scholarly journals EYS Mutations Causing Autosomal Recessive Retinitis Pigmentosa: Changes of Retinal Structure and Function with Disease Progression

Genes ◽  
2017 ◽  
Vol 8 (7) ◽  
pp. 178 ◽  
Author(s):  
David McGuigan ◽  
Elise Heon ◽  
Artur Cideciyan ◽  
Rinki Ratnapriya ◽  
Monica Lu ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Disease Progression ◽  
Autosomal Recessive ◽  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography

PLoS ONE ◽  
2019 ◽  
Vol 14 (12) ◽  
pp. e0226097 ◽  
Author(s):  
Jun Funatsu ◽  
Yusuke Murakami ◽  
Shunji Nakatake ◽  
Masato Akiyama ◽  
Kohta Fujiwara ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinitis Pigmentosa ◽  
Structure And Function ◽  
Optical Coherence ◽  
Retinal Structure ◽  
And Function

scholarly journals Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models

2015 ◽  
Vol 24 (11) ◽  
pp. 3104-3118 ◽  
Author(s):  
Lucie P. Pellissier ◽  
Peter M. Quinn ◽  
C. Henrique Alves ◽  
Rogier M. Vos ◽  
Jan Klooster ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Retinitis Pigmentosa ◽  
Mouse Models ◽  
Glial Cells ◽  
Structure And Function ◽  
Müller Glial Cells ◽  
Retinal Structure ◽  
And Function

scholarly journals The Structure and Function of the Macula in Patients with Advanced Retinitis Pigmentosa

2011 ◽  
Vol 52 (11) ◽  
pp. 8425 ◽  
Author(s):  
Rita Vámos ◽  
Erika Tátrai ◽  
János Németh ◽  
Graham E. Holder ◽  
Delia Cabrera DeBuc ◽  
...  
Keyword(s):  
Retinitis Pigmentosa ◽  
Structure And Function ◽  
And Function

Retinal Structure and Function in Perinatally HIV-Infected and cART-Treated Children: A Matched Case–Control Study

2015 ◽  
Vol 56 (6) ◽  
pp. 3945 ◽  
Author(s):  
Nazli Demirkaya ◽  
Sophie Cohen ◽  
Ferdinand W. N. M. Wit ◽  
Michael D. Abramoff ◽  
Reinier O. Schlingemann ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Structure And Function ◽  
Matched Case ◽  
Retinal Structure ◽  
And Function ◽  
Matched Case Control Study ◽  
Control Study

scholarly journals Retinal Structure and Function in Achromatopsia

Ophthalmology ◽  
2014 ◽  
Vol 121 (1) ◽  
pp. 234-245 ◽  
Author(s):  
Venki Sundaram ◽  
Caroline Wilde ◽  
Jonathan Aboshiha ◽  
Jill Cowing ◽  
Colin Han ◽  
...  
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

2018 ◽  
Vol 27 (18) ◽  
pp. 3137-3153 ◽  
Author(s):  
Peter M Quinn ◽  
C Henrique Alves ◽  
Jan Klooster ◽  
Jan Wijnholds
Keyword(s):  
Structure And Function ◽  
Retinal Structure ◽  
And Function

scholarly journals Psychosocial Stress Hastens Disease Progression and Sudden Death in Mice with Arrhythmogenic Cardiomyopathy

2020 ◽  
Vol 9 (12) ◽  
pp. 3804
Author(s):  
Jacopo Agrimi ◽  
Arianna Scalco ◽  
Julia Agafonova ◽  
Larry Williams III ◽  
Nainika Pansari ◽  
...  
Keyword(s):  
Disease Progression ◽  
Cardiac Dysfunction ◽  
Psychosocial Stress ◽  
Structure And Function ◽  
Arrhythmogenic Cardiomyopathy ◽  
Disease Penetrance ◽  
Heart Failure Progression ◽  
Per Se ◽  
Anxious Behavior ◽  
And Function

Physiological stressors, such as exercise, can precipitate sudden cardiac death or heart failure progression in patients with arrhythmogenic cardiomyopathy (ACM). Yet, whether and to what extent a highly prevalent and more elusive environmental factor, such as psychosocial stress (PSS), can also increase ACM disease progression is unexplored. Here, we first quantified perceived stress levels in patients with ACM and found these levels correlated with the extent of arrhythmias and cardiac dysfunction. To determine whether the observed correlation is due to causation, we inflicted PSS-via the resident-intruder (RI) paradigm—upon Desmoglein-2 mutant mice, a vigorously used mammalian model of ACM. We found that ACM mice succumbed to abnormally high in-trial, PSS mortality. Conversely, no sudden deaths occurred in wildtype (WT) counterparts. Desmoglein-2 mice that survived RI challenge manifested markedly worse cardiac dysfunction and remodeling, namely apoptosis and fibrosis. Furthermore, WT and ACM mice displayed similar behavior at baseline, but Desmoglein-2 mice exhibited heightened anxiety following RI-induced PSS. This outcome correlated with the worsening of cardiac phenotypes. Our mouse model demonstrates that in ACM-like subjects, PSS is incisive enough to deteriorate cardiac structure and function per se, i.e., in the absence of any pre-existing anxious behavior. Hence, PSS may represent a previously underappreciated risk factor in ACM disease penetrance.

scholarly journals Quantitative Analysis of Retinal Structure and Function in Two Chromosomally Altered Mouse Models of Down Syndrome

2020 ◽  
Vol 61 (5) ◽  
pp. 25
Author(s):  
Daniella B. Victorino ◽  
Jonah J. Scott-McKean ◽  
Mark W. Johnson ◽  
Alberto C. S. Costa
Keyword(s):  
Down Syndrome ◽  
Quantitative Analysis ◽  
Mouse Models ◽  
Structure And Function ◽  
Retinal Structure ◽  
And Function
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