scholarly journals Snails as Taxis for a Large Yeast Biodiversity

Fermentation ◽  
2020 ◽  
Vol 6 (3) ◽  
pp. 90 ◽  
Author(s):  
Madina Akan ◽  
Florian Michling ◽  
Katrin Matti ◽  
Sinje Krause ◽  
Judith Muno-Bender ◽  
...  
Keyword(s):  
Large Body ◽  
Grape Must ◽  
Human Fungal Pathogen ◽  
Yeast Ecology ◽  
Food And Beverage ◽  
Courier Service ◽  
Limited Culture ◽  
Ascomycetous Yeasts ◽  
Cepaea Hortensis

Yeasts are unicellular fungi that harbour a large biodiversity of thousands of species, of which particularly ascomycetous yeasts are instrumental to human food and beverage production. There is already a large body of evidence showing that insects play an important role for yeast ecology, for their dispersal to new habitats and for breeding and overwintering opportunities. Here, we sought to investigate a potential role of the terrestrial snails Cepaea hortensis and C. nemoralis, which in Europe are often found in association with human settlements and gardens, in yeast ecology. Surprisingly, even in a relatively limited culture-dependent sampling size of over 150 isolates, we found a variety of yeast genera, including species frequently isolated from grape must such as Hanseniaspora, Metschnikowia, Meyerozyma and Pichia in snail excrements. We typed the isolates using standard ITS-PCR-sequencing, sequenced the genomes of three non-conventional yeasts H. uvarum, Meyerozyma guilliermondii and P. kudriavzevii and characterized the fermentation performance of these three strains in grape must highlighting their potential to contribute to novel beverage fermentations. Aggravatingly, however, we also retrieved several human fungal pathogen isolates from snail excrements belonging to the Candida clade, namely Ca. glabrata and Ca. lusitaniae. Overall, our results indicate that diverse yeasts can utilise snails as taxis for dispersal. This courier service may be largely non-selective and thus depend on the diet available to the snails.

scholarly journals The MAL Protein, an Integral Component of Specialized Membranes, in Normal Cells and Cancer

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1065
Author(s):  
Armando Rubio-Ramos ◽  
Leticia Labat-de-Hoz ◽  
Isabel Correas ◽  
Miguel A. Alonso
Keyword(s):  
Epithelial Cells ◽  
Large Body ◽  
Original Description ◽  
Cell Types ◽  
Future Research ◽  
Transmembrane Segments ◽  
Epsilon Toxin ◽  
Proteolipid Proteins ◽  
Polarized Epithelial Cells

The MAL gene encodes a 17-kDa protein containing four putative transmembrane segments whose expression is restricted to human T cells, polarized epithelial cells and myelin-forming cells. The MAL protein has two unusual biochemical features. First, it has lipid-like properties that qualify it as a member of the group of proteolipid proteins. Second, it partitions selectively into detergent-insoluble membranes, which are known to be enriched in condensed cell membranes, consistent with MAL being distributed in highly ordered membranes in the cell. Since its original description more than thirty years ago, a large body of evidence has accumulated supporting a role of MAL in specialized membranes in all the cell types in which it is expressed. Here, we review the structure, expression and biochemical characteristics of MAL, and discuss the association of MAL with raft membranes and the function of MAL in polarized epithelial cells, T lymphocytes, and myelin-forming cells. The evidence that MAL is a putative receptor of the epsilon toxin of Clostridium perfringens, the expression of MAL in lymphomas, the hypermethylation of the MAL gene and subsequent loss of MAL expression in carcinomas are also presented. We propose a model of MAL as the organizer of specialized condensed membranes to make them functional, discuss the role of MAL as a tumor suppressor in carcinomas, consider its potential use as a cancer biomarker, and summarize the directions for future research.

scholarly journals Role of Matrix Gla Protein in the Complex Network of Coronary Artery Disease: A Comprehensive Review

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 737
Author(s):  
Marko Kumric ◽  
Josip A. Borovac ◽  
Tina Ticinovic Kurir ◽  
Dinko Martinovic ◽  
Ivan Frka Separovic ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Complex Network ◽  
Vascular Calcification ◽  
Vitamin K ◽  
Clinical Decision Making ◽  
Large Body ◽  
Matrix Gla Protein ◽  
Artery Disease

Coronary artery disease (CAD) is widely recognized as one of the most important clinical entities. In recent years, a large body of accumulated data suggest that coronary artery calcification, a process highly prevalent in patients with CAD, occurs via well-organized biologic processes, rather than passively, as previously regarded. Matrix Gla protein (MGP), a vitamin K-dependent protein, emerged as an important inhibitor of both intimal and medial vascular calcification. The functionality of MGP hinges on two post-translational modifications: phosphorylation and carboxylation. Depending on the above-noted modifications, various species of MGP may exist in circulation, each with their respective level of functionality. Emerging data suggest that dysfunctional species of MGP, markedly, dephosphorylated-uncarboxylated MGP, might find its application as biomarkers of microvascular health, and assist in clinical decision making with regard to initiation of vitamin K supplementation. Hence, in this review we summarized the current knowledge with respect to the role of MGP in the complex network of vascular calcification with concurrent inferences to CAD. In addition, we discussed the effects of warfarin use on MGP functionality, with concomitant implications to coronary plaque stability.

scholarly journals Assessment of Different Dimensions of Shame Proneness: Validation of the SHAME

Assessment ◽  
2018 ◽  
Vol 27 (8) ◽  
pp. 1699-1717 ◽  
Author(s):  
Corinna N. Scheel ◽  
Hedwig Eisenbarth ◽  
Katrin Rentzsch
Keyword(s):  
Clinical Sample ◽  
Large Body ◽  
Factor Analyses ◽  
Confirmatory Factor Analyses ◽  
Invariance Testing ◽  
Network Analyses ◽  
Shame Proneness ◽  
Confirmatory Factor ◽  
Different Dimensions

A large body of research revealed that shame is associated with adaptive and maladaptive correlates. The aim of this work was to validate a new dimensional instrument (SHAME), which was developed to disentangle adaptive and maladaptive dimensions of shame proneness. Confirmatory factor analyses supported the three-factorial structure (bodily, cognitive, and existential shame) in American ( n = 502) and German ( n = 496) community samples, using invariance testing. Bifactor model analyses exhibited distinct associations of adaptive (bodily and cognitive shame) and maladaptive (existential shame) dimensions of shame with psychopathology and social functioning. Network analyses highlighted the role of existential shame in psychopathology, especially for a clinical sample of patients with Borderline Personality Disorder ( n = 92). By placing shame pronenesss into a network of similar and dissimilar constructs, the current findings serve as a foundation for drawing conclusions about the adaptive and maladaptive nature of shame.

scholarly journals On the Role of Learning Theories in Furthering Software Engineering Education

2011 ◽  
pp. 1645-1666 ◽  
Author(s):  
Emily Oh Navarro
Keyword(s):  
Software Engineering ◽  
Engineering Education ◽  
Large Body ◽  
Learning Theories ◽  
Valuable Resource ◽  
Software Engineering Education ◽  
Role Learning ◽  
How People Learn

Learning theories describe how people learn. There is a large body of work concerning learning theories on which to draw, a valuable resource of which the domain of software engineering educational research has thus far not taken full advantage. In this chapter, we explore what role learning theories could play in software engineering education. We propose that learning theories can move the field of software engineering education forward by helping us to categorize, design, evaluate, and communicate about software engineering educational approaches. We demonstrate this by: (1) surveying a set of relevant learning theories, (2) presenting a categorization of common software engineering educational approaches in terms of learning theories, and (3) using one such approach (SimSE) as a case study to explore how learning theories can be used to improve existing approaches, design new approaches, and structure and guide the evaluation of an approach.

The Role of Spiritual Capital in Innovation and Performance: Evidence from Developing Economies

2017 ◽  
Vol 41 (4) ◽  
pp. 621-640 ◽  
Author(s):  
Mitchell J. Neubert ◽  
Steven W. Bradley ◽  
Retno Ardianti ◽  
Edward M. Simiyu
Keyword(s):  
Developing Economies ◽  
Large Body ◽  
Institutional Voids ◽  
Spiritual Capital ◽  
Social Forms ◽  
Significant Relationships ◽  
Start Up ◽  
Additional Influence ◽  
And Performance

Forms of capital play a significant role in the innovation and performance of start–up firms. Current entrepreneurial research has focused on the role of financial, human, and social forms of capital. We build on a large body of theory and research in sociology and economics, proposing spiritual capital as an additional influence where institutional voids are greater in the development contexts studied. Results from microcredit entrepreneurs in Kenya and Indonesia indicate significant relationships between entrepreneurs’ spiritual capital and business innovation and performance, even after accounting for other forms of capital.

Essential role of human CDT1 in DNA replication and chromatin licensing

2002 ◽  
Vol 115 (7) ◽  
pp. 1435-1440 ◽  
Author(s):  
Mickael Rialland ◽  
Francesco Sola ◽  
Corrado Santocanale
Keyword(s):  
Cell Cycle ◽  
Dna Replication ◽  
Complex Formation ◽  
Fission Yeast ◽  
Origin Recognition Complex ◽  
Essential Role ◽  
Large Body ◽  
Transformed Cells ◽  
Minichromosome Maintenance

Formation of pre-replicative complexes at origins is an early cell cycle event essential for DNA duplication. A large body of evidence supports the notion that Cdc6 protein, through its interaction with the origin recognition complex, is required for pre-replicative complex assembly by loading minichromosome maintenance proteins onto DNA. In fission yeast and Xenopus, this reaction known as the licensing of chromatin for DNA replication also requires the newly identified Cdt1 protein. We studied the role of hCdt1 protein in the duplication of the human genome by antibody microinjection experiments and analyzed its expression during the cell cycle in human non-transformed cells. We show that hCdt1 is essential for DNA replication in intact human cells, that it executes its function in a window of the cell cycle overlapping with pre-replicative complex formation and that it is necessary for the loading of minichromosome maintenance proteins onto chromatin. Intriguingly, we observed that hCdt1 protein, in contrast to other licensing factors, is already present in serum-deprived G0 arrested cells and its levels increase only marginally upon re-entry in the cell cycle.

General and specific perceptions of procedural justice: Factors associated with perceptions of police and court responses to domestic and family violence

2020 ◽  
Vol 53 (3) ◽  
pp. 333-351
Author(s):  
Silke Meyer ◽  
Harley Williamson
Keyword(s):  
Criminal Justice ◽  
Procedural Justice ◽  
Family Violence ◽  
Administrative Data ◽  
Large Body ◽  
Policy And Practice ◽  
Factors Associated ◽  
Protection Orders ◽  
Perceptions Of Police

Improving criminal justice responses to domestic and family violence is a key focus within many policy and practice reforms. The efficacy of police and court responses to domestic and family violence is central because of the role of police as first responders and courts in issuing protection orders, imposing sanctions and ensuring perpetrator cooperation and accountability. To promote compliance and satisfaction with criminal justice outcomes, a large body of research points to the role of procedural justice. This study draws on survey and administrative data from an Australian jurisdiction to examine perceptions of procedural justice in specific domestic and family violence-related encounters. Findings and implications for policy and practice are discussed.

scholarly journals Roles and Clinical Applications of Exosomes in Cardiovascular Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-8 ◽  
Author(s):  
Dong Guo ◽  
Yuerong Xu ◽  
Jian Ding ◽  
Jiaying Dong ◽  
Ning Jia ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Large Body ◽  
Bilayer Membrane ◽  
Therapeutic Agents ◽  
Therapeutic Strategies ◽  
Signal Molecules ◽  
Mortality And Morbidity ◽  
Causes Of Mortality ◽  
Bioactive Agents

Despite substantial improvements in therapeutic strategies, cardiovascular disease (CVD) is still among the leading causes of mortality and morbidity worldwide. Exosomes, extracellular vesicles with a lipid bilayer membrane of endosomal origin, have been the focus of a large body of research in CVD. Exosomes not only serve as carriers for signal molecules responsible for intercellular and interorgan communication underlying CVD pathophysiology but also are bioactive agents which are partly responsible for the therapeutic effect of stem cell therapy of CVD. We here review recent insights gained into the role of exosomes in apoptosis, hypertrophy, angiogenesis, fibrosis, and inflammation in CVD pathophysiology and progression and the application and mechanisms of exosomes as therapeutic agents for CVD.

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