scholarly journals Metallothionein Gene Expression in <em>Drosophila subobscura</em> Indicates Their Different Function in Response to Heavy Metal Exposures

2021 ◽  
Author(s):  
Mina Rakić ◽  
Mihailo Jelić ◽  
Marina Stamenković-Radak ◽  
Aleksandra Patenković ◽  
Marija Tanasković ◽  
...  
1990 ◽  
Vol 14 ◽  
pp. 7
Author(s):  
P REMONDELLI ◽  
L MINICHIELLO ◽  
S CIGLIANO ◽  
A LEONE

Gene ◽  
1989 ◽  
Vol 83 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Muhammad Zafarullah ◽  
Per-Eric Olsson ◽  
Lashitew Gedamu

1994 ◽  
Vol 13 (12) ◽  
pp. 2870-2875 ◽  
Author(s):  
R. Heuchel ◽  
F. Radtke ◽  
O. Georgiev ◽  
G. Stark ◽  
M. Aguet ◽  
...  

2004 ◽  
Vol 58 (2-5) ◽  
pp. 389-394 ◽  
Author(s):  
Andrew P.L. Cheung ◽  
Timothy H.-J. Lam ◽  
King Ming Chan

1990 ◽  
Vol 265 (25) ◽  
pp. 15267-15274 ◽  
Author(s):  
S.K. De ◽  
M.T. McMaster ◽  
G.K. Andrews

1991 ◽  
Vol 11 (7) ◽  
pp. 3676-3681
Author(s):  
W M Yang ◽  
W Gahl ◽  
D Hamer

The induction of Saccharomyces cerevisiae metallothionein gene transcription by Cu and Ag is mediated by the ACE1 transcription factor. In an effort to detect additional stimuli and factors that regulate metallothionein gene transcription, we isolated a Cu-resistant suppressor mutant of an ACE1 deletion strain. Even in the absence of metals, the suppressor mutant exhibited high basal levels of metallothionein gene transcription that required upstream promoter sequences. The suppressor gene was cloned, and its predicted product was shown to correspond to yeast heat shock transcription factor with a single-amino-acid substitution in the DNA-binding domain. The mutant heat shock factor bound strongly to metallothionein gene upstream promoter sequences, whereas wild-type heat shock factor interacted weakly with the same region. Heat treatment led to a slight but reproducible induction of metallothionein gene expression in both wild-type and suppressor strains, and Cd induced transcription in the mutant strain. These studies provide evidence for multiple pathways of metallothionein gene transcriptional regulation in S. cerevisiae.


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