scholarly journals The TVGH-NYCU Thal-Classifier: Development of a Machine-Learning Classifier for Differentiating Thalassemia and Non-Thalassemia Patients

Diagnostics ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1725
Author(s):  
Yi-Kai Fu ◽  
Hsueng-Mei Liu ◽  
Li-Hsuan Lee ◽  
Ying-Ju Chen ◽  
Sheng-Hsuan Chien ◽  
...  
Keyword(s):  
Machine Learning ◽  
Error Rate ◽  
Primary Care Physicians ◽  
Microcytic Anemia ◽  
Machine Learning Techniques ◽  
Average Error ◽  
Classification Error ◽  
Support Vector ◽  
Predictive Values ◽  
Cell Counts

Thalassemia and iron deficiency are the most common etiologies for microcytic anemia and there are indices discriminating both from common laboratory simple automatic counters. In this study a new classifier for discriminating thalassemia and non-thalassemia microcytic anemia was generated via combination of exciting indices with machine-learning techniques. A total of 350 Taiwanese adult patients whose anemia diagnosis, complete blood cell counts, and hemoglobin gene profiles were retrospectively reviewed. Thirteen prior established indices were applied to current cohort and the sensitivity, specificity, positive and negative predictive values were calculated. A support vector machine (SVM) with Monte-Carlo cross-validation procedure was adopted to generate the classifier. The performance of our classifier was compared with original indices by calculating the average classification error rate and area under the curve (AUC) for the sampled datasets. The performance of this SVM model showed average AUC of 0.76 and average error rate of 0.26, which surpassed all other indices. In conclusion, we developed a convenient tool for primary-care physicians when deferential diagnosis contains thalassemia for the Taiwanese adult population. This approach needs to be validated in other studies or bigger database.

scholarly journals Application of Various Machine Learning Techniques in Predicting Total Organic Carbon from Well Logs

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Osama Siddig ◽  
Ahmed Farid Ibrahim ◽  
Salaheldin Elkatatny
Keyword(s):  
Machine Learning ◽  
Organic Carbon ◽  
Total Organic Carbon ◽  
The Other ◽  
Well Logs ◽  
Machine Learning Techniques ◽  
Percentage Error ◽  
Average Error ◽  
Support Vector ◽  
Empirical Correlations

Unconventional resources have recently gained a lot of attention, and as a consequence, there has been an increase in research interest in predicting total organic carbon (TOC) as a crucial quality indicator. TOC is commonly measured experimentally; however, due to sampling restrictions, obtaining continuous data on TOC is difficult. Therefore, different empirical correlations for TOC have been presented. However, there are concerns about the generalization and accuracy of these correlations. In this paper, different machine learning (ML) techniques were utilized to develop models that predict TOC from well logs, including formation resistivity (FR), spontaneous potential (SP), sonic transit time (Δt), bulk density (RHOB), neutron porosity (CNP), gamma ray (GR), and spectrum logs of thorium (Th), uranium (Ur), and potassium (K). Over 1250 data points from the Devonian Duvernay shale were utilized to create and validate the model. These datasets were obtained from three wells; the first was used to train the models, while the data sets from the other two wells were utilized to test and validate them. Support vector machine (SVM), random forest (RF), and decision tree (DT) were the ML approaches tested, and their predictions were contrasted with three empirical correlations. Various AI methods’ parameters were tested to assure the best possible accuracy in terms of correlation coefficient (R) and average absolute percentage error (AAPE) between the actual and predicted TOC. The three ML methods yielded good matches; however, the RF-based model has the best performance. The RF model was able to predict the TOC for the different datasets with R values range between 0.93 and 0.99 and AAPE values less than 14%. In terms of average error, the ML-based models outperformed the other three empirical correlations. This study shows the capability and robustness of ML models to predict the total organic carbon from readily available logging data without the need for core analysis or additional well interventions.

scholarly journals Classification of vulnerability levels using multivariate biomarkers in schizophrenia: a machine-learning approach

2020 ◽  
Author(s):  
Simona Caldani ◽  
François-Benoît Vialatte ◽  
Aurélien Baelde ◽  
Maria Pia Bucci ◽  
Narjes Bendjemaa ◽  
...  
Keyword(s):  
Machine Learning ◽  
Error Rate ◽  
Error Rates ◽  
Supervised Machine Learning ◽  
Classification Error ◽  
Support Vector ◽  
Neurological Soft Signs ◽  
Neurodevelopmental Disease ◽  
Multimodal Features ◽  
Early Intervention In Psychosis

Abstract Background: Schizophrenia is a heterogeneous neurodevelopmental disease involving cognitive and motor impairments. Motor dysfunctions, such as eye movements or neurological soft signs, are proposed as endophenotypic markers. Methods: Supervised machine-learning methods (Support Vector Machines) applied on oculomotor performances using comprehensive testing with prosaccades, antisaccades, memory-guided saccade tasks and smooth pursuit, as well as neurological soft signs assessment, was used to discriminate patients with schizophrenia (SZ, N=53), full siblings of patients (FS, N=45) and healthy volunteers (C, N=48). 80% of patients were used in a training/validation set and 20% on a test set. The discrimination was measured using the classification error (rate of misclassified patients).Results: The most reliable classification was between C and SZ, with only 15% and 12% of error rates for validation and test, whereas the SZ vs. FS classification provided the highest error rates (32% of error rate in both validation and test). Interestingly, neurological soft signs were selected as the best predictor, together with a combination of measures, for the two classifications: C vs. SZ, SZ vs. FS. In addition, memory-guided saccades were consistently selected among the best two multimodal features for the classifications involving the control group (C vs. SZ or FS). Conclusions: Taken together, these results emphasize the importance of neurological soft signs and sensitive oculomotor parameters, especially memory-guided saccades. This classification provides promising avenues for improving early detection of / early intervention in psychosis.

Using Machine Learning Algorithms on Prediction of Stock Price

2020 ◽  
Vol 12 (2) ◽  
pp. 84-99
Author(s):  
Li-Pang Chen
Keyword(s):  
Machine Learning ◽  
Stock Price ◽  
Short Term Memory ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Short Term ◽  
Learning Techniques ◽  
Historical Database ◽  
Long Short Term Memory

In this paper, we investigate analysis and prediction of the time-dependent data. We focus our attention on four different stocks are selected from Yahoo Finance historical database. To build up models and predict the future stock price, we consider three different machine learning techniques including Long Short-Term Memory (LSTM), Convolutional Neural Networks (CNN) and Support Vector Regression (SVR). By treating close price, open price, daily low, daily high, adjusted close price, and volume of trades as predictors in machine learning methods, it can be shown that the prediction accuracy is improved.

A Comparative Study of Different Machine Learning Algorithms for Disease Prediction

2017 ◽  
Vol 7 (7) ◽  
pp. 172
Author(s):  
Anantvir Singh Romana
Keyword(s):  
Machine Learning ◽  
Subsequent Treatment ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Disease Prediction ◽  
Classification Problems ◽  
Learning Techniques ◽  
Neural Network Classifiers ◽  
Diagnostic Detection

Accurate diagnostic detection of the disease in a patient is critical and may alter the subsequent treatment and increase the chances of survival rate. Machine learning techniques have been instrumental in disease detection and are currently being used in various classification problems due to their accurate prediction performance. Various techniques may provide different desired accuracies and it is therefore imperative to use the most suitable method which provides the best desired results. This research seeks to provide comparative analysis of Support Vector Machine, Naïve bayes, J48 Decision Tree and neural network classifiers breast cancer and diabetes datsets.

Structure-Based Virtual Screening of Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) as Endocrine Disruptors of Androgen Receptor Activity Using Molecular Docking and Machine Learning

2020 ◽  
Author(s):  
Azhagiya Singam Ettayapuram Ramaprasad ◽  
Phum Tachachartvanich ◽  
Denis Fourches ◽  
Anatoly Soshilov ◽  
Jennifer C.Y. Hsieh ◽  
...  
Keyword(s):  
Machine Learning ◽  
Molecular Docking ◽  
Androgen Receptor ◽  
Endocrine Disruptors ◽  
Hormone Receptors ◽  
Steroid Hormone Receptors ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Polyfluoroalkyl Substances ◽  
Perfluoroalkyl And Polyfluoroalkyl Substances

Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) pose a substantial threat as endocrine disruptors, and thus early identification of those that may interact with steroid hormone receptors, such as the androgen receptor (AR), is critical. In this study we screened 5,206 PFASs from the CompTox database against the different binding sites on the AR using both molecular docking and machine learning techniques. We developed support vector machine models trained on Tox21 data to classify the active and inactive PFASs for AR using different chemical fingerprints as features. The maximum accuracy was 95.01% and Matthew’s correlation coefficient (MCC) was 0.76 respectively, based on MACCS fingerprints (MACCSFP). The combination of docking-based screening and machine learning models identified 29 PFASs that have strong potential for activity against the AR and should be considered priority chemicals for biological toxicity testing.

Binary Spectrum Feature for Improved Classifier Performance

2020 ◽  
Author(s):  
Nalika Ulapane ◽  
Karthick Thiyagarajan ◽  
sarath kodagoda
Keyword(s):  
Machine Learning ◽  
Classification Performance ◽  
Feature Reduction ◽  
Sensor Data ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Svm Classifier ◽  
Monitoring Task ◽  
Classifier Performance ◽  
Spectrum Feature

<div>Classification has become a vital task in modern machine learning and Artificial Intelligence applications, including smart sensing. Numerous machine learning techniques are available to perform classification. Similarly, numerous practices, such as feature selection (i.e., selection of a subset of descriptor variables that optimally describe the output), are available to improve classifier performance. In this paper, we consider the case of a given supervised learning classification task that has to be performed making use of continuous-valued features. It is assumed that an optimal subset of features has already been selected. Therefore, no further feature reduction, or feature addition, is to be carried out. Then, we attempt to improve the classification performance by passing the given feature set through a transformation that produces a new feature set which we have named the “Binary Spectrum”. Via a case study example done on some Pulsed Eddy Current sensor data captured from an infrastructure monitoring task, we demonstrate how the classification accuracy of a Support Vector Machine (SVM) classifier increases through the use of this Binary Spectrum feature, indicating the feature transformation’s potential for broader usage.</div><div><br></div>

Big Data to Knowledge: Application of Machine Learning to Predictive Modeling of Therapeutic Response in Cancer.

2020 ◽  
Vol 21 ◽  
Author(s):  
Sukanya Panja ◽  
Sarra Rahem ◽  
Cassandra J. Chu ◽  
Antonina Mitrofanova
Keyword(s):  
Machine Learning ◽  
Missing Values ◽  
Therapeutic Response ◽  
Patient Data ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Complex Data ◽  
Human Machine Interaction ◽  
Data Repositories ◽  
Response Modeling

Background: In recent years, the availability of high throughput technologies, establishment of large molecular patient data repositories, and advancement in computing power and storage have allowed elucidation of complex mechanisms implicated in therapeutic response in cancer patients. The breadth and depth of such data, alongside experimental noise and missing values, requires a sophisticated human-machine interaction that would allow effective learning from complex data and accurate forecasting of future outcomes, ideally embedded in the core of machine learning design. Objective: In this review, we will discuss machine learning techniques utilized for modeling of treatment response in cancer, including Random Forests, support vector machines, neural networks, and linear and logistic regression. We will overview their mathematical foundations and discuss their limitations and alternative approaches all in light of their application to therapeutic response modeling in cancer. Conclusion: We hypothesize that the increase in the number of patient profiles and potential temporal monitoring of patient data will define even more complex techniques, such as deep learning and causal analysis, as central players in therapeutic response modeling.

A Review on Machine-Learning Based Code Smell Detection Techniquesin Object-Oriented Software System(s)

2020 ◽  
Vol 13 ◽  
Author(s):  
Amandeep Kaur ◽  
Sushma Jain ◽  
Shivani Goel ◽  
Gaurav Dhiman
Keyword(s):  
Machine Learning ◽  
Programming Languages ◽  
Software Quality ◽  
Empirical Studies ◽  
Statistical Testing ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Code Smells ◽  
Detection Techniques ◽  
Code Smell

Context: Code smells are symptoms, that something may be wrong in software systems that can cause complications in maintaining software quality. In literature, there exists many code smells and their identification is far from trivial. Thus, several techniques have also been proposed to automate code smell detection in order to improve software quality. Objective: This paper presents an up-to-date review of simple and hybrid machine learning based code smell detection techniques and tools. Methods: We collected all the relevant research published in this field till 2020. We extracted the data from those articles and classified them into two major categories. In addition, we compared the selected studies based on several aspects like, code smells, machine learning techniques, datasets, programming languages used by datasets, dataset size, evaluation approach, and statistical testing. Results: Majority of empirical studies have proposed machine- learning based code smell detection tools. Support vector machine and decision tree algorithms are frequently used by the researchers. Along with this, a major proportion of research is conducted on Open Source Softwares (OSS) such as, Xerces, Gantt Project and ArgoUml. Furthermore, researchers paid more attention towards Feature Envy and Long Method code smells. Conclusion: We identified several areas of open research like, need of code smell detection techniques using hybrid approaches, need of validation employing industrial datasets, etc.

scholarly journals Predictive Modelling of Employee Turnover in Indian IT Industry Using Machine Learning Techniques

2019 ◽  
Vol 23 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Shikha N. Khera ◽  
Divya
Keyword(s):  
Machine Learning ◽  
Learning Algorithm ◽  
Confusion Matrix ◽  
Predictive Modelling ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
It Industry ◽  
Knowledge Based ◽  
Employee Attrition

Information technology (IT) industry in India has been facing a systemic issue of high attrition in the past few years, resulting in monetary and knowledge-based loses to the companies. The aim of this research is to develop a model to predict employee attrition and provide the organizations opportunities to address any issue and improve retention. Predictive model was developed based on supervised machine learning algorithm, support vector machine (SVM). Archival employee data (consisting of 22 input features) were collected from Human Resource databases of three IT companies in India, including their employment status (response variable) at the time of collection. Accuracy results from the confusion matrix for the SVM model showed that the model has an accuracy of 85 per cent. Also, results show that the model performs better in predicting who will leave the firm as compared to predicting who will not leave the company.

scholarly journals Forecasting and trading cryptocurrencies with machine learning under changing market conditions

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Helder Sebastião ◽  
Pedro Godinho
Keyword(s):  
Machine Learning ◽  
Linear Models ◽  
Test Sample ◽  
Trading Strategies ◽  
Network Activity ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Success Rates ◽  
Market Conditions ◽  
Sharpe Ratios

AbstractThis study examines the predictability of three major cryptocurrencies—bitcoin, ethereum, and litecoin—and the profitability of trading strategies devised upon machine learning techniques (e.g., linear models, random forests, and support vector machines). The models are validated in a period characterized by unprecedented turmoil and tested in a period of bear markets, allowing the assessment of whether the predictions are good even when the market direction changes between the validation and test periods. The classification and regression methods use attributes from trading and network activity for the period from August 15, 2015 to March 03, 2019, with the test sample beginning on April 13, 2018. For the test period, five out of 18 individual models have success rates of less than 50%. The trading strategies are built on model assembling. The ensemble assuming that five models produce identical signals (Ensemble 5) achieves the best performance for ethereum and litecoin, with annualized Sharpe ratios of 80.17% and 91.35% and annualized returns (after proportional round-trip trading costs of 0.5%) of 9.62% and 5.73%, respectively. These positive results support the claim that machine learning provides robust techniques for exploring the predictability of cryptocurrencies and for devising profitable trading strategies in these markets, even under adverse market conditions.

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