scholarly journals Comparative Evaluation of Dental Implant Failure among Healthy and Well-Controlled Diabetic Patients—A 3-Year Retrospective Study

2020 ◽  
Vol 17 (14) ◽  
pp. 5253 ◽  
Author(s):  
Mohammed Ghazi Sghaireen ◽  
Abdulrahman A. Alduraywish ◽  
Kumar Chandan Srivastava ◽  
Deepti Shrivastava ◽  
Santosh R Patil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Retrospective Study ◽  
Dental Implants ◽  
Dental Implant ◽  
Failure Rate ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Oral Rehabilitation ◽  
Operative Evaluation

Diabetes mellitus is known to compromise the various aspects of homeostasis, including the immune response and the composition of oral microflora. One of the oral manifestations of diabetes mellitus is tooth loss and the survival rate of dental implants chosen as a treatment modality for its rehabilitation is controversial. The current study aims to evaluate and compare the failure rate of dental implants between well-controlled diabetic and healthy patients. A retrospective study of case-control design was conceptualized with 121 well-controlled diabetic and 136 healthy individuals. Records of subjects who had undergone oral rehabilitation with dental implants between the periods of January 2013 to January 2016 were retrieved. Post-operative evaluation was carried out for all patients for about three years to assess the immediate and long-term success of the procedure. From a total of 742 dental implants, 377 were placed in well-controlled diabetic patients (case group) and 365 in healthy subjects (control group). A comparable (9.81%), but non-significant (p = 0.422) failure rate was found in the case group in comparison to the control group (9.04%). A non-significant (p = 0.392) raised number (4.98%) of failure cases were reported among females in comparison to males (4.44%). In respect to arch, the mandibular posterior region was reported as the highest failure cases (3.09%; p = 0.411), with 2.29% of cases reported in the mandibular anterior (p = 0.430) and maxillary posterior (p = 0.983) each. The maxillary anterior region was found to have the least number (1.75%; p = 0.999) of failure cases. More (4.98%; p = 0.361) cases were reported to fail during the functional loading stage in contrast to osseointegration (4.44%; p = 0.365). A well-controlled diabetic status does not impose any additional risk for individuals undergoing dental implant therapy.

scholarly journals Oral Rehabilitation on Implants and Introduction of Pathogenic Mechanisms in Relation to Oral Implants - Sugar Diabetes

2019 ◽  
Vol 70 (10) ◽  
pp. 3750-3752
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Failure Rate ◽  
Primary Stability ◽  
Advanced Technology ◽  
Diabetic Patients ◽  
Oral Rehabilitation ◽  
Complete Replacement ◽  
Oral Implants ◽  
Dental Aesthetics

Dental implants are made of medical titanium and perfectly fit into human bone tissue; the dental implant can last a lifetime. Not beeing living organic structures, there are no nerve endings, neither at the implant level nor at the artificial crown level. The use of quality implants by an experienced implantologist, assisted by advanced technology, transforms the treatment with dental implants into the medical-surgical act with the highest success rate among dental and even medical treatments.Through the complete replacement of the tooth, including the root, can artificially reproduce the function of the natural tooth, with a strong and stable base. The implant crown, made of aesthetic materials (porcelain, zirconium) and anchored to it by means of the prosthetic abutment, will be surrounded by a healthy and aesthetic gum. Especially if the prosthetic abutment (the connecting element between the implant itself and the artificial crown) will be made of zirconium - natural light will cross ceramic layers, similar to enamel and dentine, offering a white of envy and glitter to the smile. Around the porcelain crowns (whole ceramics or zirconia ceramics) the gingiva will conform healthily, without the slightest sign of inflammation. These elements, the white of the teeth and the pink of the gums define the concept of dental aesthetics. The main problems that diabetic patients may encounter, are gingival inflammation and periodontal disease, dental mobility and tooth loss. When a dental implant is influenced by the type of diabetes, its failure rate is higher in patients with type 1 diabetes than in patients with type 2 diabetes. The study included a number of 56 patients, who presented themselves for performing an implant. Of these, 7 patients did not perform an implant. Diabetes mellitus defines a chronic metabolic disorder, which may have multiple etiopathogenesis, characterized by changes in carbohydrate, lipid and protein metabolism. Stability of the implant in the bone, immediately after implantation is crucial for the success of the treatment; this immediate stability is called primary stability and is purely mechanical in nature. Keywords: Dental implants, dental treatments, diabetes, failure rate

scholarly journals Systematic review on diabetes mellitus and dental implants: an update

2022 ◽  
Vol 8 (1) ◽  
Author(s):  
Juliane Wagner ◽  
Johannes H. Spille ◽  
Jörg Wiltfang ◽  
Hendrik Naujokat
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Dental Implants ◽  
Dental Implant ◽  
International Diabetes Federation ◽  
Diabetic Patients ◽  
Oral Rehabilitation ◽  
Implant Surgery ◽  
Controlled Conditions ◽  
Dental Implant Surgery

Abstract Purpose Dental implant surgery was developed to be the most suitable and comfortable instrument for dental and oral rehabilitation in the past decades, but with increasing numbers of inserted implants, complications are becoming more common. Diabetes mellitus as well as prediabetic conditions represent a common and increasing health problem (International Diabetes Federation in IDF Diabetes Atlas, International Diabetes Federation, Brussels, 2019) with extensive harmful effects on the entire organism [(Abiko and Selimovic in Bosnian J Basic Med Sci 10:186–191, 2010), (Khader et al., in J Diabetes Complicat 20:59–68, 2006, 10.1016/j.jdiacomp.2005.05.006)]. Hence, this study aimed to give an update on current literature on effects of prediabetes and diabetes mellitus on dental implant success. Methods A systematic literature research based on the PRISMA statement was conducted to answer the PICO question “Do diabetic patients with dental implants have a higher complication rate in comparison to healthy controls?”. We included 40 clinical studies and 16 publications of aggregated literature in this systematic review. Results We conclude that patients with poorly controlled diabetes mellitus suffer more often from peri-implantitis, especially in the post-implantation time. Moreover, these patients show higher implant loss rates than healthy individuals in long term. Whereas, under controlled conditions success rates are similar. Perioperative anti-infective therapy, such as the supportive administration of antibiotics and chlorhexidine, is the standard nowadays as it seems to improve implant success. Only few studies regarding dental implants in patients with prediabetic conditions are available, indicating a possible negative effect on developing peri-implant diseases but no influence on implant survival. Conclusion Dental implant procedures represent a safe way of oral rehabilitation in patients with prediabetes or diabetes mellitus, as long as appropriate precautions can be adhered to. Accordingly, under controlled conditions there is still no contraindication for dental implant surgery in patients with diabetes mellitus or prediabetic conditions.

scholarly journals Association Between Exercise and Blood Glucose Levels In Diabetic Patients

2017 ◽  
Vol 4 (2) ◽  
pp. 188
Author(s):  
Eryna Laili Putri
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Design Data ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Average Blood Glucose ◽  
Intensity Of Exercise

Diabetes Mellitus (DM) is a chronic disease with high prevalence, associated with various debilitating complications and can decreases the quality of life in people with it. It is important for people with DM to doing exercise to control the stability of their blood glucose levels. The purpose of this study was to finding out the association between frequency, duration, and intensity of exercise with average blood glucose levels in people with DM. This was an observational study that used case control design. Data obtained from interview with 20 samples from case group and 20 samples from control group, that had been chosen with systematic random sampling technique. Dependent variable of this study was the average blood glucose levels and independents variables were frequency, duration, intensity, and the kind of exercise. This study used Chi Square test 3 × 2 contingency tables to finding out the association and risk of dependent variable with independent variables,. The results showed that exercise factors that associated to average blood glucose levels were duration of exercise (p = 0.022) and intensity of exercise (p = 0.021). The frequency of exercise does not associated to average blood glucose levels (p = 0.340). Diabetic patients who did not do any exercise have the risk of having uncontrolled blood glucose levels. The conclusion was duration and intensity of exercise related significantly to blood glucose levels. By doing exercise three times a week for 30 minutes or more can decreases the risk of uncontrolled blood glucose levels in people with DM.Keywords: Diabetes mellitus, exercise, average blood glucose levels

Evaluation of α-klotho level in insulin dependent diabetes mellitus (IDDM) children

2020 ◽  
Vol 33 (6) ◽  
pp. 761-765
Author(s):  
Fariba Tarhani ◽  
Ghobad Heidari ◽  
Alireza Nezami
Keyword(s):  
Diabetes Mellitus ◽  
Type I Diabetes ◽  
Sandwich Elisa ◽  
Serum Levels ◽  
Dependent Diabetes Mellitus ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Type I ◽  
And Control

AbstractObjectivesReduced levels of α-Klotho is associated with the pathogenesis of various diseases including diabetes. In type I diabetes, decrease in Klotho leads to apoptosis of β-cells of pancreases. The aim of this study was to evaluate the levels of α-Klotho in type I diabetic pediatric patients.MethodsIn this cross-sectional single centered study, 46 patients presenting type I diabetes mellitus (case group) and 78 control group under the age of 12, referred to our clinic were included in our study. Serum levels of soluble Klotho were measured by sandwich ELISA in case and control groups. Statistical analysis was conducted for the data recorded via questionnaire.ResultsMean age of the patients in the case and control group was 7.65 ± 3.09 and 7 ± 2.37, respectively. Type I diabetes patients had a significant reduction in the levels of serum Klotho, as compared to controls (p<0.001). However, gender and age-based comparison between patient and control group was not significant.ConclusionsThis study reports a significant decrease in the serum levels of α-Klotho in type 1 diabetic patients. Low levels of Klotho can be associated with diabetic nephropathy and other comorbidities in these patients.

scholarly journals Distribution of DD Genotype of Angiotensin-Converting Enzyme Gene and Its Correlation with Diabetic Retinopathy

2021 ◽  
Vol 1 (2) ◽  
Author(s):  
Hamid Ali-Bahar ◽  
Maysam Mard-Soltani ◽  
Yousef Paridar ◽  
Zahra Nasirbaghban ◽  
Zahra Sadat Hashemi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Angiotensin Converting Enzyme ◽  
Microvascular Complications ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Converting Enzyme ◽  
Ace Gene ◽  
And Control

Background: One of the major microvascular complications of diabetes mellitus (DM) is diabetic retinopathy (DR). Studies have shown that angiotensin-converting enzyme (ACE) gene polymorphisms are correlated with DR progression. Accordingly, the elucidation of the association between ACE gene polymorphism and the risk of DR development seems to be highly crucial. Methods: In this study, 195 individuals with type 2 diabetes mellitus (T2DM) were classified as the case group with retinopathy (99 people) and control group without retinopathy (96 people). Screening for DR was performed by ophthalmologists using clinical examination and fluorescein angiography. Different ACE genotypes (II, ID, and DD) were identified by the collection of blood samples, extraction of DNA, and PCR amplification using specific primers. Results: The frequency distribution of genotypes was significantly different between the case and control groups (P = 0.009). Interestingly, possessing a DD genotype made diabetic patients approximately 2.5 folds (95% CI = 1.271 - 4.840, P = 0.007) and 3.25 folds (95% CI = 1.312 - 8.051, P = 0.01) more susceptible to DR when compared to having DI and II genotypes, respectively. Moreover, having a D allele made diabetic individuals nearly 1.75 folds (95% CI = 1.167 - 2.623, P = 0.007) more susceptible to DR than possessing an I allele. Conclusions: Our results potentiate the hypothesis that the DD genotype and D allele of the ACE gene might play a role in the pathogenesis of DR.

scholarly journals Relationship Between Serum Ferritin Level and Hba1c in Bangladeshi Type 2 Diabetic Patients

2018 ◽  
Vol 9 (1) ◽  
pp. 29-33
Author(s):  
Farhana Khondker ◽  
Manindra Nath Roy ◽  
Purnima Rani Saha ◽  
Rubena Huq ◽  
Rumana Ahmed ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Pearson Correlation ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Endocrine Disorders ◽  
Medical College

Background: Diabetes mellitus (DM) type 2 is one of the most common endocrine disorders affecting more than 135 million people in the world. The etiology of the disease is not fully understood, but recently subclinical hemochromatosis has been considered as one of the probable causes of DM. This study was carried out to examine the relationship between serum ferritin as a marker of iron overload with DM and HbA1c.Materials & Method: This study was conducted in the Biochemistry department of Sir Salimullah Medical College, Dhaka; over a period of 18 months from July 2013 to December 2014. In this case control study, 46 patients with type 2 diabetes were taken as case, who were referred to theoutpatient department of "Ibrahim General Hospital & Diabetic care & Educational Center"(DCEC). 46 normal individuals were included as the control group, who were matched with the case group regarding age, sex, BMI and Hb%. Ferritin, hemoglobin, HbA1c and fasting plasma sugar were measured in blood samples. Exclusion criteria included anaemia, or any other disease or drug that could affect ferritin levels.Result: Results were analyzed statistically by Chi-square test, Student's t-test, Pearson correlation coefficient test and Odds ratio.Mean serum ferritin was significantly higher in diabetics than in the control group (197.97±75.99 µgm/L vs. 64.24±27.83 µgm/L, p<0.001). There was significant positive correlation between serum ferritin and HbA1cin diabetic patients (p<0.001). In this study, OR of 11.64 was also found.Conclusion: Serum ferritin is positively correlated with type 2 Diabetes Mellitus. And this may be an important and independent predictor for development of diabetes mellitus.Anwer Khan Modern Medical College Journal Vol. 9, No. 1: Jan 2018, P 29-33

scholarly journals Association Between Exercise and Blood Glucose Levels In Diabetic Patients

2017 ◽  
Vol 4 (2) ◽  
pp. 188
Author(s):  
Eryna Laili Putri
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Design Data ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Average Blood Glucose ◽  
Intensity Of Exercise

Diabetes Mellitus (DM) is a chronic disease with high prevalence, associated with various debilitating complications and can decreases the quality of life in people with it. It is important for people with DM to doing exercise to control the stability of their blood glucose levels. The purpose of this study was to finding out the association between frequency, duration, and intensity of exercise with average blood glucose levels in people with DM. This was an observational study that used case control design. Data obtained from interview with 20 samples from case group and 20 samples from control group, that had been chosen with systematic random sampling technique. Dependent variable of this study was the average blood glucose levels and independents variables were frequency, duration, intensity, and the kind of exercise. This study used Chi Square test 3 × 2 contingency tables to finding out the association and risk of dependent variable with independent variables,. The results showed that exercise factors that associated to average blood glucose levels were duration of exercise (p = 0.022) and intensity of exercise (p = 0.021). The frequency of exercise does not associated to average blood glucose levels (p = 0.340). Diabetic patients who did not do any exercise have the risk of having uncontrolled blood glucose levels. The conclusion was duration and intensity of exercise related significantly to blood glucose levels. By doing exercise three times a week for 30 minutes or more can decreases the risk of uncontrolled blood glucose levels in people with DM.Keywords: Diabetes mellitus, exercise, average blood glucose levels

scholarly journals The Increase of Periodontal Tissue in Type 2 Diabetes Mellitus Patients Based on Index CPITN

2016 ◽  
Vol 12 (1) ◽  
Author(s):  
Budiman Budiman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Periodontal Disease ◽  
Periodontal Pocket ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Periodontal Tissue ◽  
Pocket Depth

The prevalence of periodontal disease in Indonesia for all age groups has reached 96.58%. Periodontal disease has been identified as a consequence of diabetes mellitus (DM). The purpose of this study is to determine the differences of periodontal tissues in type 2 diabetes and non-diabetic patients based on CPITN index (Community periodontal index of Treatment index). This study employed case control design. The population of the study consisted of 3.544 visits in the Internal Disease Polyclinic of RSUD Cimahi Cibabat in January 2015. The samples for case group were 50 people (diabetes mellitus type 2) and control group were 50 people (non-DM). The sampling technique used accidental sampling. The study was conducted in 2015 by conducting measurement of periodontal pocket depth using CPITN index. The analysis of data was carried out with independent T test. The results show that the average pocket depth based on CPITN index in the case group of type 2 DM (4.26) is greater than control group of patients without DM (3.14). There is different condition on the periodontal tissue in the group of type 2 diabetes (value-p = 0.002 <0.05). The awareness in increasing the oral health protection is done by providing consultation related to blood glucose.

STUDY ON THE EVALUATION OF ORAL REHABILITATION USING DENTAL IMPLANT BY QANTIFYING OSTEOPROTEGERIN AND INTERLEUKIN

2020 ◽  
Author(s):  
Florin Ciprian Badea ◽  
Elvis Sachir Erdogan ◽  
Gheorghe Raftu ◽  
Victoria Badea ◽  
Mircea Grigorian
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Treatment Plan ◽  
Statistical Significance ◽  
Clinical Status ◽  
Severe Form ◽  
Control Group ◽  
Real Problem ◽  
Oral Rehabilitation ◽  
Crevicular Fluid

Partial and total edentation has been a real problem worldwide and at all times. The realization of an individualized treatment plan for each form of edentation takes into account the particularities of the edentulous prosthetic field and the materials used as well as the conventional or modern techniques applied. The study group consisted of 220 patients in whom dental implants were inserted; the control group was randomized from 10 patients with a favorable evolution out of the 210 (94.55%). At 7 and 60 days after the insertion of the dental implants and 6 months after their prosthetic loading, crevicular fluid and peri-implant fluid was harvested, for the quantitative determination of Osteoprotegerin (OPG) and Interleukin 1β (IL1-β). Of the 220 patients studied, 10 developed peri implantitis (5.45%) as follows: 4 patients with mucositis and 6 patients with severe form. The results obtained show that there are differences with statistical significance between the OPG values obtained in crevicular fluid in healthy compared to patients with mucositis after 7 days (p <0.001). Regarding IL1-β, there are differences with high statistical significance between the levels in healthy patients and those with peri-implantitis after 7 days (p <0.001). Our results show the existence of a high correlation between the clinical status and these two parameters, especially after the determinations performed at 7 and 60 days. In conclusions, the present study shows that the OPG and IL1-β can be considered useful markers in the evaluation of the patient after the insertion of the dental implant and after its prosthetic loading.

scholarly journals Effect of Masticatory Forces Transmitted by Dental Implants on the Mandibular Bone of Patients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 22 (4) ◽  
pp. 419-424
Author(s):  
Raluca-Iulia Juncar ◽  
Mihai Juncar ◽  
Florin-Onişor Gligor ◽  
Amorin-Remus Popa
Keyword(s):  
Diabetes Mellitus ◽  
Bone Resorption ◽  
Dental Implants ◽  
Dental Implant ◽  
Adult Population ◽  
Considerable Proportion ◽  
Diabetic Patients ◽  
Mandibular Bone ◽  
Implant Exposure ◽  
Bone Response

Abstract Background and Aims: Diabetes mellitus is considered to be one of the most important diseases of our society, affecting a considerable proportion of the adult population. Currently, dental implant treatment of diabetic patients is controversial, the main controversy being related to changes that occur in the jaw bones of the diabetic patient and the ensuing side effects. This preliminary study aims to evaluate the response of mandibular bone to masticatory forces transmitted by dental implants in diabetic patients. Material and Method: 11 dental implants placed in the mandible were selected, and mandibular bone resorption as a result of masticatory forces transmitted by them was evaluated. Results: The mean bone resorption rates were the following: 2.72% at the time of dental implant exposure, 10% at 3 months from dental implant exposure, and 13.63% at 6 months from exposure. Conclusions: No significant changes in mandibular bone response to the action of dental implants were found in diabetic patients compared to standard response reported in non-diabetic patients.

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