scholarly journals Severe Cardiac and Metabolic Pathology Induced by Steroid Abuse in a Young Individual

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1313
Author(s):  
Adrian Tirla ◽  
Cosmin Mihai Vesa ◽  
Simona Cavalu
Keyword(s):  
Chronic Renal Disease ◽  
Anabolic Steroids ◽  
Organ Damage ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Healthy Individuals ◽  
Secondary Diabetes ◽  
Steroid Abuse ◽  
Myocardial Infraction ◽  
Androgenic Anabolic Steroids

Androgenic-Anabolic Steroids (AAS) abuse is known to play an important role in causing the systemic inflammatory response and multiple-organ dysfunction in healthy individuals. Although many of the undesirable effects of steroid abuse have been reported, at present, little is known about the effect of anabolic supplements and the correlation between cardiac and metabolic pathology. This paper presents a case of a 25 year old patient with a complex medical history after 6 months of steroid administration. Myocardial infraction, dyslipidemia, obesity, hyperuricemia, secondary diabetes, and chronic renal disease were identified after clinical and para-clinical examinations. The particularities of this case were interpreted in the context of a literature review, highlighting the effect of multi-organ damage as a result of the uncontrolled use of anabolic steroid supplements.

ORGAN DAMAGE IS PRECEDED BY CHANGES IN PROTEIN EXTRAVASATION IN AN EXPERIMENTAL MODEL OF THE MULTIPLE ORGAN DYSFUNCTION SYNDROME

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 10-11 ◽  
Author(s):  
Grard AP Nieuwenhuijzen ◽  
Maarten FCM Knapen ◽  
Wim JG Oyen ◽  
Thijs Hendriks ◽  
Frans HM Corstens ◽  
...  
Keyword(s):  
Experimental Model ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Organ Damage ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Protein Extravasation

ORGAN DAMAGE IS PRECEDED BY CHANGES IN PROTEIN EXTRAVASATION IN AN EXPERIMENTAL MODEL OF MULTIPLE ORGAN DYSFUNCTION SYNDROME

Shock ◽  
1997 ◽  
Vol 7 (2) ◽  
pp. 98-104 ◽  
Author(s):  
Grard A.P. Nieuwenhuijzen ◽  
Maarten F.C.M. Knapen ◽  
Wim J.G. Oyen ◽  
Thijs Hendriks ◽  
Frans H.M. Corstens ◽  
...  
Keyword(s):  
Experimental Model ◽  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Organ Damage ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Protein Extravasation

scholarly journals Where Did the Pericardial Effusion Go? A Case of Cardiopulmonary Resuscitation Acting as Treatment for Pericardial Tamponade

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Varun tej Gonuguntla ◽  
Parita Soni ◽  
Nishil Dalsania ◽  
Ravi Karan Patti ◽  
Somal Navjot ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Resuscitation ◽  
Organ Damage ◽  
Pericardial Tamponade ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Therapeutic Treatment ◽  
Life Saving ◽  
Saving Measure ◽  
Thoracic Organ

Pericardial tamponade results in multiple organ dysfunction and can lead to cardiac arrest. Cardiopulmonary resuscitation (CPR), a life-saving measure performed on patients in cardiac arrest, can lead to thoracic organ damage. However, CPR rarely acts as a therapeutic treatment for pericardial tamponade. Our case describes a patient admitted with pericardial tamponade in whom CPR provided therapeutic treatment with pericardial rupture and resolution of the tamponade.

Anabolic Steroid Abuse and Cardiac Sudden Death

2001 ◽  
Vol 125 (2) ◽  
pp. 253-255 ◽  
Author(s):  
Vittorio Fineschi ◽  
Giorgio Baroldi ◽  
Floriana Monciotti ◽  
Laura Paglicci Reattelli ◽  
Emanuela Turillazzi
Keyword(s):  
Cardiac Death ◽  
Myocardial Infarct ◽  
Anabolic Steroids ◽  
Myocardial Contraction ◽  
Vascular Lesions ◽  
Steroid Abuse ◽  
Vascular Regulation ◽  
Anabolic Steroid Abuse ◽  
Androgenic Anabolic Steroids ◽  
Cardiac Sudden Death

Abstract Context.—Androgenic anabolic steroids (AAS) used for improving physical performance have been considered responsible for acute myocardial infarction and sudden cardiac death. Objective.—To establish the relationship between AAS and cardiac death. Design.—Case report. Patients.—Two young, healthy, male bodybuilders using AAS. Main Outcome Measures.—Pathologic cardiac findings associated with AAS ingestion. Results.—The autopsy revealed normal coronary arteries. In one case, we documented a typical infarct with a histologic age of 2 weeks. A segmentation of myocardial cells at the intercalated disc level was observed in the noninfarcted region. This segmentation was the only anomaly detected in the second case. No other pathologic findings in the heart or other organs were found. Urine in both subjects contained the metabolites of nortestosterone and stanozolol. Comment.—A myocardial infarct without vascular lesions is rare. To our knowledge, its association with AAS use, bodybuilding, or both lacks any evidence of a cause-effect relationship. The histologic findings in our 2 cases and in the few others reported in medical literature are nonspecific and do not prove the cardiac toxicity of AAS. A better understanding of AAS action on the neurogenic control of the cardiac function in relation to regional myocardial contraction and vascular regulation is required.

scholarly journals Wnt-Signaling Inhibitor Wnt-C59 Suppresses the Cytokine Upregulation in Multiple Organs of Lipopolysaccharide-Induced Endotoxemic Mice via Reducing the Interaction between β-Catenin and NF-κB

2021 ◽  
Vol 22 (12) ◽  
pp. 6249
Author(s):  
Jaewoong Jang ◽  
Jaewon Song ◽  
Inae Sim ◽  
Young V. Kwon ◽  
Yoosik Yoon
Keyword(s):  
Wnt Signaling ◽  
Organ Dysfunction ◽  
Proinflammatory Cytokines ◽  
Host Response ◽  
Organ Damage ◽  
Suppressive Effect ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Multiple Organs

Sepsis is characterized by multiple-organ dysfunction caused by the dysregulated host response to infection. Until now, however, the role of the Wnt signaling has not been fully characterized in multiple organs during sepsis. This study assessed the suppressive effect of a Wnt signaling inhibitor, Wnt-C59, in the kidney, lung, and liver of lipopolysaccharide-induced endotoxemic mice, serving as an animal model of sepsis. We found that Wnt-C59 elevated the survival rate of these mice and decreased their plasma levels of proinflammatory cytokines and organ-damage biomarkers, such as BUN, ALT, and AST. The Wnt/β-catenin and NF-κB pathways were stimulated and proinflammatory cytokines were upregulated in the kidney, lung, and liver of endotoxemic mice. Wnt-C59, as a Wnt signaling inhibitor, inhibited the Wnt/β-catenin pathway, and its interaction with the NF-κB pathway, which resulted in the inhibition of NF-κB activity and proinflammatory cytokine expression. In multiple organs of endotoxemic mice, Wnt-C59 significantly reduced the β-catenin level and interaction with NF-κB. Our findings suggest that the anti-endotoxemic effect of Wnt-C59 is mediated via reducing the interaction between β-catenin and NF-κB, consequently suppressing the associated cytokine upregulation in multiple organs. Thus, Wnt-C59 may be useful for the suppression of the multiple-organ dysfunction during sepsis.

scholarly journals Short QT interval is unreliable marker of anabolic androgenic steroid abuse in competitive athletes

2012 ◽  
Vol 140 (11-12) ◽  
pp. 711-716 ◽  
Author(s):  
Vitomir Djordjevic ◽  
Ivan Stankovic ◽  
Vlahovic Stipac ◽  
Biljana Putnikovic ◽  
Aleksandar Neskovic
Keyword(s):  
Qt Interval ◽  
Anabolic Steroids ◽  
Male Athletes ◽  
Steroid Abuse ◽  
Competitive Athletes ◽  
Androgenic Anabolic Steroids ◽  
Qt Interval Duration ◽  
Synthetic Derivatives ◽  
Derivatives Of

Introduction. Previous animal and human studies provided the evidence that testosterone may affect ventricular repolarization by shortening of the QT interval. Synthetic derivatives of testosterone, modified to enhance its anabolic properties, are occasionally abused by some competitive athletes. Objective. We assessed whether the QT interval duration could discriminate androgenic anabolic steroids (AAS)-using strength athletes (SA) from drug-free endurance athletes (EA), by comparing 25 formulas for QT interval correction. Methods. We recruited 22 elite male athletes involved in long-term strength or endurance training and 20 sedentary controls. All elite

GRADUAL DEVELOPMENT OF ORGAN DAMAGE IN THE MURINE ZYMOSAN-INDUCED MULTIPLE ORGAN DYSFUNCTION SYNDROME

Shock ◽  
1997 ◽  
Vol 8 (4) ◽  
pp. 261-267 ◽  
Author(s):  
Monique J. J. M. Jansen ◽  
Thijs Hendriks ◽  
Albert A. J. Verhofstad ◽  
Wil Lange ◽  
Leo M. G. Geeraedts ◽  
...  
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Organ Damage ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction ◽  
Gradual Development

scholarly journals Anabolic–Androgenic Steroid Abuse among Gym Users, Eastern Province, Saudi Arabia

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 703
Author(s):  
Walied Albaker ◽  
Ali Alkhars ◽  
Yasir Elamin ◽  
Noor Jatoi ◽  
Dhuha Boumarah ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Adverse Effects ◽  
Anabolic Steroids ◽  
Real Problem ◽  
Eastern Province ◽  
Cross Sectional ◽  
Steroid Abuse ◽  
Awareness Programs ◽  
Education And Awareness ◽  
Androgenic Anabolic Steroids

Background and Objectives: The main aim of the present study was to assess the use of androgenic–anabolic steroids (AAS) and to investigate its potentially unfavorable effects among gym members attending gym fitness facilities in Eastern Province, Saudi Arabia. Materials and Methods: A cross-sectional questionnaire-based study was carried out during the summer of 2017. Male gym users in the Eastern Province region of Saudi Arabia were the respondents. Information on socio-demographics, use of AAS, knowledge, and awareness about its side effects were collected using a self-administered questionnaire. Results: The prevalence of AAS consumption among trainees in Eastern Province was 21.3%. The percentage was highest among those 26–30 years of age (31.9%), followed by the 21–25 (27.4%) (p = 0.003) age group. Participants in the study were not aware of the potential adverse effects of AAS use. Adverse effects experienced by 77% of AAS users include psychiatric problems (47%), acne (32.7%), hair loss (14.2%), and sexual dysfunction (10.7%). Moreover, it appears that trainers and friends are major sources (75.20%) for obtaining AAS. Conclusion: AAS abuse is a real problem among gym members, along with a lack of knowledge regarding its adverse effects. Health education and awareness programs are needed not only for trainees, but also for trainers and gym owners as they are reportedly some of the primary sources of AAS.

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