scholarly journals Benefits of the Phytoestrogen Resveratrol for Perimenopausal Women

Endocrines ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 457-471
Author(s):  
Osamu Wada-Hiraike
Keyword(s):  
Ovarian Function ◽  
Protective Effects ◽  
Climacteric Symptoms ◽  
Mineral Density ◽  
Healthy Life ◽  
Prevent Bone Loss ◽  
Perimenopausal Women ◽  
Stress Functions ◽  
Antioxidative Stress ◽  
Menopausal State

Endometriosis, characterized by macroscopic lesions in the ovaries, is a serious problem for women who desire conception. Damage to the ovarian cortex is inevitable when lesions are removed via surgery, which finally decreases the ovarian reserve, thereby accelerating the transition to the menopausal state. Soon after cessation of ovarian function, in addition to climacteric symptoms, dyslipidemia and osteopenia are known to occur in women aged >50 years. Epidemiologically, there are sex-related differences in the frequencies of dyslipidemia, hypertension, and osteoporosis. Females are more susceptible to these diseases, prevention of which is important for healthy life expectancy. Dyslipidemia and hypertension are associated with the progression of arteriosclerosis, and arteriosclerotic changes in the large and middle blood vessels are one of the main causes of myocardial and cerebral infarctions. Osteoporosis is associated with aberrant fractures in the spine and hip, which may confine the patients to the bed for long durations. Bone resorption is accelerated by activated osteoclasts, and rapid bone remodeling reduces bone mineral density. Resveratrol, a plant-derived molecule that promotes the function and expression of the sirtuin, SIRT1, has been attracting attention, and many reports have shown that resveratrol might exert cardiovascular protective effects. Preclinical reports also indicate that it can prevent bone loss and endometriosis. In this review, I have described the possible protective effects of resveratrol against arteriosclerosis, osteoporosis, and endometriosis because of its wide-ranging functions, including anti-inflammatory and antioxidative stress functions. As ovarian function inevitably declines after 40 years, intake of resveratrol can be beneficial for women with endometriosis aged <40 years.

scholarly journals Relationship Between Bone Mineral Density and Ovarian Function in Perimenopausal Women With Endometriosis: A Prospective Study

2021 ◽  
Author(s):  
Mari Uehara ◽  
Osamu Wada-Hiraike ◽  
Mana Hirano ◽  
Kaori Koga ◽  
Noriko Yoshimura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Prospective Study ◽  
Bone Mineral ◽  
Ovarian Reserve ◽  
Ovarian Function ◽  
Rate Of Change ◽  
Mineral Density ◽  
Perimenopausal Women ◽  
History Of ◽  
Tsh Levels

Abstract Background In women with endometriosis, the association between ovarian function, hormones, and bone mineral density (BMD) is unclear. Therefore, this study aimed to elucidate the correlation between changes in bone mineral density (BMD) in perimenopausal women with endometriosis and clinical data, such as ovarian reserves. Methods In this prospective study, we evaluated 207 female patients who visited the Department of Obstetrics and Gynecology at the University of Tokyo Hospital between December 2015 and December 2020. We included patients aged ≥ 40 years with a history of endometriosis or who presented with endometriosis lesions. Patients with a history of smoking, steroid administration, autoimmune diseases, dyslipidaemia, and heart disease were excluded. During the study period, patients who underwent two tests, an initial and a follow-up test (n = 142, average age: 45.02 years, average BMD: 1.16 g/cm2), were evaluated at regular intervals based on the annual rate of change in BMD. Results There was a negative correlation between the follicle-stimulating hormone (FSH) and BMD, and a positive correlation between the anti-Müllerian hormone (AMH) and BMD. The annual rate of change in BMD correlated only with thyroid-stimulating hormone (TSH) levels. A large decline in BMD was associated with high TSH levels and higher average age at menopause. Patients with higher TSH exhibited a higher rate of decrease in BMD than those without. Conclusions High FSH or low AMH levels are associated with decreased BMD. Decreased ovarian reserve is associated with decreased BMD in perimenopausal women with endometriosis. High TSH levels increase the risk of BMD loss. This finding may help manage osteoporosis and BMD loss in perimenopausal women with endometriosis by predicting BMD loss from ovarian reserve and TSH levels.

Cardiovascular Risk in Perimenopausal Women

2019 ◽  
Vol 17 (6) ◽  
pp. 591-594 ◽  
Author(s):  
John C. Stevenson ◽  
Sophia Tsiligiannis ◽  
Nick Panay
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Ovarian Function ◽  
Density Lipoprotein ◽  
Premenopausal Women ◽  
Therapeutic Interventions ◽  
Additional Risk Factor ◽  
Chd Risk ◽  
Perimenopausal Women ◽  
Chd Risk Factors

Cardiovascular disease, and particularly coronary heart disease (CHD), has a low incidence in premenopausal women. Loss of ovarian hormones during the perimenopause and menopause leads to a sharp increase in incidence. Although most CHD risk factors are common to both men and women, the menopause is a unique additional risk factor for women. Sex steroids have profound effects on many CHD risk factors. Their loss leads to adverse changes in lipids and lipoproteins, with increases being seen in low density lipoprotein (LDL) cholesterol and triglycerides, and decreases in high density lipoprotein (HDL) cholesterol. There is a reduction in insulin secretion and elimination, but increases in insulin resistance eventually result in increasing circulating insulin levels. There are changes in body fat distribution with accumulation in central and visceral fat which links to the other adverse metabolic changes. There is an increase in the incidence of hypertension and of type 2 diabetes mellitus, both major risk factors for CHD. Oestrogens have potent effects on blood vessels and their loss leads to dysfunction of the vascular endothelium. All of these changes result from loss of ovarian function contributing to the increased development of CHD. Risk factor assessment in perimenopausal women is recommended, thereby permitting the timely introduction of lifestyle, hormonal and therapeutic interventions to modify or reverse these adverse changes.

F160 Physical activity, climacteric symptoms and bone mass in Hong Kong perimenopausal women

Maturitas ◽  
1996 ◽  
Vol 27 ◽  
pp. 93
Author(s):  
SC Ho ◽  
SG Chan ◽  
V Yip ◽  
C Chan ◽  
CL Law
Keyword(s):  
Physical Activity ◽  
Hong Kong ◽  
Bone Mass ◽  
Climacteric Symptoms ◽  
Perimenopausal Women

Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms

Bone ◽  
2002 ◽  
Vol 31 (4) ◽  
pp. 515-519 ◽  
Author(s):  
W Balemans ◽  
D Foernzler ◽  
C Parsons ◽  
M Ebeling ◽  
A Thompson ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Sost Gene ◽  
Perimenopausal Women

Quercetin: A Potential Candidate For The Treatment Of Arthritis

2021 ◽  
Vol 21 ◽  
Author(s):  
Ahsas Goyal ◽  
Neetu Agrawal
Keyword(s):  
Rheumatoid Arthritis ◽  
Medicinal Plants ◽  
Therapeutic Potential ◽  
Gouty Arthritis ◽  
Potential Candidate ◽  
Protective Effects ◽  
Preclinical Models ◽  
Healthy Life ◽  
Health Promoting ◽  
Dietary Component

: Diet plays a significant role in ensuring healthy life and the bioactive compounds present in food and medicinal plants may be developed as drugs that combat various illnesses. A bioactive flavanoid, quercetin which is a dietary component possesses numerous health-promoting effects. In preclinical models of rheumatoid arthritis, gouty arthritis and osteoarthritis, quercetin has shown significant joint protective effects. Taking into account the significance of this compound, the present review discusses its anti-arthritic properties, demonstrating its mechanism of action for the treatment of arthritis with its therapeutic potential.

HYPOTHALAMIC-PITUITARY-OVARIAN FUNCTION IN PERIMENOPAUSAL WOMEN

1978 ◽  
Vol 33 (2) ◽  
pp. 125-127
Author(s):  
Paul F. A. Van Look ◽  
Helen Lothian ◽  
William M. Hunter ◽  
Eileen A. Michie ◽  
David T. Baird
Keyword(s):  
Ovarian Function ◽  
Perimenopausal Women

scholarly journals Whether Sutures Reduce the Graft Laceration Caused by Interference Screw in Anterior Cruciate Ligament Reconstruction a Biomechanical Study in Vitro

2021 ◽  
Author(s):  
Yuanjun Teng ◽  
Lijun Da ◽  
Xiaohui Zhang ◽  
Hong Wang ◽  
Hua Han ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Acl Reconstruction ◽  
Cruciate Ligament ◽  
Interference Screw ◽  
Biomechanical Study ◽  
Protective Effects ◽  
Mineral Density ◽  
Interference Screws ◽  
Anterior Cruciate

Abstract Background: Interference screw is commonly used for graft fixation in anterior cruciate ligament (ACL) reconstruction However, previous studies h a d reported that the insertion of interference screws significantly caused graft laceration . The purpose of this study was to determine whether sutures reduce d the graft laceration from the insertion of interference screws in ACL reconstruction. Methods: Porcine tibias and bovine extensor tendons were used for establishing a knee model of ACL reconstruction in vitro . The ends of grafts were sutured using three different sutures, including the bioabsorbable, Ethibond and ultra high molecular weight polyethylene (UHMWPE) sutures Poly ether ether ketone (PEEK) interference screw s w ere used fortibial fixation Biomechanical tests were performed to investigate the protective effects of different sutures on grafts Results : All prepared tendons and bone specimens showed similar characteristics (length, weight, and pre tension of the tendons, tibial bone mineral density) among all groups ( P 0.05). The biomechanical test s demonstrated that PEEK interference screw s significantly caused the graft laceration P 0.05). However, all sutures (the bioabsorbable, Ethibond and UHMWPE sutures) did not reduce the graft laceration in ACL reconstruction P 0.05). Conclusions : PEEK interference screw s significantly weakened the biomechanical properties of grafts during tibial fixation in ACL reconstruction. Absorbable Ethibond and UHMWPE sutures did not provide protective effects on grafts during ACL reconstruction.

Radial bone mineral density in pre- and perimenopausal women: A prospective study of rates and risk factors for loss

2009 ◽  
Vol 7 (6) ◽  
pp. 647-657 ◽  
Author(s):  
Maryfran R. Sowers ◽  
M. Kathleen Clark ◽  
Bruce Hollis ◽  
Robert B. Wallace ◽  
Mary Jannausch
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Prospective Study ◽  
Bone Mineral ◽  
Mineral Density ◽  
Perimenopausal Women ◽  
A Prospective Study ◽  
Radial Bone

scholarly journals Estrogen modulates the recruitment of myelopoietic cell progenitors in rat through a stromal cell-independent mechanism involving apoptosis

Blood ◽  
1996 ◽  
Vol 87 (7) ◽  
pp. 2683-2692 ◽  
Author(s):  
NK Shevde ◽  
JW Pike
Keyword(s):  
Estrogen Receptor ◽  
Ovarian Function ◽  
Morphological Changes ◽  
Estrogen Treatment ◽  
Ovariectomized Rats ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Protective Effects ◽  
Hematopoietic Stem

Loss of ovarian function leads to a significant increase in the number of bone-resorbing osteoclasts. Estrogen replacement is known to manifest bone protective effects in the treatment of postmenopausal osteoporosis. In the present study, we used ovariectomized rats to examine the effects of estrogen loss at the osteoclast progenitor colony forming unit-granulocyte macrophage (CFU-GM) level. A significant increase in CFU-GM number was observed as early as 7 days following ovariectomy, and correlated directly with an increase in the number of osteoclast-like cells generated in marrow cultures. The increase in CFU-GM following ovariectomy was abrogated in animals that received estrogen treatment in vivo. A similar suppressive effect was observed on CFU-GM number when ovariectomized rat marrow was treated with estrogen in vitro. This effect was blocked in the presence of the estrogen antihormone ICI 164,384. Thus, the data suggest the possibility that estrogen exerts a direct effect on osteoclast progenitors, and does so through the estrogen receptor-mediated mechanism. Ovariectomy also led to an increase in the early hematopoietic stem/progenitor cell population (Thy 1.1+ cells) as determined by FLOW cytometry methods. Morphological changes as well as terminal deoxynucleotidyl transferase assays revealed that estrogen treatment negated growth factor-induced proliferation of these early progenitors by promoting apoptosis. The cellular effects of estrogen in vitro together with the immunocytochemical detection of the estrogen receptor in these cells, strongly support the contention that in addition to osteoclast progenitors such as CFU-GM, earlier hematopoietic progenitors are also unique cellular targets for estrogen action.

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