scholarly journals Quantitative Multispectral Imaging Differentiates Melanoma from Seborrheic Keratosis

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1315
Author(s):  
Szabolcs Bozsányi ◽  
Klára Farkas ◽  
András Bánvölgyi ◽  
Kende Lőrincz ◽  
Luca Fésűs ◽  
...  
Keyword(s):  
Multispectral Imaging ◽  
Benign Lesion ◽  
Particle Analysis ◽  
Autofluorescence Imaging ◽  
Seborrheic Keratosis ◽  
Imaging Device ◽  
Melanocytic Tumor ◽  
The Everyday ◽  
High Fluorescence ◽  
Diffuse Reflectance Imaging

Melanoma is a melanocytic tumor that is responsible for the most skin cancer-related deaths. By contrast, seborrheic keratosis (SK) is a very common benign lesion with a clinical picture that may resemble melanoma. We used a multispectral imaging device to distinguish these two entities, with the use of autofluorescence imaging with 405 nm and diffuse reflectance imaging with 525 and 660 narrow-band LED illumination. We analyzed intensity descriptors of the acquired images. These included ratios of intensity values of different channels, standard deviation and minimum/maximum values of intensity of the lesions. The pattern of the lesions was also assessed with the use of particle analysis. We found significantly higher intensity values in SKs compared with melanoma, especially with the use of the autofluorescence channel. Moreover, we found a significantly higher number of particles with high fluorescence in SKs. We created a parameter, the SK index, using these values to differentiate melanoma from SK with a sensitivity of 91.9% and specificity of 57.0%. In conclusion, this imaging technique is potentially applicable to distinguish melanoma from SK based on the analysis of various quantitative parameters. For this application, multispectral imaging could be used as a screening tool by general physicians and non-experts in the everyday practice.

scholarly journals Congenital Simple Hamartoma of Retinal Pigment Epithelium: Clinical and Imaging Findings

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Mehmet Yasin Teke ◽  
Pinar Ç. Özdal ◽  
Figen Batioglu ◽  
Ufuk Elgin ◽  
Faruk Öztürk
Keyword(s):  
Retinal Pigment Epithelium ◽  
Pigment Epithelium ◽  
Benign Lesion ◽  
Fundus Autofluorescence ◽  
Retinal Pigment ◽  
Autofluorescence Imaging ◽  
Imaging Findings ◽  
Characteristic Finding ◽  
Tumor Margins ◽  
Surface Optical

Congenital simple hamartoma of retinal pigment epithelium (CSHRPE) is a rare, asymptomatic, and incidentally detected benign lesion. However, it is very important to do the differential diagnosis from other pigmented retinal lesions. Its clinical presentation and imaging findings are very helpful in doing this differentiation. This paper presents clinical and imaging findings of a 56-year-old woman with incidentally detected CSHRPE. The lesion was small, heavily pigmented, well circumscribed, and slightly elevated. Optical coherence tomography (OCT) scanning was diagnostic and showed an elevated retina at the site of the lesion, increased optical reflectivity on its inner surface, optical shadowing of deeper structures, and clearly cut tumor margins. Ocular ultrasonography, fluorescein angiography, and fundus autofluorescence imaging which is firstly described in this report did not show any characteristic finding.

Detection of bacteria in burn wounds with a novel handheld autofluorescence wound imaging device: a pilot study

2019 ◽  
Vol 28 (8) ◽  
pp. 548-554
Author(s):  
Anouk Pijpe ◽  
Yildiz Ozdemir ◽  
Jan C. Sinnige ◽  
Kelly A.A. Kwa ◽  
Esther Middelkoop ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Fluorescence Imaging ◽  
Bacterial Load ◽  
Imaging Device ◽  
Predictive Values ◽  
Burn Wounds ◽  
Colony Forming Units ◽  
High Fluorescence ◽  
Sensitivity Specificity ◽  
Larger Sample

Objective: To compare the detection of bacteria in burn wounds between an bacterial fluorescence imaging device MolecuLight i:X, (Canada), and standard microbiological swabs. Methods: Wounds were swabbed three times on one occasion; once with a standard swab, once with a high-fluorescent area swab, indicating a bacterial load >104 colony-forming units (CFU)/gram and a finally with a non-fluorescent (nF) area swab. Proportion agreement of the microbiological results was calculated and the accuracy of the device to detect relevant bacteria was assessed. Results: A total of 14 patients with 20 wounds participated in the study. Median post-burn day at sampling time was 21 days. Of the 20 wounds, nine had a positive swab result in either of the three swabs, and 11 showed a highfluorescent area. Overall, positive and negative proportion agreement between standard swab and high-fluorescent swab sample results were 100%. Sensitivity, specificity, positive and negative predictive values of presence of high-fluorescence were 78%, 64%, 64%, and 78%, respectively. For Pseudomonas aeruginosa detection, these results were 100%, 70%, 44% and 100%, respectively. Conclusion: The diagnostic accuracy of the bacterial fluorescence imaging device to detect relevant bacteria in burn wounds was moderate and the reliability was equal to standard swabbing. Further research in larger sample sizes and on the relevance of minimal bacterial load and its potential to help with Pseudomonas aeruginosa management is needed.

scholarly journals Over 1000 nm Near-Infrared Multispectral Imaging System for Laparoscopic In Vivo Imaging

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2649
Author(s):  
Toshihiro Takamatsu ◽  
Yuichi Kitagawa ◽  
Kohei Akimoto ◽  
Ren Iwanami ◽  
Yuto Endo ◽  
...  
Keyword(s):  
Near Infrared ◽  
Multispectral Imaging ◽  
Imaging System ◽  
Data Sets ◽  
Imaging Device ◽  
Tumor Implantation ◽  
Before And After ◽  
Validation Procedure ◽  
Leave One Out

In this study, a laparoscopic imaging device and a light source able to select wavelengths by bandpass filters were developed to perform multispectral imaging (MSI) using over 1000 nm near-infrared (OTN-NIR) on regions under a laparoscope. Subsequently, MSI (wavelengths: 1000–1400 nm) was performed using the built device on nine live mice before and after tumor implantation. The normal and tumor pixels captured within the mice were used as teaching data sets, and the tumor-implanted mice data were classified using a neural network applied following a leave-one-out cross-validation procedure. The system provided a specificity of 89.5%, a sensitivity of 53.5%, and an accuracy of 87.8% for subcutaneous tumor discrimination. Aggregated true-positive (TP) pixels were confirmed in all tumor-implanted mice, which indicated that the laparoscopic OTN-NIR MSI could potentially be applied in vivo for classifying target lesions such as cancer in deep tissues.

scholarly journals Skin cancer screening – better safe than sorry

2020 ◽  
Vol 85 ◽  
pp. 02003
Author(s):  
Marta Lange ◽  
Emilija Vija Plorina ◽  
Ilze Lihacova ◽  
Aleksandrs Derjabo ◽  
Janis Spigulis
Keyword(s):  
Cancer Screening ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Multispectral Imaging ◽  
Early Stage ◽  
Screening Method ◽  
Imaging Method ◽  
Seborrheic Keratosis ◽  
Skin Cancer Screening ◽  
Non Invasive

Skin cancer is the most common type of cancers. In Latvia, on average there are approximately 200 new melanoma and 1300 non-melanoma cancer cases per year. Non-melanoma cancers are: Basal Cell Carcinoma, Squamous Cell Carcinoma and others. It is essential to discover skin cancer at an early stage when it is treatable. For this reason, a reliable, non-invasive and quantitative skin cancer screening method is necessary in order to discover skin cancer as early as possible and to help physicians such as general practitioners and dermatologists assign patients to the best treatment as soon as possible. In this article, the current skin cancer incidence as well as the screening situation in Latvia is described and a non-invasive skin screening method is proposed. The results show that this multispectral imaging method with a parameter p′ can distinguish melanoma from melanocytic nevi with sensitivity 75% and specificity 100%. Recommendations on distinguishing henangioma, seborrheic keratosis are described as well.

Polarized Multispectral Imaging for the Diagnosis of Skin Cancer

2019 ◽  
Vol 2019 (1) ◽  
pp. 381-385
Author(s):  
Laura Rey-Barroso ◽  
Francisco J. Burgos-Fernández ◽  
Santiago Royo ◽  
Susana Puig ◽  
Josep Malvehy ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Gold Standard ◽  
Multispectral Imaging ◽  
False Positives ◽  
Spectral Features ◽  
Imaging Device ◽  
Preliminary Results ◽  
Non Invasive ◽  
Comprehensive Characterization

The effective and non-invasive diagnosis of skin cancer is a hot topic in biophotonics since the current gold standard, a biopsy, is slow and costly. Non-invasive optical techniques such as polarization and multispectral imaging have arisen as powerful tools to overcome these constraints. The combination of these techniques provides a comprehensive characterization of skin chromophores including polarization, color and spectral features. Hence, in this work we propose a polarized multispectral imaging device that works from 414 nm to 995 nm and at 0º, 45º and 90º polarization configurations. Preliminary results performed over 20 nevi and 20 melanoma found statistically significant descriptors (p<0.05) that discriminated between these two lesion etiologies. A further analysis of more lesions is expected to contribute in reducing the false positives during the diagnosis process and, as a consequence, the number of necessary biopsies.

Handheld high resolution multispectral imaging device for study of Cushing syndrome (Conference Presentation)

2018 ◽  
Author(s):  
Siddharth Khare ◽  
Ali Afshari ◽  
Afrouz Anderson ◽  
Constantine A. Stratakis ◽  
Amir H. Gandjbakhche
Keyword(s):  
High Resolution ◽  
Multispectral Imaging ◽  
Cushing Syndrome ◽  
Imaging Device

scholarly journals Lensless dual-color fluorescence imaging device using hybrid filter

2021 ◽  
Author(s):  
Natcha Kulmala ◽  
Kiyotaka Sasagawa ◽  
Thanaree Treepetchkul ◽  
Hironari Takehara ◽  
Makito Haruta ◽  
...  
Keyword(s):  
Fiber Optic ◽  
Imaging System ◽  
Image Sensor ◽  
Dual Band ◽  
Hybrid Filter ◽  
Excitation Light ◽  
Imaging Device ◽  
Interference Filters ◽  
High Fluorescence ◽  
Absorption Filter

Abstract In this study, a dual-band hybrid filter that achieves high excitation light rejection performance in a lensless imaging system was fabricated and incorporated into an imaging device. The hybrid filter consisted of interference and absorption filters, and a fiber optic plate. The interference filters were attached to both sides of the fiber optic plate, which was placed on top of the absorption filter to suppress the decrease in spatial resolution. In addition, the lamination order was optimized to achieve a high fluorescence observation performance. The fabricated hybrid filter was mounted on an image sensor and had the ability to indicate the green and red fluorescence components.

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