scholarly journals The Association between Frailty Indicators and Blood-Based Biomarkers in Early-Old Community Dwellers of Thailand

2019 ◽  
Vol 16 (18) ◽  
pp. 3457 ◽  
Author(s):  
Warathit Semmarath ◽  
Mathuramat Seesen ◽  
Supachai Yodkeeree ◽  
Ratana Sapbamrer ◽  
Pisittawoot Ayood ◽  
...  
Keyword(s):  
Healthy Aging ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Frailty Phenotype ◽  
Cross Sectional ◽  
Frailty Status ◽  
Reactive Protein ◽  
Hand Grip ◽  
The Status ◽  
Community Dwellers

Thailand has officially reached the status of an “aged society” and become the developing country with the 2nd largest proportion of senior citizens in Southeast Asia. A cross-sectional study of 526 early-old community dwellers was conducted for the Fried frailty phenotype assessment, This included five indicators: Weakness, slowness, physical activity, exhaustion, and weight loss. C-reactive protein (CRP), interleukin-6 (IL-6), insulin-like growth factor-1, and CD4+:CD8+ Ratio which serve as blood-based biomarkers of frailty. The prevalence of frailty and pre-frail in this population was found to be 15% and 69.6% respectively and was higher among women than men. Frail (n = 58) and non-frail (n = 60) participants were evaluated for the associations between the frail indicators and the blood-based biomarkers. Serum levels of IL-6 and CRP from frail group were significantly elevated when compared with the non-frail counterparts (p = 0.044 and 0.033, respectively), and were significantly associated with the frailty status with an Odd RatioIL-6 [OR] of 1.554-fold (95% confidence interval [CI], 1.229–1.966) and an ORCRP of 1.011-fold (95 CI, 1.006–1.016). Decreased hand-grip strength was the only frailty indicator that was significantly associated with both inflammatory biomarkers, (ORIL-6 of 1.470-fold and ORCRP of 1.008-fold). Our study is the first to assess the frailty status among the early-old population in Thailand. These findings will encourage general practitioners to combine frailty indicators and serum biomarkers as early detection tools for at-risk older adults to achieve the goal of healthy aging.

A STUDY TO EVALUATE THE ROLE OF HIGH SENSITIVITY C-REACTIVE PROTEIN IN CEREBROVASCULAR ACCIDENT IN THE DARBHANGA MEDICAL COLLEGE AND HOSPITAL

2021 ◽  
pp. 71-73
Author(s):  
Amit Kumar Tiwari ◽  
Umesh Chandra Jha ◽  
Debarshi Jana
Keyword(s):  
Cerebrovascular Accident ◽  
High Sensitivity ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Abrupt Onset ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Medical College ◽  
Reactive Protein ◽  
Hs Crp

INTRODUCTION:Cerebrovascular accident (commonly called stroke) is dened as an abrupt onset of a neurologic decit that is attributable to a focal vascular cause. Thus, the diagnosis of stroke is clinical and laboratory studies including brain imaging are used to support the diagnosis AIMS AND OBJECTIVES: To evaluate the serum levels of high sensitivity C-reactive protein (hsCRP) in different types of cerebrovascular accidents on admission. MATERIALS AND METHODS: This study was an institution based cross-sectional study designed to investigate the association of hs-CRP levels with stroke and its types in Indian patients. The study was done in the Department of Medicine, Darbhanga Medical College and Hospital, Laheriasarai, Bihar from march 2019 to March 2020. 50 patients of either sex above 12 years of age admitted in Medicine Department of DMCH, Laheriasarai, Bihar with clinically or radiologically diagnosed stroke. RESULT: The mean level of hsCRP (mean ± s.d.) of the cases in our study was 7.65±7.01 with range 1.4 – 26 and the median was 3.7 and 58% of the cases were having level of hsCRP≥3 (p=0.023).Mean level of hsCRPof cases was signicantly higher than that of control (t98=7.25;p=0.001). CONCLUSION:We concluded that hs-CRPlevel is increased in cases of cerebrovascular accident- ischemic as well as haemorrhagic, suggesting an inammatory response in acute cerebrovascular accident. hs-CRP level is increased in patients with ischemic cerebrovascular accident dramatically but not in haemorrhagic cerebrovascular accident which might be considered as useful adjunct method for determining type of stroke in patients with cerebrovascular problems.

Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: an observational study

2021 ◽  
Author(s):  
Tasrina Rabia Choudhury ◽  
Sk. Zubaer Zaman ◽  
Tanzina Iveen Chowdhury ◽  
Bilkis Ara Begum ◽  
Md. Anwarul Islam ◽  
...  
Keyword(s):  
Large Scale ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Urine Samples ◽  
Metal Exposure ◽  
Heavy Metal Exposure ◽  
Cross Sectional ◽  
Potential Association ◽  
The Status ◽  
Large Scale Epidemiological Study

Abstract The traditional causes of Chronic Kidney Damage (CKD) are Diabetes and Hypertension. However, recent studies reported the possible relations between metal exposure and CKD. This study aims to explore the status of metals in CKD patients compared to their healthy counterparts at Narayanganj, Bangladesh, through a cross-sectional study. In this study, 50 volunteers have involved; 30 CKD patients and 20 healthy controls. Five metals were measured from serum (Cu and Zn) and urine (Pb, Cd, and Cr) using Atomic Absorption Spectrophotometer (Varian AA240 FS). Compared to the controls and the CKD patients were exhibited a significantly higher level of Pb and Cr in their urine samples. As expected, it was observed that the cases had higher levels of Pb, Cd, and Cr in their urine. This signifies a potential association between heavy metal exposure and CKD. The serum levels of Cu were much higher than expected for CKD patients than controls, and the Zn values were in accordance with established literature. However, the level of Zn in blood was significantly lower in the CKD group compared to the control. This data suggests that the Cu imbalance in the serum of the CKD subjects might have been related to a myriad of reasons, one of which being exposed to large concentrations of the nephrotoxic metals such as Pb and Cr in this study. Large scale epidemiological study is warranted in Bangladesh to examine environmental health in relation to nephrology.

scholarly journals CORRELATION BETWEEN SERUM C-REACTIVE PROTEIN LEVEL WITH SEVERITY OF THE DISEASE IN COVID-19 PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Sangeeta Gahlot ◽  
Surendra Yadav ◽  
Makkhan Lal Saini
Keyword(s):  
Severe Disease ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Group I ◽  
Moderate Disease ◽  
Severity Of The Disease

Background: To find the levels of serum CRP in confirmed Covid-19 patients and to compare their levels in patients with mild to moderate disease and patients with severe disease who required ICU care for management. Methods: A Cross sectional study was carried out on 100 confirmed cases of Covid-19, in whom Serum levels of Random sugar (RBS), Creatinine, Urea, C- reactive protein (CRP) were measured. Results: The levels of serum Urea, Creatinine were significantly increased in group II when compared to group 1, and the levels of CRP were significantly increased with p value <0.0001 in group IIwhen compared to group I. Conclusion: Findings of our study suggest that determination of biochemical parameters like CRP at the time of hospitalization helps in predicting the severity of disease and need for ICU for better treatment management and prevention of adverse outcome. Keywords: Severe acute respiratory syndrome, Covid-19, C- reactive protein, Intensive care unit.

scholarly journals P054: Do biomarkers need clinical attention among pre-frail injured seniors seen in the ED

CJEM ◽  
2017 ◽  
Vol 19 (S1) ◽  
pp. S96
Author(s):  
M. Blouin ◽  
M. Sirois ◽  
M. Aubertin-Leheudre ◽  
L.E. Griffith ◽  
L. Nadeau ◽  
...  
Keyword(s):  
Functional Decline ◽  
Cross Sectional Study ◽  
Serum Biomarkers ◽  
Clinical Frailty Scale ◽  
Cross Sectional ◽  
Insulin Growth Factor ◽  
Frailty Status ◽  
Reactive Protein ◽  
Minor Injuries ◽  
A Minor

Introduction: Frailty is associated with functional decline and physiological impairments in seniors with minor injuries. Serum biomarkers have also been suggested as potential markers of these impairments in clinical studies. However, no study has addressed the usefulness of serum biomarkers among pre-frail seniors consulting emergency departments (ED) in order to detect these impairments.Objectives: The purpose of the present study was to explore the association between several serum biomarkers and the frailty status of seniors seen in ED for a minor injury who are at risk of functional decline and 2) assist professionals in clinical decisions while identifying frail seniors in whom interventions should be started in order to prevent potential functional decline. Methods: This cross-sectional study includes 190 seniors retrieved from the larger CETI cohort and discharged home from 4 EDs after treatment of minor injuries. Their frailty status was measured by the Canadian Study of Health &amp; Aging-Clinical Frailty Scale (CSHA-CFS). Then, patients were classified as “Robust” (CHSA-CFS levels 1 and 2) vs. “Pre-frail/Frail” (CHSA-CFS levels ≥3). Biomarkers (Albumin, Creatinine, C-reactive protein (CRP), Vitamin D, Ferritin, Glucose and Insulin-Growth Factor (IGF-1)) were obtained from blood samples. “Normal” vs. “Impaired” (low and/or high) clinical threshold values were used for statistical analyses. Results: The proportion of patients with clinically high creatinine levels (&gt;105 µmol/L for male and &gt;85 µmol/L for female) was higher in Pre-frails/Frails when compared to Robusts (P-value=0.01). Also, regarding IGF-1, we observed that the proportion of patients with lower IGF-1 levels (&lt;50 µg/L) was higher in patients showing Pre-frail/Frail status (P-value=0.01). Finally, a significant correlation was found between frailty status and blood glucose (r=0.22; P-value=0.02) whereas a tendency was noted for CRP level (r=0.14; P-value=0.1). Conclusion: When compared to Robust seniors, Pre-frail/Frail individuals presenting to EDs tend to have physiological dysregulations that may help detect pre-frail status in community-dwellers. Larger prospective studies are needed to specify the usefulness and clinical implications of frailty biomarkers in the continuum of acute elder care.

scholarly journals Evaluation of the glycemic effect of methotrexate in psoriatic arthritis patients with metabolic syndrome: A pilot study

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Tannaz Dehpouri ◽  
Ghasem Rahmatpour Rokni ◽  
Nematollah Ahangar Narenjbon ◽  
Mohamad Goldust ◽  
Paul S. Yamauchi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Psoriatic Arthritis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Potential Association ◽  
Before And After ◽  
The Status ◽  
Hba1c Levels

Methotrexate (MTX) is a systemic immunosuppressant drug used for the treatment of psoriasis and psoriatic arthritis. Previous studies demonstrated a potential association between psoriasis and diabetes mellitus, obesity, atherosclerosis, hypertension, eventuating into metabolic syndrome. This study aimed at exploring the glycemic effects of MTX in psoriatic arthritis (PsA) patients. In this prospective cross-sectional study, 27 patients with PsA were evaluated. The status of PsA and presence of accompanying metabolic syndrome was determined by standard criteria and indices. Blood indicators including HbA1c, erythrocyte sedimentation rate, fasting blood sugar, total cholesterol, high-density lipoprotein, triglycerides, and C-reactive protein were examined before and 12 weeks after MTX therapy. There were no significant changes between HbA1c levels before and after MTX therapy in both genders (men: P=0.131, women: P=0.803). In addition, HbA1c levels in PsA patients with metabolic syndrome were not different before and after treatment (P=0.250). Finally, HbA1c levels did not change in PsA patients without metabolic syndrome before and after therapy (P=0.506). MTX in PsA patients does not appear to have hyperglycaemic effects in the short-term and can be safely used in patients with metabolic syndrome and diabetes.

scholarly journals Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study

2021 ◽  
Author(s):  
Raden Muharam ◽  
Muhammad Saiful Rizal
Keyword(s):  
Inflammatory Diseases ◽  
Inflammatory Marker ◽  
Delayed Diagnosis ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Pathological Examination ◽  
Sectional Study ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein

Background: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs- CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. Objective: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. Materials and Methods: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the Phical® ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. Results: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = –0.16, p = 0.278). Conclusion: There is no correlation between calprotectin serum levels and the degrees of endometriosis. Key words: Calprotectin, Endometriosis, C-reactive protein, Inflammation.

scholarly journals Adipokine Profile and Urinary Albumin Excretion in Isolated Growth Hormone Deficiency

2010 ◽  
Vol 95 (2) ◽  
pp. 693-698 ◽  
Author(s):  
Carla R. P. Oliveira ◽  
Roberto Salvatori ◽  
Rafael A. Meneguz-Moreno ◽  
Manuel H. Aguiar-Oliveira ◽  
Rossana M. C. Pereira ◽  
...  
Keyword(s):  
Risk Factors ◽  
Urinary Albumin Excretion ◽  
Receptor Gene ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Urinary Albumin ◽  
Hormone Deficiency ◽  
Cross Sectional ◽  
Albumin Excretion ◽  
Reactive Protein

Abstract Background: GH deficiency (GHD) is often associated with cardiovascular risk factors, including abdominal fat accumulation, hypercholesterolemia, and increased C-reactive protein. Despite the presence of these risk factors, adults with congenital lifetime isolated GHD (IGHD) due to an inactivating mutation in the GHRH receptor gene do not have premature atherosclerosis. Objective: The aim was to study the serum levels of adiponectin and leptin (antiatherogenic and atherogenic adipokine, respectively), and the urinary albumin excretion (UAE) in these IGHD individuals. Design and Patients: We conducted a cross-sectional study of 20 IGHD individuals (seven males; age, 50.8 ± 14.6 yr) and 22 control subjects (eight males; age, 49.9 ± 11.5 yr). Main Outcome Measures: Anthropometric factors, body composition, blood pressure, serum adiponectin, leptin, and UAE were measured. Results: Adiponectin was higher [12.8 (7.1) vs. 9.7 (5) ng/ml; P = 0.041] in IGHD subjects, whereas no difference was observed in leptin [7.3 (6.3) vs. 9.3 (18.7 ng/ml] and UAE [8.6 (13.8) vs. 8.5 (11.1) μg/min]. Conclusions: Subjects with lifetime untreated IGHD have an adipokine profile with high adiponectin and normal leptin levels that may delay vascular damage and lesions of the renal endothelium.

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