scholarly journals A Brief Overview of Medical Fiber Optic Biosensors and Techniques in the Modification for Enhanced Sensing Ability

Diagnostics ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 23 ◽  
Author(s):  
Shannon Mowbray ◽  
Amir Amiri

In this paper, we provide a brief overview of fiber optic biosensors for use in MedTech, specifically to aid in the diagnoses and treatment of those with chronic medical conditions. Fiber optic cables as components of biological sensors make them especially effective in biological systems that may require ultra-sensitive detection of low-frequency signals in hard to reach areas. This systematic review focuses on the differentiating factors of fiber-optic biosensors, which are tailored to apply the sensor to specific health needs. The main components of FOBS (fiber optic biosensors) such as biosensing elements, fiber optic cables, optical element enhancements, transducers, sensing strategies, photodetectors, and signal processing are covered in detail by showcasing the recent developments in modifications to these components. This paper pays particular attention to the alterations made in biosensing elements including pH elements, enzymatic elements, as well as those sensors utilizing antibodies and whole-cell bacteria. This paper reviews and discusses several published examples in the research stage of development or to give the reader an overall scope of the field. The need for research on biosensing equipment is increasing, as the number of individuals with chronic diseases and the geriatric population require more effective, accurate, and mobile sensing ability and redcued invasiveness. FOBS offer a sensing solution that is accurate, tailorable to almost any clinical need, has abundant and relatively cheap material requirements, and a well-established technological base in fiber optic technology. This small price tag and large market potential make FOBS a desirable research area.

2016 ◽  
Vol 23 (2) ◽  
pp. 309-316
Author(s):  
Marcin Lipiński ◽  
Przemysław Krehlik ◽  
Łukasz Śliwczyński ◽  
Łukasz Buczek ◽  
Jacek Kołodziej

Abstract The low-frequency optical-signal phase noise induced by mechanical vibration of the base occurs in field-deployed fibers. Typical telecommunication data transfer is insensitive to this type of noise but the phenomenon may influence links dedicated to precise Time and Frequency (T&F) fiber-optic transfer that exploit the idea of stabilization of phase or propagation delay of the link. To measure effectiveness of suppression of acoustic noise in such a link, a dedicated measurement setup is necessary. The setup should enable to introduce a low-frequency phase corruption to the optical signal in a controllable way. In the paper, a concept of a setup in which the mechanically induced acoustic-band optical signal phase corruption is described and its own features and measured parameters are presented. Next, the experimental measurement results of the T&F transfer TFTS-2 system’s immunity as a function of the fibre-optic length vs. the acoustic-band noise are presented. Then, the dependency of the system immunity on the location of a noise source along the link is also pointed out.


Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2528 ◽  
Author(s):  
Hiroshi Yamazaki ◽  
Ichiro Kurose ◽  
Michiko Nishiyama ◽  
Kazuhiro Watanabe

In this paper, a novel pendulum-type accelerometer based on hetero-core fiber optics has been proposed for structural health monitoring targeting large-scale civil infrastructures. Vibration measurement is a non-destructive method for diagnosing the failure of structures by assessing natural frequencies and other vibration patterns. The hetero-core fiber optic sensor utilized in the proposed accelerometer can serve as a displacement sensor with robustness to temperature changes, in addition to immunity to electromagnetic interference and chemical corrosions. Thus, the hetero-core sensor inside the accelerometer measures applied acceleration by detecting the rotation of an internal pendulum. A series of experiments showed that the hetero-core fiber sensor linearly responded to the rotation angle of the pendulum ranging within (−6°, 4°), and furthermore the proposed accelerometer could reproduce the waveform of input vibration in a frequency band of several Hz order.


Author(s):  
Pham Viet Hai ◽  
Nguyen Dinh Hoang Long ◽  
Nguyen Thi Diem Thuy ◽  
Le Hoang Anh ◽  
Dao Nguyen Khoi

The objective of this study was to develop a set of sustainable development indicators on environmental aspects and apply them to assess the level of environmental sustainability in Phu Quy district, Binh Thuan province. The set of sustainable development indicators was built based on the screening of indicators from some previous studies, as well as developing new indicators to match the research area. The indicators were then be grouped into topics based on the United Nations' 17 sustainable development goals to 2030. In terms of environment, the set of sustainable development indicators includeed 6 topics (main components), 19 indicators (sub-components), of which 6 new indicators were researched and developed for the island and sea area. The result showed that the level of environmental sustainability of the Phu Quy district was good (0.846). In addition, the results showed that the local environmental aspects attained levels of sustainability. Accordingly, main components including clean water - sanitation (MT1), habitat (MT3), natural disaster prevention (MT4) and ocean conservation - sustainable use (MT5) reached the good level of sustainability and tend to keep stable. While sustainable energy (MT2) and forest protection and development (MT6) are quite sustainable. However, the MT6 component tended to decrease that indicated the forest degradation and the impacts on environmental sustainability in Phu Quy district in the future.


2021 ◽  
Author(s):  
M Nagoor Meeran ◽  
S.P. Saravanan ◽  
H.H Hegazy

Abstract Recent research demonstrate that promising gas sensing materials are called metal-organic structures (MOFs) and their products due to their tunable form, elevated surface area, and extremely porous structure and physisorption towards gases with relatively low temperature.In this report, recent developments in transition-metal (Zn, Mn, Cu)-based MOFs and their derivatives are synthesized as sensing materials. The sensors samples were analyzed by XRD, SEM, TEM, BET and XPS in order to know the textural, structural and electronic state of the samples. Fiber optic clad modified sensors were fabricated and tested gas sensing properties towards H2 gas with various concentrations (0-1000 ppm). Among the three sensing material, Zn doped MOFs sensor showed outstanding selectivity with high sensitivity (115 counts/kpa) towards H2 gas. Moreover, it has shown high response (20 s) and recovery time (27 s) as well as long term stability. The designed sensors may be required to apply to the production of an outstanding sensor for H2 for commercial uses.


2021 ◽  
Vol 15 ◽  
Author(s):  
Fabian Kiepe ◽  
Nils Kraus ◽  
Guido Hesselmann

Self-generated auditory input is perceived less loudly than the same sounds generated externally. The existence of this phenomenon, called Sensory Attenuation (SA), has been studied for decades and is often explained by motor-based forward models. Recent developments in the research of SA, however, challenge these models. We review the current state of knowledge regarding theoretical implications about the significance of Sensory Attenuation and its role in human behavior and functioning. Focusing on behavioral and electrophysiological results in the auditory domain, we provide an overview of the characteristics and limitations of existing SA paradigms and highlight the problem of isolating SA from other predictive mechanisms. Finally, we explore different hypotheses attempting to explain heterogeneous empirical findings, and the impact of the Predictive Coding Framework in this research area.


2020 ◽  
pp. 8-12
Author(s):  
Mariia Nikolaevna Sarkisova ◽  
Natalia Viktorovna Biriukova

This article describes ways of using various types of honey in the history of medicine as well as its current stage of development. The authors consider the main components of different types of honey and the national standards of naturally sourced honey. An analysis of research papers on medical uses of honey has been performed, as well as a comparative analysis of recent honey-based medicines available in the pharmaceutical market. On the basis of collected data, some possible prospects for further use of honey in medicine have been outlined.


Author(s):  
Sergey V. Dorozhkin

There has been much recent activity in the research area of nanoparticles and nanocrystalline materials, in many fields of science and technology. This is due to their outstanding and unique physical, mechanical, chemical and biological characteristics. Recent developments in biomineralization have demonstrated that nano-sized particles play an important role in the formation of the hard tissues of animals. It is well established that the basic inorganic building blocks of bones and teeth of mammals are nano-sized and nanocrystalline calcium orthophosphates (in the form of apatites) of a biological origin. In mammals, tens to hundreds of nanocrystals of biological apatite are found to combine into self-assembled structures under the control of bio-organic matrixes. It was also confirmed experimentally that the structure of both dental enamel and bones could be mimicked by an oriented aggregation of nano-sized calcium orthophosphates, determined by the biomolecules. The application and prospective use of nano-sized and nanocrystalline calcium orthophosphates for clinical repair of damaged bones and teeth are also known. For example, a greater viability and a better proliferation of various cells were detected on smaller crystals of calcium orthophosphates. Furthermore, studies revealed that the differentiation of various cells was promoted by nano-sized calcium orthophosphates. Thus, the nano-sized and nanocrystalline forms of calcium orthophosphates have the potential to revolutionize the field of hard tissue engineering, in areas ranging from bone repair and augmentation to controlled drug delivery devices. This paper reviews the current state of knowledge and recent developments of various nano-sized and nanocrystalline calcium orthophosphates, covering topics from the synthesis and characterization to biomedical and clinical applications. This review also provides possible directions of future research and development.


2011 ◽  
pp. 451-490 ◽  
Author(s):  
William B. Spillman

Author(s):  
Sreenath Gupta

Abstract Due to several recent developments in lasers and optics, laser igniters can now be designed to be (i) compact so as to have the same footprint as a standard spark plug, (ii) have low power draw, usually less than 50 Watts, and (iii) have vibration and temperature resistance at levels typical of reciprocating engines. Primary advantages of these laser igniters remain (i) extension of lean or dilution limits for ignition of combustible mixtures, and (ii) improved ignition at higher pressures. Recently, tests performed in a 350 kW 6-cylinder stationary natural gas reciprocating engine retrofitted with these igniters showed an extension of the operational envelope to yield efficiency improvements of the order of 2.6% points while being compliant with the mandated emission regulations. Even though laser igniters offer promise, fouling of the final optical element that introduces the laser into the combustion chamber is of concern. After performing a thorough literature search, a test plan was devised to evaluate various fouling mitigation strategies. The final approach that was used is a combination of three strategies and helped sustain an optical transmissivity exceeding 98% even after 1500 hrs. of continuous engine operation at 2400 rpm. Based on the observed trend in transmissivity, it now appears that laser igniters can last up to 6000 hrs. of continuous engine operation in a stationary engine running at 1800 rpm.


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