scholarly journals Numerical Study of Bloodstream Diffusion of the New Generation of Drug-Eluting Stents in Coronary Arteries

Fluids ◽  
2021 ◽  
Vol 6 (2) ◽  
pp. 71
Author(s):  
Leandro Marques ◽  
Gustavo R. Anjos
Keyword(s):  
Coronary Artery ◽  
Cross Sections ◽  
Numerical Study ◽  
Navier Stokes ◽  
Drug Eluting Stents ◽  
Drug Eluting Stent ◽  
Variable Cross ◽  
Navier Stokes Equation ◽  
Drug Eluting ◽  
New Generation

The present work aims at developing a numerical study on the drug diffusion in the bloodstream in a coronary artery with drug-eluting stent implanted. The blood was modeled as a single-phase, incompressible and Newtonian fluid and the Navier–Stokes equation was approximated according to the Finite Element Method (FEM). The dynamics of drug-eluting concentration in bloodstream was investigated using four drug-eluting stents with different mass diffusivities in microchannels with variable cross sections, including a real coronary artery geometry with atherosclerosis. The results reveal complex drug concentration patterns and accumulation in the vicinity of the fat buildup.

Long-term efficacy of drug coated balloons compared with new generation drug-eluting stents for the treatment of de novo coronary artery lesions

2018 ◽  
Vol 92 (5) ◽  
pp. E317-E326 ◽  
Author(s):  
Dimitrios Venetsanos ◽  
Sofia Sederholm Lawesson ◽  
Georgios Panayi ◽  
Tim Tödt ◽  
Ulf Berglund ◽  
...  
Keyword(s):  
Coronary Artery ◽  
De Novo ◽  
Drug Eluting Stents ◽  
Coronary Artery Lesions ◽  
Term Efficacy ◽  
Drug Eluting ◽  
New Generation

Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients

2019 ◽  
Vol 56 (5) ◽  
pp. 911-918 ◽  
Author(s):  
Vasileios F Panoulas ◽  
Charles J Ilsley ◽  
Konstantinos Kalogeras ◽  
Habib Khan ◽  
Maria Monteagudo Vela ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Real World ◽  
Artery Bypass ◽  
Coronary Intervention ◽  
Drug Eluting Stents ◽  
Term Survival ◽  
Percutaneous Coronary ◽  
All Cause Mortality ◽  
Drug Eluting ◽  
New Generation

Abstract OBJECTIVES The intermediate-term all-cause mortality rate of real-world patients with multivessel disease (MVD) treated with percutaneous coronary intervention (PCI) with new-generation drug-eluting stents or coronary artery bypass grafting (CABG) remains unknown. We sought to compare the intermediate-term all-cause mortality rates of real-world patients with MVD including left main stem disease, treated with CABG or PCI. METHODS All consecutive all-comer patients with MVD undergoing CABG or PCI with second/third generation drug-eluting stents from 2007 to 2015 in Harefield Hospital, UK were included in this study. The revascularization modality was based on heart team discussions. Primary outcome was all-cause mortality. Mean follow-up of the study was 3.3 years. Cox regression analysis and propensity matching were used. RESULTS Of 6383 patients with MVD, 4230 underwent CABG, whereas 2153 had PCI with new-generation stents. In the CABG group, the mean age was 66.4 ± 10 years, whereas in the PCI group it was 65.3 ± 12.1 years (P < 0.001). Fewer female patients with MVD were treated with CABG than were treated with PCI (18.5% vs 20.5%; P = 0.026). There was a higher 5-year estimated survival rate among patients having CABG (88% vs 78.3%; Plog-rank < 0.001). The adjusted hazard ratio (HR) for PCI over CABG was 1.74 [95% confidence interval (CI) 1.41–2.16; P < 0.001]. A total of 653 patients having CABG and 653 having PCI were included in the propensity-matched groups. At mean follow-up, PCI was associated with a higher adjusted HR for all-cause mortality (2.18, 95% CI 1.54–3.1; P < 0.001). CONCLUSIONS In this contemporary cohort of real-world patients with MVD, CABG was associated with increased intermediate-term survival compared to PCI with new-generation drug-eluting stents.

scholarly journals SERIAL OCT AND HISTOPATHOLOGY ANALYSIS FOLLOWING 1ST AND NEW GENERATION DRUG ELUTING STENTS IMPLANTATION IN SWINE CORONARY ARTERY

2012 ◽  
Vol 59 (13) ◽  
pp. E219
Author(s):  
Hiranuma Noritoshi ◽  
Toshiro Shinke ◽  
Gaku Nakazawa ◽  
Hiromasa Otake ◽  
Matsumoto Daisuke ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Drug Eluting Stents ◽  
Drug Eluting ◽  
New Generation

Coronary pseudoaneurysm in a non-polymer drug-eluting stent: a rare entity

2011 ◽  
Vol 19 (6) ◽  
pp. 407-410 ◽  
Author(s):  
Aditya Kapoor ◽  
Aditya Batra ◽  
Sudeep Kumar ◽  
Shantanu Pandey ◽  
SK Agarwal ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass Grafting ◽  
Coronary Artery Bypass ◽  
Artery Bypass ◽  
Drug Eluting Stents ◽  
Drug Eluting Stent ◽  
Bypass Grafting ◽  
Rare Entity ◽  
Coronary Pseudoaneurysm ◽  
Drug Eluting

Coronary pseudoaneurysms following implantation of drug-eluting stents, although rare, are not unknown. Nearly all such cases have been reported in patients with sirolimus or paclitaxel polymer-based stents. We describe a case of coronary pseudoaneurysm developing with a non-polymer-based drug-eluting stent in a 50-year-old man who was successfully managed by coronary artery bypass grafting.

Sign in / Sign up

Export Citation Format

Share Document