scholarly journals Skin Healing of Deep Second Degree Burn Injuries in Four Individuals Sustained in a Boat Explosion—Results after Different Approaches

2020 ◽  
Vol 1 (1) ◽  
pp. 191-195
Author(s):  
Vincent März ◽  
Peter M. Vogt
Keyword(s):  
Family Members ◽  
Burn Injuries ◽  
Long Term Results ◽  
Skin Area ◽  
Skin Substitutes ◽  
Skin Burn ◽  
Difficult Decision ◽  
Burned Skin ◽  
Skin Healing ◽  
Second Degree

Intermediate and deep second-degree skin burn injuries are an ongoing challenge for burn surgeons, with the difficult decision regarding whether to handle them with either conservative or operative methods. In this study, the outcome of similar deep second-degree skin burn injuries is shown with the example of four family members. Clinical outcomes of the four family members which were treated at our burn center in 2017 were analyzed. The areas of burned skin (IIa°-IIb°) extended from 14% to 38% of the total burned skin area. Surgical treatment was adjusted to the rate of epithelialization after the first debridement. The excellent cosmetic long-term results of this patient cohort support the importance of stage-related therapy of deep dermal burn injuries. An initial debridement followed by early coverage is the key to early reconstitution of the epidermal barrier. However, with regard to the late effects of skin substitutes, more sensory alterations, dysesthesia, hyperpigmentation and unstable skin areas are still visible after coverage with glycerol conserved skin. The best results were seen after the use of autologous STGS and synthetic skin.

scholarly journals The The Effectiveness of Amniotic Membrane as Skin Graft Fixator and Graft Take Accelerator, a Clinical Research Study

2016 ◽  
Vol 1 (1) ◽  
pp. 70-75
Author(s):  
Dana A Abdilkarim
Keyword(s):  
Skin Graft ◽  
Amniotic Membrane ◽  
Graft Loss ◽  
Fetal Membrane ◽  
Skin Substitutes ◽  
Burned Skin ◽  
Graft Take ◽  
Innermost Layer ◽  
Skin Healing ◽  
A Prospective Study

The amnion is a thin semi-transparent tissue forming the innermost layer of the fetal membrane. It has been claimed to be one of the most effective biological skin substitutes used in burn wounds, with efficiency of maintaining low bacteria count.This study was set to evaluate the effectiveness of amniotic membrane as skin graft fixator and graft take accelerator.This work is a prospective study carried out in Burns and Plastic Surgery Hospital in Sulaimani for period from 1st of April to end of August 2015 on convenient sample of 33 burned patients.Mean age of burned patients was 24±19 years, Most (93.9%) of burned patients were treated by covering raw area with meshed SSG and only two patients were treated by covering with sheet SSG. Most (90.9%) of burned patients who had treated with covered SSG had taken in comparison with non-covered SSG with amniotic membrane. Postoperative complications for skin areas treated with covered technique were 3; graft loss due to infection, graft loss due to shearing and graft loss due to hematoma.Amniotic membrane induces the graft take among burned skin and fastening the skin healing with fewer complications.

Development of a Skin Burn Technique Protection Afforded Rats by Prescald Subcutaneous Air Insufflation

1958 ◽  
Vol 192 (2) ◽  
pp. 258-262
Author(s):  
Albert Einheber
Keyword(s):  
Body Weight ◽  
Protective Action ◽  
The Body ◽  
Dorsal Skin ◽  
Skin Burn ◽  
Burned Skin ◽  
Skin Region ◽  
Ad Libitum ◽  
Air Insufflation ◽  
Enzymatic Debridement

Experimental skin burns induced by scalding may result in inadvertent damage to subdermal structures. To avoid this, a technique is used which employs the prescald injection of 200 ml of air subcutaneously in the dorsal skin region to be scalded (30–40% of body surface area). Lightly etherized rats preinsufflated with air and scalded at 90°C for 30 seconds showed a greater survival rate up to 72 hours postburn than noninsufflated, similarly scalded rats. The protective action of prescald subcutaneous air insufflation was demonstrated in a series of rats that was permitted food and water ad libitum after burn and in another series that was given, by gavage, a volume of 5% dextrose in 0.9% saline equivalent to 2% of the body weight immediately after burn but deprived of all food and fluid thereafter. At necropsy, air-insufflated, scalded rats showed no visible damage to underlying muscle; noninsufflated scalded rats did. This burn technic should prove valuable for studies on the possible release of deleterious factors from the site of the burn and studies on the enzymatic debridement of burned skin.

scholarly journals Development of a Vascularized Skin Construct Using Adipose-Derived Stem Cells from Debrided Burned Skin

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Rodney K. Chan ◽  
David O. Zamora ◽  
Nicole L. Wrice ◽  
David G. Baer ◽  
Evan M. Renz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Burn Injury ◽  
Point Of Care ◽  
Normal Skin ◽  
Large Body ◽  
Skin Substitutes ◽  
Surface Areas ◽  
Burned Skin ◽  
Stem Cell Isolation ◽  
Isolation Device

Large body surface area burns pose significant therapeutic challenges. Clinically, the extent and depth of burn injury may mandate the use of allograft for temporary wound coverage while autografts are serially harvested from the same donor areas. The paucity of donor sites in patients with burns involving large surface areas highlights the need for better skin substitutes that can achieve early and complete coverage and retain normal skin durability with minimal donor requirements. We have isolated autologous stem cells from the adipose layer of surgically debrided burned skin (dsASCs), using a point-of-care stem cell isolation device. These cells, in a collagen—polyethylene glycol fibrin-based bilayer hydrogel, differentiate into an epithelial layer, a vascularized dermal layer, and a hypodermal layer.All-trans-retinoicacid and fenofibrate were used to differentiate dsASCs into epithelial-like cells. Immunocytochemical analysis showed a matrix- and time-dependent change in the expression of stromal, vascular, and epithelial cell markers. These results indicate that stem cells isolated from debrided skin can be used as a single autologous cell source to develop a vascularized skin construct without culture expansion or addition of exogenous growth factors. This technique may provide an alternative approach for cutaneous coverage after extensive burn injuries.

Skin substitutes in the treatment of deep partial skin thickness burns in children: clinical experience and long-term results

Burns ◽  
1991 ◽  
Vol 17 (1) ◽  
pp. 52-55 ◽  
Author(s):  
G.A. Grisolia ◽  
P. Pelli ◽  
E. Pinzauti ◽  
G. Panozzo ◽  
A. Stuto ◽  
...  
Keyword(s):  
Clinical Experience ◽  
Long Term Results ◽  
Skin Thickness ◽  
Skin Substitutes

Are corticosteroids effective for prevention of scar formation after second-degree skin burn?

2013 ◽  
Vol 25 (4) ◽  
pp. 360-362 ◽  
Author(s):  
Arash Taheri ◽  
Parisa Mansoori ◽  
Amir Al-Dabagh ◽  
Steven R. Feldman
Keyword(s):  
Scar Formation ◽  
Skin Burn ◽  
Second Degree
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