scholarly journals Predicting the Associations between Meridians and Chinese Traditional Medicine Using a Cost-Sensitive Graph Convolutional Neural Network

Author(s):  
Hsiang-Yuan Yeh ◽  
Chia-Ter Chao ◽  
Yi-Pei Lai ◽  
Huei-Wen Chen

Natural products are the most important and commonly used in Traditional Chinese Medicine (TCM) for healthcare and disease prevention in East-Asia. Although the Meridian system of TCM was established several thousand years ago, the rationale of Meridian classification based on the ingredient compounds remains poorly understood. A core challenge for the traditional machine learning approaches for chemical activity prediction is to encode molecules into fixed length vectors but ignore the structural information of the chemical compound. Therefore, we apply a cost-sensitive graph convolutional neural network model to learn local and global topological features of chemical compounds, and discover the associations between TCM and their Meridians. In the experiments, we find that the performance of our approach with the area under the receiver operating characteristic curve (ROC-AUC) of 0.82 which is better than the traditional machine learning algorithm and also obtains 8%–13% improvement comparing with the state-of-the-art methods. We investigate the powerful ability of deep learning approach to learn the proper molecular descriptors for Meridian prediction and to provide novel insights into the complementary and alternative medicine of TCM.

2019 ◽  
Vol 147 (8) ◽  
pp. 2827-2845 ◽  
Author(s):  
David John Gagne II ◽  
Sue Ellen Haupt ◽  
Douglas W. Nychka ◽  
Gregory Thompson

Abstract Deep learning models, such as convolutional neural networks, utilize multiple specialized layers to encode spatial patterns at different scales. In this study, deep learning models are compared with standard machine learning approaches on the task of predicting the probability of severe hail based on upper-air dynamic and thermodynamic fields from a convection-allowing numerical weather prediction model. The data for this study come from patches surrounding storms identified in NCAR convection-allowing ensemble runs from 3 May to 3 June 2016. The machine learning models are trained to predict whether the simulated surface hail size from the Thompson hail size diagnostic exceeds 25 mm over the hour following storm detection. A convolutional neural network is compared with logistic regressions using input variables derived from either the spatial means of each field or principal component analysis. The convolutional neural network statistically significantly outperforms all other methods in terms of Brier skill score and area under the receiver operator characteristic curve. Interpretation of the convolutional neural network through feature importance and feature optimization reveals that the network synthesized information about the environment and storm morphology that is consistent with our understanding of hail growth, including large lapse rates and a wind shear profile that favors wide updrafts. Different neurons in the network also record different storm modes, and the magnitude of the output of those neurons is used to analyze the spatiotemporal distributions of different storm modes in the NCAR ensemble.


2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Peter M. Maloca ◽  
Philipp L. Müller ◽  
Aaron Y. Lee ◽  
Adnan Tufail ◽  
Konstantinos Balaskas ◽  
...  

AbstractMachine learning has greatly facilitated the analysis of medical data, while the internal operations usually remain intransparent. To better comprehend these opaque procedures, a convolutional neural network for optical coherence tomography image segmentation was enhanced with a Traceable Relevance Explainability (T-REX) technique. The proposed application was based on three components: ground truth generation by multiple graders, calculation of Hamming distances among graders and the machine learning algorithm, as well as a smart data visualization (‘neural recording’). An overall average variability of 1.75% between the human graders and the algorithm was found, slightly minor to 2.02% among human graders. The ambiguity in ground truth had noteworthy impact on machine learning results, which could be visualized. The convolutional neural network balanced between graders and allowed for modifiable predictions dependent on the compartment. Using the proposed T-REX setup, machine learning processes could be rendered more transparent and understandable, possibly leading to optimized applications.


2021 ◽  
Author(s):  
Aria Abubakar ◽  
Mandar Kulkarni ◽  
Anisha Kaul

Abstract In the process of deriving the reservoir petrophysical properties of a basin, identifying the pay capability of wells by interpreting various geological formations is key. Currently, this process is facilitated and preceded by well log correlation, which involves petrophysicists and geologists examining multiple raw log measurements for the well in question, indicating geological markers of formation changes and correlating them with those of neighboring wells. As it may seem, this activity of picking markers of a well is performed manually and the process of ‘examining’ may be highly subjective, thus, prone to inconsistencies. In our work, we propose to automate the well correlation workflow by using a Soft- Attention Convolutional Neural Network to predict well markers. The machine learning algorithm is supervised by examples of manual marker picks and their corresponding occurrence in logs such as gamma-ray, resistivity and density. Our experiments have shown that, specifically, the attention mechanism allows the Convolutional Neural Network to look at relevant features or patterns in the log measurements that suggest a change in formation, making the machine learning model highly precise.


2021 ◽  
Author(s):  
Naveen Kumar ◽  
Shashank Srivast

Abstract NDN Pending Interest Table (PIT) helps NDN by storing the state of a request within the router. This state information helps the router to redirect the data packet towards the requester. However, an attacker can send malicious requests, which could flood the PIT; this attack is known as Interest Flooding Attack (IFA). In our previous work, we have found the most relevant features needed to detect IFA and applied a few machine learning approaches for the offline detection of IFA. In this article, a trained Artificial Neural Network (ANN) classifier has been deployed on each NDN router for the online detection of IFA. A novel traceback-based mitigation is proposed, which is triggered after the detection. The proposed approach is found better than the previous approach in terms of the satisfaction ratio and throughput of the legitimate consumers.


The applications of a content-based image retrieval system in fields such as multimedia, security, medicine, and entertainment, have been implemented on a huge real-time database by using a convolutional neural network architecture. In general, thus far, content-based image retrieval systems have been implemented with machine learning algorithms. A machine learning algorithm is applicable to a limited database because of the few feature extraction hidden layers between the input and the output layers. The proposed convolutional neural network architecture was successfully implemented using 128 convolutional layers, pooling layers, rectifier linear unit (ReLu), and fully connected layers. A convolutional neural network architecture yields better results of its ability to extract features from an image. The Euclidean distance metric is used for calculating the similarity between the query image and the database images. It is implemented using the COREL database. The proposed system is successfully evaluated using precision, recall, and F-score. The performance of the proposed method is evaluated using the precision and recall.


2021 ◽  
Vol 8 ◽  
Author(s):  
Ann N. Allen ◽  
Matt Harvey ◽  
Lauren Harrell ◽  
Aren Jansen ◽  
Karlina P. Merkens ◽  
...  

Passive acoustic monitoring is a well-established tool for researching the occurrence, movements, and ecology of a wide variety of marine mammal species. Advances in hardware and data collection have exponentially increased the volumes of passive acoustic data collected, such that discoveries are now limited by the time required to analyze rather than collect the data. In order to address this limitation, we trained a deep convolutional neural network (CNN) to identify humpback whale song in over 187,000 h of acoustic data collected at 13 different monitoring sites in the North Pacific over a 14-year period. The model successfully detected 75 s audio segments containing humpback song with an average precision of 0.97 and average area under the receiver operating characteristic curve (AUC-ROC) of 0.992. The model output was used to analyze spatial and temporal patterns of humpback song, corroborating known seasonal patterns in the Hawaiian and Mariana Islands, including occurrence at remote monitoring sites beyond well-studied aggregations, as well as novel discovery of humpback whale song at Kingman Reef, at 5∘ North latitude. This study demonstrates the ability of a CNN trained on a small dataset to generalize well to a highly variable signal type across a diverse range of recording and noise conditions. We demonstrate the utility of active learning approaches for creating high-quality models in specialized domains where annotations are rare. These results validate the feasibility of applying deep learning models to identify highly variable signals across broad spatial and temporal scales, enabling new discoveries through combining large datasets with cutting edge tools.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Arya Panji Pamuncak ◽  
Mohammad Reza Salami ◽  
Augusta Adha ◽  
Bambang Budiono ◽  
Irwanda Laory

PurposeStructural health monitoring (SHM) has gained significant attention due to its capability in providing support for efficient and optimal bridge maintenance activities. However, despite the promising potential, the effectiveness of SHM system might be hindered by unprecedented factors that impact the continuity of data collection. This research presents a framework utilising convolutional neural network (CNN) for estimating structural response using environmental variations.Design/methodology/approachThe CNN framework is validated using monitoring data from the Suramadu bridge monitoring system. Pre-processing is performed to transform the data into data frames, each containing a sequence of data. The data frames are divided into training, validation and testing sets. Both the training and validation sets are employed to train the CNN models while the testing set is utilised for evaluation by calculating error metrics such as mean absolute error (MAE), mean absolute percentage error (MAPE) and root mean square error (RMSE). Comparison with other machine learning approaches is performed to investigate the effectiveness of the CNN framework.FindingsThe CNN models are able to learn the trend of cable force sensor measurements with the ranges of MAE between 10.23 kN and 19.82 kN, MAPE between 0.434% and 0.536% and RMSE between 13.38 kN and 25.32 kN. In addition, the investigation discovers that the CNN-based model manages to outperform other machine learning models.Originality/valueThis work investigates, for the first time, how cable stress can be estimated using temperature variations. The study presents the first application of 1-D CNN regressor on data collected from a full-scale bridge. This work also evaluates the comparison between CNN regressor and other techniques, such as artificial neutral network (ANN) and linear regression, in estimating bridge cable stress, which has not been performed previously.


Author(s):  
Vijayaprabakaran K. ◽  
Sathiyamurthy K. ◽  
Ponniamma M.

A typical healthcare application for elderly people involves monitoring daily activities and providing them with assistance. Automatic analysis and classification of an image by the system is difficult compared to human vision. Several challenging problems for activity recognition from the surveillance video involving the complexity of the scene analysis under observations from irregular lighting and low-quality frames. In this article, the authors system use machine learning algorithms to improve the accuracy of activity recognition. Their system presents a convolutional neural network (CNN), a machine learning algorithm being used for image classification. This system aims to recognize and assist human activities for elderly people using input surveillance videos. The RGB image in the dataset used for training purposes which requires more computational power for classification of the image. By using the CNN network for image classification, the authors obtain a 79.94% accuracy in the experimental part which shows their model obtains good accuracy for image classification when compared with other pre-trained models.


2020 ◽  
Vol 102-B (6_Supple_A) ◽  
pp. 101-106
Author(s):  
Romil F. Shah ◽  
Stefano A. Bini ◽  
Alejandro M. Martinez ◽  
Valentina Pedoia ◽  
Thomas P. Vail

Aims The aim of this study was to evaluate the ability of a machine-learning algorithm to diagnose prosthetic loosening from preoperative radiographs and to investigate the inputs that might improve its performance. Methods A group of 697 patients underwent a first-time revision of a total hip (THA) or total knee arthroplasty (TKA) at our institution between 2012 and 2018. Preoperative anteroposterior (AP) and lateral radiographs, and historical and comorbidity information were collected from their electronic records. Each patient was defined as having loose or fixed components based on the operation notes. We trained a series of convolutional neural network (CNN) models to predict a diagnosis of loosening at the time of surgery from the preoperative radiographs. We then added historical data about the patients to the best performing model to create a final model and tested it on an independent dataset. Results The convolutional neural network we built performed well when detecting loosening from radiographs alone. The first model built de novo with only the radiological image as input had an accuracy of 70%. The final model, which was built by fine-tuning a publicly available model named DenseNet, combining the AP and lateral radiographs, and incorporating information from the patient’s history, had an accuracy, sensitivity, and specificity of 88.3%, 70.2%, and 95.6% on the independent test dataset. It performed better for cases of revision THA with an accuracy of 90.1%, than for cases of revision TKA with an accuracy of 85.8%. Conclusion This study showed that machine learning can detect prosthetic loosening from radiographs. Its accuracy is enhanced when using highly trained public algorithms, and when adding clinical data to the algorithm. While this algorithm may not be sufficient in its present state of development as a standalone metric of loosening, it is currently a useful augment for clinical decision making. Cite this article: Bone Joint J 2020;102-B(6 Supple A):101–106.


Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 181
Author(s):  
Anna Landsmann ◽  
Jann Wieler ◽  
Patryk Hejduk ◽  
Alexander Ciritsis ◽  
Karol Borkowski ◽  
...  

The aim of this study was to investigate the potential of a machine learning algorithm to accurately classify parenchymal density in spiral breast-CT (BCT), using a deep convolutional neural network (dCNN). In this retrospectively designed study, 634 examinations of 317 patients were included. After image selection and preparation, 5589 images from 634 different BCT examinations were sorted by a four-level density scale, ranging from A to D, using ACR BI-RADS-like criteria. Subsequently four different dCNN models (differences in optimizer and spatial resolution) were trained (70% of data), validated (20%) and tested on a “real-world” dataset (10%). Moreover, dCNN accuracy was compared to a human readout. The overall performance of the model with lowest resolution of input data was highest, reaching an accuracy on the “real-world” dataset of 85.8%. The intra-class correlation of the dCNN and the two readers was almost perfect (0.92) and kappa values between both readers and the dCNN were substantial (0.71–0.76). Moreover, the diagnostic performance between the readers and the dCNN showed very good correspondence with an AUC of 0.89. Artificial Intelligence in the form of a dCNN can be used for standardized, observer-independent and reliable classification of parenchymal density in a BCT examination.


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