ca2, Acp5, mmp9, CtsK, Oscar, and Atp6v0d2. In vivo, bone mineral density and structure model index were improved by administration of CPB. In conclusion, CPB prevented osteoclast differentiation in vitro and prevented bone loss in vivo. Therefore, CPB could be a potential alternative medicine for bone diseases, such as osteoporosis.

Treatment with QiBaoMeiRan, a Chinese herbal formula, prevents bone loss in ovariectomized rat

Climacteric ◽  
2015 ◽  
Vol 19 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Y. Xu ◽  
X. Ma ◽  
J. An ◽  
J. Ding ◽  
G. Dai ◽  
...  
Keyword(s):  
Bone Loss ◽  
Ovariectomized Rat ◽  
Herbal Formula ◽  
Chinese Herbal Formula ◽  
Chinese Herbal

scholarly journals In Vivo Bone Effects of a Novel Bisphosphonate‐EP4a Conjugate Drug (C3) for Reversing Osteoporotic Bone Loss in an Ovariectomized Rat Model

JBMR Plus ◽  
2019 ◽  
Vol 3 (12) ◽  
Author(s):  
Zeeshan Sheikh ◽  
Gang Chen ◽  
Faik Al‐Jaf ◽  
Marion Thévenin ◽  
Kate Banks ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Osteoporotic Bone

Effects of trans-Resveratrol from Polygonum cuspidatum on Bone Loss Using the Ovariectomized Rat Model

2005 ◽  
Vol 8 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Z.P. Liu ◽  
W.X. Li ◽  
B. Yu ◽  
J. Huang ◽  
J. Sun ◽  
...  
Keyword(s):  
Bone Loss ◽  
Rat Model ◽  
Ovariectomized Rat ◽  
Polygonum Cuspidatum
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