scholarly journals Outbreak of Ampicillin/Piperacillin-Resistant Klebsiella Pneumoniae in a Neonatal Intensive Care Unit (NICU): Investigation and Control Measures

2013 ◽  
Vol 10 (3) ◽  
pp. 808-815 ◽  
Author(s):  
Giuliana Fabbri ◽  
Manuela Panico ◽  
Laura Dallolio ◽  
Roberta Suzzi ◽  
Matilde Ciccia ◽  
...  
1988 ◽  
Vol 16 (4) ◽  
pp. 167-172 ◽  
Author(s):  
Beth Hewitt Stover ◽  
Karen M. Cost ◽  
Charles Hamm ◽  
Garrett Adams ◽  
Larry N. Cook

Author(s):  
Paola Pidal ◽  
Erna Cona ◽  
Carolina Torrejón ◽  
Contanza Airola ◽  
Javier Cifuentes ◽  
...  

Background: The epidemiological–microbiological characteristics and effective intervention measures in an outbreak due to extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae in a neonatal intensive care unit are described. Materials and methods: Cases from June 22, 2018 to February 11, 2019 were analyzed. Microbiological analysis of intestinal carriage of ESBL-producing K. pneumoniae and environmental samples was conducted. Strain relationships were studied by pulsed-field gel electrophoresis (PFGE). Results: A 35-week outbreak affecting 41 patients, with eight infected, 33 colonized, and two deceased patients occurred. Two stages of the outbreak were observed with differences in the frequency of intestinal carriage of ESBL-producing K. pneumoniae. The same genetic subtype was seen in patient strains and was different from strains isolated from the environment. Deficiencies in contact precautions, hand hygiene, and handling of breast milk were observed. Conclusions: A monoclonal outbreak by ESBL-producing K. pneumoniae that occurred in two phases and the different control measures in each of the stages is described. Effective control measures are mainly based on improving compliance with standard precautions and contact precautions, and other complementary measures are described such as proper handling of breast milk, periodic carriage studies, and the generation of three patient cohorts.


Author(s):  
Tanja Artelt ◽  
Martin Kaase ◽  
Ivonne Bley ◽  
Helmut Eiffert ◽  
Alexander Mellmann ◽  
...  

Isolation precautions required for neonatal intensive care units are part of a bundle with the aim to prevent transmission, colonization, and infection with multidrug-resistant gram-negative pathogens as neonates face an increased risk of mortality and morbidity in case of infection. The following short report describes a transmission of 3MDRGN Klebsiella pneumoniae on a neonatal intensive care unit in a university hospital in Germany. This transmission occurred even though intensified infection control measures were in place, which impressively shows the importance of surveillance, outbreak management, and awareness of contributing factors regarding outbreak situations.


2003 ◽  
Vol 25 (1) ◽  
pp. 89-101 ◽  
Author(s):  
Takako IKENO ◽  
Tadao TANABE ◽  
Tetsuro MURATANI ◽  
Noriko NAKANO ◽  
Tomoko KOTAKE ◽  
...  

2012 ◽  
Vol 33 (6) ◽  
pp. 631-634 ◽  
Author(s):  
Pranita D. Tamma ◽  
Patrice Savard ◽  
Tibor Pál ◽  
Ágnes Sonnevend ◽  
Trish M. Perl ◽  
...  

We present a large outbreak of ESBL-producing Klebsiella pneumoniae in a neonatal intensive care unit that resulted in 31 colonized infants, 10 invasive infections, and 5 attributable deaths over a 5-month period. Although the source of infection was unknown, overcrowding and understaffing appeared to have been aggravating factors.


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