scholarly journals The Incidence and Nature of Claims against Dentists Related to Periodontal Treatment in Israel during the Years 2005–2019

2021 ◽  
Vol 18 (8) ◽  
pp. 4153
Author(s):  
Dima Nassar ◽  
Nirit Tagger-Green ◽  
Haim Tal ◽  
Carlos Nemcovsky ◽  
Eitan Mijiritsky ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Dental Treatment ◽  
Categorical Variables ◽  
P Value ◽  
Fisher Exact Test ◽  
Final Decision ◽  
Chi Square ◽  
Exact Test ◽  
Malpractice Claims ◽  
Dental Practitioners

Background: In recent years, worldwide dental malpractice claims have dramatically increased. The purpose of the present study is to analyze periodontal therapy related claims in Israel that led to legal decisions. Methods: This retrospective cohort study includes malpractice claims against dental practitioners related to periodontology between 2005 and 2019. Only closed cases where a final decision was made were included. The chi-square test or Fisher exact test for categorical variables were performed and a p value of <0.05 was considered statistically significant. Results: During the study period there were 508 legal claims related to periodontal disease. Most plaintiffs were women (63.4%), and 71.3% of the patients were >35 years old. Most claims (82.8%) were settled out of court and ended in compromise. Claims concerning the treatment of periodontal disease by periodontists accounted only for 4.5% (23/508) of the cases while 95.5% (485/508) of the claims were for complications secondary to another treatment. Prosthodontic treatment was involved with the highest number 54.5%, followed by dental implants 17.7%, and endodontics 11.6%. The allegations were related to pain and distress (84.8%), aggravation of existent periodontal disease (83.3%), tooth loss (78.1%), and violation of autonomy (47%). Conclusions: The main cause for lawsuits was related to aggravation of periodontal disease during prosthetic or implant therapy and related to suspected faulty or inexistent preoperative diagnosis and planning. Practical implications: Periodontal consultation before dental treatment may reduce malpractice risks, adverse events, and un-necessary changes of treatment plans.

scholarly journals FAKTOR-FAKTOR YANG MEMENGARUHI NEUROPATI PERIFER TERKAIT HIV DI MANADO

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Deivy Cirayow ◽  
Arthur Hendrik Philips Mawuntu ◽  
Herlyani Khosama
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Influencing Factors ◽  
Categorical Variables ◽  
Fisher Exact Test ◽  
Hiv Dementia ◽  
Chi Square ◽  
Exact Test ◽  
International Hiv Dementia Scale ◽  
Hiv Aids

FACTORS THAT INFLUENCE HIV ASSOCIATED PERIPHERAL NEUROPATHY IN MANADOABSTRACTIntroduction: There are  several sociodemographic and clinical factors that influence the development of HIV associated peripheral  neuropathy (HIV-PN). Manado has different sociodemographic and clinical characteristics  from other regions. However, the percentage of HIV-PN and its influencing factors are unknown.Aims: To know the percentage of HIV-PN and factors that influence this disorder in Manado.Methods: A crosssectional study conducted in HIV/AIDS clinic R.D. Kandou hospital Manado between November2016–January 2017. Neuropathy evaluation was performed using brief peripheral neuropathy screening (BPNS), neuropathic pain diagnostic questionnaire (DN4), and electroneurography. A Chi-square or Fisher exact test was done to analyze categorical variables, independent T or Mann-Whitney test was done for numerical variables, and linear regression was done in multivariate analysis.Results: 50 subjects were included, most were male (70%), and the mean age was 32.98 (±9.726) years, with HIV- NP percentage was 46%. Age >30 years old, low hemoglobin count, CD4, and low international  HIV dementia scale (IHDS) significantly associated with HIV-NP. Working subjects were 13.6 times more likely to have HIV-PN.Discussion: HIV-PN prevalence was relatively high, influenced by age >30 years old an low hemoglobin, CD4, andIHDS. As a factor, working was escalating the likelihood of NP-HIV by 13.9 times.Keywords: HIV/AIDS, influencing factors, peripheral neuropathyABSTRAKPendahuluan: Neuropati perifer terkait human immunodeficiency virus/HIV (NP-HIV) dapat dipengaruhi oleh beberapa faktor klinis dan sosiodemografis. Manado mempunyai karakteristik yang berbeda dengan daerah lain, namun belum diketahui persentase NP-HIV dan faktor-faktor yang memengaruhinya.Tujuan: Mengetahui persentase NP-HIV dan faktor-faktor yang memengaruhinya di Manado.Metode: Penelitian potong lintang terhadap pasien HIV/AIDS di poliklinik HIV/AIDS RSUP Prof. dr. R.D. Kandou, Manado, pada November 2016–Januari 2017.  Evaluasi neuropati dilakukan menggunakan brief peripheral  neuropathy screening (BPNS), neuropathic pain diagnostic questionnaire (DN4), dan elektroneurografi. Digunakan uji Chi-square atau Fisher exact untuk menganalisis variabel kategorik, uji T independen atau Mann-Whitney untuk variabel numerik, dan regresi linear untuk analisis multivariat.Hasil: Didapatkan 50 subjek yang memenuhi kriteria penelitian dengan mayoritas laki-laki (70%), rerata usia32,98±9,726 tahun, dan mengalami NP-HIV sebanyak 46%. Usia >30 tahun, kadar hemoglobin, jumlah CD4, dan skor international  HIV dementia scale (IHDS) yang rendah berhubungan secara bermakna dengan adanya NP-HIV. Adapun subjek yang bekerja berisiko 13,6 kali lebih besar mengalami NP-HIV.Diskusi: Didapatkan prevalensi NP-HIV yang cukup tinggi dengan dipengaruhi oleh usia >30 tahun serta kadar hemoglobin, CD4, dan skor IHDS yang rendah. Faktor bekerja juga meningkatkan kecenderungan 13,9 kali mengalami NP terkait HIV.Kata kunci: Faktor-faktor yang memengaruhi, HIV/AIDS, neuropati perifer

Kontribusi Karakteristik Ibu Terhadap kejadian Stunting Pada Anak Usia 24-36 Bulan Di Sleman Yogyakarta

2019 ◽  
Vol 12 (02) ◽  
Author(s):  
Prastiwi Putri Basuki ◽  
Triana Uminingsih
Keyword(s):  
P Value ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Purposive Sampling

Stunting pada masa balita perlu mendapat perhatian khusus termasuk pada anak usia 24-36 bulan. Usia 24-36 bulan merupakan usia anak yang mengalami perkembangan pesat dalam kemampuan kognitif dan motorik. Banyak faktor yang mempengaruhi terjadinya kejadian stunting pada anak, antara lain karakteristik ibu. Tujuan dari penelitian ini adalah mengetahui kontribusi karakteristik ibu terhadap kejadian stunting pada anak usia 24-36 bulan. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional yang dilakukan di Desa Sendang Mulyo Minggir Sleman Yogyakarta. Sampel yang diambil sebanyak 75 anak usia 24-36 bulan dengan teknik purposive sampling. Analisis data  bivariat menggunakan Chi Square dan Fisher Exact Test dan analisis multivariat menggunakan regresi linier. Hasil penelitian menunjukkan bahwa pendidikan ibu (p value=0,000), pengetahuan ibu (p value=0,022) dan pemberian ASI Ekslusif (p value=0,011) yang artinya terdapat hubungan dengan kejadian stunting. Sedangkan status pekerjaan ibu (p value=0,217) tidak signifikan berhubungan dengan kejadian stunting. Berdasarkan analisis multivariat regresi linier menunjukkan hasil bahwa pendidikan ibu, status  pekerjaan ibu, pengetahuan ibu tentang gizi, dan pemberian ASI Ekslusif bersama-sama mempunyai kontribusi terhadap kejadian stunting sebesar 88,2%. Perlu peningkatan program multisektoral dengan melibatkan semua lapisan masyarakat untuk mengurangi kejadian stunting.

Concomitant Traumatic Brain Injury and Hemorrhagic Shock: Outcomes Using the Spanish Trauma ICU Registry (RETRAUCI)

2020 ◽  
pp. 000313482094999
Author(s):  
Mario Chico-Fernández ◽  
Jesús A. Barea-Mendoza ◽  
Jon Pérez-Bárcena ◽  
Iker García-Sáez ◽  
Manuel Quintana-Díaz ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Hemorrhagic Shock ◽  
Fresh Frozen Plasma ◽  
Categorical Variables ◽  
P Value ◽  
Trauma Patients ◽  
Chi Square ◽  
Exact Test ◽  
Fresh Frozen

Background To compare the main outcomes of trauma patients with and without traumatic brain injury (TBI), hemorrhagic shock, and the combination of both using data from the Spanish trauma intensive care unit (ICU) registry (RETRAUCI). Methods Patients admitted to the participating ICUs from March 2015 to May 2019 were included in the study. The main outcomes were analyzed according to the presence of TBI, hemorrhagic shock, and/or both. Comparison of groups with quantitative variables was performed using the Kruskal-Wallis test, and differences between groups with categorical variables were compared using the Chi-square test or Fisher’s exact test as appropriate. A P value <.05 was considered significant. Results Overall, 310 patients (3.98%) were presented with TBI and hemorrhagic shock. Patients with TBI and hemorrhagic shock received more red blood cell (RBC) concentrates, fresh frozen plasma (FFP), a higher ratio FFP/RBC, and had a higher incidence of trauma-induced coagulopathy (60%) ( P < .001). These patients had higher mortality ( P < .001). Intracranial hypertension was the leading cause of death (50.4%). Conclusions Concomitant TBI and hemorrhagic shock occur in nearly 4% of trauma ICU patients. These patients required a higher amount of RBC concentrates and FFP and had an increased mortality.

Circulating tumor DNA (ctDNA) landscape in metastatic castrate-resistant prostate cancer patients with germline alterations.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 200-200
Author(s):  
Marcus W. Moses ◽  
Peter Steinwald ◽  
Ellen Jaeger ◽  
Whitley Hatton ◽  
Patrick Cotogno ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
San Francisco ◽  
Splice Variants ◽  
Circulating Tumor Dna ◽  
P Value ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Exact Test ◽  
Viable Approach ◽  
Tumor Dna

200 Background: Circulating tumor-DNA (ctDNA) in mCRPC patients (pts) provides a viable approach for examining the genetic landscape of prostate cancer. In this follow-up, we report ctDNA variants in germline tested mCRPC pts. Methods: ctDNA alterations in 73 genes were detected using Guardant360 (G360) assays. Alteration types assessed were missense, frameshift, insertions, splice variants, truncations, amplifications (amp), deletions, and other. Pts included in the analysis received germline genetic testing (Invitae Corporation, San Francisco, CA) and ctDNA assays at various treatment timepoints. Statistical analyses were performed using chi-square and fisher exact test with p-value <0.05 for significance. Results: Germline and ctDNA testing was completed in 270 mCRPC pts. 13% (35/270) of pts had pathogenic germline alterations. Germline alterations detected were BRCA2 (43%, n=15), ATM (8.5%, n=3), CHEK2 (8.5%, n=3), and BRCA1 (6%, n=2). Of the 673 alterations detected in G360 assays, TP53 (25%, n=167) and AR (17%, n=117) were most commonly observed. ctDNA alteration breakdown for germline negative/positive pts is summarized in Tables A/B. Germline negative pts had more AR alterations compared to germline positive (p = 0.023). Also, germline negative pts presented with more amps (p < 0.001) and germline positive pts with more frameshift alterations (p = 0.005). The association of ctDNA alteration to clinical outcomes in germline positive/negative pts was also assessed and is ongoing. Conclusions: Pts with germline positive alterations had few somatic AR alterations and higher frequency of deleterious mutation in comparison to their germline negative counterparts.[Table: see text][Table: see text]

scholarly journals INVESTIGATION OF SUSPECTED PERIPHERAL NEUROPATHY OUTBREAK IN DECHENTSEMO CENTRAL SCHOOL, THINLEYGANG, PUNAKHA

2016 ◽  
Vol 2 (3) ◽  
pp. 118-124 ◽  
Author(s):  
Tshe Ten ◽  
Laigden Dzed ◽  
Sangay Thinley ◽  
Deki Tshomo ◽  
Karma Dechen ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Vitamin B1 ◽  
Categorical Variables ◽  
P Value ◽  
Chi Square ◽  
Exact Test ◽  
Daily Allowance ◽  
And Control ◽  
Control Study ◽  
Fischer Exact Test

Background: A suspected peripheral neuropathy outbreak was reported from Dechentsemo Central School, Thinleygang, Punakha, following which the investigation team was immediately dispatched in the field.Objective: The aim of investigation was to ascertain the cause and risk factor for the outbreak in order to implement control measures.Methods: A case control study was devised for the investigation to study about the past exposure or deficiencies in order to find out the suspected cause and risk factors.  A semi-quantitative food frequency questionnaire was administered to both cases and controls to collect information on the type of food they have consumed. The information garnered was analyzed using Chi-Square or Fischer Exact test for categorical variables and Man-Whitney U-test for quantitative variables. Results: All 17 cases were females with mean age of 13 years (SD 2.7 years). The average daily amount of thiamine intake was 0.6 mg/day for case and 0.8 mg/day for controls against the recommended daily allowance (RDA) of 1.2 mg/day. Case and control patients differed significantly with respect to fat intake (p-value = 0.02), more strongly with folate and iron intake (p-value 0.01).Conclusion: The outbreak of peripheral neuropathy in Dechentsemo Central School appears to be linked to reduced dietary intake rich in vitamin B1 coupled with low intake of folate and iron in their diet.

scholarly journals Relationship between Parenting Style and Substance Use Adolescents in Denpasar City

2021 ◽  
Vol 13 (2) ◽  
pp. 1006-1012
Author(s):  
Ni Made Leni ◽  
Luh Nyoman Alit Aryani ◽  
Anak Ayu Sri Wahyuni ◽  
Ni Ketut Putri Ariani ◽  
Cokorda Bagus Jaya Lesmana ◽  
...  
Keyword(s):  
Substance Use ◽  
Parenting Style ◽  
Drug Users ◽  
Transition Period ◽  
Self Control ◽  
Primary Data ◽  
P Value ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Exact Test

Background: Adolescent is a transition period from childhood to adulthood, seeking self-identity, anti-social behavior, violence and substance use. Parenting style is one of the risk factors determining substance use behavior among adolescents to prevent and overcome this behavior's consequences. This study aims to determine the relationship between parenting style toward substance use among adolescents in Denpasar. Methods: This research is an analytic observational study with a case-control study design. This research sample is adolescent drug users aged 12-25 years who live with their parents aged 0-17 years. The study was carried out in/at the Class IIA Kerobokan Denpasar Prison from August 2020 to September 2020. The data sources are primary data that taken from the PSQ (Parenting Style Questionnaire) and WHO-ASSIST questionnaires. The independent variable is the parenting style, while the dependent variable is the level of substance use. The data were/are analyzed using the chi-square/Fisher exact test with p-value of <0.05 is considered as significant. Result: The results show that there is a significant relationship between unexpected parenting style according to parents/guardians and drug abuse among adolescents (r = 0.34; p <0.05) and that increased the risk of moderate-heavy drug use among adolescents (OR = 5.93; 95% CI = 1.362-25.788; p = 0.011). Conclusions: Unexpected parenting style is associated to/with higher levels of substance use due to guilt, abusive parenting, neglect, which lead to negative self-esteem in children, emotional submission, insecurity and a lack of self-control in children.

scholarly journals Knowledge of pregnant women about anemia is related with adherence to iron tablets

2018 ◽  
Vol 26 (1) ◽  
pp. 26
Author(s):  
Baksono Winardi ◽  
Elga Caecaria Grahardika Andani
Keyword(s):  
Pregnant Women ◽  
Cross Sectional Study ◽  
P Value ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Cross Sectional ◽  
Significance Level ◽  
Exact Test ◽  
Study Population ◽  
Almost All

Objectives: to identify association between knowledge of pregnant women about anemia and the adherence to consume iron tablets in BPM Titik Suharti, Surabaya, IndonesiaMaterials and Methods: Observational analysis cross sectional study. Population consisted of 55 trimester pregnant women in BPM Titik Suharti, Surabaya, in March-April 2017. Samples were recruited using consecutive sampling. The number of sample was 35 respondents. Data were analyzed using chi-square test.Results: This research showed that all of the less knowledgeable women on anemia (100.00%) were non-adherent to consume iron tablets, almost all moderately knowledgeable women (92.9%) were adherent, and all of the fully knowledgeable women (100.00%) were adherent. Fisher exact test in significance level of 0.05 revealed p value equal to 0.0001, indicating association between knowledge about anemia and adherence to consume iron tablets at BPM Titik Suharti, Surabaya, Indonesia.Conclusion: There is an association between knowledge of pregnant women about anemia with adherence to iron tablets.

scholarly journals Determinan Yang Berhubungan Dengan Premenstrual Syndrome (PMS) Pada Remaja Putri Di SMPN 7 Kota Jambi

2018 ◽  
Vol 2 (1) ◽  
pp. 59-70
Author(s):  
Septa Decelita Wahyuni ◽  
Asparian . ◽  
M. Dody Izhar
Keyword(s):  
Premenstrual Syndrome ◽  
Random Sampling ◽  
P Value ◽  
Fisher Exact Test ◽  
Stratified Random Sampling ◽  
Chi Square ◽  
Exact Test

Premenstrual syndrome (PMS) merupakan gejala yang banyak dirasakan oleh remaja selama satu minggu sebelum menstruasi. Apabila tidak diperhatikan akan berdampak menimbulkan masalah dan produktivitas. Tujuan penelitian untuk mengetahui determinan yang berhubungan dengan PMS. Jenis penelitian yaitu rancangan penelitian cros sectional. Penelitian dilakukan di SMPN 7 Kota Jambi. Waktu penelitian dari bulan  November 2017- Juni 2018. Populasinya yaitu 628 remaja putri dengan 93 sampel yang diambil menggunakan teknik stratified random sampling. Data dikumpulkan melalui wawancara menggunakan kuesioner sPAF untuk mengukur gejala PMS. Analisis data menggunaan chi square dan fisher exact test pada = 5%. Hasil: PMS tidak mengalami - ringan yaitu 71% dan gejala sedang hingga berat yaitu 29%. Remaja putri yang mengalami usia menarche prekok sebesar 4,3% , berstatus gizi gemuk sebesar 25,5%, serta memiliki gejala stres sebesar 90,3%. Hasil uji statistik yaitu tidak terdapat hubungan antara usia menarche dengan PMS dengan p-value yaitu 1,000 dengan POR 0,808. Tidak terdapat hubungan antara status gizi dan PMS dengan p-value yaitu 0,186 namun status gizi gemuk beresiko meningkatkan 2,185 PMS sedang-berat. Tidak terdapat hubungan antara stres dengan PMS pada remaja putri di SMPN 7 Kota Jambi p-value yaitu 0,276, namun stres beresiko meningkatkan 3,586 kali PMS sedang-berat. Kesimpulan: Terdapat kecenderungan gemuk dan stres dapat beresiko terhadap PMS sedang-berat. Diharapkan remaja putri mampu mengetahui siklus menstruasinya, menerapkan pola gizi seimbang dan aktif dalam memanfaatkan sarana UKS.

scholarly journals Kebiasaan Sarapan Pagi dengan Prestasi Belajar Siswa SD Negeri 01 Rajabasa Bandar Lampung

2020 ◽  
Vol 11 (1) ◽  
pp. 164-169
Author(s):  
Ringgo Alfarisi ◽  
Yuniastini Yuniastini ◽  
Astri Pinilih ◽  
Putri Nur Oktavia Jauhari
Keyword(s):  
P Value ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Cross Sectional ◽  
Exact Test ◽  
Purposive Sampling

Latar Belakang: Latar Belakang: Energi yang adekuat pada saat sarapan pagi diperlukan untuk menunjang aktivitas belajar khusunya bagi anak sekolah. Energi diperoleh dari makanan atau minuman yang dikonsumsi oleh masing-masing anak. Anak yang seringkali melewatkan sarapan sangat tidak dianjurkan. Melewatkan sarapan membuat anak tidak berenergi karena perut kosong sehingga anak menjadi susah untuk memfokuskan pikiran di sekolah. Hal tersebut sangat tidak mendukung dalam peningkatan prestasi belajar. Tujuan Penelitian: Untuk mengetahui adakah hubungan kebiasaan sarapan pagi dengan prestasi belajar pada siswa-siswi Sekolah Dasar Negeri 01 Rajabasa di Bandar Lampung. Metode Penelitian: Jenis penelitian ini adalah penelitian kuantitatif dengan pendekatan cross sectional. Pengambilan sampel menggunakan teknik purposive sampling. Analisis bivariat yang digunakan adalah uji Chi Square. Hasil Penelitian: Dengan jumlah sampel sebanyak 60 responden, responden dengan sarapan pagi tidak rutin didapatkan 12 siswa, dimana 8 siswa (66,7%) prestasi belajar dibawah rata-rata dan 4 (33,3%) siswa prestasi belajar diatas rata-rata. Kemudian, responden yang sarapan pagi rutin didapatkan 48 siswa, dimana 6 siswa (12,5%) prestasi belajar dibawah rata-rata, dan 42 siswa (76,0%) prestasi belajar diatas rata-rata. Berdasarkan hasil uji fisher exact test hasil penelitian menunjukkan nilai p value sebesar 0,000 (≤0,05) yang berarti bahwa sarapan pagi dengan rutin mendukung dalam peningkatan prestasi belajar siswa OR = 14. Kesimpulan : Terdapat hubungan yang signifikan antara kebiasaan sarapan pagi dengan prestasi belajar siswa-siswi SDN 01 Rajabasa Bandar Lampung. Kata Kunci : Prestasi belajar, Sarapan pagi

scholarly journals Risiko Kejadian Perdarahan Pasca Rawat Inap pada Penggunaan Bersamaan Warfarin dan Antibiotik

2021 ◽  
Vol 8 (2) ◽  
pp. 164
Author(s):  
Nazulanita Rahma ◽  
Tri Murti Andayani ◽  
Arief Nurrochmad
Keyword(s):  
Hazard Ratio ◽  
T Test ◽  
Adjusted Hazard Ratio ◽  
Control Group ◽  
P Value ◽  
Fisher Exact Test ◽  
Chi Square ◽  
Exact Test

Penggunaan warfarin dan antibiotik bersamaan diketahui dapat meningkatkan risiko perdarahan. Kejadian perdarahan mayor terkait warfarin dapat berupa perdarahan fatal hingga menyebabkan kematian. Penelitian ini bertujuan untuk menganalisis interaksi warfarin dan antibiotik dan efeknya terhadap kejadian perdarahan pada pemeriksaan pertama pasca rawat inap di RSUD Wates. Desain studi berupa kohort retrospektif pada 67 kasus penggunaan warfarin dengan/tanpa antibiotik oleh pasien rawat inap. Data berupa diagnosis, terapi, pemeriksaan pendukung, dan kejadian perdarahan saat rawat inap hingga pemeriksaan pertama diambil dari rekam medik pasien tertanggal Januari 2018 hingga September 2020. Analisis data dilakukan secara statistika menggunakan ­uji Chi-square atau uji Fisher exact test dan uji independent t-test atau uji Mann Whitney U test. Terdapat perbedaan bermakna pada kejadian perdarahan dalam waktu 7 hari pasca rawat inap antara kelompok antibiotik dan kontrol (16%; 0%; p = 0.017). Antibiotik yang digunakan oleh pasien dengan kejadian perdarahan yaitu golongan sefalosporin, kuinolon, azitromisin, dan ampisilin-sulbaktam. Kejadian perdarahan yang terjadi meliputi hematemesis melena (25%), hematuria (50%), tidak diketahui (25%). Studi ini menyimpulkan bahwa penggunaan bersamaan warfarin dan antibiotik saat rawat inap dapat berpengaruh terhadap kejadian perdarahan dalam waktu 7 hari setelah pasien dipulangkan.Penggunaan warfarin dan antibiotik bersamaan diketahui dapat meningkatkan risiko perdarahan. Kejadian perdarahan mayor terkait warfarin dapat berupa perdarahan fatal hingga menyebabkan kematian. Penelitian ini bertujuan untuk menganalisis interaksi warfarin dan antibiotik dan efeknya terhadap kejadian perdarahan pada pemeriksaan pertama pasca rawat inap di RSUD Wates. Desain studi berupa kohort retrospektif [A1] [A2] pada 67 kasus penggunaan warfarin dengan/tanpa antibiotik oleh pasien rawat inap. Data berupa diagnosis, terapi, pemeriksaan pendukung, dan kejadian perdarahan saat rawat inap hingga pemeriksaan pertama diambil dari rekam medik pasien tertanggal Januari 2018 hingga September 2020. Analisis data dilakukan secara statistika menggunakan ­uji Chi-square atau uji Fisher exact test dan uji independent t-test atau uji Mann Whitney U test. Terdapat perbedaan bermakna pada kejadian perdarahan dalam waktu tujuh hari pasca rawat inap antara kelompok antibiotik dan kontrol (16%; 0%; p = 0.017). [A3] [A4] Antibiotik yang digunakan oleh pasien dengan kejadian perdarahan yaitu azitromisin, ampisilin-sulbaktam, golongan sefalosporin, dan golongan kuinolon.[A5] [A6]  Kejadian perdarahan yang terjadi meliputi hematemesis melena (25%), hematuria (50%), tidak diketahui (25%). Studi ini menyimpulkan bahwa penggunaan bersamaan warfarin dan antibiotik saat rawat inap dapat berpengaruh terhadap kejadian perdarahan dalam waktu tujuh hari setelah pasien dipulangkan [A1]Penulis disarankan mempelajari artikel https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398292/ untuk lebih memahami penulisan artikel dengan desain kohort. [A2]Baik, terimakasih [A3]Tampilan hasil uji dalam studi kohort (adjusted hazard ratio [AHR] = ?; 95% CI, ?; p-value = ) [A4]Tidak dilakukan analisis survival, sementara kejadian perdarahan pada control group adalah 0 sehingga RR adalah tidak terbatas [A5]Ini bukan golongan obat; untuk menghindari multitafsir..kedua obat ini ditulis di awal, sementara yang golongan obat di bagian setelahnya [A6]Sudah kami ubah redaksionalnya

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