scholarly journals Spatio-Temporal Epidemiology of Human West Nile Virus Disease in South Dakota

2013 ◽  
Vol 10 (11) ◽  
pp. 5584-5602 ◽  
Author(s):  
Michael Wimberly ◽  
Paolla Giacomo ◽  
Lon Kightlinger ◽  
Michael Hildreth
Keyword(s):  
West Nile Virus ◽  
South Dakota ◽  
Virus Disease ◽  
West Nile ◽  
Human West Nile Virus ◽  
Spatio Temporal

scholarly journals Human West Nile Virus Disease Outbreak in Pakistan, 2015–2016

2018 ◽  
Vol 6 ◽  
Author(s):  
Erum Khan ◽  
Kelli L. Barr ◽  
Joveria Qais Farooqi ◽  
Dhani Prakoso ◽  
Alizeh Abbas ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
West Nile ◽  
Human West Nile Virus

scholarly journals Corrigendum: Human West Nile Virus Disease Outbreak in Pakistan, 2015–2016

2019 ◽  
Vol 6 ◽  
Author(s):  
Erum Khan ◽  
Kelli L. Barr ◽  
Joveria Qais Farooqi ◽  
Dhani Prakoso ◽  
Alizeh Abbas ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Disease ◽  
Disease Outbreak ◽  
West Nile ◽  
Human West Nile Virus

scholarly journals Spatio-temporal impacts of aerial adulticide applications on populations of West Nile virus vector mosquitoes

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Karen M. Holcomb ◽  
Robert C. Reiner ◽  
Christopher M. Barker
Keyword(s):  
West Nile Virus ◽  
Temporal Trends ◽  
Larval Habitat ◽  
Post Treatment ◽  
Additive Models ◽  
Dispersal Ability ◽  
Stochastic Variation ◽  
West Nile ◽  
Spatial Coverage ◽  
Spatio Temporal

Abstract Background Aerial applications of insecticides that target adult mosquitoes are widely used to reduce transmission of West Nile virus to humans during periods of epidemic risk. However, estimates of the reduction in abundance following these treatments typically focus on single events, rely on pre-defined, untreated control sites and can vary widely due to stochastic variation in population dynamics and trapping success unrelated to the treatment. Methods To overcome these limitations, we developed generalized additive models fitted to mosquito surveillance data collected from CO2-baited traps in Sacramento and Yolo counties, California from 2006 to 2017. The models accounted for the expected spatial and temporal trends in the abundance of adult female Culex (Cx.) tarsalis and Cx. pipiens in the absence of aerial spraying. Estimates for the magnitude of deviation from baseline abundance following aerial spray events were obtained from the models. Results At 1-week post-treatment with full spatial coverage of the trapping area by pyrethroid or pyrethrin products, Cx. pipiens abundance was reduced by a mean of 52.4% (95% confidence intrval [CI] − 65.6, − 36.5%) while the use of at least one organophosphate pesticide resulted in a mean reduction of 76.2% (95% CI − 82.8, − 67.9%). For Cx. tarsalis, at 1-week post-treatment with full coverage there was a reduction in abundance of 30.7% (95% CI − 54.5, 2.5%). Pesticide class was not a significant factor contributing to the reduction. In comparison, repetition of spraying over three to four consecutive weeks resulted in similar estimates for Cx. pipiens and estimates of somewhat smaller magnitude for Cx. tarsalis. Conclusions Aerial adulticides are effective for achieving a rapid short-term reduction of the abundance of the primary West Nile virus vectors, Cx. tarsalis and Cx. pipiens. A larger magnitude of reduction was estimated in Cx. pipiens, possibly due to the species’ focal distribution. Effects of aerial sprays on Cx. tarsalis populations are likely modulated by the species’ large dispersal ability, population sizes and vast productive larval habitat present in the study area. Our modeling approach provides a new way to estimate effects of public health pesticides on vector populations using routinely collected observational data and accounting for spatio-temporal trends and contextual factors like weather and habitat. This approach does not require pre-selected control sites and expands upon past studies that have focused on the effects of individual aerial treatment events.

scholarly journals 1787. The Effects of a Systemwide Diagnostic Stewardship Change on West Nile Virus Disease Ordering Practices

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S658-S658
Author(s):  
Andrew H Karaba ◽  
Paul W Blair ◽  
Kevin M Martin ◽  
Mustapha O Saheed ◽  
Karen C Carroll ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Virus Disease ◽  
Case Fatality ◽  
Cost Savings ◽  
Primary Objective ◽  
Neurological Deficits ◽  
West Nile ◽  
Hospital System ◽  
Elisa Testing ◽  
Before And After

Abstract Background Neuroinvasive West Nile Virus (WNV) often leads to prolonged neurological deficits and carries a high case fatality rate. The CSF IgM (MAC-ELISA) is preferred over the CSF nucleic acid-based test (NAAT) by the CDC due to its higher sensitivity. However, our hospital system was observed to have an over-utilization of NAAT testing compared with MAC-ELISA testing. The primary objective was to compare the number of MAC-ELISA and NAAT WNV tests ordered before and after a diagnostic stewardship intervention. The secondary objectives were to determine whether this change to lead to any cost savings and increased detection of probable cases of WNV-ND. Methods In an effort to increase the use of the MAC-ELISA and to decrease unnecessary NAAT testing, the NAAT test was removed in April 2018 from the test menu in the electronic health record of a health system comprising five hospitals in the Maryland and Washington, D.C. area. NAAT testing remained possible via a paper order form. This study was a retrospective review of WNV testing done on CSF samples from July 2016 through December 2018. The seasonal and yearly number of total tests, positive tests, and total costs were determined from the period of July, 2017 to April, 2018 and were compared with May, 2018 to January, 2019. A paired t-test was performed to evaluate for differences in total testing, total positives, and total costs during non-winter months before and after the intervention. Results A total of 12.59 MAC-ELISA tests/month (95% CI: 10.29, 14.89) increased to 41 tests/month (95% CI: 34.35, 47.65) which was significantly different (P < 0.001). In contrast, there were 46.23 NAAT tests/month (95% CI: 39.55, 52.91) which decreased to 0 NAAT tests/month after the intervention (P < 0.001). This resulted in an average decrease in WNV test spending from $7200 per month to $471 per month (P < 0.001). Preceding the intervention in test ordering, 0.23% of WNV CSF tests were positive (NAAT+MAC-ELISA) while 2.44% WNV CSF tests were positive after the intervention (P = 0.03). Conclusion Elimination of electronic WNV NAAT ordering is an effective way of decreasing inappropriate WNV NAAT testing, decreasing associated costs, and may lead to improved diagnosis of WNV-ND. Disclosures All authors: No reported disclosures.

scholarly journals Meteorological Conditions Associated with Increased Incidence of West Nile Virus Disease in the United States, 2004–2012

2015 ◽  
Vol 92 (5) ◽  
pp. 1013-1022 ◽  
Author(s):  
Micah B. Hahn ◽  
Roger S. Nasci ◽  
Mark J. Delorey ◽  
Rebecca J. Eisen ◽  
Andrew J. Monaghan ◽  
...  
Keyword(s):  
United States ◽  
West Nile Virus ◽  
Virus Disease ◽  
The United States ◽  
Meteorological Conditions ◽  
West Nile

scholarly journals Environmental Predictors of Human West Nile Virus Infections, Colorado

2007 ◽  
Vol 13 (11) ◽  
pp. 1788-1790 ◽  
Author(s):  
Jennifer L. Patnaik ◽  
Lara Juliusson ◽  
Richard L. Vogt
Keyword(s):  
West Nile Virus ◽  
Virus Infections ◽  
Environmental Predictors ◽  
West Nile ◽  
Human West Nile Virus
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