scholarly journals SilvAdapt.Net: A Site-Based Network of Adaptive Forest Management Related to Climate Change in Spain

Forests ◽  
2021 ◽  
Vol 12 (12) ◽  
pp. 1807
Author(s):  
Antonio J. Molina ◽  
Rafael M. Navarro-Cerrillo ◽  
Javier Pérez-Romero ◽  
Reyes Alejano ◽  
Juan F. Bellot ◽  
...  
Keyword(s):  
Forest Management ◽  
Forest Ecology ◽  
Research Groups ◽  
Logical Frameworks ◽  
Open Questions ◽  
Adaptive Forest Management ◽  
Key Aspects ◽  
And Function ◽  
Research Initiatives ◽  
A Site

Adaptive forest management (AFM) is an urgent need because of the uncertainty regarding how changes in the climate will affect the structure, composition and function of forests during the next decades. Current research initiatives for the long-term monitoring of impacts of silviculture are scattered and not integrated into research networks, with the consequent losses of opportunities and capacity for action. To increase the scientific and practical impacts of these experiences, it is necessary to establish logical frameworks that harmonize the information and help us to define the most appropriate treatments. In this context, a number of research groups in Spain have produced research achievements and know-how during the last decades that can allow for the improvement in AFM. These groups address the issue of AFM from different fields, such as ecophysiology, ecohydrology and forest ecology, thus resulting in valuable but dispersed expertise. The main objective of this work is to introduce a comprehensive strategy aimed to study the implementation of AFM in Spain. As a first step, a network of 34 experimental sites managed by 14 different research groups is proposed and justified. As a second step, the most important AFM impacts on Mediterranean pines, as one of the most extended natural and planted forest types in Spain, are presented. Finally, open questions dealing with key aspects when attempting to implement an AFM framework are discussed. This study is expected to contribute to better outlining the procedures and steps needed to implement regional frameworks for AFM.

scholarly journals Structure and Function of 4-Hydroxyphenylacetate Decarboxylase and Its Cognate Activating Enzyme

2016 ◽  
Vol 26 (1-3) ◽  
pp. 76-91 ◽  
Author(s):  
Brinda Selvaraj ◽  
Wolfgang Buckel ◽  
Bernard T. Golding ◽  
G. Matthias Ullmann ◽  
Berta M. Martins
Keyword(s):  
Small Subunit ◽  
Structure And Function ◽  
Binding Motif ◽  
Prosthetic Group ◽  
New Class ◽  
Glycyl Radical ◽  
Open Questions ◽  
Substrate Conversion ◽  
And Function ◽  
A Site

4-Hydroxyphenylacetate decarboxylase (4Hpad) is the prototype of a new class of Fe-S cluster-dependent glycyl radical enzymes (Fe-S GREs) acting on aromatic compounds. The two-enzyme component system comprises a decarboxylase responsible for substrate conversion and a dedicated activating enzyme (4Hpad-AE). The decarboxylase uses a glycyl/thiyl radical dyad to convert 4-hydroxyphenylacetate into <i>p</i>-cresol (4-methylphenol) by a biologically unprecedented Kolbe-type decarboxylation. In addition to the radical dyad prosthetic group, the decarboxylase unit contains two [4Fe-4S] clusters coordinated by an extra small subunit of unknown function. 4Hpad-AE reductively cleaves S-adenosylmethionine (SAM or AdoMet) at a site-differentiated [4Fe-4S]<sup>2+/+</sup> cluster (RS cluster) generating a transient 5′-deoxyadenosyl radical that produces a stable glycyl radical in the decarboxylase by the abstraction of a hydrogen atom. 4Hpad-AE binds up to two auxiliary [4Fe-4S] clusters coordinated by a ferredoxin-like insert that is C-terminal to the RS cluster-binding motif. The ferredoxin-like domain with its two auxiliary clusters is not vital for SAM-dependent glycyl radical formation in the decarboxylase, but facilitates a longer lifetime for the radical. This review describes the 4Hpad and cognate AE families and focuses on the recent advances and open questions concerning the structure, function and mechanism of this novel Fe-S-dependent class of GREs.

Asking More than Where: Developing a Site Contextual Model Based on Reconstructing past Environments

1997 ◽  
Vol 17 (4) ◽  
pp. 307-336
Author(s):  
Douglas S. Frink
Keyword(s):  
Native American ◽  
Phase I ◽  
Contextual Model ◽  
Model Based ◽  
European Settlement ◽  
Level Data ◽  
Limited Application ◽  
And Function ◽  
A Site ◽  
Phase Ii And Iii

Contract archaeology accounts for the majority of archaeological studies conducted in Vermont. As these studies serve the development community, the focus of investigation has been to identify and avoid sites, not to research and evaluate the information they contain. Native-American site locational models have limited application because they are based primarily on the landforms' proximity to water. The Archaeology Consulting Team is developing a contextual model based on reconstructing the pre-European settlement environment. Hypotheses comparing expected size and function of Native-American sites in different environments can be posed at the Phase I level of archaeological studies. Furthermore, with Phase I level data, these hypotheses can provide the framework for research designs at Phase II and III levels of archaeological study.

scholarly journals Gut Microbiota–Host Interactions in Inborn Errors of Immunity

2021 ◽  
Vol 22 (3) ◽  
pp. 1416
Author(s):  
Riccardo Castagnoli ◽  
Francesca Pala ◽  
Marita Bosticardo ◽  
Amelia Licari ◽  
Ottavia M. Delmonte ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Wide Spectrum ◽  
Adaptive Immune System ◽  
Clinical Feature ◽  
Inborn Errors ◽  
Mucosal Permeability ◽  
Microbial Dysbiosis ◽  
Inborn Errors Of Immunity ◽  
Key Aspects ◽  
And Function

Inborn errors of immunity (IEI) are a group of disorders that are mostly caused by genetic mutations affecting immune host defense and immune regulation. Although IEI present with a wide spectrum of clinical features, in about one third of them various degrees of gastrointestinal (GI) involvement have been described and for some IEI the GI manifestations represent the main and peculiar clinical feature. The microbiome plays critical roles in the education and function of the host’s innate and adaptive immune system, and imbalances in microbiota-immunity interactions can contribute to intestinal pathogenesis. Microbial dysbiosis combined to the impairment of immunosurveillance and immune dysfunction in IEI, may favor mucosal permeability and lead to inflammation. Here we review how immune homeostasis between commensals and the host is established in the gut, and how these mechanisms can be disrupted in the context of primary immunodeficiencies. Additionally, we highlight key aspects of the first studies on gut microbiome in patients affected by IEI and discuss how gut microbiome could be harnessed as a therapeutic approach in these diseases.

scholarly journals Molecular biology approaches in bioadhesion research

2014 ◽  
Vol 5 ◽  
pp. 983-993 ◽  
Author(s):  
Marcelo Rodrigues ◽  
Birgit Lengerer ◽  
Thomas Ostermann ◽  
Peter Ladurner
Keyword(s):  
Molecular Biology ◽  
Biological Function ◽  
Molecular Approach ◽  
Research Groups ◽  
Blast Search ◽  
Search Facility ◽  
New Research ◽  
And Function ◽  
Functional Analyses

The use of molecular biology tools in the field of bioadhesion is still in its infancy. For new research groups who are considering taking a molecular approach, the techniques presented here are essential to unravelling the sequence of a gene, its expression and its biological function. Here we provide an outline for addressing adhesion-related genes in diverse organisms. We show how to gradually narrow down the number of candidate transcripts that are involved in adhesion by (1) generating a transcriptome and a differentially expressed cDNA list enriched for adhesion-related transcripts, (2) setting up a BLAST search facility, (3) perform an in situ hybridization screen, and (4) functional analyses of selected genes by using RNA interference knock-down. Furthermore, latest developments in genome-editing are presented as new tools to study gene function. By using this iterative multi-technologies approach, the identification, isolation, expression and function of adhesion-related genes can be studied in most organisms. These tools will improve our understanding of the diversity of molecules used for adhesion in different organisms and these findings will help to develop innovative bio-inspired adhesives.

Distribution of amniotic stem cells in human term amnion membrane

Microscopy ◽  
2021 ◽  
Author(s):  
Nobuyuki Koike ◽  
Jun Sugimoto ◽  
Motonori Okabe ◽  
Kenichi Arai ◽  
Makiko Nogami ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Markers ◽  
Epithelial Stem Cells ◽  
Human Amnion ◽  
Transporter Protein ◽  
Amniotic Mesenchymal Stem Cells ◽  
Amnion Membrane ◽  
And Function ◽  
A Site

Abstract Amnion membrane studies related to miscarriage have been conducted in the field of obstetrics and gynecology. However, the distribution of stem cells within the amnion and the differences in the properties of each type of stem cells are still not well understood. We address this gap in knowledge in the present study where we morphologically classified the amnion membrane, and we clarified the distribution of stem cells here to identify functionally different amniotic membrane–derived stem cells. The amnion can be divided into a site that is continuous with the umbilical cord (region A), a site that adheres to the placenta (region B), and a site that is located opposite the placenta (region C). We found that human amnion epithelial stem cells (HAECs) that strongly express stem cell markers were abundant in area A. HAEC not only expressesed stem cell-specific surface markers TRA-1-60, Tra-1-81, SSEA4, SSEA3, but was also OCT-3/4 positive and had alkaline phosphatase activity. Human amniotic mesenchymal stem cells expressed KLF-A, OCTA, Oct3/4, c-MYC and Sox2 which is transcription factor. Especially, in regions A and B they have expressed CD73, and the higher expression of BCRP which is drug excretion transporter protein than the other parts. These data suggest that different types of stem cells may have existed in different area. The understanding the relation with characteristics of the stem cells in each area and function would allow for the efficient harvest of suitable HAE and HAM stem cells as using tool for regenerative medicine.

scholarly journals The impact of adaptive forest management on water fluxes and growth dynamics in a water-limited low-biomass oak coppice

2019 ◽  
Vol 264 ◽  
pp. 266-282 ◽  
Author(s):  
Antonio D. del Campo ◽  
María González-Sanchis ◽  
Alberto García-Prats ◽  
Carlos J. Ceacero ◽  
Cristina Lull
Keyword(s):  
Forest Management ◽  
Growth Dynamics ◽  
Water Fluxes ◽  
Adaptive Forest Management ◽  
The Impact

The asialoglycoprotein receptor: relationships between structure, function, and expression

1995 ◽  
Vol 75 (3) ◽  
pp. 591-609 ◽  
Author(s):  
R. J. Stockert
Keyword(s):  
Translational Regulation ◽  
Chemotherapeutic Agents ◽  
Asialoglycoprotein Receptor ◽  
Receptor Expression ◽  
Coated Pits ◽  
Receptor Mediated Endocytosis ◽  
Intracellular Compartments ◽  
Foreign Genes ◽  
And Function ◽  
A Site

Transport of macromolecules into the cell by receptor-mediated endocytosis follows a complex series of intracellular transfers, passing through distinct environments. The asialoglycoprotein receptor is a prototype of the class of receptors that constitutively enters cells via coated pits and delivers ligand to these intracellular compartments. In addition to being a model of receptor-mediated endocytosis, the presence of the receptor on hepatocytes provides a membrane-bound active site for cell-to-cell interactions, has made possible the selective targeting of chemotherapeutic agents and foreign genes, and has also been implicated as a site mediating hepatitis B virus uptake. Regulated expression of receptor subunits and their intracellular trafficking during biosynthesis and endocytosis has provided insights into the relationship of receptor structure to its overall function. As a marker of hepatocellular differentiation, its study has uncovered a unique response to intracellular guanosine 3',5'-cyclic monophosphate and translational regulation of the receptor. In this review, an overview of these diverse findings is provided in an attempt to relate the various aspects of structure and function as they impact on receptor expression.

scholarly journals TUG1 promotes prostate cancer progression by acting as a ceRNA of miR-26a

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Bin Yang ◽  
Xiaodi Tang ◽  
Zhixin Wang ◽  
Daju Sun ◽  
Xin Wei ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Migration And Invasion ◽  
Tumor Cell Migration ◽  
Real Time Quantitative Pcr ◽  
Non Coding Rna ◽  
Key Aspects ◽  
And Function ◽  
First Time ◽  
Long Non Coding Rna

Previous studies have demonstrated that taurine-upregulated gene 1 (TUG1) was aberrantly expressed and involved in multiple types of cancer; however, the expression profile and potential role of TUG1 in prostate cancer (PCa) remains unclear. The aim of the present study was to evaluate the expression and function of TUG1 in PCa. In the present study, we analyzed TUG1 expression levels of PCa patients in tumor and adjacent normal tissue by real-time quantitative PCR. Knockdown of TUG1 by RNAi was performed to explore its roles in cell proliferation, migration, and invasion. Here we report, for the first time, that TUG1 promotes tumor cell migration, invasion, and proliferation in PCa by working in key aspects of biological behaviors. TUG1 could negatively regulate the expression of miR-26a in PCa cells. The bioinformatics prediction revealed putative miR-26a-binding sites within TUG1 transcripts. In conclusion, our study suggests that long non-coding RNA (lncRNA) TUG1 acts as a functional oncogene in PCa development.

The Changing Face and Function of Museums

1998 ◽  
Vol 89 (1) ◽  
pp. 47-61 ◽  
Author(s):  
Robin Trotter
Keyword(s):  
Material Culture ◽  
Identity Formation ◽  
Economic Forces ◽  
The Face ◽  
National Museums ◽  
And Function ◽  
A Site ◽  
Internal Pressures ◽  
New Museology

Museums are currently undergoing a number of changes as a repercussion of their histories and professional developments, and of new social and cultural contexts, not to mention as a result of pressure from competition and economic forces. This article explores the current ‘reinvention’ of museums — in particular, national museums — by examining some of the factors of change — some of the major internal pressures that have been the result of museological initiatives and also various exogenous influences. New museology and postcolonialism represent not only separate forces, but also a synthesis of pressures that are not only changing the face, but also the role, of museums, whilst also transforming relationships between museums and their users. A concern of this study is to look at those museums which have a ‘nationalising’ function, and to determine whether changing policies and practices are inhibiting or advance a renegotiation of the relationships between museums and their constituencies. In the last two decades, we have seen some trends confirmed. There has been a move from material culture studies to concern with the ideas contained in objects, whilst the older notion of the museum as a treasure house has given way to a stronger educative role and, more recently, an information centre and also a site of leisure, entertainment and identity-formation. These ‘reinventive’ processes, it is suggested, are closely allied to a postcolonial imperative.

Neurologic Emergencies

2019 ◽  
pp. 125-136
Author(s):  
Ross P. Martini ◽  
Ines P. Koerner
Keyword(s):  
Status Epilepticus ◽  
Intracranial Pressure ◽  
Structure And Function ◽  
Neurosurgical Procedures ◽  
Transition Of Care ◽  
Comatose Patient ◽  
Neurologic Emergencies ◽  
Brain Structure And Function ◽  
Key Aspects ◽  
And Function

The primary goal of the neuroanaesthetist and neurointensivist is to preserve brain structure and function, especially in the setting of neurologic insults. Neurologic emergencies can also develop peri-operatively in patients undergoing non-neurosurgical procedures, which the general anaesthetist should be prepared to manage. This chapter on neurologic emergencies discusses herniation syndromes (including pathophysiology of intracranial hypertension, symptoms of herniation, and therapies to reduce intracranial pressure and reverse herniation). It also covers coma (including differential diagnoses of postoperative coma, clinical evaluation of the comatose patient, CT imaging, advanced tests, and directed therapies). Finally, it discusses key aspects of ischaemic stroke, status epilepticus, and transition of care.

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