scholarly journals Enhancing Spatio-Temporal Identity: States of Existence and Presence

2016 ◽  
Vol 5 (5) ◽  
pp. 62 ◽  
Author(s):  
Pierre Hallot ◽  
Roland Billen
Keyword(s):  
Temporal Identity ◽  
Spatio Temporal

scholarly journals Limits on the Use of Simulation in Physical Reasoning

2019 ◽  
Author(s):  
Ethan Ludwin-Peery ◽  
Neil R Bramley ◽  
Ernest Davis ◽  
Todd Matthew Gureckis
Keyword(s):  
Boundary Conditions ◽  
Simulation Theory ◽  
Conjunction Fallacy ◽  
Mental Simulation ◽  
Physical Reasoning ◽  
Temporal Identity ◽  
Spatio Temporal

In this paper, we describe three experiments involving simple physical judgments and predictions, and argue their results are generally inconsistent with three core commitments of probabilistic mental simulation theory (PMST). The first experiment shows that people routinely fail to track the spatio-temporal identity of objects. The second experiment shows that people often incorrectly reverse the order of consequential physical events when making physical predictions. Finally, we demonstrate a physical version of the conjunction fallacy where participants rate the probability of two joint events as more likely to occur than a constituent event of that set. These results highlight the limitations or boundary conditions of simulation theory.

Shame and Blame: The Self through Time and Change

Dialogue ◽  
1995 ◽  
Vol 34 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Jennifer Radden
Keyword(s):  
Personal Identity ◽  
The Self ◽  
Concentration Camp ◽  
Factory Worker ◽  
Temporal Identity ◽  
Spatio Temporal ◽  
Ivan The Terrible ◽  
Cleveland Ohio

Do our customary notions of shame, blame and guilt require us to adopt a particular view of the self's singularity and invariance through time? Consider the intriguing case of John Demjanjuk, tried in Israel during 1987 and 1988 for the crimes of “Ivan the Terrible,” a concentration camp guard at Treblinka in Poland, during 1942–43. John Demjanjuk, a retired factory worker living in Cleveland, Ohio, appeared banal at his trial—old, quiet, ordinary and helpless; descriptions from survivors of Treblinka cast Ivan as monstrous in his vigorous brutality. Should John be found guilty and punished for Ivan's crimes? This question takes us beyond any answers sought at the trial. Even if the spatio-temporal identity of the later John and earlier Ivan had been established conclusively, still the justice of punishing the later man for the earlier one's crimes may be questioned. For a philosophical puzzle of personal identity lingers: is the later John the same person as the earlier Ivan? In cases such as this the passage of time and radical changes of character and personality seem to invite the notion that one self or person has succeeded another in the same body. If this were so, would—or should—culpability transfer undiminished from one self to another?

scholarly journals Limits on the Use of Simulation in Physical Reasoning

2019 ◽  
Author(s):  
Ethan Ludwin-Peery ◽  
Neil R Bramley ◽  
Ernest Davis ◽  
Todd Matthew Gureckis
Keyword(s):  
Boundary Conditions ◽  
Simulation Theory ◽  
Conjunction Fallacy ◽  
Mental Simulation ◽  
Physical Reasoning ◽  
Temporal Identity ◽  
Spatio Temporal

In this paper, we describe three experiments involving simple physical judgments and predictions, and argue their results are generally inconsistent with three core commitments of probabilistic mental simulation theory (PMST). The first experiment shows that people routinely fail to track the spatio-temporal identity of objects. The second experiment shows that people often incorrectly reverse the order of consequential physical events when making physical predictions. Finally, we demonstrate a physical version of the conjunction fallacy where participants rate the probability of two joint events as more likely to occur than a constituent event of that set. These results highlight the limitations or boundary conditions of simulation theory.

E3 ubiquitin ligases

2005 ◽  
Vol 41 ◽  
pp. 15-30 ◽  
Author(s):  
Helen C. Ardley ◽  
Philip A. Robinson
Keyword(s):  
Protein Complexes ◽  
Loss Of Function ◽  
Direct Role ◽  
Cellular Processes ◽  
Substrate Protein ◽  
Protein Ubiquitination ◽  
C Terminus ◽  
Full Complement ◽  
Spatio Temporal ◽  
Eukaryotic Organisms

The selectivity of the ubiquitin–26 S proteasome system (UPS) for a particular substrate protein relies on the interaction between a ubiquitin-conjugating enzyme (E2, of which a cell contains relatively few) and a ubiquitin–protein ligase (E3, of which there are possibly hundreds). Post-translational modifications of the protein substrate, such as phosphorylation or hydroxylation, are often required prior to its selection. In this way, the precise spatio-temporal targeting and degradation of a given substrate can be achieved. The E3s are a large, diverse group of proteins, characterized by one of several defining motifs. These include a HECT (homologous to E6-associated protein C-terminus), RING (really interesting new gene) or U-box (a modified RING motif without the full complement of Zn2+-binding ligands) domain. Whereas HECT E3s have a direct role in catalysis during ubiquitination, RING and U-box E3s facilitate protein ubiquitination. These latter two E3 types act as adaptor-like molecules. They bring an E2 and a substrate into sufficiently close proximity to promote the substrate's ubiquitination. Although many RING-type E3s, such as MDM2 (murine double minute clone 2 oncoprotein) and c-Cbl, can apparently act alone, others are found as components of much larger multi-protein complexes, such as the anaphase-promoting complex. Taken together, these multifaceted properties and interactions enable E3s to provide a powerful, and specific, mechanism for protein clearance within all cells of eukaryotic organisms. The importance of E3s is highlighted by the number of normal cellular processes they regulate, and the number of diseases associated with their loss of function or inappropriate targeting.

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

2019 ◽  
Vol 47 (6) ◽  
pp. 1733-1747 ◽  
Author(s):  
Christina Klausen ◽  
Fabian Kaiser ◽  
Birthe Stüven ◽  
Jan N. Hansen ◽  
Dagmar Wachten
Keyword(s):  
Cyclic Amp ◽  
Adenosine Monophosphate ◽  
Adenylyl Cyclases ◽  
Temporal Precision ◽  
Fluorescent Biosensors ◽  
Subcellular Domains ◽  
Spatio Temporal ◽  
Hydrolysis Of ◽  
Shed Light ◽  
Cyclic Amp Signaling

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.

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