scholarly journals Strong Association of the rs4986790 Single Nucleotide Polymorphism (SNP) of the Toll-Like Receptor 4 (TLR4) Gene with Human Immunodeficiency Virus (HIV) Infection: A Meta-Analysis

Genes ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 36
Author(s):  
Yong-Chan Kim ◽  
Byung-Hoon Jeong
Keyword(s):  
Hiv Infection ◽  
Meta Analysis ◽  
Strong Association ◽  
Toll Like Receptor ◽  
Nucleotide Polymorphism ◽  
Toll Like Receptor 4 ◽  
Single Nucleotide ◽  
Immunodeficiency Virus ◽  
Tlr4 Gene ◽  
Hiv 1

Human immunodeficiency virus (HIV) causes acquired immune deficiency syndrome (AIDS) and enters the host cell via CD4 and either CC-chemokine receptor 5 (CCR) or CXC-chemokine receptor 4 (CXCR4). HIV is directly recognized by toll-like receptor 4 (TLR4) and affects downstream immune-related signal pathways. In addition, stimulated TLR4 inhibits HIV-1 invasion, and the rs4986790 single nucleotide polymorphism (SNP) (D299G) of the TLR4 gene contributes to the risk of HIV-1 infection in an Indian population. To evaluate whether the rs4986790 SNP of the TLR4 gene is related to vulnerability to HIV-1 infection, we collected genetic information from HIV-1 patients in previous studies and performed an association analysis with a matched control population obtained from the 1000 Genomes Project. In addition, to strengthen the results of association analysis, we performed a meta-analysis. We identified a strong association between the rs4986791 SNP and susceptibility to HIV infection in HIV-infected patients in previous studies and a matched control population obtained from the 1000 Genomes Project. In addition, we found that the G allele of the rs4986791 SNP in the TLR4 gene is strongly related to susceptibility to HIV infection in three Caucasian populations (odd ratio = 2.29, 95% confidence interval: 1.72–3.07, p = 1.438 × 10−7) and all four populations (odd ratio = 2.22, 95% confidence interval: 1.74–2.84, p = 2 × 10−10) in a meta-analysis. To the best our knowledge, this was the first meta-analysis on the association between the rs4986791 SNP of the TLR4 gene and susceptibility to HIV infection.

scholarly journals Association between rs12252 and influenza susceptibility and severity: an updated meta-analysis

2018 ◽  
Vol 147 ◽  
Author(s):  
T. Chen ◽  
M. Xiao ◽  
J. Yang ◽  
Y. K. Chen ◽  
T. Bai ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Strong Association ◽  
Dominant Model ◽  
Healthy Individuals ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Model C ◽  
Allelic Model

AbstractIn several lately published studies, the association between single-nucleotide polymorphism (SNP, rs12252) of IFITM3 and the risk of influenza is inconsistent. To further understand the association between the SNP of IFITM3 and the risk of influenza, we searched related studies in five databases including PubMed published earlier than 9 November 2017. Ten sets of data from nine studies were included and data were analysed by Revman 5.0 and Stata 12.0 in our updated meta-analysis, which represented 1365 patients and 5425 no-influenza controls from four different ethnicities. Here strong association between rs12252 and influenza was found in all four genetic models. The significant differences in the allelic model (C vs. T: odds ratio (OR) = 1.35, 95% confidence interval (CI) (1.03–1.79), P = 0.03) and homozygote model (CC vs. TT: OR = 10.63, 95% CI (3.39–33.33), P < 0.00001) in the Caucasian subgroup were discovered, which is very novel and striking. Also novel discoveries were found in the allelic model (C vs. T: OR = 1.37, 95% CI (1.08–1.73), P = 0.009), dominant model (CC + CT vs. TT: OR = 1.48, 95% CI (1.08–2.02), P = 0.01) and homozygote model (CC vs. TT: OR = 2.84, 95% CI (1.36–5.92), P = 0.005) when we compared patients with mild influenza with healthy individuals. Our meta-analysis suggests that single-nucleotide T to C polymorphism of IFITM3 associated with increasingly risk of severe and mild influenza in both Asian and Caucasian populations.

scholarly journals Association Study of the M132L Single Nucleotide Polymorphism With Susceptibility to Chronic Wasting Disease in Korean Elk: A Meta-Analysis

2022 ◽  
Vol 8 ◽  
Author(s):  
In-Soon Roh ◽  
Yong-Chan Kim ◽  
Sae-Young Won ◽  
Kyung-Je Park ◽  
Hoo-Chang Park ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Prion Protein ◽  
Association Analysis ◽  
Chronic Wasting Disease ◽  
Meta Analysis ◽  
Strong Association ◽  
Amplicon Sequencing ◽  
Nucleotide Polymorphism ◽  
Wasting Disease ◽  
Single Nucleotide

Chronic wasting disease (CWD) is a deleterious brain proteinopathy caused by a pathogenic form of prion protein (PrPSc), which is converted from a benign form of prion protein (PrPC) encoded by the prion protein gene (PRNP). In elk, the M132L single nucleotide polymorphism (SNP) of the PRNP gene likely plays a pivotal role in susceptibility to CWD. However, the association of the M132L SNP with susceptibility to CWD has not been evaluated in Korean elk to date. To estimate the association of the M132L SNP with susceptibility to CWD in Korean elk, we investigated the genotype and allele frequencies of the M132L SNP by amplicon sequencing and performed association analysis between CWD-positive and CWD-negative elk. In addition, we performed a meta-analysis to evaluate the association between the M132L SNP and susceptibility to CWD in quantitatively synthesized elk populations. Furthermore, we estimated the effect of the M132L SNP on elk PrP using in silico programs, including PolyPhen-2, PROVEAN, AMYCO and Swiss-PdbViewer. We did not identify a significant association between the M132L SNP of PRNP and susceptibility to CWD in Korean elk. The meta-analysis also did not identify a strong association between the M132L SNP of PRNP and susceptibility to CWD in quantitatively synthesized elk populations. Furthermore, we did not observe significant changes in structure, amyloid propensity or electrostatic potential based on the M132L SNP in elk PrP. To the best of our knowledge, this was the first report of an association analysis and meta-analysis in Korean elk and quantitatively synthesized elk populations, respectively.

scholarly journals Erratum to: Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population

2015 ◽  
Vol 34 (12) ◽  
pp. 2087-2087
Author(s):  
Marija Perica ◽  
Mandica Vidović ◽  
Lovro Lamot ◽  
Lana Tambić Bukovac ◽  
Sanja Kapitanović ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Toll Like Receptor ◽  
Nucleotide Polymorphism ◽  
Toll Like Receptor 4 ◽  
Single Nucleotide ◽  
Juvenile Spondyloarthritis

scholarly journals A Single Nucleotide Polymorphism in 3′-Untranslated Region Contributes to the Regulation of Toll-like Receptor 4 Translation

2012 ◽  
Vol 287 (30) ◽  
pp. 25163-25172 ◽  
Author(s):  
Kayo Sato ◽  
Atsutoshi Yoshimura ◽  
Takashi Kaneko ◽  
Takashi Ukai ◽  
Yukio Ozaki ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Untranslated Region ◽  
Toll Like Receptor ◽  
Nucleotide Polymorphism ◽  
Toll Like Receptor 4 ◽  
Single Nucleotide

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population

2015 ◽  
Vol 34 (12) ◽  
pp. 2079-2086 ◽  
Author(s):  
Marija Perica ◽  
Mandica Vidović ◽  
Lovro Lamot ◽  
Lana Tambić Bukovac ◽  
Sanja Kapitanović ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Toll Like Receptor ◽  
Nucleotide Polymorphism ◽  
Toll Like Receptor 4 ◽  
Single Nucleotide ◽  
Juvenile Spondyloarthritis
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