scholarly journals Evaluation of Mesh Size in Model Polymer Networks Consisting of Tetra-Arm and Linear Poly(ethylene glycol)s

Gels ◽  
2018 ◽  
Vol 4 (2) ◽  
pp. 50 ◽  
Author(s):  
Yui Tsuji ◽  
Xiang Li ◽  
Mitsuhiro Shibayama
Keyword(s):  
Ethylene Glycol ◽  
Polymer Networks ◽  
Mesh Size ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene

scholarly journals Controlling Fluid Diffusion and Release through Mixed-Molecular-Weight Poly(ethylene) Glycol Diacrylate (PEGDA) Hydrogels

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3381 ◽  
Author(s):  
Kieran O’Donnell ◽  
Adrian Boyd ◽  
Brian J. Meenan
Keyword(s):  
Tissue Engineering ◽  
Molecular Weight ◽  
Ethylene Glycol ◽  
Mesh Size ◽  
Material Structure ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Fluorescence Measurements ◽  
Fluid Permeability ◽  
Poly Ethylene

Due to their inherent ability to swell in the presence of aqueous solutions, hydrogels offer a means for the delivery of therapeutic agents in a range of applications. In the context of designing functional tissue-engineering scaffolds, their role in providing for the diffusion of nutrients to cells is of specific interest. In particular, the facility to provide such nutrients over a prolonged period within the core of a 3D scaffold is a critical consideration for the prevention of cell death and associated tissue-scaffold failure. The work reported here seeks to address this issue via fabrication of hybrid 3D scaffolds with a component fabricated from mixed-molecular-weight hydrogel formulations capable of storing and releasing nutrient solutions over a predetermined time period. To this end, poly(ethylene) glycol diacrylate hydrogel blends comprising mixtures of PEGDA-575 Mw and PEGDA-2000 Mw were prepared via UV polymerization. The effects of addition of the higher-molecular-weight component and the associated photoinitiator concentration on mesh size and corresponding fluid permeability have been investigated by diffusion and release measurements using a Theophylline as an aqueous nutrient model solution. Fluid permeability across the hydrogel films has also been determined using a Rhodamine B solution and associated fluorescence measurements. The results indicate that addition of PEGDA-2000 Mw to PEGDA-575 Mw coupled with the use of a specific photoinitiator concentration provides a means to change mesh size in a hydrogel network while still retaining an overall microporous material structure. The range of mesh sizes created and their distribution in a 3D construct provides for the conditions required for a more prolonged nutrient release profile for tissue-engineering applications.

scholarly journals Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

2019 ◽  
Vol 5 (2) ◽  
pp. eaav9322 ◽  
Author(s):  
Dali Wang ◽  
Jiaqi Lin ◽  
Fei Jia ◽  
Xuyu Tan ◽  
Yuyan Wang ◽  
...  
Keyword(s):  
Rna Interference ◽  
Ethylene Glycol ◽  
Target Genes ◽  
Area Under The Curve ◽  
Fold Increase ◽  
Small Interfering Rnas ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene

Nonhepatic delivery of small interfering RNAs (siRNAs) remains a challenge for development of RNA interference–based therapeutics. We report a noncationic vector wherein linear poly(ethylene glycol) (PEG), a polymer generally considered as inert and safe biologically but ineffective as a vector, is transformed into a bottlebrush architecture. This topology provides covalently embedded siRNA with augmented nuclease stability and cellular uptake. Consisting almost entirely of PEG and siRNA, the conjugates exhibit a ~25-fold increase in blood elimination half-life and a ~19-fold increase in the area under the curve compared with unmodified siRNA. The improved pharmacokinetics results in greater tumor uptake and diminished liver capture. Despite the structural simplicity these conjugates efficiently knock down target genes in vivo without apparent toxic and immunogenic reactions. Given the benign biological nature of PEG and its widespread precedence in biopharmaceuticals, we anticipate the brush polymer–based technology to have a significant impact on siRNA therapeutics.

Dendritic Polyglycerol–Poly(ethylene glycol)-Based Polymer Networks for Biosensing Application

2014 ◽  
Vol 6 (12) ◽  
pp. 8937-8941 ◽  
Author(s):  
Pradip Dey ◽  
Miriam Adamovski ◽  
Simon Friebe ◽  
Artavazd Badalyan ◽  
Radu-Cristian Mutihac ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Networks ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Enzymatically crosslinked hydrogels based on linear poly(ethylene glycol) polymer: performance and mechanism

2017 ◽  
Vol 8 (45) ◽  
pp. 7017-7024 ◽  
Author(s):  
Kaixuan Ren ◽  
Bin Li ◽  
Qinghua Xu ◽  
Chunsheng Xiao ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene ◽  
Performance And Mechanism

A horseradish peroxidase-catalyzed hydrogel based on a double-end tyramine conjugated linear poly(ethylene glycol) polymer is developed and clarified.

scholarly journals Long-Term Controlled Protein Release from Poly(Ethylene Glycol) Hydrogels by Modulating Mesh Size and Degradation

2015 ◽  
Vol 15 (12) ◽  
pp. 1679-1686 ◽  
Author(s):  
Xinming Tong ◽  
Soah Lee ◽  
Layla Bararpour ◽  
Fan Yang
Keyword(s):  
Ethylene Glycol ◽  
Mesh Size ◽  
Protein Release ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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