scholarly journals Diverse LEF/TCF Expression in Human Colorectal Cancer Correlates with Altered Wnt-Regulated Transcriptome in a Meta-Analysis of Patient Biopsies

Genes ◽  
2020 ◽  
Vol 11 (5) ◽  
pp. 538 ◽  
Author(s):  
Claus-Dieter Mayer ◽  
Soizick Magon de La Giclais ◽  
Fozan Alsehly ◽  
Stefan Hoppler
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Progression ◽  
Target Genes ◽  
Meta Analysis ◽  
Cellular Transformation ◽  
Colorectal Tumor ◽  
Human Colorectal Cancer ◽  
Tumor Sample

Aberrantly activated Wnt signaling causes cellular transformation that can lead to human colorectal cancer. Wnt signaling is mediated by Lymphoid Enhancer Factor/T-Cell Factor (LEF/TCF) DNA-binding factors. Here we investigate whether altered LEF/TCF expression is conserved in human colorectal tumor sample and may potentially be correlated with indicators of cancer progression. We carried out a meta-analysis of carefully selected publicly available gene expression data sets with paired tumor biopsy and adjacent matched normal tissues from colorectal cancer patients. Our meta-analysis confirms that among the four human LEF/TCF genes, LEF1 and TCF7 are preferentially expressed in tumor biopsies, while TCF7L2 and TCF7L1 in normal control tissue. We also confirm positive correlation of LEF1 and TCF7 expression with hallmarks of active Wnt signaling (i.e., AXIN2 and LGR5). We are able to correlate differential LEF/TCF gene expression with distinct transcriptomes associated with cell adhesion, extracellular matrix organization, and Wnt receptor feedback regulation. We demonstrate here in human colorectal tumor sample correlation of altered LEF/TCF gene expression with quantitatively and qualitatively different transcriptomes, suggesting LEF/TCF-specific transcriptional regulation of Wnt target genes relevant for cancer progression and survival. This bioinformatics analysis provides a foundation for future more detailed, functional, and molecular analyses aimed at dissecting such functional differences.

scholarly journals Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2

2019 ◽  
Vol 17 (12) ◽  
pp. 2469-2479 ◽  
Author(s):  
Rui Wang ◽  
Hongwei Liu ◽  
Yingying Shao ◽  
Kailong Wang ◽  
Shuangshuang Yin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Progression

Prognostic significance of Bcl-xL gene expression in human colorectal cancer

2011 ◽  
Vol 113 (8) ◽  
pp. 810-814 ◽  
Author(s):  
Yang Jin-Song ◽  
Wang Zhao-Xia ◽  
Lv Cheng-Yu ◽  
Liang Xiao-Di ◽  
Sun Ming ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Prognostic Significance ◽  
Human Colorectal Cancer

scholarly journals Effects of olive oil polyphenols on fatty acid synthase gene expression and activity in human colorectal cancer cells

2010 ◽  
Vol 6 (1) ◽  
pp. 63-69 ◽  
Author(s):  
Maria Notarnicola ◽  
Simona Pisanti ◽  
Valeria Tutino ◽  
Domenica Bocale ◽  
Maria Teresa Rotelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Fatty Acid ◽  
Olive Oil ◽  
Cancer Cells ◽  
Fatty Acid Synthase ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells ◽  
Expression And Activity

Gene Expression Profiles as Predictors of Poor Outcomes in Stage II Colorectal Cancer: A Systematic Review and Meta-analysis

2009 ◽  
Vol 8 (4) ◽  
pp. 207-214 ◽  
Author(s):  
An-Ting T. Lu ◽  
Shelley R. Salpeter ◽  
Anthony E. Reeve ◽  
Steven Eschrich ◽  
Patrick G. Johnston ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Systematic Review ◽  
Expression Profiles ◽  
Meta Analysis ◽  
Gene Expression Profiles ◽  
Stage Ii ◽  
Stage Ii Colorectal Cancer ◽  
Poor Outcomes

scholarly journals Up-regulation of miR-24-1-5p is involved in the chemoprevention of colorectal cancer by black raspberry anthocyanins

2018 ◽  
Vol 122 (5) ◽  
pp. 518-526 ◽  
Author(s):  
He Zhang ◽  
Jun Guo ◽  
Liping Mao ◽  
Qianqian Li ◽  
Mengnan Guo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Target Genes ◽  
Black Raspberry ◽  
Differential Analysis ◽  
Human Colorectal Cancer ◽  
Colon Tissue ◽  
Downstream Target ◽  
Enhanced Expression ◽  
Regulate Protein ◽  
Regulatory Loop

AbstractAs important epigenetic regulators, microRNA regulate protein expression by triggering the degradation of target mRNA and/or by inhibiting their translation. Dysregulation of microRNA expression has been reported in several cancers, including colorectal cancer. In this study, microRNA-array differential analysis revealed strongly enhanced expression of miR-24-1-5p in the colon tissue of azoxymethane/dextran sulphate sodium-induced mice that were fed with black raspberry anthocyanins for 9 weeks. Overexpression of miR-24-1-5p in human colorectal cancer cells significantly repressed β-catenin expression, and simultaneously decreased cell proliferation, migration and survival. Furthermore, miR-24-1-5p could target β-catenin and trigger a negative regulatory loop for β-catenin and its downstream target genes. β-Catenin signalling is vital to the formation and progression of human colorectal cancer. The current findings therefore identified miR-24-1-5p as a potent regulator of β-catenin, and this may provide a novel chemopreventive and therapeutic strategy for β-catenin signalling-driven colorectal cancer.

scholarly journals P4HA1 regulates human colorectal cancer cells through HIF1α‑mediated Wnt signaling

2020 ◽  
Vol 21 (2) ◽  
Author(s):  
Qiang Zhang ◽  
Yue Yin ◽  
Hongye Zhao ◽  
Yan Shi ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Human Colorectal Cancer ◽  
Colorectal Cancer Cells ◽  
Human Colorectal Cancer Cells

scholarly journals Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Petros Tsantoulis ◽  
Mauro Delorenzi ◽  
Ivan Bièche ◽  
Sophie Vacher ◽  
Pascale Mariani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Uveal Melanoma ◽  
Meta Analysis ◽  
Prognostic Score ◽  
Penalized Regression ◽  
Breast Cancer Patients ◽  
Public Data

AbstractPredicting the risk of liver metastasis can have important prognostic and therapeutic implications, given the availability of liver-directed therapy. Uveal melanoma has a striking predisposition for liver metastasis despite the absence of anatomical proximity. Understanding its biology may uncover factors promoting liver metastasis in other malignancies. We quantified gene expression by RNAseq in 76 uveal melanomas and combined with public data in a meta-analysis of 196 patients. The meta-analysis of uveal melanoma gene expression identified 63 genes which remained prognostic after adjustment for chromosome 3 status. Two genes, PTP4A3 and JPH1, were selected by L1-penalized regression and combined in a prognostic score. The score predicted liver-specific relapse in a public pan-cancer dataset and in two public colorectal cancer datasets. The score varied between colorectal consensus molecular subtypes (CMS), as did the risk of liver relapse, which was lowest in CMS1. Additional prospective validation was done by real-time PCR in 463 breast cancer patients. The score was significantly correlated with liver relapse in hormone receptor positive tumors. In conclusion, the expression of PTP4A3 and JPH1 correlates with risk of liver metastasis in colorectal cancer and breast cancer. The underlying biological mechanism is an interesting area for further research.

Meta-analysis of human colorectal cancer transcriptome

2011 ◽  
Vol 27 (8) ◽  
pp. 1125-1128 ◽  
Author(s):  
Hua Ye ◽  
Chao-Hui Yu ◽  
Lan Li ◽  
Cheng-Fu Xu ◽  
Xue-Qun Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Meta Analysis ◽  
Human Colorectal Cancer ◽  
Cancer Transcriptome

Analysis of gene expression in human colorectal cancer tissues by cDNA array

2002 ◽  
Vol 37 (S14) ◽  
pp. 83-86 ◽  
Author(s):  
Hiroyuki Yamamoto ◽  
Arisa Imsumran ◽  
Hiroshi Fukushima ◽  
Yasushi Adachi ◽  
Yongfen Min ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cdna Array ◽  
Human Colorectal Cancer ◽  
Cancer Tissues
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