scholarly journals Modeling Superparamagnetic Particles in Blood Flow for Applications in Magnetic Drug Targeting

Fluids ◽  
2017 ◽  
Vol 2 (2) ◽  
pp. 29 ◽  
Author(s):  
Iris Rukshin ◽  
Josef Mohrenweiser ◽  
Pengtao Yue ◽  
Shahriar Afkhami
Keyword(s):  
Blood Flow ◽  
Drug Targeting ◽  
Magnetic Drug Targeting ◽  
Superparamagnetic Particles

SIMULATION OF MAGNETIC NANOPARTICLES IN BLOOD FLOW FOR MAGNETIC DRUG TARGETING APPLICATIONS

nano Online ◽  
2016 ◽  
Author(s):  
I Slabu ◽  
A Röth ◽  
G Güntherodt ◽  
T Schmitz-Rode ◽  
M Baumann
Keyword(s):  
Blood Flow ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Magnetic Drug Targeting

On the motion of superparamagnetic particles in magnetic drug targeting

2011 ◽  
Vol 223 (3) ◽  
pp. 505-527 ◽  
Author(s):  
Pengtao Yue ◽  
Shernita Lee ◽  
Shahriar Afkhami ◽  
Yuriko Renardy
Keyword(s):  
Drug Targeting ◽  
Magnetic Drug Targeting ◽  
Superparamagnetic Particles

scholarly journals Two-Phase Biofluid Flow Model for Magnetic Drug Targeting

Symmetry ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1083 ◽  
Author(s):  
Ioannis D. Boutopoulos ◽  
Dimitrios S. Lampropoulos ◽  
George C. Bourantas ◽  
Karol Miller ◽  
Vassilios C. Loukopoulos
Keyword(s):  
Magnetic Field ◽  
Blood Flow ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Volume Fraction ◽  
Numerical Results ◽  
Magnetic Drug Targeting ◽  
Two Phase ◽  
The Magnetic Field

Magnetic drug targeting (MDT) is a noninvasive method for the medical treatment of various diseases of the cardiovascular system. Biocompatible magnetic nanoparticles loaded with medicinal drugs are carried to a tissue target in the human body (in vivo) under the applied magnetic field. The present study examines the MDT technique in various microchannels geometries by adopting the principles of biofluid dynamics (BFD). The blood flow is considered as laminar, pulsatile and the blood as an incompressible and non-Newtonian fluid. A two-phase model is adopted to resolve the blood flow and the motion of magnetic nanoparticles (MNPs). The numerical results are obtained by utilizing a meshless point collocation method (MPCM) alongside with the moving least squares (MLS) approximation. The numerical results are verified by comparing with published numerical results. We investigate the effect of crucial parameters of MDT, including (1) the volume fraction of nanoparticles, (2) the location of the magnetic field, (3) the strength of the magnetic field and its gradient, (4) the way that MNPs approach the targeted area, and (5) the bifurcation angle of the vessel.

scholarly journals In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

2020 ◽  
Vol 6 (3) ◽  
pp. 543-546
Author(s):  
Michael Fink ◽  
Stefan J. Rupitsch ◽  
Helmut Ermert ◽  
Stefan Lyer
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Drug Targeting ◽  
Imaging Technique ◽  
Small Animal ◽  
Magnetic Drug Targeting ◽  
Oxide Nanoparticles ◽  
Medical Procedures ◽  
First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

scholarly journals C5.3 - Sonographic Detection of Nanoparticles used for Magnetic Drug Targeting

2015 ◽  
Author(s):  
M. Fink ◽  
H. Ermert ◽  
M Löffler ◽  
A. Sutor ◽  
B. Tewes ◽  
...  
Keyword(s):  
Drug Targeting ◽  
Magnetic Drug Targeting

Intrathecal Magnetic Drug Targeting: A New Approach to Treating Diseases of the Central Nervous System

2013 ◽  
Author(s):  
Eric Lueshen ◽  
Indu Venugopal ◽  
Andreas Linninger
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Spinal Canal ◽  
Drug Targeting ◽  
Superparamagnetic Nanoparticles ◽  
Magnetic Drug Targeting ◽  
The Central Nervous System ◽  
Drug Doses

Intrathecal (IT) drug delivery is a standard technique which involves direct injection of drugs into the cerebrospinal fluid (CSF)-filled space within the spinal canal to treat many diseases of the central nervous system. Currently, in order to reach the therapeutic drug concentration at certain locations within the spinal canal, high drug doses are used. With no method to deliver the large drug doses locally, current IT drug delivery treatments are hindered with wide drug distributions throughout the central nervous system (CNS) which cause harmful side effects. In order to overcome the current limitations of IT drug delivery, we have developed the novel method of intrathecal magnetic drug targeting (IT-MDT). Gold-coated magnetite nanoparticles are infused into a physiologically and anatomically relevant in vitro human spine model and then targeted to a specific site using external magnetic fields, resulting in a substantial increase in therapeutic nanoparticle localization at the site of interest. Experiments aiming to determine the effect of key parameters such as magnet strength, duration of magnetic field exposure, location of magnetic field, and ferrous implants on the collection efficiency of our superparamagnetic nanoparticles in the targeting region were performed. Our experiments indicate that intrathecal magnetic drug targeting and implant-assisted IT-MDT are promising techniques for concentrating and localizing drug-functionalized nanoparticles at required target sites within the spinal canal for potential treatment of diseases affecting the central nervous system.

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