scholarly journals The effects of polar and non polar compounds from endophytic actinomycetes in Ocmium tenuiflorum (Tulsi) and Azadirachta indica (Neem) on veterinary and human pathogens

2018 ◽  
Author(s):  
Rabia Tanvir ◽  
Fatima Nawaz ◽  
Muhammad Nawaz ◽  
Aqeel Javeed ◽  
Imran Sajid
Keyword(s):  
Azadirachta Indica ◽  
Polar Compounds ◽  
Human Pathogens ◽  
Endophytic Actinomycetes

scholarly journals Insecticidal activity of endophytic actinomycetes isolated from Azadirachta indica against Myzus persicae

2018 ◽  
Vol 70 (2) ◽  
pp. 349-357 ◽  
Author(s):  
Yan Chen ◽  
Jamil Shafi ◽  
Maohai Li ◽  
Danni Fu ◽  
Mingshan Ji
Keyword(s):  
Insecticidal Activity ◽  
Azadirachta Indica ◽  
Myzus Persicae ◽  
Endophytic Actinomycetes

Endophytic Actinomycetes from Azadirachta indica A. Juss.: Isolation, Diversity, and Anti-microbial Activity

2008 ◽  
Vol 57 (4) ◽  
pp. 749-756 ◽  
Author(s):  
Vijay C. Verma ◽  
Surendra K. Gond ◽  
Anuj Kumar ◽  
Ashish Mishra ◽  
Ravindra N. Kharwar ◽  
...  
Keyword(s):  
Microbial Activity ◽  
Azadirachta Indica ◽  
Endophytic Actinomycetes

scholarly journals Analysis of secondary metabolites and in vitro evaluation of extracts of Carica papaya and Azadirachta indica leaves on selected human pathogens

2020 ◽  
Vol 12 (1) ◽  
pp. 57-73
Author(s):  
Mansurat B. FALANA ◽  
Quadri O. NURUDEEN
Keyword(s):  
Azadirachta Indica ◽  
High Performance ◽  
Carica Papaya ◽  
Acetone Extract ◽  
Hexane Extract ◽  
Human Pathogens ◽  
Diffusion Technique ◽  
Zones Of Inhibition ◽  
Acetone Extracts

Extraction of the leaves of Carica papaya (family Caricaceae) and Azadirachta indica (family Meliacea) were done using solvents with varying polarities (acetone, hexane and ethylacetate). The crude extracts were screened for phytoconstituents using the preliminary method and high-performance liquid chromatography (HPLC) for separation and quantification of the constituents. Susceptibility of three medically important microorganisms (Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Candida alblicans) to the solvent extracts was tested at 100 mg/mL, 50 mg/mL and 25 mg/mL concentrations the disc diffusion technique. Tannins, saponins, alkaloids, steroids, flavonoids and anthraquinone were present in all the solvent extracts of A. indica and C. papaya. Protein was present in all the solvent extracts of A. indica but absent in all the solvent extracts of C. papaya. Terpenoid was only present in hexane extract of A. indica but absent in other solvent extracts of A. indica and C. papaya. Flavonoid was present in all but only absent in ethylacetate extract of A. indica. Glycoside was present in all but absent in hexane extract of A. indica. Coumarin was only present in acetone extracts of both plants and absent in other solvent extracts of the two plants. Extracts of Carica papaya and Azadirachta indica displayed varying inhibitory activities (between 5.00-15.00 mm) against the organisms at all the tested concentrations. Acetone extract of A. indica produced zones of inhibition ranging from 5.00-14.00 mm while acetone extract of C. papaya produces a range of 4.00-10.00 mm. Also, hexane extract of A. indica produced inhibition range of 7.00-10.00 mm whereas hexane extract of C. papaya produces a range of 5.00-15.00 mm. However, ethylacetate extract of A. indica produced inhibition range of 5.00-13.67 mm, while ethylacetate extract of C. papaya produce a range of 5.00-15.00 mm. Different compounds quantified as different peaks by HPLC in the different solvent extracts of Carica papaya are acacic acid, genistein, protodioscin, betulinic acid, phorbolester, creptolepinone, brusatol and alpha ionone while the fractions from the solvent extracts of Azadirachta indica are myricetin, azadirachtol, azadirachtin a, pentadecane, phytol, azadirachnol, quercetin, b caryophyllen, alpha ionone, ascaridole, trams.b.farnes. Results obtained in this work indicated that all the solvent extracts of Carica papaya and Azadirachta indica contained active phytoconstituents and the extracts displayed good potentials at preventing diseases associated with the microorganisms tested in this work.

scholarly journals Isolation of endophytic actinomycetes from Syzygium cumini and their antimicrobial activity against human pathogens

2016 ◽  
Vol 8 (1) ◽  
pp. 416-422 ◽  
Author(s):  
Preeti Saini ◽  
Madhurama Gangwar ◽  
Anu Kalia ◽  
Narinder Singh ◽  
Deepti Narang
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Chitinase Activity ◽  
Syzygium Cumini ◽  
Human Pathogens ◽  
Endophytic Actinomycetes ◽  
Antistaphylococcal Activity ◽  
Leaf Tissues ◽  
Drug Resistant Strains ◽  
Promising Source

Isolation of endophytic actinomycetes is an important step to screen antimicrobial compounds to curb the threat of drug-resistant strains of human pathogens. Out of the 50 endophytic actinomycetes obtained from surface sterilized root, stem and leaf tissues of Syzygium cumini, 50 isolates (30%) exhibited antimicrobial activity. Antistaphylococcal activity was displayed by most of the isolates, with maximum percent inhibition by J-10 (Mean of Inhibition Factor=12.12 mm2). A total of 8 isolates (4 each) were able to hydrolyse protein (proteinase activity) and solubilize chitin (chitinase activity). Results of thin layer chromatography confirm the production of chloramphenicol family |antibiotic by the isolate J-5. This is the first report providing an insight into untapped endophytic actinomycete milieu of Syzygium cumini yet to be explored which might be a promising source for novel antimicrobial agents.

Plasminogen Activation by Invasive Human Pathogens

1997 ◽  
Vol 77 (01) ◽  
pp. 001-010 ◽  
Author(s):  
Michael D P Boyle ◽  
Richard Lottenberg
Keyword(s):  
Plasminogen Activators ◽  
Plasminogen Activation ◽  
Potential Importance ◽  
Human Pathogens

SummaryIn this review the interaction between invasive human pathogens expressing plasmin(ogen) receptors and/or producing plasminogen activators with the human plasmin(ogen) system is described. Evidence is presented for multiple mechanisms by which human pathogens can acquire a surface bound form of plasmin that cannot be regulated by host serpins. The potential importance of these pathways in providing the organisms with the ability to cross tissue barriers is discussed.

Sign in / Sign up

Export Citation Format

Share Document