scholarly journals Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives

Genes ◽  
2018 ◽  
Vol 9 (11) ◽  
pp. 529 ◽  
Author(s):  
Carla Esposito ◽  
Silvia Catuogno ◽  
Gerolama Condorelli ◽  
Paola Ungaro ◽  
Vittorio de Franciscis
Keyword(s):  
Nucleic Acid ◽  
Therapeutic Delivery ◽  
Specific Recognition ◽  
Efficient Delivery ◽  
Target Effects

Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissues. In this review, we revise the most recent contributes on bispecific and multifunctional aptamer therapeutic chimeras. We will discuss key examples of aptamer-mediated delivery of nucleic acid and peptide-based therapeutics underlying their great potentiality and versatility. Achieved objectives and challenges will be highlighted as well.

scholarly journals Measurement and standardization challenges for extracellular vesicle therapeutic delivery vectors

Nanomedicine ◽  
2020 ◽  
Vol 15 (22) ◽  
pp. 2149-2170
Author(s):  
Bryant C Nelson ◽  
Samantha Maragh ◽  
Ionita C Ghiran ◽  
Jennifer C Jones ◽  
Paul C DeRose ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Lipid Bilayer ◽  
Cell Types ◽  
Extracellular Vesicle ◽  
Clinical Therapeutics ◽  
Measurement Systems ◽  
Therapeutic Delivery ◽  
Efficient Delivery ◽  
Standardized Measurement

Extracellular vesicles (EVs), such as exosomes and microvesicles, are nonreplicating lipid bilayer particles shed by most cell types which have the potential to revolutionize the development and efficient delivery of clinical therapeutics. This article provides an introduction to the landscape of EV-based vectors under development for the delivery of protein- and nucleic acid-based therapeutics. We highlight some of the most pressing measurement and standardization challenges that limit the translation of EVs to the clinic. Current challenges limiting development of EVs for drug delivery are the lack of: standardized cell-based platforms for the production of EV-based therapeutics; EV reference materials that allow researchers/manufacturers to validate EV measurements and standardized measurement systems for determining the molecular composition of EVs.

scholarly journals Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery

Biomedicines ◽  
2020 ◽  
Vol 8 (5) ◽  
pp. 120 ◽  
Author(s):  
Bakhtiar Bukari ◽  
Rasika M. Samarasinghe ◽  
Jinjutha Noibanchong ◽  
Sarah L. Shigdar
Keyword(s):  
Brain Tissue ◽  
Targeted Delivery ◽  
Focused Ultrasound ◽  
Circulatory System ◽  
Non Invasive ◽  
Therapeutic Delivery ◽  
Macromolecular Drugs ◽  
Efficient Delivery ◽  
Alternative Delivery ◽  
The Brain

The blood-brain barrier (BBB) is a highly specialised network of blood vessels that effectively separates the brain environment from the circulatory system. While there are benefits, in terms of keeping pathogens from entering the brain, the BBB also complicates treatments of brain pathologies by preventing efficient delivery of macromolecular drugs to diseased brain tissue. Although current non-invasive strategies of therapeutics delivery into the brain, such as focused ultrasound and nanoparticle-mediated delivery have shown various levels of successes, they still come with risks and limitations. This review discusses the current approaches of therapeutic delivery into the brain, with a specific focus on non-invasive methods. It also discusses the potential for aptamers as alternative delivery systems and several reported aptamers with promising preliminary results.

Bioreducible poly(urethane amine)s for robust nucleic acid transfection in stem cells

2019 ◽  
Vol 7 (8) ◽  
pp. 3510-3518
Author(s):  
Ying Ye ◽  
Rong Jin ◽  
Xiaoxin Hu ◽  
Juhua Zhuang ◽  
Wei Xia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Nucleic Acid ◽  
Embryonic Stem ◽  
Highly Efficient ◽  
Efficient Delivery ◽  
Low Cytotoxicity

Bioreducible poly(urethane amine)s can be designed and optimized for highly efficient delivery in vitro of DNA or SiRNA into adult or embryonic stem cells with low cytotoxicity.

Tuning Surface Charge and PEGylation of Biocompatible Polymers for Efficient Delivery of Nucleic Acid or Adenoviral Vector

2015 ◽  
Vol 26 (8) ◽  
pp. 1818-1829 ◽  
Author(s):  
Joung-Woo Choi ◽  
Jaesung Kim ◽  
Quang Nam Bui ◽  
Yi Li ◽  
Chae-Ok Yun ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Surface Charge ◽  
Adenoviral Vector ◽  
Biocompatible Polymers ◽  
Efficient Delivery

Towards Safe Nanoparticle Technologies for Nucleic Acid Therapeutics

2008 ◽  
Vol 94 (2) ◽  
pp. 234-245 ◽  
Author(s):  
Andrew D Miller
Keyword(s):  
Nucleic Acid ◽  
New Technologies ◽  
Imperial College ◽  
Nucleic Acid Therapeutics ◽  
Animal Models Of Disease ◽  
Efficient Delivery ◽  
Or Gene ◽  
Models Of Disease ◽  
Functional Nucleic Acids

Nucleic acid therapeutics (or gene therapy) has to date failed to deliver on promise but rapid improvements in the understanding and use of delivery technologies should reverse this situation. In this review of work performed in and in collaboration with the Imperial College Genetic Therapies Centre, progress towards safe nanoparticles for efficient delivery of functional nucleic acids in vivo is described. The intention is to demonstrate the fruits of a journey from the results of initial studies in animal models of disease that suggested that so much should be possible so quickly, to the realization that new technologies are rarely successful so quickly, through to developments in the present day that appear to be approaching the preclinical/clinical threshold with realism but measured confidence. New chemistry is central to the design and formulation of safe nanotechnologies. Chemistry should have a central role to play in ensuring that nucleic acid therapeutics truly live up to their potential for therapy and cure, none more so than in the derivation of newer and better therapies for cancers.

scholarly journals Peptide-based Drug Delivery for Curing Cancer

2019 ◽  
Vol 9 (1-s) ◽  
pp. 387-389
Author(s):  
Wenzhe Huang
Keyword(s):  
Drug Delivery ◽  
Delivery System ◽  
Complex Diseases ◽  
Therapeutic Delivery ◽  
Efficient Delivery ◽  
Cancer Tumor

Peptides have numerous advantages as the chains help treat cancer, tumor and several complex diseases. The review details on the different structures of peptides that can ensure actual and efficient delivery of therapy to tumor and cancer cases. The co-delivery system mainly aims to improve the therapeutic delivery process regarding manufacturing, targeting, and impact. Keywords: Nanotechnology, Peptide-based Drug Delivery, cancer

scholarly journals microRNAs as Novel Therapeutics in Cancer

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1526
Author(s):  
Giulia Romano ◽  
Mario Acunzo ◽  
Patrick Nana-Sinkam
Keyword(s):  
Molecular Mechanisms ◽  
New Technologies ◽  
Migration And Invasion ◽  
Functional Roles ◽  
Therapeutic Delivery ◽  
Efficient Delivery ◽  
Tumor Tissues ◽  
Substantial Progress ◽  
The Stability ◽  
Made In

In the last 20 years, the functional roles for miRNAs in gene regulation have been well established. MiRNAs act as regulators in virtually all biological pathways and thus have been implicated in numerous diseases, including cancer. They are particularly relevant in regulating the basic hallmarks of cancer, including apoptosis, proliferation, migration, and invasion. Despite the substantial progress made in identifying the molecular mechanisms driving the deregulation of miRNAs in cancer, the clinical translation of these important molecules to therapy remains in its infancy. The paucity of vehicles available for the safe and efficient delivery of miRNAs and ongoing concerns for toxicity remain major obstacles to clinical application. Novel formulations and the development of new vectors have significantly improved the stability of oligonucleotides, increasing the effectiveness of therapy. Furthermore, the use of specific moieties for delivery in target tissues or cells has increased the specificity of treatment. The use of new technologies has allowed small but important steps toward more specific therapeutic delivery in tumor tissues and cells. Although a long road remains, the path ahead holds great potential. Currently, a few miRNA drugs are under investigation in human clinical trials with promising results ahead.

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