scholarly journals A Mouse Model for Studying Nutritional Programming: Effects of Early Life Exposure to Soy Isoflavones on Bone and Reproductive Health

2016 ◽  
Vol 13 (5) ◽  
pp. 488 ◽  
Author(s):  
Wendy Ward ◽  
Jovana Kaludjerovic ◽  
Elsa Dinsdale
Keyword(s):  
Reproductive Health ◽  
Mouse Model ◽  
Early Life ◽  
Soy Isoflavones ◽  
Nutritional Programming ◽  
Early Life Exposure

scholarly journals Effects of early-life exposure to THIP on brainstem neuronal excitability in the Mecp2 -null mouse model of Rett syndrome before and after drug withdrawal

2017 ◽  
Vol 5 (2) ◽  
pp. e13110 ◽  
Author(s):  
Weiwei Zhong ◽  
Christopher M. Johnson ◽  
Ningren Cui ◽  
Max F. Oginsky ◽  
Yang Wu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Rett Syndrome ◽  
Early Life ◽  
Neuronal Excitability ◽  
Drug Withdrawal ◽  
Null Mouse ◽  
Early Life Exposure ◽  
Before And After

scholarly journals Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

2016 ◽  
Vol 8 (1) ◽  
Author(s):  
Weiwei Zhong ◽  
Christopher Mychal Johnson ◽  
Yang Wu ◽  
Ningren Cui ◽  
Hao Xing ◽  
...  
Keyword(s):  
Mouse Model ◽  
Rett Syndrome ◽  
Early Life ◽  
Early Life Exposure

Chemically Contaminated Eel Fed to Pregnant and Lactating Mouse Dams Causes Hyperactivity in Their Offspring

2016 ◽  
Vol 86 (1-2) ◽  
pp. 36-47 ◽  
Author(s):  
Imen Dridi ◽  
Nidhal Soualeh ◽  
Torsten Bohn ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Open Field ◽  
Early Life ◽  
Home Cage ◽  
Anguilla Anguilla ◽  
Acetylcholinesterase Activity ◽  
Female Offspring ◽  
Significant Inhibition ◽  
Standard Diet ◽  
Early Life Exposure ◽  
Cage Test

Abstract.This study examined whether perinatal exposure to polluted eels (Anguilla anguilla L.) induces changes in the locomotor activity of offspring mice across lifespan (post-natal days (PNDs) 47 – 329), using the open field and the home cage activity tests. Dams were exposed during gestation and lactation, through diets enriched in eels naturally contaminated with pollutants including PCBs. Analysis of the eel muscle focused on the six non-dioxin-like (NDL) indicator PCBs (Σ6 NDL-PCBs: 28, 52, 101, 138, 153 and 180). Four groups of dams (n = 10 per group) received either a standard diet without eels or eels (0.8 mg/kg/day) containing 85, 216, or 400 ng/kg/day of ϵ6 NDL-PCBs. The open field test showed that early-life exposure to polluted eels increased locomotion in female offspring of exposed dams but not in males, compared to controls. This hyperlocomotion appeared later in life, at PNDs 195 and 329 (up to 32 % increase, p < 0.05). In addition, overactivity was observed in the home cage test at PND 305: exposed offspring females showed a faster overall locomotion speed (3.6 – 4.2 cm/s) than controls (2.9 cm/s, p <0.05); again, males remained unaffected. Covered distances in the home cage test were only elevated significantly in offspring females exposed to highest PCB concentrations (3411 ± 590 cm vs. 1377 ± 114 cm, p < 0.001). These results suggest that early-life exposure to polluted eels containing dietary contaminants including PCBs caused late, persistent and gender-dependent neurobehavioral hyperactive effects in offspring mice. Furthermore, female hyperactivity was associated with a significant inhibition of acetylcholinesterase activity in the hippocampus and the prefrontal cortex.

Prenatal and Early-Life Exposure to Indoor Air-Polluting Factors and Allergic Sensitization at 2 Years of Age

PEDIATRICS ◽  
2020 ◽  
Vol 146 (Supplement 4) ◽  
pp. S332.2-S333
Author(s):  
Suzanne R. Kochis ◽  
Jennifer Dantzer
Keyword(s):  
Indoor Air ◽  
Early Life ◽  
Allergic Sensitization ◽  
Early Life Exposure

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1999-P ◽  
Author(s):  
HYE LIM NOH ◽  
SUJIN SUK ◽  
RANDALL H. FRIEDLINE ◽  
KUNIKAZU INASHIMA ◽  
DUY A. TRAN ◽  
...  
Keyword(s):  
Energy Balance ◽  
Adult Male ◽  
Early Life ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Early Life Exposure ◽  
Fat Feeding
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