scholarly journals Nonsyndromic Oral Cleft in First-Degree Relatives of Patients with Acute Lymphoblastic Leukemia

2020 ◽  
Vol 8 (1) ◽  
pp. 23
Author(s):  
Verônica Oliveira Dias ◽  
Daniella Reis Barbosa Martelli ◽  
Maria Santos ◽  
Célia Fernandes Maia ◽  
Rodrigo Soares de Andrade ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Control Group ◽  
Demographic Information ◽  
Oral Clefts ◽  
Exact Test ◽  
Positive History ◽  
First Degree Relatives ◽  
History Of ◽  
Different Populations

Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, n = 50) and controls (n = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher’s exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61–274.6, p = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological relationship between cancer and nonsyndromic oral clefts.

scholarly journals Absence of history of oral cleft in first-degree relatives of patients with prostate cancer

2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Cláudia De Alvarenga Diniz Fonseca ◽  
Daniella Reis Barbosa Martelli ◽  
Ianná Luana Freitas Almeida ◽  
Galeno Hassen Sales ◽  
Rodrigo Soares de Andrade ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Family History ◽  
Cleft Lip ◽  
Control Group ◽  
Chi Square ◽  
Exact Test ◽  
First Degree Relatives ◽  
History Of ◽  
Risk Magnitude ◽  
Magnitude Assessment

Objective: To evaluate the occurrence of nonsyndromic cleft lip and/or palate (NSCL/P) in families of patients with prostate cancer (PC).Study design: We conducted a case-control study involving a total of 748 individuals, 280 of which had PC, and 468 were free-cancer healthy individuals. The patients answered a questionnaire with basic demographic information and family history of NSCL/P in first-degree relatives. The information collected was stored in a database and analyzed by using the statistical program SPSS® 24.0 for Windows (Chicago, IL, USA). In order to determine the association with NSCL/P, chi-square and Fisher’s exact test and odds ratio (OR) with its 95% confidence interval (95% CI) for risk magnitude assessment. Values with p<0.05 were considered statistically significant.Results: Of total patients with PC, 2 had a positive history of NSCL/P. In the control group, 7 patients reported family history of NSCL/P (1df chi-square, p=0.34; Fisher´s exact test, p=0.49). The average age of the cases diagnosed with PC was 71.35±7.70 years, and control group was 64.42±9.67 years.Conclusion: Despite the limited population, the frequency of NSCL/P was not significantly increased in the first-degree relatives of patients with PC. Studies with larger samples and molecular analyses are needed to better understand the possible relationships in the etiology of cancer and NSCL/P.

scholarly journals Evaluation of an oral preventive protocol in children with acute lymphoblastic leukemia

2003 ◽  
Vol 17 (2) ◽  
pp. 147-150 ◽  
Author(s):  
Edja Maria Melo de Brito Costa ◽  
Maria Zélia Fernandes ◽  
Lêda Bezerra Quinderé ◽  
Lélia Batista de Souza ◽  
Leão Pereira Pinto
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Intervention Study ◽  
Lymphoblastic Leukemia ◽  
Preventive Treatment ◽  
Pediatric Dentistry ◽  
Control Group ◽  
Mouth Rinse ◽  
Exact Test ◽  
Antineoplastic Treatment ◽  
Present Trial

This study was designed to assess the effectiveness of a preventive oral protocol in children receiving antineoplastic treatment for acute lymphoblastic leukemia (ALL) before initiating a larger intervention study. During a seven month period, fourteen children from two to ten years old with a diagnosis of ALL were evaluated. Patients with ALL who received a 0.12% chlorhexidine mouth rinse (seven children) were compared to a control group of patients who were not given the same preventive treatment (seven children) as to the occurrence of oral mucosal complications. Children in both groups received daily oral hygiene care, and were examined daily by the pediatric dentistry team until discharge. A significant decrease in the incidence of oral mucositis and ulceration was observed in the children who received a 0.12% chlorhexidine mouth rinse (p < 0.05 by Fisher's exact test). The findings obtained in the present trial are encouraging, and suggest that the systematic application of a preventive protocol reduces the incidence of oral complications in children with ALL receiving chemotherapy.

scholarly journals DNA Methylation in T-Cell Acute Lymphoblastic Leukemia: In Search for Clinical and Biological Meaning

2021 ◽  
Vol 22 (3) ◽  
pp. 1388
Author(s):  
Natalia Maćkowska ◽  
Monika Drobna-Śledzińska ◽  
Michał Witt ◽  
Małgorzata Dawidowska
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Epigenetic Modification ◽  
Lymphoblastic Leukemia ◽  
Leukemic Cells ◽  
Global Methylation ◽  
Current State ◽  
History Of ◽  
Cell Acute Lymphoblastic Leukemia

Distinct DNA methylation signatures, related to different prognosis, have been observed across many cancers, including T-cell acute lymphoblastic leukemia (T-ALL), an aggressive hematological neoplasm. By global methylation analysis, two major phenotypes might be observed in T-ALL: hypermethylation related to better outcome and hypomethylation, which is a candidate marker of poor prognosis. Moreover, DNA methylation holds more than a clinical meaning. It reflects the replicative history of leukemic cells and most likely different mechanisms underlying leukemia development in these T-ALL subtypes. The elucidation of the mechanisms and aberrations specific to (epi-)genomic subtypes might pave the way towards predictive diagnostics and precision medicine in T-ALL. We present the current state of knowledge on the role of DNA methylation in T-ALL. We describe the involvement of DNA methylation in normal hematopoiesis and T-cell development, focusing on epigenetic aberrations contributing to this leukemia. We further review the research investigating distinct methylation phenotypes in T-ALL, related to different outcomes, pointing to the most recent research aimed to unravel the biological mechanisms behind differential methylation. We highlight how technological advancements facilitated broadening the perspective of the investigation into DNA methylation and how this has changed our understanding of the roles of this epigenetic modification in T-ALL.

scholarly journals Case Report: A rare association between SLE and Acute Lymphatic Leukemia

2018 ◽  
Vol 1 (3) ◽  
pp. 01-02
Author(s):  
P.K. Sasidharan
Keyword(s):  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Past History ◽  
Lymphoblastic Leukemia ◽  
Acute Lymphatic Leukemia ◽  
Rare Association ◽  
Lymphatic Leukemia ◽  
History Of

A 30-year-old housewife with past history of acute lymphoblastic leukemia 12 years back, still in remission, was admitted with polyarthritis of 2 months duration. She was evaluated and found to have SLE with positive ANA and Anti ds DNA which were strongly positive.

scholarly journals Identification and Validation of Serum Autoantibodies in Children with B-cell Acute Lymphoblastic Leukemia by Serological Proteome Analysis

2021 ◽  
Author(s):  
Runhong Yu ◽  
Shiwei Yang ◽  
Yufeng Liu ◽  
Zunmin Zhu
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Western Blot ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Immunohistochemical Analysis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Children ◽  
Expression Levels ◽  
Cell Acute Lymphoblastic Leukemia

Abstract Purpose: Study was by intention to screen serum autoantibodies that may contribute to the early detection of B-cell acute lymphoblastic leukemia (B-ALL) in children.Patients and methods: The total protein from three pooled B-ALL cell lines(NALM-6, REH and BALL-1 cells) was separated using two-dimensional gel electrophoresis(2-DE), which was followed by Western blot by mixed serum from B-ALL patients (n=20) or healthy children(n=20). We obtained and analyzed the images of 2-D gel and Western blot by PDQuest software,and then identify the spots of immune responses in B-ALL samples compared with those in control samples.The proteins from spots were identified using mass spectrometry (MS). The autoantibodies against α-enolase and voltage-dependent anion-selective channel protein 1(VDAC1) were further validated on the use of enzyme-linked immunosorbent assay(ELISA). The protein expression levels of the candidate antigens α-enolase and VDAC1 in B-ALL were thoroughly studied by immunohistochemical analysis.Results: Six protein dots were identified with MS as Aconitase,apoptosis-inducing factor(AIF),dihydrolipoamide dehydrogenase(DLD), α-enolase,medium-chain acyl-CoA dehydrogenase(MCAD) and VDAC 1.The frequencies of autoantibodies against α-enolase and VDAC1 in children with B-ALL were 27% and 23%, respectively, which were significantly higher than those in normal controls(4% and 0). Immunohistochemical analysis showed the expression of α-enolase and VDAC1 was positive in 95% and 85% of B-ALL patients, respectively, but negative expression levels were showed in the control group. Conclusion: This study incidates that α-enolase and VDAC1 may be the antigen associated with B-ALL .α-enolase and VDAC1 autoantibodies may develop into potential serological markers of B-ALL in children.Other proteins also need to be confirmed in a large number of serum samples.

scholarly journals Determination of Advanced Oxidation Protein Products, E3 SUMO-Protein Ligase NSE2[NSMCE2], as a Marker to Predict Child Acute Lymphoblastic Leukemia

2014 ◽  
Vol 11 (1) ◽  
pp. 128-138 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Blood Cell ◽  
White Blood Cell ◽  
Total Protein ◽  
Lymphoblastic Leukemia ◽  
Advanced Oxidation ◽  
Control Group ◽  
Advanced Oxidation Protein Products ◽  
Sumo Protein

Acute lymphoblastic leukemia (ALL) is a cancer of the blood and bone marrow (spongy tissue in the center of bone). In ALL, too many bone marrow stem cells develop into a type of white blood cell called lymphocytes. These abnormal lymphocytes are not able to fight infection very well. The aim of this study was to investigate possible links between E3 SUMO-Protein Ligase NSE2 [NSMCE2] and increase DNA damage in the childhood patients with Acute lymphoblastic leukemia (ALL). Laboratory investigations including hemoglobin(Hb) ,white blood cell (WBC) , serum total protein , albumin ,globulin , in addition to serum total antioxidant activity (TAA) , Advanced oxidation protein products(AOPP) and E3 SUMO-Protein Ligase NSE2[NSMCE2]. Blood samples were collected from 60 patients diagnosed to Acute lymphoblastic leukemia (ALL) after one month treatment with induction therapy. Age and sex matched 30 healthy persons selected as control.serum total protein , albumin and globulin showed A significant decrease in patients group when compared to control group( P

scholarly journals Familial Trend and Socioeconomic Status of the Hypertensive Patients attending at Hypertension Clinic

2012 ◽  
Vol 13 (1) ◽  
pp. 10-15
Author(s):  
Kazi Jahangir Hossain ◽  
Nazma Parvin ◽  
A Wazed ◽  
Md Shamsul Alam ◽  
Md Mustafa Kamal
Keyword(s):  
Socioeconomic Status ◽  
College Hospital ◽  
Hypertensive Patients ◽  
Positive History ◽  
Medical College ◽  
First Degree Relatives ◽  
Hypertension Clinic ◽  
History Of ◽  
Prevention Of Hypertension ◽  
Second Degree

The aim of the study was to investigate familial trend and socioeconomic status of the hypertensive patients attending at the Hypertension Clinic of Dhaka Medical College Hospital, Dhaka. The study period was from July 2009 to June 2010.  A total of 417 patients were recruited of which 245 were male and 172 female respectively, and selected consecutively on the basis of defined criteria.  The research instrument was an interviewer-administered questionnaire. For assessment of familial trend of hypertension, first and second degree relatives of the respondents were investigated.   Results showed that majority of the respondents were educated of which 22.1%(n=92), 18.2%(n=76), 19.9%(83) and 13.7%(n=57) were secondary, higher secondary, graduate and postgraduate educated respectively. In profession, 64.4%(n=111) female had household works, and 56.8%(n=139) male were in service and 41.2%(n=101) businessmen and had monthly income of  Tk. 10,000 to 80,000. The mean age of them was 47.4±6.9 years and BMI was 25.5±3.0 kg/m2. The nutritional status of them were normal in 40.5%(n=169) and rest had different degree of malnutrition.  In malnutrition, 53.1%(n=130) male were overweight, 2.9%(n=7) obese and 0.8%(n=2) undernourished; and 51.2%(n=88) female were overweight, 11.0(n=19) obese and 1.2%(n=2) undernourished respectively.   About 70.5%(n=294) of the studied hypertensive patients had positive history of hypertension in first and second degree relatives of which 17.3%(n=72) had single member positive history of hypertension, 18.2%(n=76) two, 16.8%(n=70) three, 14.1%(n=69) four and 4.1%(n=17) five members. In single member positive, most of them were in first degree relatives; in two members, 67.1%(n=51) were in first degree relatives and 27.6%(n=21) in both first and 2nd degree relatives; in three members, 64.3%(n=45) were in 1st degree and 31.4%(n=22) in both 1st and 2nd degree; in four members, 31.9%(n=22) were in 1st degree relationship, 17.4%(n=12) in 2nd degree and 50.7%(n=35) in both 1st and 2nd degree; and in five members, 17.6%(n=3) and 82.4%(n=14) in second degree, and both 1st and 2nd degree relatives respectively. Heath education and behavioral change intervention programs among the hypertensive population may be one of the most important applicable ways to control and/or prevention of hypertension and its complications in Bangladesh. DOI: http://dx.doi.org/10.3329/jom.v13i1.5941 JOM 2012; 13(1): 10-15

Sign in / Sign up

Export Citation Format

Share Document