scholarly journals Comparative Study on Epstein-Barr Virus-Positive Mucocutaneous Ulcer and Methotrexate-Associated Lymphoproliferative Disorders Developed in the Oral Mucosa: A Case Series of 10 Patients and Literature Review

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1375
Author(s):  
Kyoichi Obata ◽  
Tatsuo Okui ◽  
Sawako Ono ◽  
Koki Umemori ◽  
Shoji Ryumon ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Case Series ◽  
Underlying Disease ◽  
Immunosuppressive Drugs ◽  
Barr Virus ◽  
Ebv Infection ◽  
Number Of Patients ◽  
Epstein Barr

Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is an iatrogenic immunodeficiency-associated lymphoproliferative disorder that occurs mainly with MTX use. This disorder has been associated with Epstein-Barr virus (EBV) infection. In 2017, the WHO newly defined the disease concept of EBV-positive mucocutaneous ulcer (EBV-MCU) as a good-prognosis EBV-related disease. Here, we report 10 cases of MTX-LPD or EBV-MCU in the oral mucosa. This retrospective, observational study was conducted with MTX-LPD or EBV-MCU in the oral mucosa patients who visited us during the nine year period from 2012 to 2021. We gathered the basic information, underlying disease, histopathological evaluation, treatment and prognosis for the subjects. All were being treated with MTX for rheumatoid arthritis. EBV infection was positive in all cases by immunohistochemistry. A complete or partial response was obtained in all cases with the withdrawal of MTX. Our results suggests that the most common risk factor for developing EBV-MCU is the use of immunosuppressive drugs. The most common site of onset is the oral mucosa, which may be attributed to the mode of EBV infection and the high incidence of chronic irritation of the oral mucosa. A small number of patients had been diagnosed with MTX-LPD, but we consider that these cases were EBV-MCU based on our study.

Hydroa vacciniforme-like lymphoproliferative disorder in Ecuadorian children: A case series

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Eduardo Garzón ◽  
John Jairo Dávila-Rodríguez
Keyword(s):  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Case Series ◽  
Epstein Barr Virus Infection ◽  
Histopathologic Examination ◽  
Barr Virus ◽  
Solar Exposure ◽  
Hydroa Vacciniforme ◽  
Epstein Barr ◽  
Barr Virus Infection

We report the clinical and histopathological features of hydroa vacciniforme-like lymphoproliferative disorder in five indigenous and Mestizo children. All the children resided at higher altitudes, experiencing maximal solar exposure. All cases presented with prurigo along with Epstein-Barr virus infection. Histopathologic examination showed an atypical, CD30 + lymphocytic infiltrate with angiocentricity in all, while three cases demonstrated panniculitis-like infiltrate.

scholarly journals Sever hepatitis induced by Epstein-Barr virus: case series

2018 ◽  
Vol 31 (1) ◽  
pp. 44-46
Author(s):  
Mohammad Reza Hasanjani Roushan ◽  
Mostafa Javanian ◽  
Zahra Aliramaji ◽  
Soheil Ebrahimpour
Keyword(s):  
Epstein Barr Virus ◽  
Case Series ◽  
Liver Function Tests ◽  
Case Histories ◽  
Respiratory Complications ◽  
Serological Tests ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Current Report

AbstractEpstein-Barr virus (EBV) is a causative agent of infectious mononucleosis syndrome. This infection often resolves over a period of several months without outcomes, but may occasionally be complicated by a great variety of neurologic, hepatic, hematologic and respiratory complications. In the current report, we present the case histories of three patients with acute hepatitis following EBV infection when previously healthy. The patients showed fever, nausea, weakness, as well as yellowing of the skin, and then in the course of examination, sore throat. They were managed supportively and their clinical condition improved. Liver function tests such as ALT, AST, ALP, were undertaken and bilirubin were elevated. The serological tests for EBV infection were consistent with the acute phase of infection. The monospot test was also positive. The patients were managed supportively, and their critical condition was improved.

scholarly journals Features of Chronic Active Epstein-Barr virus Infection and Related Human Diseases

2011 ◽  
Vol 5 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Motohiko Okano
Keyword(s):  
Poor Prognosis ◽  
Lymphoproliferative Disorder ◽  
Epstein Barr Virus ◽  
Nk Cell ◽  
Epstein Barr Virus Infection ◽  
Barr Virus ◽  
Ebv Infection ◽  
Epstein Barr ◽  
Barr Virus Infection ◽  
Symptoms And Signs

A chronic undefined illness characterized by infectious mononucleosis (IM)-like symptoms and signs, possibly associated with Epstein-Barr virus (EBV) infection, designated as so-called chronic active EBV infection (CAEBV), is focused and discussed in this mini-review. Patients with CAEBV often develop T cell lymphoproliferative disorder (LPD)/lymphoma or NK cell LPD/lymphoma. Unique manifestations with generally poor prognosis of the disease prompt us to understand in particular the entity, diagnosis and treatment.

scholarly journals Clinical features and outcomes of brucellosis complicated with Epstein-Barr virus infection

2019 ◽  
Author(s):  
Hai Jiang ◽  
Chaoxia Sun ◽  
Hongyan Zhao ◽  
Xiuying Ni ◽  
Li Zhao ◽  
...  
Keyword(s):  
Epstein Barr Virus ◽  
Antiviral Treatment ◽  
Clinical Manifestations ◽  
Control Group ◽  
Epstein Barr Virus Infection ◽  
Observation Group ◽  
Barr Virus ◽  
Ebv Infection ◽  
Number Of Patients ◽  
Epstein Barr

Abstract Objective To analyze the clinical, laboratory characteristics and prognosis of brucellosis patients with co-existing Epstein-Barr virus (EBV) infection at a major hospital in Shandong, a brucellosis epidemic region of China.Methods A total of 576 inpatients diagnosed with brucellosis at Yidu Central Hospital, between July 2013 and July 2018, were selected and tested for EBV DNA. 22 patients were found to be positive for co-infection with EBV. The clinical data of these 22 patients (observation group) and 100 patients (control group) with only brucellosis were retrospectively compared.Results The observation group (the group with the EBV co-infection) had more severe clinical manifestations in the form of fever, headache, and hepatosplenomegaly. Further, the observation group also had a significantly higher number of patients with elevated alanine transaminase(ALT) and aspartate-aminotransferase (AST), reduced WBC, and elevated PLT count. The incidence of abnormal levels of cardiac enzyme was also significantly higher in the observation group, as was the recovery time and average hospitalization period.Conclusions It is important to consider EBV infection and other potentially latent viral infections in patients with brucellosis, as these infections can further complicate the disease course. Further, patients diagnosed with a co-infection should be administered combined antibacterial and antiviral treatment and kept under observation and followed up for a longer period.

Epstein-Barr Virus in Patients with Chronic Lymphocytic Leukemia.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2113-2113
Author(s):  
Apostolia-Maria Tsimberidou ◽  
Michael J. Keating ◽  
Carlos Bueso-Ramos ◽  
Razelle Kurzrock
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Epstein Barr Virus ◽  
Lymphocytic Leukemia ◽  
Cancer Center ◽  
University Of Texas ◽  
Barr Virus ◽  
Ebv Infection ◽  
Number Of Patients ◽  
Epstein Barr ◽  
The University

Abstract Purpose: The Epstein-Barr virus (EBV) is implicated in the development of Richter’s transformation in patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). The objective of this study was to assess the incidence and the clinical significance of EBV in patients with CLL/SLL. Patients and Methods: Patients with CLL/SLL who presented at The University of Texas M. D. Anderson Cancer Center over a two-year period, and had available marrow paraffin blocks were studied for evidence of EBV infection using a highly specific in-situ hybridization assay for detection of EBV encoded RNA (EBERs). Results were analyzed in relation to other presenting characteristics and outcome. Results: Thirty-two patients were examined. EBERs were detected in 12 of 32 (38%) CLL/SLL marrows versus 0 of 20 normal marrows (p = 0.002). EBERs were observed in sporadic granulocytes alone or in addition to its presence in lymphocytes in nine of the twelve EBV-positive patients. EBERs were detected less frequently in patients with Rai stage 0-1 disease (20%) compared with Rai stage 2–4 (66%; p=0.008); EBER-positive patients tended to have higher lactate dehydrogenase (LDH) levels (p=0.053). The 10-year survival rate was 22% versus 58% for patients with and without discernible EBERs (log-rank, p=0.08). Figure Figure Conclusions: Evidence of EBV infection was found in 38% of CLL/SLL patients assessed. Despite the small number of patients tested, discernable EBERs were significantly more common in individuals with more advanced Rai stage, and there was a trend toward shorter survival in patients in whom EBV EBERs were discerned. Larger studies are needed to determine the prognostic value and role of EBV infection in patients with CLL/SLL.

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