scholarly journals Pericardial NT-Pro-BNP and GDF-15 as Biomarkers of Atrial Fibrillation and Atrial Matrix Remodeling in Aortic Stenosis

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1422
Author(s):  
Mariana Fragão-Marques ◽  
Isaac Barroso ◽  
Rui Farinha ◽  
Isabel M Miranda ◽  
Diana Martins ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Tertiary Hospital ◽  
Pericardial Fluid ◽  
Matrix Remodeling ◽  
Biological Matrices ◽  
Replacement Surgery ◽  
Col3a1 Gene ◽  
Valve Replacement Surgery

Aims: This study aimed to evaluate the association of GDF-15 and NT-pro-BNP in two different biological matrices with AF in severe aortic stenosis patients undergoing aortic valve replacement surgery (AVR), its association with atrial matrix remodeling, as well as with 30-day postoperative outcomes. Main Methods: One hundred and twenty-six patients between 2009 and 2019 with severe aortic stenosis undergoing AVR surgery in a tertiary hospital were assessed. Key Findings: pericardial fluid GDF-15 and pericardial fluid and serum NT-pro-BNP were increased in AF patients with aortic stenosis. COL1A1 and COL3A1 gene expression increased when pericardial fluid NT-pro-BNP values were higher. TIMP4 was positively correlated with pericardial fluid GDF-15. Significance: GDF-15 and NT-pro-BNP in the pericardial fluid are biomarkers of atrial fibrillation in aortic stenosis and correlate with atrial matrix remodeling. AKI is predicted by both serum and pericardial fluid GDF-15.

scholarly journals Atrial Matrix Remodeling in Atrial Fibrillation Patients With Aortic Stenosis

2020 ◽  
Author(s):  
Mariana Fragão-Marques ◽  
I Miranda ◽  
D Martins ◽  
Isaac Barroso ◽  
C Mendes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atrial Fibrillation ◽  
Extracellular Matrix ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Tertiary Hospital ◽  
Matrix Remodeling ◽  
Matrix Gene ◽  
Collagen Iii

Abstract Background: This study aimed to evaluate atrium extracellular matrix remodeling in Atrial fibrillation (AF) patients with severe aortic stenosis, through histological fibrosis quantification and extracellular matrix gene expression analysis, as well as serum quantification of selected protein targets. Methods: A posthoc analysis of a prospective study was performed in a cohort of aortic stenosis patients. Between 2014 and 2019, 56 patients with severe aortic stenosis submitted to Aortic valve replacement (AVR) surgery in a tertiary hospital were selected. Results: Fibrosis was significantly increased in the AF group when compared to Sinus Rhythm (SR) patients (p=0.024). Moreover, cardiomyocyte area was significantly higher in AF patients vs SR patients (p=0.008). Conversely, collagen III gene expression was increased in AF patients (p=0.038). TIMP1 was less expressed in the atria of AF patients. MMP16/TIMP4 ratio was significantly decreased in AF patients (p=0.006). TIMP1 (p=0.004) and TIMP2 (p=0.012) were significantly increased in the serum of AF patients. Aortic valve maximum (p=0.0159) and mean (p=0.031) gradients demonstrated a negative association with serum TIMP1. Conclusion: Atrial fibrillation patients with severe aortic stenosis present increased atrial fibrosis and collagen type III synthesis, with extracellular matrix remodelling demonstrated by a decrease in the MMP16/TIMP4 ratio, along with an increased serum TIMP1 and TIMP2 proteins.

scholarly journals Atrial matrix remodeling in atrial fibrillation patients with aortic stenosis

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Mariana Fragão-Marques ◽  
I. Miranda ◽  
D. Martins ◽  
I. Barroso ◽  
C. Mendes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atrial Fibrillation ◽  
Extracellular Matrix ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Tertiary Hospital ◽  
Matrix Remodeling ◽  
Matrix Gene ◽  
Collagen Iii

Abstract Background This study aimed to evaluate atrium extracellular matrix remodeling in atrial fibrillation (AF) patients with severe aortic stenosis, through histological fibrosis quantification and extracellular matrix gene expression analysis, as well as serum quantification of selected protein targets. Methods A posthoc analysis of a prospective study was performed in a cohort of aortic stenosis patients. Between 2014 and 2019, 56 patients with severe aortic stenosis submitted to aortic valve replacement surgery in a tertiary hospital were selected. Results Fibrosis was significantly increased in the AF group when compared to sinus rhythm (SR) patients (p = 0.024). Moreover, cardiomyocyte area was significantly higher in AF patients versus SR patients (p = 0.008). Conversely, collagen III gene expression was increased in AF patients (p = 0.038). TIMP1 was less expressed in the atria of AF patients. MMP16/TIMP4 ratio was significantly decreased in AF patients (p = 0.006). TIMP1 (p = 0.004) and TIMP2 (p = 0.012) were significantly increased in the serum of AF patients. Aortic valve maximum (p = 0.0159) and mean (p = 0.031) gradients demonstrated a negative association with serum TIMP1. Conclusions Atrial fibrillation patients with severe aortic stenosis present increased atrial fibrosis and collagen type III synthesis, with extracellular matrix remodelling demonstrated by a decrease in the MMP16/TIMP4 ratio, along with an increased serum TIMP1 and TIMP2 proteins.

Adverse remodeling in atrial fibrillation following isolated aortic valve replacement surgery

Perfusion ◽  
2020 ◽  
pp. 026765912094921
Author(s):  
João Pedro Oliveira ◽  
Mariana Fragão-Marques ◽  
André Lourenço ◽  
Inês Falcão-Pires ◽  
Adelino Leite-Moreira
Keyword(s):  
Atrial Fibrillation ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Aortic Valve Replacement ◽  
Valve Replacement ◽  
Ventricular Remodeling ◽  
Severe Aortic Stenosis ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

Background: Atrial fibrillation (AF) is the most common arrhythmia with adverse clinical outcomes. Aortic valve replacement (AVR) is one of the most frequently performed cardiac surgeries, although there is scarce evidence on arrhythmic outcomes. We aimed to evaluate AF during the first year post- isolated aortic valve replacement surgery and its clinical, analytical, and echocardiographic predictors. Methods: Severe aortic stenosis patients with no prior atrial fibrillation submitted to isolated aortic valve replacement surgery were included in our study, of which 316 remained in sinus rhythm and 24 developed AF. We performed logistic regression searching for AF predictors and a longitudinal comparison between pre and post-operative echocardiographic data. Results: Postoperative AF (POAF), diabetes, and follow-up indexed Left Atrium Diameter (iLAD) were significantly higher in the group of patients developing AF. POAF and iLAD were independent AF predictors at follow-up. No differences between groups were found regarding baseline and follow-up echocardiographic data except for indexed Left Ventricle End-diastolic Diameter (LVED), which failed to decrease after surgery in the AF group. Conclusions: POAF and iLAD independently predicted AF at 1 year following isolated AVR surgery in aortic stenosis patients with no AF history. iLVED did not decrease significantly at follow-up in AF patients, possibly reflecting adverse ventricular remodeling.

scholarly journals Atrial Matrix Remodeling in Atrial Fibrillation Patients with Aortic Stenosis

2020 ◽  
Author(s):  
Mariana Fragão-Marques ◽  
I Miranda ◽  
D Martins ◽  
Isaac Barroso ◽  
C Mendes ◽  
...  
Keyword(s):  
Gene Expression ◽  
Atrial Fibrillation ◽  
Extracellular Matrix ◽  
Aortic Valve ◽  
Aortic Stenosis ◽  
Severe Aortic Stenosis ◽  
Tertiary Hospital ◽  
Matrix Remodeling ◽  
Matrix Gene ◽  
Collagen Iii

Abstract Background: This study aimed to evaluate atrium extracellular matrix remodeling in Atrial fibrillation (AF) patients with severe aortic stenosis, through histological fibrosis quantification and extracellular matrix gene expression analysis, as well as serum quantification of selected protein targets. Methods: A posthoc analysis of a prospective study was performed in a cohort of aortic stenosis patients. Between 2014 and 2019, 56 patients with severe aortic stenosis submitted to Aortic valve replacement (AVR) surgery in a tertiary hospital were selected. Results: Fibrosis was significantly increased in the AF group when compared to Sinus Rhythm (SR) patients (p=0.024). Moreover, cardiomyocyte area was significantly higher in AF patients vs SR patients (p=0.008). Conversely, collagen III gene expression was increased in AF patients (p=0.038). TIMP1 was less expressed in the atria of AF patients. MMP16/TIMP4 ratio was significantly decreased in AF patients (p=0.006). TIMP1 (p=0.004) and TIMP2 (p=0.012) were significantly increased in the serum of AF patients. Aortic valve maximum (p=0.0159) and mean (p=0.031) gradients demonstrated a negative association with serum TIMP1. Conclusion: Atrial fibrillation patients with severe aortic stenosis present increased atrial fibrosis and collagen type III synthesis, with extracellular matrix remodelling demonstrated by a decrease in the MMP16/TIMP4 ratio, along with an increased serum TIMP1 and TIMP2 proteins.

scholarly journals Transvalvular Flow, Sex, and Survival After Valve Replacement Surgery in Patients With Severe Aortic Stenosis

2020 ◽  
Vol 75 (16) ◽  
pp. 1897-1909 ◽  
Author(s):  
Ezequiel Guzzetti ◽  
Anthony Poulin ◽  
Mohamed-Salah Annabi ◽  
Bin Zhang ◽  
Dimitri Kalavrouziotis ◽  
...  
Keyword(s):  
Aortic Stenosis ◽  
Valve Replacement ◽  
Severe Aortic Stenosis ◽  
Replacement Surgery ◽  
Valve Replacement Surgery

scholarly journals Mitochondrial DNA haplogroups influence the risk of aortic stenosis

2018 ◽  
Vol 27 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Maria E. Serrano-Teruel ◽  
Maria Garcia-Vieites ◽  
Ignacio Rego-Perez ◽  
Nieves Domenech-Garcia ◽  
Francisco Blanco-Garcia ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Aortic Stenosis ◽  
Odds Ratio ◽  
Lower Risk ◽  
Protective Factor ◽  
Severe Aortic Stenosis ◽  
Replacement Surgery ◽  
Pathological Conditions ◽  
Valve Replacement Surgery ◽  
Pathophysiologic Mechanisms

Aim The underlying pathophysiologic mechanisms of aortic stenosis are not clear. Mitochondrial dysfunction plays a role in many pathological conditions including cardiac diseases. We aimed to analyze the mitochondrial DNA haplogroups in a group of patients undergoing valve replacement surgery due to severe aortic stenosis. Methods Mitochondrial DNA haplogroups were assessed in 176 patients with severe aortic stenosis and 308 control subjects. Cardiovascular risk factors and demographics were similar in both groups. Results Patients carrying haplogroup Uk had a lower risk of developing aortic stenosis, especially compared to patients carrying haplogroup H (odds ratio = 0.507; 95% confidence interval: 0.270–0.952, p = 0.035). Conclusions Mitochondrial DNA haplogroups could be involved in the development of severe aortic stenosis. Specifically, haplogroup H could be a risk factor and Uk a protective factor for severe aortic stenosis in a population from Spain.

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