scholarly journals Eight Weeks of Aerobic Interval Training Improves Psychomotor Function in Patients with Parkinson’s Disease—Randomized Controlled Trial

2019 ◽  
Vol 16 (5) ◽  
pp. 880 ◽  
Author(s):  
Jarosław Marusiak ◽  
Beth Fisher ◽  
Anna Jaskólska ◽  
Krzysztof Słotwiński ◽  
Sławomir Budrewicz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Control ◽  
Executive Function ◽  
Cognitive Function ◽  
Usual Care ◽  
Grip Force ◽  
Interval Training ◽  
Moderate Intensity ◽  
Aerobic Interval Training

Background: This study examined the generalized effects of cycle ergometer aerobic interval training (AIT) on psychomotor behaviors in individuals with Parkinson’s disease (PD), including bimanual motor control, cognitive function, and neurological motor and non-motor parkinsonian signs. Methods: Twenty mild to moderate PD patients were randomly allocated to the following groups: (1) trained group (PD-TR, n = 10), which besides receiving usual care, underwent an 8-week moderate intensity AIT program; or (2) control group (PD-CO, n = 10) which received usual care, including participation in conventional physical therapy. Both groups were tested before and after the 8-week AIT program period with the following assessments: (1) laboratory analyses of bimanual motor control, (2) psychological evaluation of cognitive function, and (3) an evaluation of neurological parkinsonian signs. Results: The PD-TR group exhibited improved (1) bimanual motor control, reflected by a decreased time (p = 0.013) and increased rate of grip force development (p = 0.013) in the manipulating hand and a decreased time delay between grip force initiation in the manipulating and stabilizing hand (p = 0.020); (2) executive function, reflected by decreased performance time in part II of the Stroop Test (p = 0.007); and (3) neurological parkinsonian signs, reflected by an amelioration of upper-extremity bradykinesia (p = 0.015) and improvement in daily life manual functions (p = 0.004), mood, and intellectual function (p = 0.005). Conclusions: Following an 8-week moderate intensity AIT program, patients with PD exhibited improved psychomotor behaviors, reflected by bimanual motor control, executive function, and neurological parkinsonian signs.

Ambulatory Activity in People with Early Parkinson's Disease

2015 ◽  
Vol 17 (1) ◽  
pp. 87-98 ◽  
Author(s):  
Robyn M. Lamont ◽  
Meg E. Morris ◽  
Marjorie H. Woollacott ◽  
Sandra G. Brauer
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Function ◽  
Disease Severity ◽  
High Intensity ◽  
Community Dwelling ◽  
Cognitive Capacity ◽  
Moderate Intensity ◽  
Activity Levels ◽  
Ambulatory Activity

People with Parkinson's disease (PD) are encouraged to participate in physical activity levels equivalent to those recommended for the general population. Understanding factors that influence this activity is important for facilitating this participation. This study examined factors associated with participation in moderate and high intensity daily ambulatory activity in people with mild to moderate PD. Fifty community-dwelling people with mild-moderate PD were monitored with accelerometers over three days to characterise their daily ambulatory activity levels. Personal factors, disease characteristics, gait and cognitive capacity were measured. Prediction models were created to identify factors influencing ambulation activity. People with PD spent approximately 77 minutes walking per day, mostly at a moderate intensity resulting in a median of 6300 steps/day. Disease severity predicted time spent in moderate ambulation bouts (R2 = 0.116, p = .017). Gait (Timed Up and Go (TUG) Test) and executive function together predicted engagement in high intensity ambulatory activity (R2 > 0.170, p < .022). While disease severity, gait performance and executive function were predictive of engagement in moderate and high intensity walking activity, additional personal and social factors should be considered and are likely to also strongly impact on activity levels.

scholarly journals Association between Community Ambulation Walking Patterns and Cognitive Function in Patients with Parkinson’s Disease: Further Insights into Motor-Cognitive Links

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Aner Weiss ◽  
Talia Herman ◽  
Nir Giladi ◽  
Jeffrey M. Hausdorff
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Function ◽  
Cognitive Function ◽  
Postural Control ◽  
Real Life ◽  
Gait Pattern ◽  
Cognitive Score ◽  
Nonverbal Memory ◽  
Computerized Measures

Background. Cognitive function is generally evaluated based on testing in the clinic, but this may not always reflect real-life function. We tested whether parameters derived from long-term, continuous monitoring of gait are associated with cognitive function in patients with Parkinson’s disease (PD).Methods. 107 patients with PD (age: 64.9 ± 9.3 yrs; UPDRS motor sum “off”: 40.4 ± 13.2; 25.23% women) wore a 3D accelerometer on their lower back for 3 days. Computerized measures of global cognitive function, executive function, attention, and nonverbal memory were assessed. Three-day acceleration derived measures included cadence, variability, bilateral coordination, and dynamic postural control. Associations between the acceleration derived measures and cognitive function were determined.Results. Linear regression showed associations between vertical gait variability and cadence and between global cognitive score, attention, and executive function (p≤0.048). Dynamic postural control was associated with global cognitive score and attention (p≤0.027). Nonverbal memory was not associated with the acceleration-derived measures.Conclusions. These findings suggest that metrics derived from a 3-day worn body-fixed sensor reflect cognitive function, further supporting the idea that the gait pattern may be altered as cognition declines and that gait provides a window into cognitive function in patients with PD.

Integration of Virtual Reality into Transcranial Magnetic Stimulation Improves Cognitive Function in Patients with Parkinson’s Disease with Cognitive Impairment: A Proof-of-Concept Study

2021 ◽  
pp. 1-14
Author(s):  
Tsai-Chin Cheng ◽  
Shih-Fong Huang ◽  
Shang-Yu Wu ◽  
Fu-Gong Lin ◽  
Wang-Sheng Lin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Virtual Reality ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Function ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Vr Training

Background: Emerging evidence has indicated the positive effects of repetitive transcranial magnetic stimulation (rTMS) on patients with Parkinson’s disease (PD) for the treatment of mild cognitive impairment (MCI). Objective: Investigating whether combining virtual reality (VR) training with rTMS can further enhance cognitive improvement induced by rTMS treatment. Methods: We randomly assigned 40 patients with PD and MCI into three groups, namely the rTMS-VR group (n = 13), rTMS group (n = 11), and sham rTMS group (n = 16). rTMS was administered as 10 consecutive sessions of intermittent theta burst stimulation (iTBS) over the left dorsolateral prefrontal cortex. In the rTMS-VR group, VR training was administered immediately after each rTMS session. Cognitive function was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Montreal Cognitive Assessment (MoCA) at baseline, immediately after intervention, and at 3-month follow-up. Results: Compared with the rTMS group, the rTMS-VR group exhibited significantly more improvements in total and delayed memory scores of the RBANS and the visuospatial/executive function score of the MoCA after intervention (p = 0.000∼0.046) and the delayed memory score of the RBANS at 3-month follow-up (p = 0.028). Conclusion: The integrated rTMS-VR protocol achieved a superior outcome in global cognitive function, more effectively enhancing working memory and visuospatial executive function than did the rTMS protocol alone. The combination of VR and rTMS can be an effective regimen for improving the cognitive function of patients with PD.

Anxiety and cognitive load affect upper limb motor control in Parkinson's disease during medication phases

2021 ◽  
Author(s):  
Zahra Nodehi ◽  
Hajar Mehdizadeh ◽  
Akram Azad ◽  
Maryam Mehdizadeh ◽  
Elham Reyhanian ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Control ◽  
Cognitive Load ◽  
Upper Limb

O3-06-08: The therapeutic effect of donepezil on attention and executive function in patients with Parkinson's disease dementia (PDD)

2008 ◽  
Vol 4 ◽  
pp. T173-T173
Author(s):  
Jina E. Swartz ◽  
Margaret L. Moline ◽  
Julian Gray ◽  
Gail Thomas ◽  
Mark Harre ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Executive Function ◽  
Therapeutic Effect ◽  
Parkinson’S Disease Dementia
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