scholarly journals Self-Organization of the Biological Evolution

Genes ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 854
Author(s):  
Arber
Keyword(s):  
Genetic Variants ◽  
Molecular Genetic ◽  
Bacterial Genome ◽  
Genetic Research ◽  
Biological Evolution ◽  
Living Organism ◽  
Bacterial Strains ◽  
Different Types ◽  
Set Up ◽  
The One

We report here experiments carried out with nonpathogenic Escherichia coli bacterial strains and their phages. This research yielded interesting insights into their activities, occasionally producing genetic variants of different types. In order to not interfere with the genetic stability of the parental strains involved, we found that the bacteria are genetically equipped to only rarely produce a genetic variant, which may occur by a number of different approaches. On the one hand, the genes of relevance for the production of specific genetic variants are relatively rarely expressed. On the other hand, other gene products act as moderators of the frequencies that produce genetic variants. We call the genes producing genetic variants and those moderating the frequencies of genetic variation “evolution genes”. Their products are generally not required for daily bacterial life. We can, therefore, conclude that the bacterial genome has a duality. Some of the bacterial enzymes involved in biological evolution have become useful tools (e.g., restriction endonucleases) for molecular genetic research involving the genetic set-up of any living organism.

scholarly journals «Vanishing heritability» – a new paradox in the context of an old problem

2016 ◽  
Vol 5 (4) ◽  
pp. 5-12
Author(s):  
T.M. Mariutina
Keyword(s):  
Personality Traits ◽  
Genetic Polymorphisms ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Population Based ◽  
The Other ◽  
Other Hand ◽  
The One

«Vanishing heritability» is a linguistic metaphor, reflecting the phenomenonof noncoincidence between impact assessments for the operation of the genotype of the psyche in norm and pathology, which are fixed in two different methods: population-related and molecular-genetic. On the one hand, population-based studies of kinship (twins, siblings, parents-children), when assessing their cognitive and personality traits, have received high values of the basic statistic index - heritability. On the other hand, the molecular-genetic research has shownthat certain genetic polymorphisms cannot explain a large part ofheritabilityof this kind of psyche both in normal and pathology. The article deals with the background of the problem, examines the possible causes of this phenomenon and the ways out of the situation.

scholarly journals Genetic variants identified in children with recurrent infections

2021 ◽  
Vol 20 (4) ◽  
pp. 13-17
Author(s):  
A. S. Levina ◽  
E. N. Suspitsin ◽  
N. V. Skripchenko ◽  
O. V. Goleva ◽  
O. M. Ibragimova
Keyword(s):  
Immune System ◽  
Primary Immunodeficiency ◽  
Genetic Variants ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Recurrent Infections ◽  
Laboratory Studies ◽  
Inflammatory Disorders ◽  
Pathogenic Variants ◽  
Rare Genetic Variants

Currently, the most effective way to diagnose hereditary defects of the immune system is molecular genetic research, the results of which are evaluated in conjunction with the data of clinical and laboratory studies.Aims of the sudy: to evaluate the frequency and spectrum of rare genetic variants associated with the development of primary immunodeficiency (PID) in children with recurrent infections.Materials and methods: DNA samples from 113 children with recurrent infections were analyzed by targeted multigene sequencing of 338 PID-associated genes. Results: Pathogenic variants appropriate to the potential diagnosis of PID were identified in 8% of patients. Interestingly, 47.8% of children had variants associated with auto-inflammatory disorders.

scholarly journals The spectrum of genetic variants of the a- and b-globin clusters in patients with hemoglobinopathies living in the Republic of Dagestan

2020 ◽  
Vol 19 (3) ◽  
pp. 50-53
Author(s):  
S. G. Mann ◽  
E. V. Raikina ◽  
I. M. Yunusova
Keyword(s):  
Genetic Variants ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Research Center ◽  
Federal State ◽  
Endemic Region ◽  
Pediatric Hematology ◽  
Common Genetic Variants ◽  
Abnormal Hemoglobin ◽  
The Republic

Hemoglobinopathies are a group of hereditary hemolytic anemias common in the countries of the Mediterranean, Southeast Asia and Africa, where malaria was previously common. Due to population migration and an increase in the number of mixed marriages, hemoglobinopathies are also relevant to Russia. Among the Russian Federation's subjects, the Republic of Dagestan is the most endemic region for the incidence of hemoglobinopathies. This study aimed to identify the spectrum of mutations in patients with hemoglobinopathies living in the Republic of Dagestan. The research was approved by Independent ethic committee and the academic board of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology (Moscow, Russia). Material from 100 patients was sent for molecular genetic research to the Laboratory of Molecular Biology, Federal State Budget Scientific Institution Scientific Research Center for Surgery named after Dmitry Rogachev. Genetic variants of the genes of the a- and b-globin clusters were determined using multiplex ligase-dependent amplification of samples and Sequencing by the Sanger method. Eighteen genetic variants with different frequencies were detected. The mutation frequency of the b-globin cluster was 62.5%, the a-globin cluster was 23.2%, and the variants leading to the appearance of abnormal hemoglobin were 14.3%. The five most common genetic variants among this cohort were also identified: CD8(-AA) and IVSI-110 (G>A), -(a) 3.7 and -(a) 20.5 and the CD6 variant GAG>GTG [Glu>Val] leading to abnormal hemoglobin S.

scholarly journals A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1333
Author(s):  
Benjamin Motais ◽  
Sandra Charvátová ◽  
Matouš Hrdinka ◽  
Michal Šimíček ◽  
Tomáš Jelínek ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Blood Cancer ◽  
Cell Based Therapy ◽  
Cell Source ◽  
Different Types ◽  
Cell Sources ◽  
The One ◽  
Initial Results

Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

scholarly journals A New Supported Manganese-Based Coordination Complex as a Nano-Catalyst for the Synthesis of Indazolophthalazinetriones and Investigation of Its Antibacterial Activity

Chemistry ◽  
2021 ◽  
Vol 3 (3) ◽  
pp. 783-799
Author(s):  
Maryam Ariannezhad ◽  
Davood Habibi ◽  
Somayyeh Heydari ◽  
Vahideh Khorramabadi
Keyword(s):  
Antibacterial Activity ◽  
Simple Procedure ◽  
Condensation Reaction ◽  
Antibacterial Properties ◽  
Coordination Complex ◽  
Bacterial Strains ◽  
One Pot ◽  
Nano Catalyst ◽  
Ft Ir ◽  
The One

A new magnetic supported manganese-based coordination complex (Fe3O4@SiO2@CPTMS@MBOL@ Mn) was prepared in consecutive stages and characterized via various techniques (VSM, SEM, TEM, XRD, FT-IR, EDX, TG-DTA, and ICP). To evaluate its application, it was used for synthesis of divers Indazolophthalazinetriones in a simple procedure via the one-pot three-component condensation reaction of aldehydes, dimedone, and phthalhydrazide in ethanol under reflux conditions. The Mn catalyst can be recycled without any noticeable loss in catalytic activity. Additionally, the antibacterial properties of the nano-catalyst were studied against some bacterial strains.

scholarly journals Population Genetic Structure Analysis Reveals Decreased but Moderate Diversity for the Oriental Fire-Bellied Toad Introduced to Beijing after 90 Years of Independent Evolution

Animals ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1429
Author(s):  
Yang Teng ◽  
Jing Yang ◽  
Guofen Zhu ◽  
Fuli Gao ◽  
Yingying Han ◽  
...  
Keyword(s):  
Genetic Structure ◽  
Structure Analysis ◽  
Phylogenetic Trees ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Haplotype Diversity ◽  
Botanical Garden ◽  
Source Population ◽  
Independent Evolution ◽  
Loop Region

Detailed molecular genetic research on amphibian populations has a significant role in understanding the genetic adaptability to local environments. The oriental fire-bellied toads (Bombina orientalis) were artificially introduced to Beijing from Shandong Province in 1927, and since then, this separated population went through an independent evolution. To explore the differentiation of the introduced population with its original population, this study analyzed the genetic structure of the oriental fire-bellied toad, based on the mitochondrial genome control region and six microsatellite sites. The results showed that the haplotype diversity and nucleotide diversity of the mitochondrial D-loop region partial sequences of the Beijing Botanical Garden population and the Baiwangshan population were lower than those of the Shangdong Kunyushan population. Microsatellite marker analysis also showed that the observed heterozygosity and expected heterozygosity of the Beijing populations were lower than those of the Kunyushan population. The phylogenetic trees and network diagrams of haplotypes indicated that the three populations were not genetically separated. However, the structure analysis showed a genetic differentiation and categorized the sampling individuals into Beijing and Shandong genetic clusters, which indicated a tendency for isolated evolution in the Beijing population. Although the Beijing populations showed a decline in genetic diversity, it was still at a moderate level, which could maintain the survival of the population. Thus, there is no need to reintroduce new individuals from the Kunyushan source population.

scholarly journals Somatic embryo induction and Agrobacterium-mediated transformation of embryonic callus tissue in Phoebe bournei, an endangered woody species in Lauraceae

2020 ◽  
Vol 48 (2) ◽  
pp. 572-587
Author(s):  
Wenting XU ◽  
Miao ZHANG ◽  
Chen WANG ◽  
Xiongzhen LOU ◽  
Xiao HAN ◽  
...  
Keyword(s):  
Genetic Transformation ◽  
Germination Rate ◽  
Molecular Genetic ◽  
Genetic Research ◽  
Woody Species ◽  
Technical System ◽  
Transformation Rate ◽  
Original Material ◽  
Embryonic Callus ◽  
Phoebe Bournei

Phoebe bournei, a plant species endemic to China, is a precious timber tree and widely used in landscaping. This tree contains numerous secondary metabolites, underscoring its potential economic value. However, studies on this species, including molecular genetic research, remain limited. In this study, both a somatic embryogenesis (SE) technical system and Agrobacterium-mediated genetic transformation were successfully employed in P. bournei for the first time. The SE technical system was constructed using immature embryos as original material. The primary embryo and embryonic callus induction rates were 30.66% and 41.67%, respectively. The highest rate of embryonic callus proliferation was 3.84. The maximum maturity coefficient and germination rate were 53.44/g and 39%, respectively. Agrobacterium-mediated genetic transformation was performed using the SE technical system, and the highest transformation rate was 11.24%. The results presented here are the first to demonstrate an efficient approach to achieve numerous P. bournei plantlets, which serves as the basis for artificial cultivation and resource conservation. Furthermore, the genetic transformation platform constructed in this study will facilitate assessment of gene function and molecular regulation.

Plausibility and Aesthetic Interpretation

1977 ◽  
Vol 7 (2) ◽  
pp. 327-340 ◽  
Author(s):  
Denis Dutton
Keyword(s):  
Scientific Inquiry ◽  
The Other ◽  
Inquiry Science ◽  
Works Of Art ◽  
Different Types ◽  
Logical Structures ◽  
The One

If a catalogue were made of terms commonly used to affirm the adequacy of critical interpretations of works of art, one word certain to be included would be “plausible.” Yet this term is one which has received precious little attention in the literature of aesthetics. This is odd, inasmuch as I find the notion of plausibility central to an understanding of the nature of criticism. “Plausible” is a perplexing term because it can have radically different meanings depending on the circumstances of its employment. ln the following discussion, I will make some observations about the logic of this concept in connection with its uses in two rather different contexts: the context of scientific inquiry on the one hand, and that of aesthetic interpretation on the other. In distinguishing separate senses of “plausible,” I shall provide reason to resist the temptation to imagine that because logical aspects of two different types of inquiry—science and criticism—happen to be designated by the same term, they may to that extent be considered to have similar logical structures.

scholarly journals The Swiss National Park

Oryx ◽  
1955 ◽  
Vol 3 (2) ◽  
pp. 64-70
Author(s):  
G. N. Zimmerli
Keyword(s):  
National Park ◽  
Swiss Society ◽  
Large Area ◽  
Nature Protection ◽  
Swiss National Park ◽  
Plant Life ◽  
Eastern Border ◽  
Set Up ◽  
The One ◽  
Protection Commission

The idea of a Swiss national park originated with the Swiss Society for Nature Research and this Society played the leading part in its realization. In 1906 the Society set up as part of its own organization a Swiss Nature Protection Commission and charged it to search for an area in Switzerland suitable for establishment as a reserve, in which all the animal and plant life could be protected against interference by man and so could be left entirely to the play of natural forces. It was not easy to find in Switzerland a suitably large area which still retained its original characteristics, was virtually free from human settlement, and contained some wealth of fauna and flora. After a careful survey of the whole country it became clear that the most suitable region was the Lower Engadine, with its isolated valleys on the eastern border of the country. The district in which, at the beginning of the century, bears had still lived was the one in which primitive nature could be found in its truest state.

Screening and Isolation of Bacterial Strains with the Biotechnological Potential to Destruct Cyanide-Bearing Compounds under the Conditions of Extreme Continental Climate

2015 ◽  
Vol 1130 ◽  
pp. 19-22
Author(s):  
M.P. Belykh ◽  
S.V. Petrov ◽  
V.F. Petrov ◽  
A.Yu. Chikin ◽  
N.L. Belkova
Keyword(s):  
Microbial Communities ◽  
Gold Mining ◽  
Molecular Genetic ◽  
Heap Leaching ◽  
Bacterial Strains ◽  
Mining Operations ◽  
Biotechnological Potential ◽  
Enriched Cultures ◽  
Continental Climate

The methods of biodegradation are of special interest because they help solving environmental problems of wastes detoxification from gold-mining operations. The use of bacterial strains is a promising approach in the field of biotechnology to destruct cyanide-bearing compounds. The diversity of microbial communities both in heap in situ and in the enriched cultures was studied with molecular genetic methods. The differences in representation of bacteria, cultivated in unexploitable and operating heaps, are territory, site and heap specific. The strains of Pseudomonas sp. and Methylobacterium sp. possess the biotechnological potential and might be used in biodegradation of heap leaching wastes in extreme continental climate.

Sign in / Sign up

Export Citation Format

Share Document