scholarly journals Antisense Gene Silencing: Therapy for Neurodegenerative Disorders?

Genes ◽  
2013 ◽  
Vol 4 (3) ◽  
pp. 457-484 ◽  
Author(s):  
Troels Nielsen ◽  
Jørgen Nielsen
Keyword(s):  
Gene Silencing ◽  
Neurodegenerative Disorders ◽  
Antisense Gene

scholarly journals The mechanism of graft transmission of sense and antisense gene silencing in tomato plants

FEBS Letters ◽  
2006 ◽  
Vol 580 (28-29) ◽  
pp. 6579-6586 ◽  
Author(s):  
Noor A. Shaharuddin ◽  
Yuanhuai Han ◽  
Hongying Li ◽  
Don Grierson
Keyword(s):  
Gene Silencing ◽  
Antisense Gene ◽  
Tomato Plants ◽  
Graft Transmission

Insights into amyloid disease from fly models

2014 ◽  
Vol 56 ◽  
pp. 69-83 ◽  
Author(s):  
Ko-Fan Chen ◽  
Damian C. Crowther
Keyword(s):  
Drosophila Melanogaster ◽  
Neurodegenerative Disorders ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Disease Pathogenesis ◽  
Amyloid Aggregates ◽  
Aβ Amyloid ◽  
Polypeptide Chains ◽  
Amyloid Diseases

The formation of amyloid aggregates is a feature of most, if not all, polypeptide chains. In vivo modelling of this process has been undertaken in the fruitfly Drosophila melanogaster with remarkable success. Models of both neurological and systemic amyloid diseases have been generated and have informed our understanding of disease pathogenesis in two main ways. First, the toxic amyloid species have been at least partially characterized, for example in the case of the Aβ (amyloid β-peptide) associated with Alzheimer's disease. Secondly, the genetic underpinning of model disease-linked phenotypes has been characterized for a number of neurodegenerative disorders. The current challenge is to integrate our understanding of disease-linked processes in the fly with our growing knowledge of human disease, for the benefit of patients.

968: Gelsolin Gene Silencing Involving Unusual Chromatin Structures and a Novel Stem Loop Structure of the Promoter Region in Human Bladder Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 256-257
Author(s):  
Kazunori Haga ◽  
Ataru Sazawa ◽  
Toru Harabayashi ◽  
Nobuo Shinohara ◽  
Minoru Nomoto ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Gene Silencing ◽  
Promoter Region ◽  
Loop Structure ◽  
Human Bladder Cancer ◽  
Human Bladder ◽  
Stem Loop ◽  
Stem Loop Structure

Polyphenol health effects on cardiovascular and neurodegenerative disorders: a meta-analysis

2019 ◽  
Author(s):  
Giorgia Spaggiari ◽  
Francesco Poti ◽  
Francesca Zimetti ◽  
Ilaria Zanotti ◽  
Daniele Santi
Keyword(s):  
Health Effects ◽  
Neurodegenerative Disorders ◽  
Meta Analysis
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