scholarly journals Synthesis, biological evaluation and membranotropic properties of quinoline-antimicrobial peptide conjugates as antibacterial drugs

2019 ◽  
Author(s):  
Pierre Laumaillé ◽  
Alexandra Dassonville-Klimpt ◽  
Sophie Da Nascimento ◽  
Catherine Mullié ◽  
François Peltier ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Biological Evaluation ◽  
Peptide Conjugates ◽  
Antibacterial Drugs ◽  
Membranotropic Properties

Novel “ruthenium cyclopentadienyl”–peptide conjugate complexes against human FGFR(+) breast cancer

2020 ◽  
Vol 49 (18) ◽  
pp. 5974-5987
Author(s):  
João Franco Machado ◽  
Miguel Machuqueiro ◽  
Fernanda Marques ◽  
M. Paula Robalo ◽  
M. Fátima M. Piedade ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Biological Evaluation ◽  
Peptide Conjugates ◽  
Half Sandwich

Synthesis of the first half-sandwich ruthenium(ii)-cyclopentadienyl peptide conjugates and their biological evaluation against human FGFR(+) and FGFR(−) breast cancer cells.

scholarly journals Design, Synthesis and Biological Evaluation ofN-Sulfonylphenyl glyoxamide-Based Antimicrobial Peptide Mimics as Novel Antimicrobial Agents

2017 ◽  
Vol 2 (12) ◽  
pp. 3452-3461 ◽  
Author(s):  
Tsz Tin Yu ◽  
Shashidhar Nizalapur ◽  
Kitty K. K. Ho ◽  
Eugene Yee ◽  
Thomas Berry ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Peptide Mimics ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals pH-Selective Cytotoxicity of pHLIP-Antimicrobial Peptide Conjugates

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Kelly E. Burns ◽  
Tanner P. McCleerey ◽  
Damien Thévenin
Keyword(s):  
Antimicrobial Peptide ◽  
Peptide Conjugates ◽  
Selective Cytotoxicity

scholarly journals Preparation and first biological evaluation of novel Re-188/Tc-99m peptide conjugates with substance-P

2014 ◽  
Vol 92 ◽  
pp. 25-31 ◽  
Author(s):  
Katarina Smilkov ◽  
Emilija Janevik ◽  
Remo Guerrini ◽  
Micol Pasquali ◽  
Alessandra Boschi ◽  
...  
Keyword(s):  
Substance P ◽  
Biological Evaluation ◽  
Peptide Conjugates

scholarly journals Chemical synthesis and biological evaluation of an antimicrobial peptide gonococcal growth inhibitor

Amino Acids ◽  
2012 ◽  
Vol 43 (6) ◽  
pp. 2279-2283 ◽  
Author(s):  
John D. Wade ◽  
Feng Lin ◽  
Mohammed Akhter Hossain ◽  
Raymond M. Dawson
Keyword(s):  
Chemical Synthesis ◽  
Antimicrobial Peptide ◽  
Growth Inhibitor ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

scholarly journals Synthesis, Radiolabeling, and Biological Evaluation of 68Ga-Mucin1 and Its Folate Hybrid Peptide Conjugates for the Diagnosis of Ovarian Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Samiah Alhabardi ◽  
Hesham Radwan ◽  
Basim Alotaibi ◽  
Yousif Almalki ◽  
Ehab Elzayat ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Biological Evaluation ◽  
Molecular Probe ◽  
Response To Treatment ◽  
Normal Female ◽  
Hybrid Peptide ◽  
Peptide Conjugates ◽  
Synthesis Time ◽  
Biodistribution Studies

Because of our interest in developing new hybrid peptide radioconjugates with suitable biochemical properties for multiple-receptors targeting properties that are overexpressed on many human cancers especially ovarian cancer, we have synthesized 68Ga-NODAGA-MUC1 and 68Ga-NODAGA-MUC1-FA hybrid peptide conjugates using a straightforward and one-step simple reaction. Radiochemical yields were found to be higher than 95% (decay corrected), with a total synthesis time of less than 20 min. Radiochemical purities were always higher than 95% without HPLC purification. In vitro studies on KB cancer cells showed that substantial amounts of the radioconjugates were associated with cell fractions and held great affinities and specificities toward the KB cell line. In vivo characterization in normal female Balb/c mice revealed rapid blood clearance of these radioconjugates with excretion predominantly by the urinary system. Biodistribution studies in nude mice bearing human KB cell line xenografts demonstrated significant tumor uptake and favorable biodistribution profile for 68Ga-NODAGA-MUC1-FA hybrid peptide conjugate compared to the 68Ga-NODAGA-MUC1 peptide monomeric counterpart. The uptake in the tumors was blocked by the excess injection of hybrid peptide, suggesting a receptor-mediated process. These results demonstrate that 68Ga-NODAGA-MUC1-FA hybrid peptide conjugate may be useful as a molecular probe for early detection and staging of folate and MUC1 receptor-positive cancers such as ovarian cancer and their metastasis as well as monitoring tumor response to treatment.

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