scholarly journals Urinary Biomarkers of Exposure to Volatile Organic Compounds from the Population Assessment of Tobacco and Health Study Wave 1 (2013–2014)

2020 ◽  
Vol 17 (15) ◽  
pp. 5408 ◽  
Author(s):  
Víctor R. De Jesús ◽  
Deepak Bhandari ◽  
Luyu Zhang ◽  
Christopher Reese ◽  
Kimberly Capella ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Urinary Metabolites ◽  
The United States ◽  
Tobacco Product ◽  
Health Study ◽  
Linear Regression Models ◽  
Population Assessment ◽  
Biomarkers Of Exposure ◽  
Volatile Organic

Volatile organic compounds (VOCs) are ubiquitous in the environment. In the United States (U.S.), tobacco smoke is the major non-occupational source of exposure to many harmful VOCs. Exposure to VOCs can be assessed by measuring their urinary metabolites (VOCMs). The Population Assessment of Tobacco and Health (PATH) Study is a U.S. national longitudinal study of tobacco use in the adult and youth civilian non-institutionalized population. We measured 20 VOCMs in urine specimens from a subsample of adults in Wave 1 (W1) (2013–2014) to characterize VOC exposures among tobacco product users and non-users. We calculated weighted geometric means (GMs) and percentiles of each VOCM for exclusive combustible product users (smokers), exclusive electronic cigarette (e-cigarette) users, exclusive smokeless product users, and tobacco product never users. We produced linear regression models for six VOCMs with sex, age, race, and tobacco user group as predictor variables. Creatinine-ratioed levels of VOCMs from exposure to acrolein, crotonaldehyde, isoprene, acrylonitrile, and 1,3-butadiene were significantly higher in smokers than in never users. Small differences of VOCM levels among exclusive e-cigarette users and smokeless users were observed when compared to never users. Smokers showed higher VOCM concentrations than e-cigarette, smokeless, and never users. Urinary VOC metabolites are useful biomarkers of exposure to harmful VOCs.

scholarly journals Pulmonary Health Effects of Indoor Volatile Organic Compounds—A Meta-Analysis

2021 ◽  
Vol 18 (4) ◽  
pp. 1578 ◽  
Author(s):  
Kyle L. Alford ◽  
Naresh Kumar
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Effect Size ◽  
Meta Analysis ◽  
The United States ◽  
High Income ◽  
Pulmonary Diseases ◽  
Health Concern ◽  
Pubmed Database ◽  
Volatile Organic

Volatile organic compounds (VOCs) are commonly found in consumer products, including furniture, sealants and paints. Thus, indoor VOCs have become a public health concern, especially in high-income countries (HICs), where people spend most of their time indoors, and indoor and outdoor air exchange is minimal due to a lack of ventilation. VOCs produce high levels of reaction with the airway epithelium and mucosa membrane and is linked with pulmonary diseases. This paper takes a stock of the literature to assess the strength of association (measured by effect size) between VOCs and pulmonary diseases with the focus on asthma and its related symptoms by conducting a meta-analysis. The literature was searched using the PubMed database. A total of 49 studies that measured VOCs or VOC types and pulmonary health outcomes were included in the analysis. The results of these studies were tabulated, and standard effect size of each study was computed. Most studies were conducted in high-income countries, including France (n = 7), Japan (n = 7) and the United States (n = 6). Our analysis suggests that VOCs have a medium-sized effect on pulmonary diseases, including the onset of asthma (effect size (or Cohen’s d) ~0.37; 95% confidence interval (CI) = 0.25–0.49; n = 23) and wheezing (effective size ~0.26; 95% CI = 0.10–0.42; n = 10). The effect size also varied by country, age and disease type. Multiple stakeholders must be engaged in strategies to mitigate and manage VOC exposure and its associated pulmonary disease burden.

Biomarkers of Exposure to Semi-Volatile Organic Compounds (SVOC) among Pregnant Women in Puerto Rico

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
John Meeker ◽  
Deborah Watkins ◽  
Zaira Rosario ◽  
Jose Cordero ◽  
Akram Alshawabkeh
Keyword(s):  
Puerto Rico ◽  
Volatile Organic Compounds ◽  
Pregnant Women ◽  
Organic Compounds ◽  
Biomarkers Of Exposure ◽  
Volatile Organic

Volatile Organic Compounds in Untreated Ambient Groundwater of the United States, 1985−1995

1999 ◽  
Vol 33 (23) ◽  
pp. 4176-4187 ◽  
Author(s):  
Paul J. Squillace ◽  
Michael J. Moran ◽  
Wayne W. Lapham ◽  
Curtis V. Price ◽  
Rick M. Clawges ◽  
...  
Keyword(s):  
United States ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
The United States ◽  
Volatile Organic ◽  
Ambient Groundwater

scholarly journals Associations between residential exposure to volatile organic compounds (VOCs) and liver injury markers

2021 ◽  
Author(s):  
Banrida Wahlang ◽  
Tyler C. Gripshover ◽  
Hong Gao ◽  
Tatiana Krivokhizhina ◽  
Rachel J. Keith ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Liver Injury ◽  
Organic Compounds ◽  
Linear Models ◽  
Smoking Status ◽  
Occupational Exposures ◽  
Urinary Metabolites ◽  
Cross Sectional ◽  
Disease Biomarkers ◽  
Volatile Organic

ABSTRACTOccupational exposures to volatile organic compounds (VOCs) have been associated with numerous health complications including steatohepatitis and liver cancer. However, the potential impact of environmental/residential VOC exposures on liver health and function is largely unknown. To address this knowledge gap, the objective of this cross-sectional study is to investigate associations between VOCs and liver injury biomarkers in community residents. Subjects were recruited from six Louisville neighborhoods, and informed consent was obtained. Exposure biomarkers included 16 creatinine-adjusted urinary metabolites corresponding to 12 parent VOCs. Serological disease biomarkers measured included cytokertain-18 (K18 M65 and M30), liver enzymes and direct bilirubin. Associations between exposure and disease biomarkers were assessed using generalized linear models. Smoking status was confirmed through urinary cotinine levels. The population comprised of approximately 60% females and 40% males; White persons accounted 78% of the population; with more nonsmokers (n=413) than smokers (n=250). When compared to nonsmokers, Males (45%) and Black persons (26%) were more likely to be smokers. In the overall population, metabolites of acrolein, acrylonitrile, acrylamide, 1,3-butadiene, crotonaldehyde, styrene and xylene were positively associated with alkaline phosphatase (ALP). These associations persisted in smokers, with the exception of crotonaldehyde, and addition of N,N dimethylformamide and propylene oxide metabolites. Although no positive associations were observed for K18 M30, the benzene metabolite was positively associated with bilirubin, irrespective of smoking status. Taken together, the results demonstrated that selected VOCs were positively associated with liver injury biomarkers. These findings will enable better risk assessment and identification of populations vulnerable to liver disease.

The occurrence of volatile organic compounds in aquifers of the United States

2006 ◽  
Author(s):  
Wayne W. Lapham ◽  
Janet M. Carter ◽  
John S. Zogorski ◽  
Joshua F. Valder
Keyword(s):  
United States ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
The United States ◽  
Volatile Organic
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