scholarly journals A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines

Proceedings ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 42 ◽  
Author(s):  
Sandra C. Ramírez-López ◽  
M.V. Basavanag Unnamatla ◽  
Rocío Gámez-Montaño
Keyword(s):  
Multicomponent Reaction ◽  
Medicinal Chemistry ◽  
Bioactive Molecules ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Preparation And Evaluation ◽  
Privileged Scaffolds

An efficient synthesis of alkyne-3-tetrazolyl-tetrazolo[1,5-a] quinolones via a one-pot isocyanide-based multicomponent reaction (IMCR) process: I-MCR Ugi-azide/SNAr/ring-chain azido tautomerization was performed under eco-friendly conditions. We report the one-pot synthesis of tris-heterocycles containing a tetrazolo[1,5-a] quinoline connected to a 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of these compounds is of great interest in synthetic and medicinal chemistry because these heterocycles are considered privileged scaffolds and their preparation and evaluation may lead to the discovery of novel bioactive molecules.

scholarly journals A Multicomponent Reaction for the One-Pot Synthesis of 4-Aza-2,3-didehydropodophyllotoxin and Derivatives.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
Christophe Tratrat ◽  
Sylviane Giorgi-Renault ◽  
Henri-Philippe Husson
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

A Multicomponent Reaction for the One-Pot Synthesis of 4-Aza-2,3-didehydropodophyllotoxin and Derivatives

2002 ◽  
Vol 4 (19) ◽  
pp. 3187-3189 ◽  
Author(s):  
Christophe Tratrat ◽  
Sylviane Giorgi-Renault ◽  
Henri-Philippe Husson
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

An efficient synthesis of novel dibenzoxdiazepine-fused heterocycles through a multicomponent reaction

RSC Advances ◽  
2014 ◽  
Vol 4 (92) ◽  
pp. 50947-50949 ◽  
Author(s):  
Zhiwei Qian ◽  
Anjiang Yang ◽  
Weiteng An ◽  
Ting Yu ◽  
Xin Wang ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Fused Heterocycles ◽  
Three Component Reaction

A one-pot synthesis of 6-oxa-2,2a1,11-triazadibenzo[cd,g]azulenes by a three-component reaction of a 2-aminoheterocycle, aldehydes, and 2-isocyanophenyl acetate is presented.

scholarly journals Friedel-Crafts approach to the one-pot synthesis of methoxy substituted thioxanthylium salts

2019 ◽  
Author(s):  
Kenta Tanaka ◽  
Yuta Tanaka ◽  
Mami Kishimoto ◽  
Yujiro Hoshino ◽  
Kiyoshi Honda
Keyword(s):  
Red Shift ◽  
Maximum Absorption ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Promising Tool ◽  
The One ◽  
Benzoyl Chlorides

An efficient synthesis of methoxy substituted thioxanthylium salts has been developed. The reaction of diaryl sulfides with benzoyl chlorides in the presence of TfOH smoothly proceeded to give the desired thioxanthylium salts in good yields. In their UV-vis spectra, the maximum absorption wavelengths of methoxy functionalized thioxanthylium salts were observed at around 460 nm, which show a drastic red shift compared to the parent thioxanthylium salts. The present reaction provides a versatile access to functionalized thioxanthylium salts, and therefore it constitutes a promising tool for the synthesis of biologically and photochemically active molecules.

An Efficient Synthesis of New 7-Trifluoromethyl-2,5-disubstituted Pyrazolo[1,5-a]pyrimidines

Synthesis ◽  
2018 ◽  
Vol 50 (08) ◽  
pp. 1675-1686 ◽  
Author(s):  
Mohamed Abarbri ◽  
Badr Jismy ◽  
Hassan Allouchi ◽  
Gérald Guillaumet ◽  
Mohamed Akssira
Keyword(s):  
Bond Activation ◽  
Bond Formation ◽  
Building Blocks ◽  
Synthetic Route ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Biological Interest ◽  
The One

A novel two-step synthesis of trifluoromethylated 3,5-disubstituted pyrazolo[1,5-a]pyrimidines is reported from 3-aminopyrazoles and ethyl 4,4,4-trifluorobut-2-ynoate. The synthetic route begins with the one-pot synthesis of 7-trifluoromethylated pyrazolo[1,5-a]pyrimidin-5-ones by condensation of 3-aminopyrazoles with a fluorinated alkyne. The products obtained are used as building blocks to synthesize directly, with excellent yields via C–O bond activation, a library of new fluorinated 3,5-disubstituted pyrazolo[1,5-a]pyrimidines of biological interest. This operation efficiently allows C–C, C–N and C–S bond formation.

One-pot Synthesis of Novel 2-(Benzofuran-2-yl)-4-Phenylquinoline-3-Carboxylates

2017 ◽  
Vol 41 (1) ◽  
pp. 45-49
Author(s):  
Wentao Gao ◽  
Xinbo Fu ◽  
Yanan Zhao ◽  
Dongfang Wang
Keyword(s):  
Transition Metal ◽  
Efficient Synthesis ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis ◽  
The One

A facile and efficient synthesis of novel ethyl 2-(benzofuran-2-yl)-4-phenylquinoline-3-carboxylates and the corresponding acids through the one-pot three-step reaction of ethyl 2-(chloromethyl)-4-phenylquinoline-3-carboxylate with a series of salicylaldehydes is described. It allows an efficient and practical access to some 2-(benzofuran-2-yl)quinolines under transition-metal-free conditions.

scholarly journals Friedel–Crafts approach to the one-pot synthesis of methoxy-substituted thioxanthylium salts

2019 ◽  
Vol 15 ◽  
pp. 2105-2112
Author(s):  
Kenta Tanaka ◽  
Yuta Tanaka ◽  
Mami Kishimoto ◽  
Yujiro Hoshino ◽  
Kiyoshi Honda
Keyword(s):  
Red Shift ◽  
Maximum Absorption ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Promising Tool ◽  
The One ◽  
Benzoyl Chlorides

An efficient synthesis of methoxy-substituted thioxanthylium salts has been developed. The reaction of diaryl sulfides with benzoyl chlorides in the presence of TfOH smoothly proceeded to give the desired thioxanthylium salts in good yields. In their UV–vis spectra, the maximum absorption wavelengths of methoxy-functionalized thioxanthylium salts were observed at around 460 nm, which show a drastic red shift compared to the parent thioxanthylium salts. The present reaction provides a versatile access to functionalized thioxanthylium salts, and therefore it constitutes a promising tool for the synthesis of biologically and photochemically active molecules.

One-pot synthesis of 3,5-diaryl substituted-1,2,4-oxadiazoles using gem-dibromomethylarenes

2019 ◽  
Vol 97 (9) ◽  
pp. 690-696 ◽  
Author(s):  
Kambappa Vinaya ◽  
Ganganahalli K. Chandrashekara ◽  
Prasanna D. Shivaramu
Keyword(s):  
Benzoic Acid ◽  
Medicinal Chemistry ◽  
Heterocyclic Ring ◽  
Efficient Synthesis ◽  
One Pot ◽  
Ring Systems ◽  
One Pot Synthesis ◽  
Material Chemistry ◽  
Two Component

1,2,4-Oxadiazole is one of the most promising heterocyclic ring systems in medicinal chemistry. In the present paper, we report the method for an efficient one-pot synthesis of 3,5-diaryl substituted 1,2,4-oxadiazoles using a two-component reaction of gem-dibromomethylarenes with amidoximes in good yields. In this method, gem-dibromomethylarenes are used as benzoic acid equivalents for the efficient synthesis of aryl-substituted 1,2,4-oxadiazoles. It is anticipated that this methodology will have versatile applications in the practical syntheses of various molecules of both medicinal and material chemistry importance.

Rust-derived Fe2O3 nanoparticles as a green catalyst for the one-pot synthesis of hydrazinyl thiazole derivatives

2020 ◽  
Vol 18 (24) ◽  
pp. 4575-4582 ◽  
Author(s):  
Rutikesh Gurav ◽  
Santosh Kumar Surve ◽  
Santosh Babar ◽  
Prafulla Choudhari ◽  
Devashree Patil ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Fe2o3 Nanoparticles ◽  
Thiazole Derivatives ◽  
One Pot ◽  
Green Catalyst ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
The One

A novel route of one-pot multicomponent reaction of tosylates, aryl aldehydes and thiosemicarbazide for the synthesis of hydrazinyl thiazole is reported using Fe2O3 NPs derived from rust iron as a catalyst.

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