scholarly journals Identification of Prognostic Factors and Predicting the Therapeutic Effect of Laser Photocoagulation for DME Treatment

Electronics ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1420
Author(s):  
Nataly Ilyasova ◽  
Aleksandr Shirokanev ◽  
Dmitriy Kirsh ◽  
Nikita Demin ◽  
Evgeniy Zamytskiy ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Prognostic Factors ◽  
Therapeutic Effect ◽  
Laser Photocoagulation ◽  
Vision Loss ◽  
Laser Coagulation ◽  
Factors Affecting ◽  
Quality Of Therapy ◽  
Positive Therapeutic Effect ◽  
Intelligent Analysis

Diabetic retinopathy is among the most severe complications of diabetes, most often leading to rapid and irreversible vision loss. The laser coagulation procedure, which consists of applying microburns to the fundus, has proven to be an effective method for treating diabetic retinopathy. Unfortunately, modern research does not pay enough attention to the study of the arrangement of microburns in the edema area—one of the key factors affecting the quality of therapy. The aim of this study was to propose a computational decision-making support system for retina laser photocoagulation based on the analysis of photocoagulation plans. Firstly, we investigated a set of prognostic factors based on 29 features describing the geometric arrangement of coagulates. Secondly, we designed a technology for the intelligent analysis of the photocoagulation plan that allows the effectiveness of the treatment to be predicted. The studies were carried out using a large database of fundus images from 108 patients collected in clinical trials. The results demonstrated a high classification accuracy at a level of over 85% using the proposed prognostic factors. Moreover, the designed technology proved the superiority of the proposed algorithms for the automatic arrangement of coagulates, predicting a 99% chance of a positive therapeutic effect.

scholarly journals COMPARATIVE ESTIMATION OF LASER COAGULATION EFFICIENCY IN MACULAR AND MICROPHOTOCOAGULATION OF HIGH DENSITYIN DIABETIC MACULOPATHY TREATMENT

2015 ◽  
Vol 7 (1) ◽  
pp. 74-77
Author(s):  
A S Izmaylov ◽  
T V Kotsur
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Edema ◽  
Laser Photocoagulation ◽  
Retinal Pigment ◽  
Laser Coagulation ◽  
Retinal Sensitivity ◽  
Diabetic Maculopathy ◽  
Laser Applications ◽  
Clinically Significant ◽  
Modern Standard

The modern standard of treatment of clinically significant diabetic macular edema is macular laser photocoagulation was suggested in the reports of the Early Treatment of Diabetic Retinopathy Study (ETDRS, 1985-1990). Subthreshold microphotocoagulation (MicroPulase) leads to developing barely visible or invisible retinal burns and also has been shown to be effective in treating macular edema with no side effects comparing with ETDRS methodic (retinal pigment and choroidal atrophy, decreasing of retinal sensitivity). Effectiveness of microphotocoagulation may arise in high density laser applications, however in modern literature exists rare publications concerning this question.

Multisubstance Analysis of Reflection Spectra before and after Laser Photocoagulation for Proliferative Diabetic Retinopathy

1997 ◽  
Vol 7 (4) ◽  
pp. 317-321 ◽  
Author(s):  
R. Augsten ◽  
E. Königsdörffer ◽  
D. Schweitzer ◽  
J. Strobel
Keyword(s):  
Diabetic Retinopathy ◽  
Proliferative Diabetic Retinopathy ◽  
Laser Photocoagulation ◽  
Scattered Light ◽  
Laser Coagulation ◽  
Spectrometric Method ◽  
Reflection Spectra ◽  
Type Ii ◽  
Before And After ◽  
Type Ii Diabetics

Purpose The aim of the study was to provide new data that add to the understanding of diabetic retinopathy and its treatment by photocoagulation. Patients and Methods. Using a spectrometric method, the reflection spectra of the macula in six type II diabetics with proliferative diabetic retinopathy were measured before and after laser photocoagulation and compared with normals. The investigations were done one day before laser photocoagulation and again the day after. Further measurements were made 14 days, 6 weeks and 4 months after coagulation. The reflection spectra were assessed by multisubstance analysis. Results and Conclusions. The contents of xanthophyll, melanin and choroidal oxyhemoglobin and the intensity of scattered light were significantly altered after laser coagulation. For example, in patients with proliferative diabetic retinopathy the content of oxyhemoglobin in the choroid was lower than normal, but it rose after laser treatment. This suggests an improved oxygen supply of the choroid after laser coagulation, implying reduced retinal hypoxia.

scholarly journals The CURRENT TRENDS AND TREATMENTS IN DIABETIC RETINOPATHY

2019 ◽  
pp. 27-33
Author(s):  
FIROZ MV ◽  
VISHAL GUPTA N ◽  
SANDEEP KANNA
Keyword(s):  
Diabetic Retinopathy ◽  
Laser Photocoagulation ◽  
Vision Loss ◽  
Renin Angiotensin System ◽  
Chemical Degradation ◽  
Common Causes ◽  
The World ◽  
Different Types ◽  
New Treatment ◽  
Endothelial Growth Factor

The drastically increasing issues of the disease scenario currently are with different types of diabetes all over the world. It has been reported, approximately 592 million are suffering from the disease throughout the world. It affects differently in different patients with the disease. There have been reports that it is affected differently and also has different side effects. It is also been reported that diabetes mellitus leads to the cause of diabetic retinopathy (DR) and also diabetic macular edema. It is considered as one of the most common causes which is linked to DR. DR has been considered as one of the most important causes for the loss of vision or impaired vision. The drugs show different types of incompatibility such as toxicity, solubility issues, aggregation, and chemical degradation these can be improved by applying several methods. DR is classified according to “Airlie House” into different categories and based on different strategies and consideration. It was found that DR is the main cause for vision loss and also there no much strategies for development of new treatment. The treatment involved is laser photocoagulation and vitrectomy, among these the effective treatment, was found to be laser photocoagulation. This is mainly characterized as proliferative and non-proliferative DR. Different therapeutic agents have been taken for the study these includes vascular endothelial growth factor, renin-angiotensin system inhibitors and nonsteroidal anti-inflammatory drugs, they are certainly different interventions for the treatment, they are nanotechnology and liposome. Nanotechnology applied is the most effective and also acceptable way of treatment.

scholarly journals Diabetic retinopathy: history, modern approaches to management, prospective views of prevention and treatment

2020 ◽  
Vol 23 (1) ◽  
pp. 95-105
Author(s):  
Tatiana Y. Demidova ◽  
Alexander A. Kozhevnikov
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
Vision Loss ◽  
Diabetic Macular Oedema ◽  
Obstructive Sleep Apnoea Syndrome ◽  
Laser Coagulation ◽  
Ongoing Research ◽  
Obstructive Sleep ◽  
Prevention And Treatment ◽  
The Impact

Diabetic retinopathy (DR) is a serious complication of diabetes mellitus (DM). As DR progresses, it could be complicated with a significant decrease or complete loss of vision. It is the leading cause of blindness in the working-age population and, according to global estimates, occurs in one in every three patients with diabetes. DR has been studied for more than 160 years, and the implementation of retinal laser coagulation into clinical practice in the 20th century, and then vascular endothelial growth factor (VEGF) inhibitors in the 21th century, allowed us to influence vascular proliferation in DR and reduce the risk of vision loss from diabetic macular oedema (DME). However, these tools can only stop the progression of DR at the stages with risk of complications with vision loss, and prevention screenings and the impact on risk factors (hyperglycaemia, arterial hypertension, and dyslipidemia) remains as the main method of management of DR. Possible new risk factors (hypodynamy, obesity, body weight deficiency, and obstructive sleep apnoea syndrome) attract a lot of attention, and there is ongoing research for early markers of DR in the fundus, which could allow more active influence on the pathological process in its early stages. This review focuses on epidemiology, history of research, proven and possible risk factors, and current and promising approaches to the prevention and treatment of DR, including accurate, less traumatic laser techniques (PASCAL, NAVILAS, and D-MPL), and intravitreal antiangiogenic drugs in studies.

Changes in the level of pro- and antiinflammatory cytokines in patients with diabetic retinopathy after laser coagulation of the retina

2010 ◽  
Vol 24 (2) ◽  
pp. 4-7
Author(s):  
N. Pasechnikova ◽  
◽  
V. Naumenko ◽  
I. Metelitsina ◽  
V. Belyaev ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Laser Coagulation

Laser photocoagulation for diabetic retinopathy

2008 ◽  
Author(s):  
Brendan Dineen ◽  
Frank Waldron-Lynch ◽  
Fiona Harney ◽  
Sean F Dinneen ◽  
Andrew Murphy
Keyword(s):  
Diabetic Retinopathy ◽  
Laser Photocoagulation

scholarly journals In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kolja Becker ◽  
Holger Klein ◽  
Eric Simon ◽  
Coralie Viollet ◽  
Christian Haslinger ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Rna Sequencing ◽  
Molecular Mechanisms ◽  
Vision Loss ◽  
Ganglion Cells ◽  
Expression Profiles ◽  
Cell Types ◽  
Sequencing Data ◽  
Disease Stages ◽  
Post Transcriptional Regulation

AbstractDiabetic Retinopathy (DR) is among the major global causes for vision loss. With the rise in diabetes prevalence, an increase in DR incidence is expected. Current understanding of both the molecular etiology and pathways involved in the initiation and progression of DR is limited. Via RNA-Sequencing, we analyzed mRNA and miRNA expression profiles of 80 human post-mortem retinal samples from 43 patients diagnosed with various stages of DR. We found differentially expressed transcripts to be predominantly associated with late stage DR and pathways such as hippo and gap junction signaling. A multivariate regression model identified transcripts with progressive changes throughout disease stages, which in turn displayed significant overlap with sphingolipid and cGMP–PKG signaling. Combined analysis of miRNA and mRNA expression further uncovered disease-relevant miRNA/mRNA associations as potential mechanisms of post-transcriptional regulation. Finally, integrating human retinal single cell RNA-Sequencing data revealed a continuous loss of retinal ganglion cells, and Müller cell mediated changes in histidine and β-alanine signaling. While previously considered primarily a vascular disease, attention in DR has shifted to additional mechanisms and cell-types. Our findings offer an unprecedented and unbiased insight into molecular pathways and cell-specific changes in the development of DR, and provide potential avenues for future therapeutic intervention.

scholarly journals Visual Cortex Transcranial Direct Current Stimulation for Proliferative Diabetic Retinopathy Patients: A Double-Blinded Randomized Exploratory Trial

2021 ◽  
Vol 11 (2) ◽  
pp. 270
Author(s):  
Angelito Braulio F. de Venecia ◽  
Shane M. Fresnoza
Keyword(s):  
Diabetic Retinopathy ◽  
Visual Cortex ◽  
Proliferative Diabetic Retinopathy ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Vision Loss ◽  
Sham Stimulation ◽  
Direct Current Stimulation ◽  
Residual Vision ◽  
Cathodal Tdcs

Proliferative diabetic retinopathy (PDR) is a severe complication of diabetes. PDR-related retinal hemorrhages often lead to severe vision loss. The main goals of management are to prevent visual impairment progression and improve residual vision. We explored the potential of transcranial direct current stimulation (tDCS) to enhance residual vision. tDCS applied to the primary visual cortex (V1) may improve visual input processing from PDR patients’ retinas. Eleven PDR patients received cathodal tDCS stimulation of V1 (1 mA for 10 min), and another eleven patients received sham stimulation (1 mA for 30 s). Visual acuity (logarithm of the minimum angle of resolution (LogMAR) scores) and number acuity (reaction times (RTs) and accuracy rates (ARs)) were measured before and immediately after stimulation. The LogMAR scores and the RTs of patients who received cathodal tDCS decreased significantly after stimulation. Cathodal tDCS has no significant effect on ARs. There were no significant changes in the LogMAR scores, RTs, and ARs of PDR patients who received sham stimulation. The results are compatible with our proposal that neuronal noise aggravates impaired visual function in PDR. The therapeutic effect indicates the potential of tDCS as a safe and effective vision rehabilitation tool for PDR patients.

scholarly journals Rho-Kinase Inhibitors for the Treatment of Refractory Diabetic Macular Oedema

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1683
Author(s):  
Milagros Mateos-Olivares ◽  
Luis García-Onrubia ◽  
Fco. Javier Valentín-Bravo ◽  
Rogelio González-Sarmiento ◽  
Maribel Lopez-Galvez ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Macular Oedema ◽  
Standard Therapy ◽  
Vision Loss ◽  
Therapeutic Potential ◽  
Rho Kinase ◽  
Diabetic Macular Oedema ◽  
New Drugs ◽  
Anti Vegf

Diabetic macular oedema (DMO) is one of the leading causes of vision loss associated with diabetic retinopathy (DR). New insights in managing this condition have changed the paradigm in its treatment, with intravitreal injections of antivascular endothelial growth factor (anti-VEGF) having become the standard therapy for DMO worldwide. However, there is no single standard therapy for all patients DMO refractory to anti-VEGF treatment; thus, further investigation is still needed. The key obstacles in developing suitable therapeutics for refractory DMO lie in its complex pathophysiology; therefore, there is an opportunity for further improvements in the progress and applications of new drugs. Previous studies have indicated that Rho-associated kinase (Rho-kinase/ROCK) is an essential molecule in the pathogenesis of DMO. This is why the Rho/ROCK signalling pathway has been proposed as a possible target for new treatments. The present review focuses on the recent progress on the possible role of ROCK and its therapeutic potential in DMO. A systematic literature search was performed, covering the years 1991 to 2021, using the following keywords: “rho-Associated Kinas-es”, “Diabetic Retinopathy”, “Macular Edema”, “Ripasudil”, “Fasudil” and “Netarsudil”. Better insight into the pathological role of Rho-kinase/ROCK may lead to the development of new strategies for refractory DMO treatment and prevention.

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