scholarly journals Exploring Machine Learning Techniques to Predict the Response to Omalizumab in Chronic Spontaneous Urticaria

Diagnostics ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 2150
Author(s):  
Davide Stefano Sardina ◽  
Giuseppe Valenti ◽  
Francesco Papia ◽  
Carina Gabriela Uasuf
Keyword(s):  
Machine Learning ◽  
Response To Therapy ◽  
Chronic Spontaneous Urticaria ◽  
Machine Learning Techniques ◽  
Response To Treatment ◽  
Learning Techniques ◽  
Svm Model ◽  
Importance Analysis ◽  
Urticaria Activity Score ◽  
D Dimer

Background: Omalizumab is the best treatment for patients with chronic spontaneous urticaria (CSU). Machine learning (ML) approaches can be used to predict response to therapy and the effectiveness of a treatment. No studies are available on the use of ML techniques to predict the response to Omalizumab in CSU. Methods: Data from 132 CSU outpatients were analyzed. Urticaria Activity Score over 7 days (UAS7) and treatment efficacy were assessed. Clinical and demographic characteristics were used for training and validating ML models to predict the response to treatment. Two methodologies were used to label the data based on the response to treatment (UAS7 ³ 6): (A) at 1, 3 and 5 months; (B) classifying the patients as early responders (ER), late responders (LR) or non-responders (NR) (ER: UAS 7 ³ 6 at first month, LR: UAS 7 ³ 6 at third month, NR: if none of the previous conditions occurred). Results: ER were predominantly characterized by hypertension, while LR mainly suffered from asthma and hypothyroidism. A slight positive correlation (R2 = 0.21) was found between total IgE levels and UAS7 at 1 month. Variable Importance Analysis (VIA) reported D-dimer and C-reactive proteins as the key blood tests for the performance of learning techniques. Using methodology (A), SVM (specificity of 0.81) and k-NN (sensitivity of 0.8) are the best models to predict LR at the third month. Conclusion: k-NN plus the SVM model could be used to identify the response to treatment. D-dimer and C-reactive proteins have greater predictive power in training ML models.

scholarly journals Evaluation of the Risk of Recurrence in Patients with Local Advanced Rectal Tumours by Different Radiomic Analysis Approaches

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Alaa Khadidos ◽  
Adil Khadidos ◽  
Olfat M. Mirza ◽  
Tawfiq Hasanin ◽  
Wegayehu Enbeyle ◽  
...  
Keyword(s):  
Machine Learning ◽  
Image Analysis ◽  
Deep Learning ◽  
Locally Advanced ◽  
Textural Analysis ◽  
Machine Learning Techniques ◽  
Response To Treatment ◽  
Learning Techniques ◽  
Potential Applications ◽  
Analysis Models

The word radiomics, like all domains of type omics, assumes the existence of a large amount of data. Using artificial intelligence, in particular, different machine learning techniques, is a necessary step for better data exploitation. Classically, researchers in this field of radiomics have used conventional machine learning techniques (random forest, for example). More recently, deep learning, a subdomain of machine learning, has emerged. Its applications are increasing, and the results obtained so far have demonstrated their remarkable effectiveness. Several previous studies have explored the potential applications of radiomics in colorectal cancer. These potential applications can be grouped into several categories like evaluation of the reproducibility of texture data, prediction of response to treatment, prediction of the occurrence of metastases, and prediction of survival. Few studies, however, have explored the potential of radiomics in predicting recurrence-free survival. In this study, we evaluated and compared six conventional learning models and a deep learning model, based on MRI textural analysis of patients with locally advanced rectal tumours, correlated with the risk of recidivism; in traditional learning, we compared 2D image analysis models vs. 3D image analysis models, models based on a textural analysis of the tumour versus models taking into account the peritumoural environment in addition to the tumour itself. In deep learning, we built a 16-layer convolutional neural network model, driven by a 2D MRI image database comprising both the native images and the bounding box corresponding to each image.

Machine learning techniques applied to prediction of residual strength of clay

2011 ◽  
Vol 3 (4) ◽  
Author(s):  
Sarat Das ◽  
Pijush Samui ◽  
Shakilu Khan ◽  
Nagarathnam Sivakugan
Keyword(s):  
Machine Learning ◽  
Residual Strength ◽  
Training Data ◽  
Machine Learning Techniques ◽  
Sensitivity Analyses ◽  
Support Vector ◽  
Index Properties ◽  
Learning Techniques ◽  
Svm Model ◽  
Ann Models

AbstractStability with first time or reactivated landslides depends upon the residual shear strength of soil. This paper describes prediction of the residual strength of soil based on index properties using two machine learning techniques. Different Artificial Neural Network (ANN) models and Support Vector Machine (SVM) techniques have been used. SVM aims at minimizing a bound on the generalization error of a model rather than at minimizing the error on the training data only. The ANN models along with their generalizations capabilities are presented here for comparisons. This study also highlights the capability of SVM model over ANN models for the prediction of the residual strength of soil. Based on different statistical parameters, the SVM model is found to be better than the developed ANN models. A model equation has been developed for prediction of the residual strength based on the SVM for practicing geotechnical engineers. Sensitivity analyses have been also performed to investigate the effects of different index properties on the residual strength of soil.

scholarly journals Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques

2020 ◽  
Author(s):  
Hao Li ◽  
Liqian Cui ◽  
Liping Cao ◽  
Yizhi Zhang ◽  
Yueheng Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bipolar Disorder ◽  
Functional Mri ◽  
Added Value ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Accurate Identification ◽  
Learning Techniques ◽  
Svm Model

Abstract Background: Bipolar disorder (BPD) is a common mood disorder that is often goes misdiagnosed or undiagnosed. Recently, machine learning techniques have been combined with neuroimaging methods to aid in the diagnosis of BPD. However, most studies have focused on the construction of classifiers based on single-modality MRI. Hence, in this study, we aimed to construct a support vector machine (SVM) model using a combination of structural and functional MRI, which could be used to accurately identify patients with BPD.Methods: In total, 44 patients with BPD and 36 healthy controls were enrolled in the study. Clinical evaluation and MRI scans were performed for each subject. Next, image pre-processing, VBM and ReHo analyses were performed. The ReHo values of each subject in the clusters showing significant differences were extracted. Further, LASSO approach was recruited to screen features. Based on selected features, the SVM model was established, and discriminant analysis was performed.Results: After using the two-sample t-test with multiple comparisons, a total of 8 clusters were extracted from the data (VBM = 6; ReHo = 2). Next, we used both VBM and ReHo data to construct the new SVM classifier, which could effectively identify patients with BPD at an accuracy of 87.5% (95%CI: 72.5-95.3%), sensitivity of 86.4% (95%CI: 64.0-96.4%), and specificity of 88.9% (95%CI: 63.9-98.0%) in the test data (p=0.0022). Conclusions: A combination of structural and functional MRI can be of added value in the construction of SVM classifiers to aid in the accurate identification of BPD in the clinic.

scholarly journals An Individualized Algorithm to Predict Mortality in COVID-19 Pneumonia: a Machine Learning Based Study

2022 ◽  
Author(s):  
Maria Elena Laino ◽  
Elena Generali ◽  
Tobia Tommasini ◽  
Giovanni Angelotti ◽  
Alessio Aghemo ◽  
...  
Keyword(s):  
Machine Learning ◽  
Hospital Mortality ◽  
Risk Score ◽  
Machine Learning Techniques ◽  
Clinical Settings ◽  
Risk Of Mortality ◽  
Learning Techniques ◽  
Machine Learning Approach ◽  
Importance Analysis ◽  
High Level

IntroductionIdentifying SARS-CoV-2 patients at higher risk of mortality is crucial in the management of a pandemic. Artificial intelligence techniques allow to analyze big amount of data to find hidden patterns. We aimed to develop and validate a mortality score at admission for COVID-19 based on high-level machine learning.Material and methodsWe conducted a retrospective cohort study on hospitalized adults COVID-19 patients between March and December 2020. The primary outcome was in-hospital mortality. A machine learning approach on vital parameters, laboratory values, and demographic features was applied to develop different models. Then, a feature importance analysis was performed to reduce the number of variables included in the model, to develop a risk score with good overall performance, that was finally evaluated in terms of discrimination and calibration capabilities. All results underwent cross-validation.Results1,135 consecutive patients (median age 70 years, 64% males) were enrolled, 48 patients were excluded, the cohort was randomly divided in training (760) and test (327). During hospitalization, 251 (22%) patients died. After feature selection, the best performing classifier was random forest (AUC 0.88±0.03). Based on the relative importance of each variable, a pragmatic score was developed, showing good performances (AUC 0.85, ±0.025), and three levels were defined that correlated well with in-hospital mortality.ConclusionsMachine learning techniques were applied in order to develop an accurate in-hospital mortality risk score for COVID-19 based on ten variables. The application of the proposed score has utility in clinical settings to guide the management and prognostication of COVID-19 patients.

scholarly journals Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques

2020 ◽  
Author(s):  
Hao Li ◽  
Liqian Cui ◽  
Liping Cao ◽  
Yizhi Zhang ◽  
Yueheng Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bipolar Disorder ◽  
Functional Mri ◽  
Added Value ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Accurate Identification ◽  
Learning Techniques ◽  
Svm Model

Abstract Background: Bipolar disorder (BPD) is a common mood disorder that is often goes misdiagnosed or undiagnosed. Recently, machine learning techniques have been combined with neuroimaging methods to aid in the diagnosis of BPD. However, most studies have focused on the construction of classifiers based on single-modality MRI. Hence, in this study, we aimed to construct a support vector machine (SVM) model using a combination of structural and functional MRI, which could be used to accurately identify patients with BPD.Methods: In total, 44 patients with BPD and 36 healthy controls were enrolled in the study. Clinical evaluation and MRI scans were performed for each subject. Next, image pre-processing, VBM and ReHo analyses were performed. The ReHo values of each subject in the clusters showing significant differences were extracted. Further, LASSO approach was recruited to screen features. Based on selected features, the SVM model was established, and discriminant analysis was performed.Results: After using the two-sample t-test with multiple comparisons, a total of 8 clusters were extracted from the data (VBM = 6; ReHo = 2). Next, we used both VBM and ReHo data to construct the new SVM classifier, which could effectively identify patients with BPD at an accuracy of 87.5% (95%CI: 72.5-95.3%), sensitivity of 86.4% (95%CI: 64.0-96.4%), and specificity of 88.9% (95%CI: 63.9-98.0%) in the test data (p=0.0022). Limitations: The sample size was small, and we were unable to eliminate the potential effects of medications. Conclusions: A combination of structural and functional MRI can be of added value in the construction of SVM classifiers to aid in the accurate identification of BPD in the clinic.

scholarly journals Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Hao Li ◽  
Liqian Cui ◽  
Liping Cao ◽  
Yizhi Zhang ◽  
Yueheng Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bipolar Disorder ◽  
Functional Mri ◽  
Added Value ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Accurate Identification ◽  
Learning Techniques ◽  
Svm Model

Abstract Background Bipolar disorder (BPD) is a common mood disorder that is often goes misdiagnosed or undiagnosed. Recently, machine learning techniques have been combined with neuroimaging methods to aid in the diagnosis of BPD. However, most studies have focused on the construction of classifiers based on single-modality MRI. Hence, in this study, we aimed to construct a support vector machine (SVM) model using a combination of structural and functional MRI, which could be used to accurately identify patients with BPD. Methods In total, 44 patients with BPD and 36 healthy controls were enrolled in the study. Clinical evaluation and MRI scans were performed for each subject. Next, image pre-processing, VBM and ReHo analyses were performed. The ReHo values of each subject in the clusters showing significant differences were extracted. Further, LASSO approach was recruited to screen features. Based on selected features, the SVM model was established, and discriminant analysis was performed. Results After using the two-sample t-test with multiple comparisons, a total of 8 clusters were extracted from the data (VBM = 6; ReHo = 2). Next, we used both VBM and ReHo data to construct the new SVM classifier, which could effectively identify patients with BPD at an accuracy of 87.5% (95%CI: 72.5–95.3%), sensitivity of 86.4% (95%CI: 64.0–96.4%), and specificity of 88.9% (95%CI: 63.9–98.0%) in the test data (p = 0.0022). Conclusions A combination of structural and functional MRI can be of added value in the construction of SVM classifiers to aid in the accurate identification of BPD in the clinic.

Machine Learning about Treatment Effect Heterogeneity: The Case of Household Energy Use

2021 ◽  
Vol 111 ◽  
pp. 440-444
Author(s):  
Christopher R. Knittel ◽  
Samuel Stolper
Keyword(s):  
Machine Learning ◽  
Energy Use ◽  
Machine Learning Techniques ◽  
Response To Treatment ◽  
Heterogeneous Treatment Effects ◽  
Household Energy ◽  
Learning Techniques ◽  
Home Value ◽  
Pre Treatment ◽  
Effect Heterogeneity

We use causal forests to evaluate the heterogeneous treatment effects (TEs) of repeated behavioral nudges toward household energy conservation. The average response to treatment is a monthly electricity reduction of 9 kilowatt-hours (kWh), but the full distribution of responses ranges from -40 to +10 kWh. Households learn to reduce more over time, conditional on having responded in year one. Pre-treatment consumption and home value are the most commonly used predictors in the forest. The results suggest the ability to use machine learning techniques for improved targeting and tailoring of treatment.

scholarly journals Identification of bipolar disorder using a combination of multimodality magnetic resonance imaging and machine learning techniques

2020 ◽  
Author(s):  
Hao Li ◽  
Liqian Cui ◽  
Liping Cao ◽  
Yizhi Zhang ◽  
Yueheng Liu ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bipolar Disorder ◽  
Functional Mri ◽  
Added Value ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Accurate Identification ◽  
Learning Techniques ◽  
Svm Model

Abstract Background: Bipolar disorder (BPD) is a common mood disorder that is often goes misdiagnosed or undiagnosed for years. Recently, machine learning techniques have been combined with neuroimaging methods to aid in the diagnosis of BPD. However, most studies have focused on the construction of classifiers based on single-modality MRI. Hence, in this study, we aimed to construct a support vector machine (SVM) model using a combination of structural and functional MRI, which could be used to accurately identify patients with BPD.Methods: In total, 44 patients with BPD and 36 healthy controls were enrolled in the study. Clinical evaluation and MRI scans were performed for each subject. Next, image pre-processing, voxel-based morphometry (VBM), and ReHo analyses were performed. The ReHo values of each subject in the clusters showing significant differences were extracted. Further, LASSO approach was recruited to screen features. Based on selected features, the SVM model was established, and discriminant analysis was performed.Results: After using the two-sample t-test with multiple comparisons, a total of 8 clusters were extracted from the data (VBM = 6; ReHo = 2). Next, we used both VBM and ReHo data to construct the new SVM classifier, which could effectively identify patients with BPD at an accuracy of 87.5%, sensitivity of 86.4%, and specificity of 88.9% in the test data (p=0.0022).Conclusions: A combination of structural and functional MRI can be of added value in the construction of SVM classifiers to aid in the accurate identification of BPD in the clinic.

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