scholarly journals Single-Cell Reprogramming in Mouse Embryo Development through a Critical Transition State

Entropy ◽  
2017 ◽  
Vol 19 (11) ◽  
pp. 584 ◽  
Author(s):  
Masa Tsuchiya ◽  
Alessandro Giuliani ◽  
Kenichi Yoshikawa
Keyword(s):  
Transition State ◽  
Single Cell ◽  
Embryo Development ◽  
Mouse Embryo ◽  
Cell Reprogramming ◽  
Critical Transition ◽  
Mouse Embryo Development

scholarly journals Single-Cell Genome Dynamics in Early Embryo Development: A Statistical Thermodynamics Approach

2017 ◽  
Author(s):  
Alessandro Giuliani ◽  
Masa Tsuchiya ◽  
Kenichi Yoshikawa
Keyword(s):  
Single Cell ◽  
Embryo Development ◽  
Mouse Embryo ◽  
Statistical Thermodynamics ◽  
Early Embryo ◽  
Self Organization ◽  
Critical Transition ◽  
Critical States ◽  
Genome Expression ◽  
Mouse Embryo Development

AbstractA statistical thermodynamics approach to the temporal development of biological regulation provides a phenomenological description of the dynamical behavior of genome expression in terms of autonomous self-organization with a critical transition (Self-Organized Criticality: SOC). In early mouse embryo development, the dynamical change in the self-organization of overall expression determines how and when reprogramming of the genome-expression state occurs. Reprogramming occurs via a transition state (climbing over an epigenetic landscape), where the critical-regulation pattern of the zygote state disappears. A critical transition is well captured in terms of the bimodality of expression ensembles, which reflects distinct thermodynamic states (critical states). These critical states exhibit a genome avalanche pattern: competition between order (scaling) and disorder (divergence) around a critical point. The genome avalanche in mouse embryo development, which is committed to erase a previous ordered state, reveals that the direction of early embryo single-cell development traverses the same steps as in differentiation, but in the opposite order of self-organization.

scholarly journals Single-Cell Reprogramming of Mouse Embryo Development Through a Critical Transition State

2017 ◽  
Author(s):  
Masa Tsuchiya ◽  
Alessandro Giuliani ◽  
Kenichi Yoshikawa
Keyword(s):  
Transition State ◽  
Single Cell ◽  
Critical State ◽  
Early Embryo ◽  
Self Organization ◽  
Cell Reprogramming ◽  
Critical Transition ◽  
Critical States ◽  
Oscillatory Dynamics ◽  
Soc Control

AbstractOur work dealing with the temporal development of the genome-expression profile in single-cell mouse early embryo indicated that reprogramming occurs via a critical transition state, where the critical-regulation pattern of the zygote state disappears. In this report, we unveil the detailed mechanism of how the dynamic interaction of thermodynamic states (critical states) enables the genome system to pass through the critical transition state to achieve genome reprogramming.Self-organized criticality (SOC) control of overall expression provides a snapshot of self-organization and explains the coexistence of critical states at a certain experimental time point. The time-development of self-organization is dynamically modulated by exchanges in expression flux between critical states through the cell nucleus milieu, where sequential global perturbations involving activation-inhibition of multiple critical states occur from the early state to the late 2-cell state. Two cyclic fluxes act as feedback flow and generate critical-state coherent oscillatory dynamics. Dynamic perturbation of these cyclic flows due to vivid activation of the ensemble of low-variance expression (sub-critical state) genes allows the genome system to overcome a transition state during reprogramming.Our findings imply that a universal mechanism of long-term global RNA oscillation underlies autonomous SOC control, and the critical gene ensemble at a critical point (CP) drives genome reprogramming. Unveiling the corresponding molecular players will be essential to understand single-cell reprogramming.

Comparative effects of essential and nonessential metals on preimplantation mouse embryo development in vitro

Toxicology ◽  
1997 ◽  
Vol 116 (1-3) ◽  
pp. 123-131 ◽  
Author(s):  
Lynn A. Hanna ◽  
Jeffrey M. Peters ◽  
Lynn M. Wiley ◽  
Michael S. Clegg ◽  
Carl L. Keen
Keyword(s):  
Embryo Development ◽  
Mouse Embryo ◽  
Mouse Embryo Development ◽  
Preimplantation Mouse Embryo ◽  
Preimplantation Mouse ◽  
Development In Vitro

scholarly journals Effects of peritoneal fluid on preimplantation mouse embryo development and apoptosis in vitro

2005 ◽  
Vol 11 (5) ◽  
pp. 615-619 ◽  
Author(s):  
Navid Esfandiari ◽  
Tommaso Falcone ◽  
Jeffrey M Goldberg ◽  
Ashok Agarwal ◽  
Rakesh K Sharma
Keyword(s):  
Embryo Development ◽  
Mouse Embryo ◽  
Peritoneal Fluid ◽  
Mouse Embryo Development ◽  
Preimplantation Mouse Embryo ◽  
Preimplantation Mouse
Sign in / Sign up

Export Citation Format

Share Document